IMP

Process View

Danio rerio

9 genes annotated in zebrafish

Multi-species View

positive regulation of defense response

GO:0031349

Any process that activates or increases the frequency, rate or extent of a defense response.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of defense response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of defense response" (in gray)

Name	Description	Probability	Func Analog Organism
nod1	nucleotide-binding oligomerization domain containing 1	0.537
il8	interleukin 8	0.285
stc1l	stanniocalcin 1, like	0.283
pdcd2	programmed cell death 2	0.258
cyp3a65	cytochrome P450, family 3, subfamily A, polypeptide 65	0.218
LOC557072	caspase recruitment domain-containing protein 11-like	0.170
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.165
tlr9	toll-like receptor 9	0.162
il1b	interleukin 1, beta and interleukin 1, beta	0.145	Mouse
vasa	vasa homolog	0.139
defbl3	defensin, beta-like 3	0.133
pea3	ETS-domain transcription factor pea3	0.112
fgfr3	fibroblast growth factor receptor 3	0.103	Fly
epas1b	endothelial PAS domain protein 1b	0.099
tnfb	tumor necrosis factor b (TNF superfamily, member 2)	0.096	Mouse Rat
ripk2	receptor-interacting serine-threonine kinase 2	0.085
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.065	Mouse Fly
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.063	Mouse Rat
copa	coatomer protein complex, subunit alpha	0.057
f2rl1.2	coagulation factor II (thrombin) receptor-like 1.2	0.057
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.054
fzd2	frizzled homolog 2	0.052
LOC100000934	hypothetical protein LOC100000934	0.052
tlr18	toll-like receptor 18	0.051
spi1l	spleen focus forming virus (SFFV) proviral integration oncogene spi1 like	0.051
csf3r	colony stimulating factor 3 receptor (granulocyte)	0.048
nanos3	nanos homolog 3	0.044
zgc:56136	zgc:56136	0.041
shbg	sex hormone binding globulin	0.036
pth1a	parathyroid hormone 1a	0.034
ip6k2	inositol hexaphosphate kinase 2	0.034
itln1	intelectin 1	0.034
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.033
mmp9	matrix metalloproteinase 9	0.033
fxr2	fragile X mental retardation, autosomal homolog 2	0.033
otul	OTU like protein	0.031
fadd	Fas (tnfrsf6)-associated via death domain	0.031
ptgs1	prostaglandin-endoperoxide synthase 1	0.030
cdh23	cadherin-like 23	0.030
sgpl1	sphingosine-1-phosphate lyase 1	0.030
caspa	caspase a	0.030
phrf1	PHD and ring finger domains 1	0.029
gcm2	glial cells missing homolog 2 (Drosophila)	0.029
bhlhe40	basic helix-loop-helix family, member e40	0.027
cd40lg	CD40 ligand	0.027
ef1a	elongation factor 1-alpha	0.026
stat1b	signal transducer and activator of transcription 1b	0.025
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.025
ifng1-2	interferon, gamma 1-2	0.024
sh3gl1b	SH3-domain GRB2-like 1b	0.024
slco1d1	solute carrier organic anion transporter family, member 1D1	0.024
fn1b	fibronectin 1b	0.023
hspb6	heat shock protein, alpha-crystallin-related, b6	0.021
ighz	immunoglobulin heavy constant zeta	0.021
rhogb	ras homolog gene family, member Gb	0.021
tlr21	toll-like receptor 21	0.020
dnd	dead end	0.020
si:dkey-8l13.4	si:dkey-8l13.4	0.020
tlr4bb	toll-like receptor 4b, duplicate b	0.019	Human Mouse
LOC100150090	sphingosine kinase 2-like	0.018
lpp	LIM domain containing preferred translocation partner in lipoma	0.018
copg2	coatomer protein complex, subunit gamma 2	0.018
naa15b	N(alpha)-acetyltransferase 15, NatA auxiliary subunit b	0.018
clic2	chloride intracellular channel 2	0.017
fbln4	fibulin 4	0.017
sb:cb134	sb:cb134	0.017
si:ch211-195h23.3	si:ch211-195h23.3	0.016
fabp7b	fatty acid binding protein 7, brain, b	0.016
polb	polymerase (DNA directed), beta	0.016
meis1	myeloid ecotropic viral integration 1	0.016
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.016
runx2a	runt-related transcription factor 2a	0.016
grifin	galectin related inter-fiber protein	0.016
LOC567678	avidin-like	0.015
ecscr	endothelial cell-specific chemotaxis regulator	0.015
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.015
gsk3b	glycogen synthase kinase 3 beta	0.014
pdgfaa	platelet-derived growth factor alpha a	0.014
fes	feline sarcoma oncogene	0.014
arrb2b	arrestin, beta 2b	0.014	Mouse
paqr7b	progestin and adipoQ receptor family member VII, b	0.014
tlr20a	toll-like receptor 20a	0.014
yth2	YTH domain family 2	0.014
kpna3	karyopherin (importin) alpha 3	0.014
unc5c	unc-5 homolog C (C. elegans)	0.014
plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.014
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.014
ccr6a	chemokine (C-C motif) receptor 6a	0.013
pcsk9	proprotein convertase subtilisin/kexin type 9	0.013
atoh1b	atonal homolog 1b	0.013
tirap	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.013
mapk8b	mitogen-activated protein kinase 8b	0.013
bmp7b	bone morphogenetic protein 7b	0.013
cd247l	CD247 antigen like	0.013
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.013	Mouse Rat
hcrt	hypocretin (orexin) neuropeptide precursor	0.013
sb:cb429	sb:cb429	0.013
im:7141132	im:7141132	0.013
keap1a	kelch-like ECH-associated protein 1a	0.013
hdr	hematopoietic death receptor	0.013
c1qc	complement component 1, q subcomponent, C chain	0.013
st8sia6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	0.013
sgpp1	sphingosine-1-phosphate phosphatase 1	0.012
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.012
c1qb	complement component 1, q subcomponent, B chain	0.012
igf1ra	insulin-like growth factor 1a receptor	0.012
smc1al	structural maintenance of chromosomes 1A, like	0.012
pygb	phosphorylase, glycogen; brain	0.012
LOC100536021	spectrin beta chain, brain 1-like	0.012
wls	wntless homolog (Drosophila)	0.012
nos2a	nitric oxide synthase 2a, inducible	0.012
yars	tyrosyl-tRNA synthetase	0.012
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.012
zgc:92020	zgc:92020	0.012
celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.011
zgc:153921	zgc:153921	0.011
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.011
angpt2	angiopoietin 2	0.011
zgc:101598	zgc:101598	0.011
dmrt1	doublesex and mab-3 related transcription factor 1	0.011
pparg	peroxisome proliferator activated receptor gamma	0.011
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.011
notch2	notch homolog 2	0.011
si:dkey-236e20.6	si:dkey-236e20.6	0.011
pmp22a	peripheral myelin protein 22a	0.011
aplp2	amyloid beta (A4) precursor-like protein 2	0.011
ncf1	neutrophil cytosolic factor 1	0.011
tlr20f	toll-like receptor 20f	0.011
ptger2b	prostaglandin E receptor 2b (subtype EP2)	0.010
lfng	lunatic fringe homolog	0.010
fas	Fas (TNF receptor superfamily, member 6)	0.010
tmprss4b	transmembrane protease, serine 4b	0.010
epor	erythropoietin receptor	0.010
slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	0.010
c1qa	complement component 1, q subcomponent, A chain	0.010