IMP

Process View

Mus musculus

9 genes annotated in mouse

mitotic spindle checkpoint

A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic spindle checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mitotic spindle checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.986
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.864	Yeast
Trp53	transformation related protein 53	0.769
Rpgrip1l	Rpgrip1-like	0.726
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.625	Fly
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.416	Yeast
Brca2	breast cancer 2	0.390
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.345	Yeast
Cdk1	cyclin-dependent kinase 1	0.279
Rnf2	ring finger protein 2	0.245
Ccnb2	cyclin B2	0.197
Prc1	protein regulator of cytokinesis 1	0.164
Sgol2	shugoshin-like 2 (S. pombe)	0.163
Cenpe	centromere protein E	0.158
Kdm2b	lysine (K)-specific demethylase 2B	0.155
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.125
Lrrk2	leucine-rich repeat kinase 2	0.122
Cdca8	cell division cycle associated 8	0.115
Ccnb1	cyclin B1	0.103	Human
Kif20a	kinesin family member 20A	0.103
Spag5	sperm associated antigen 5	0.102
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.094
Ccna2	cyclin A2	0.082
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.072	Yeast
Skp1a	S-phase kinase-associated protein 1A	0.064
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.061
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.057
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.057	Yeast
Ube2c	ubiquitin-conjugating enzyme E2C	0.056
Pot1a	protection of telomeres 1A	0.052
Ooep	oocyte expressed protein homolog (dog)	0.050
Nlrp5	NLR family, pyrin domain containing 5	0.046
Birc5	baculoviral IAP repeat-containing 5	0.040
Kif4	kinesin family member 4	0.036
Cenpk	centromere protein K	0.036
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.036
Kif2c	kinesin family member 2C	0.035
Trp63	transformation related protein 63	0.033
Depdc1a	DEP domain containing 1a	0.032
Kif22	kinesin family member 22	0.031
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.030
Set	SET nuclear oncogene	0.030
Mdm4	transformed mouse 3T3 cell double minute 4	0.028
Mki67	antigen identified by monoclonal antibody Ki 67	0.025
Melk	maternal embryonic leucine zipper kinase	0.025
Sgol1	shugoshin-like 1 (S. pombe)	0.024
Eno1	enolase 1, alpha non-neuron	0.024
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.024
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.023
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.021
Gsk3b	glycogen synthase kinase 3 beta	0.021
Ccnf	cyclin F	0.020
Kif23	kinesin family member 23	0.020
Plk1	polo-like kinase 1 (Drosophila)	0.019	Human
Mis18bp1	MIS18 binding protein 1	0.019
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.019
Aurka	aurora kinase A	0.019
Cdkn3	cyclin-dependent kinase inhibitor 3	0.019
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.019
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.018
Brca1	breast cancer 1	0.018
Hoxa13	homeobox A13	0.017
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.016
6720463M24Rik	RIKEN cDNA 6720463M24 gene	0.016
Acd	adrenocortical dysplasia	0.016
Ckap2	cytoskeleton associated protein 2	0.016
Lig4	ligase IV, DNA, ATP-dependent	0.016
Fbxo5	F-box protein 5	0.015
Cenpn	centromere protein N	0.015
Cbl	Casitas B-lineage lymphoma	0.014
Ncapg	non-SMC condensin I complex, subunit G	0.014
Cdk2	cyclin-dependent kinase 2	0.014
Kdm1a	lysine (K)-specific demethylase 1A	0.013
Hspa8	heat shock protein 8	0.013
E2f8	E2F transcription factor 8	0.013
Mdm2	transformed mouse 3T3 cell double minute 2	0.013
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.013
Scaf4	SR-related CTD-associated factor 4	0.013
Cenpf	centromere protein F	0.012
Suv39h2	suppressor of variegation 3-9 homolog 2 (Drosophila)	0.012
Fignl1	fidgetin-like 1	0.012
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.012
Mns1	meiosis-specific nuclear structural protein 1	0.012
Hist1h2bm	histone cluster 1, H2bm	0.012
Trp73	transformation related protein 73	0.012
Purb	purine rich element binding protein B	0.012
Dppa3	developmental pluripotency-associated 3	0.012
Irf6	interferon regulatory factor 6	0.011
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.011
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.011	Human
Msh2	mutS homolog 2 (E. coli)	0.011
Mastl	microtubule associated serine/threonine kinase-like	0.011
Blm	Bloom syndrome, RecQ helicase-like	0.011
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.011
Cbx8	chromobox homolog 8 (Drosophila Pc class)	0.011
Hist2h2ab	histone cluster 2, H2ab	0.011
Rbbp4	retinoblastoma binding protein 4	0.011
Hist2h4	histone cluster 2, H4	0.010
Hist1h2aa	histone cluster 1, H2aa	0.010
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.010