IMP

Process View

Rattus norvegicus

14 genes annotated in rat

ubiquitin dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ubiquitin dependent protein catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ubiquitin dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Psma5	proteasome (prosome, macropain) subunit, alpha type 5	0.993	Yeast
Psmb3	proteasome (prosome, macropain) subunit, beta type 3	0.886	Yeast
Psma4	proteasome (prosome, macropain) subunit, alpha type 4	0.722	Yeast
Psmb6	proteasome (prosome, macropain) subunit, beta type 6	0.658	Yeast
Psmb4	proteasome (prosome, macropain) subunit, beta type 4	0.609	Yeast
Psma3	proteasome (prosome, macropain) subunit, alpha type 3	0.495	Yeast
Psmc1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.487
Psma7	proteasome (prosome, macropain) subunit, alpha type 7	0.483	Yeast
Psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.346	Yeast
Psme2	proteasome (prosome, macropain) activator subunit 2	0.305
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.293
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.276	Human Yeast
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.265	Yeast
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.232	Yeast
Psmd7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.206
Psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.205
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.199
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.187
Cand1	cullin-associated and neddylation-dissociated 1	0.174
Psmb2	proteasome (prosome, macropain) subunit, beta type 2	0.171	Yeast
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.152	Yeast
Txnl1	thioredoxin-like 1	0.132
Ube2d3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.130
Psma2	proteasome (prosome, macropain) subunit, alpha type 2	0.130	Yeast
Zfand5	zinc finger, AN1-type domain 5	0.113
Nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.101
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.099	Yeast
Senp2	Sumo1/sentrin/SMT3 specific peptidase 2	0.099
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.088
Cnbp	CCHC-type zinc finger, nucleic acid binding protein	0.079
Psmb5	proteasome (prosome, macropain) subunit, beta type 5	0.079	Yeast Mouse
Ube2i	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.074
LOC362855	P55	0.065
Cdc37	cell division cycle 37 homolog (S. cerevisiae)	0.061
Psmb1	proteasome (prosome, macropain) subunit, beta type 1	0.061	Yeast
Dctn4	dynactin 4	0.060
Pomp	proteasome maturation protein	0.058
Vcp	valosin-containing protein	0.057
Pfn1	profilin 1	0.056
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.054
Alkbh5	alkB, alkylation repair homolog 5 (E. coli)	0.053
Eif2s2	eukaryotic translation initiation factor 2, subunit 2 beta	0.053
Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	0.053
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.052
Mgat2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.051
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.048	Human Mouse
Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.045
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.043
Serp1	stress-associated endoplasmic reticulum protein 1	0.043
Rab21	RAB21, member RAS oncogene family	0.042
Psma1	proteasome (prosome, macropain) subunit, alpha type 1	0.041	Yeast
Usp47	ubiquitin specific peptidase 47	0.041
Brcc3	BRCA1/BRCA2-containing complex, subunit 3	0.040
Ppp1r2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.040
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.040
Psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.040
Tollip	toll interacting protein	0.039
Ccnb1	cyclin B1	0.038
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.038	Yeast
Phax	phosphorylated adaptor for RNA export	0.037
Pdia3	protein disulfide isomerase family A, member 3	0.037
Ubc	ubiquitin C	0.036
RGD1309102	similar to TRS85 homolog	0.035
Socs6	suppressor of cytokine signaling 6	0.035
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.033
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.033
Zfp364	zinc finger protein 364	0.033	Human
Ufd1l	ubiquitin fusion degradation 1 like (yeast)	0.033
March5	membrane-associated ring finger (C3HC4) 5	0.031
Lsm14a	LSM14A, SCD6 homolog A (S. cerevisiae)	0.031
Rnf2	ring finger protein 2	0.031
Ndfip2	Nedd4 family interacting protein 2	0.029
Foxm1	forkhead box M1	0.028
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.028	Yeast
Mdm2	Mdm2 p53 binding protein homolog (mouse)	0.027
Irf1	interferon regulatory factor 1	0.027
Eif4a2	eukaryotic translation initiation factor 4A, isoform 2	0.027
Dnpep	aspartyl aminopeptidase	0.026
Usp15	ubiquitin specific peptidase 15	0.026
Rbbp7	retinoblastoma binding protein 7	0.026
Pdia4	protein disulfide isomerase family A, member 4	0.026
Txnrd1	thioredoxin reductase 1	0.025
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.024
Ifi35	interferon-induced protein 35	0.023
Rybp	RING1 and YY1 binding protein	0.023
Vapa	VAMP (vesicle-associated membrane protein)-associated protein A	0.023
LOC100364212	heterogeneous nuclear ribonucleoprotein K-like	0.023
Canx	calnexin	0.022
Pttg1	pituitary tumor-transforming 1	0.022
Usp14	ubiquitin specific peptidase 14	0.022
Tbcb	tubulin folding cofactor B	0.022
Rab11a	RAB11a, member RAS oncogene family	0.021
Rps5	ribosomal protein S5	0.021
Slc35b1	solute carrier family 35, member B1	0.021
Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.021
Ergic3	ERGIC and golgi 3	0.021
Slmap	sarcolemma associated protein	0.020
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.020
Stx12	syntaxin 12	0.020
Dnajc21	DnaJ (Hsp40) homolog, subfamily C, member 21	0.019
Ypel5	yippee-like 5 (Drosophila)	0.019
Wdr26	WD repeat domain 26	0.018
Rgs19	regulator of G-protein signaling 19	0.018
Ctxn1	cortexin 1	0.018
Plk1	polo-like kinase 1 (Drosophila)	0.018	Human Rat
Ldha	lactate dehydrogenase A	0.017
Tox4	TOX high mobility group box family member 4	0.017
Calr	calreticulin	0.017
Cdc42	cell division cycle 42 (GTP binding protein)	0.016
Nars	asparaginyl-tRNA synthetase	0.016
Mat2b	methionine adenosyltransferase II, beta	0.016
Smad4	SMAD family member 4	0.016
Mbd2	methyl-CpG binding domain protein 2	0.016
Rnf146	ring finger protein 146	0.016	Human
Ccnb2	cyclin B2	0.016
Azi2	5-azacytidine induced 2	0.016
Psmd8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.015
Dr1	down-regulator of transcription 1	0.015
Tcea2	transcription elongation factor A (SII), 2	0.015
Lman1	lectin, mannose-binding, 1	0.015
Traf4af1	TRAF4 associated factor 1	0.015
Pdk2	pyruvate dehydrogenase kinase, isozyme 2	0.015
Bat5	HLA-B associated transcript 5	0.015
Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	0.015
Azin1	antizyme inhibitor 1	0.015
LOC100362155	cysteine and histidine rich 1	0.014
Ccdc47	coiled-coil domain containing 47	0.014
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.014
Rnf14	ring finger protein 14	0.014
Spcs3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.014
Tagln3	transgelin 3	0.014
Gorasp2	golgi reassembly stacking protein 2	0.014
Clic4	chloride intracellular channel 4	0.014
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.014	Human Yeast Worm Fly
Myo1b	myosin Ib	0.014
Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	0.014
Kif22	kinesin family member 22	0.014
LOC100360501	ribonuclease inhibitor-like	0.014
Kif2c	kinesin family member 2C	0.013
Erp29	endoplasmic reticulum protein 29	0.013
Bcr	breakpoint cluster region	0.013
Atp6v1g1	ATPase, H transporting, lysosomal V1 subunit G1	0.013
Copb2	coatomer protein complex, subunit beta 2 (beta prime)	0.013
LOC100310874	antisense RNA overlapping MCH	0.013
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.013
Kpna1	karyopherin alpha 1	0.013
Ubxn4	UBX domain protein 4	0.013
Cdca3	cell division cycle associated 3	0.013
Glg1	golgi apparatus protein 1	0.012
Chmp1b	chromatin modifying protein 1B	0.012
Pctk2	PCTAIRE protein kinase 2	0.012
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.012
Jak2	Janus kinase 2	0.012
Fam91a1	family with sequence similarity 91, member A1	0.012
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.012	Yeast
Spc25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.012
Top2a	topoisomerase (DNA) II alpha	0.012
Rbm8a	RNA binding motif protein 8A	0.012
Klhdc3	kelch domain containing 3	0.012
Trim3	tripartite motif-containing 3	0.012
Birc2	baculoviral IAP repeat-containing 2	0.012
Coro1a	coronin, actin binding protein 1A	0.012
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.012	Yeast
Spag5	sperm associated antigen 5	0.011
Oaz1	ornithine decarboxylase antizyme 1	0.011
Kars	lysyl-tRNA synthetase	0.011
Hhatl	hedgehog acyltransferase-like	0.011
Prkar1a	protein kinase, cAMP-dependent, regulatory, type I, alpha	0.011
Kif18b	kinesin family member 18B	0.011
Pdia6	protein disulfide isomerase family A, member 6	0.011
Tcp11l2	t-complex 11 (mouse) like 2	0.011
Troap	trophinin associated protein	0.011
Rpl36	ribosomal protein L36	0.011
Pfn2	profilin 2	0.011
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.011
Ubxn1	UBX domain protein 1	0.011	Human
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.010	Human
Map2k1	mitogen activated protein kinase kinase 1	0.010
Cops2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.010
Psmc5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.010	Human Yeast
Cenpi	centromere protein I	0.010
Slc30a4	solute carrier family 30 (zinc transporter), member 4	0.010
Prdm4	PR domain containing 4	0.010
Rnf19a	ring finger protein 19A	0.010
Prdx5	peroxiredoxin 5	0.010
Lamc1	laminin, gamma 1	0.010
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.010
Safb	scaffold attachment factor B	0.010
Akt1s1	AKT1 substrate 1 (proline-rich)	0.010
Pak2	p21 protein (Cdc42/Rac)-activated kinase 2	0.010
Psmd5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.010