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Danio rerio

8 genes annotated in zebrafish

posterior lateral line neuromast hair cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "posterior lateral line neuromast hair cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "posterior lateral line neuromast hair cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
ptf1a	pancreas specific transcription factor, 1a	0.982	Zebrafish
isl1	islet1	0.929
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.901
dla	deltaA	0.806
pax2a	paired box gene 2a	0.768
atoh1a	atonal homolog 1a	0.746
alcama	activated leukocyte cell adhesion molecule a	0.585
eng2b	engrailed 2b	0.562
irx1b	iroquois homeobox protein 1, b	0.503	Zebrafish
neurog1	neurogenin 1	0.481	Zebrafish
tfap2a	transcription factor AP-2 alpha	0.393
pax6b	paired box gene 6b	0.374
eng2a	engrailed 2a	0.367
atoh1b	atonal homolog 1b	0.294	Zebrafish
socs3a	suppressor of cytokine signaling 3a	0.271
fgf8a	fibroblast growth factor 8 a	0.269
neurod4	neurogenic differentiation 4	0.235	Zebrafish
gbx2	gastrulation brain homeo box 2	0.233
hmx3	homeo box (H6 family) 3	0.213
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.208
tbx5a	T-box 5a	0.203
hoxc6a	homeo box C6a	0.202
sox3	SRY-box containing gene 3	0.200
cdh2	cadherin 2, neuronal	0.199
calb2b	calbindin 2b, (calretinin)	0.199
smad1	MAD homolog 1 (Drosophila)	0.192
nrp2b	neuropilin 2b	0.187
junb	jun B proto-oncogene	0.184
six1b	sine oculis homeobox homolog 1b	0.180
irx4b	iroquois homeobox protein 4b	0.177	Zebrafish
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.175
irx4a	iroquois homeobox protein 4a	0.174
irx1a	iroquois homeobox protein 1, a	0.169	Zebrafish
atf3	activating transcription factor 3	0.155
ppdpfa	pancreatic progenitor cell differentiation and proliferation factor a	0.151
irx5a	iroquois homeobox protein 5a	0.139	Zebrafish
met	met proto-oncogene (hepatocyte growth factor receptor)	0.136
olfm2	olfactomedin 2	0.132
bhlhe22	basic helix-loop-helix family, member e22	0.131
prox1	prospero-related homeobox gene 1	0.130
sox9a	SRY-box containing gene 9a	0.124
tbx2b	T-box 2b	0.121
six4b	sine oculis homeobox homolog 4b	0.117
isl2a	islet2a	0.101
neurod	neurogenic differentiation	0.093
pax3a	paired box gene 3a	0.089
lhx1a	LIM homeobox 1a	0.081
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.081
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.076
chrna6	cholinergic receptor, nicotinic, alpha 6	0.075
slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.075
epha4b	eph receptor A4b	0.069
neurod6a	neurogenic differentiation 6a	0.066
traf4a	tnf receptor-associated factor 4a	0.066
tbx1	T-box 1	0.066
edn1	endothelin 1	0.062
six2a	sine oculis-related homeobox 2a	0.060
phox2a	paired-like homeobox 2a	0.059
notch1a	notch homolog 1a	0.055
shhb	sonic hedgehog b	0.052
fgf10a	fibroblast growth factor 10a	0.051
her8a	hairy-related 8a	0.050
gbx1	gastrulation brain homeobox 1	0.046
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.044
sox2	SRY-box containing gene 2	0.043
hoxb2a	homeo box B2a	0.042
hlxb9la	homeo box HB9 like a	0.041
fzd8a	frizzled homolog 8a	0.041
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.039
mab21l2	mab-21-like 2	0.039
gpr126	G protein-coupled receptor 126	0.038
axin2	axin 2 (conductin, axil)	0.038
dlb	deltaB	0.037
gad2	glutamate decarboxylase 2	0.036
barhl2	BarH-like 2	0.036
tfap2b	transcription factor AP-2 beta	0.035
meis2.1	myeloid ecotropic viral integration site 2.1	0.035
sox1a	SRY-box containing gene 1a	0.033
hoxa2b	homeo box A2b	0.033
rorb	RAR-related orphan receptor B	0.033
large	like-glycosyltransferase	0.033
fgf8b	fibroblast growth factor 8 b	0.032
lhx1b	LIM homeobox 1b	0.031
otpb	orthopedia homolog b	0.031
irx3a	iroquois homeobox protein 3a	0.031	Zebrafish
hspa5	heat shock protein 5	0.030
rx3	retinal homeobox gene 3	0.030
lrrc6	leucine rich repeat containing 6	0.030
six4a	sine oculis homeobox homolog 4a	0.029
otx2	orthodenticle homolog 2	0.028
pcdh10b	protocadherin 10b	0.028
lhx5	LIM homeobox 5	0.028
dbx1a	developing brain homeobox 1a	0.027
pax6a	paired box gene 6a	0.027
irf11	interferon regulatory factor 11	0.027
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.026
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.026
hmgb3a	high-mobility group box 3a	0.025
scn8aa	sodium channel, voltage-gated, type VIII, alpha a	0.025
her3	hairy-related 3	0.024
tlx2	T-cell leukemia, homeobox 2	0.024
olig3	oligodendrocyte transcription factor 3	0.023
olig4	oligodendrocyte transcription factor 4	0.023
vsx2	visual system homeobox 2	0.023
rx1	retinal homeobox gene 1	0.023
stat3	signal transduction and activation of transcription 3	0.023
foxa1	forkhead box A1	0.023
vsx1	visual system homeobox 1 homolog, chx10-like	0.023
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.023
myo7aa	myosin VIIAa	0.022
irx5b	iroquois homeobox protein 5b	0.022
cntn1b	contactin 1b	0.021
hhip	hedgehog interacting protein	0.021
hoxa3a	homeo box A3a	0.021
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.020
cdh10	cadherin 10, type 2 (T2-cadherin)	0.020
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.020
hoxb3a	homeo box B3a	0.020
prtga	protogenin homolog a (Gallus gallus)	0.020
iclp1	invariant chain-like protein 1	0.020
irx2a	iroquois homeobox protein 2, a	0.019	Zebrafish
wnt1	wingless-type MMTV integration site family, member 1	0.019
cntn2	contactin 2	0.019
gdf6b	growth differentiation factor 6b	0.019
wnk1	WNK lysine deficient protein kinase 1	0.018
tnnt2a	troponin T2a, cardiac	0.018
hoxc4a	homeo box C4a	0.018
lmo1	LIM domain only 1	0.018
meis3	myeloid ecotropic viral integration site 3	0.016
nppa	natriuretic peptide precursor A	0.016
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.016
fosl2	fos-like antigen 2	0.016
foxg1a	forkhead box G1a	0.016
LOC797331	novel protein similar to vertebrate solute carrier family 12, (potassium-chloride transporter) member 5 (SLC12A5)	0.016
egr1	early growth response 1	0.015
s1pr2	sphingosine-1-phosphate receptor 2	0.015
sp5l	Sp5 transcription factor-like	0.015
pou4f2	POU domain, class 4, transcription factor 2	0.015
zic6	zic family member 6	0.014
otx5	orthodenticle homolog 5	0.014
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.014
hmx4	H6 family homeobox 4	0.014
zgc:92242	zgc:92242	0.014
robo2	roundabout homolog 2	0.014
insm1b	insulinoma-associated 1b	0.013
ptch1	patched 1	0.013
jun	jun proto-oncogene	0.013
slc1a3b	solute carrier family 1 (glial high affinity glutamate transporter), member 3b	0.013
six3b	sine oculis homeobox homolog 3b	0.013
chst11	carbohydrate (chondroitin 4) sulfotransferase 11	0.013
runx3	runt-related transcription factor 3	0.013
mafl	v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L	0.013
cbfb	core-binding factor, beta subunit	0.013
vldlr	very low density lipoprotein receptor	0.013
il6st	interleukin 6 signal transducer	0.013
socs1	suppressor of cytokine signaling 1	0.013	Zebrafish
dmbx1a	diencephalon/mesencephalon homeobox 1a	0.013
atoh7	atonal homolog 7	0.013	Zebrafish
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.012
notch3	notch homolog 3	0.012
hoxb5b	homeo box B5b	0.012
hoxd4a	homeo box D4a	0.012
sox11a	SRY-box containing gene 11a	0.012
cyp2aa4	cytochrome P450, family 2, subfamily AA, polypeptide 4	0.012
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.012
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.012
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.012
rtn1a	reticulon 1a	0.012
ascl1b	achaete-scute complex-like 1b (Drosophila)	0.011
efna5a	ephrin A5a	0.011
barx1	BarH-like homeobox 1	0.011
igfbp3	insulin-like growth factor binding protein 3	0.011
gabbr1a	gamma-aminobutyric acid (GABA) B receptor, 1a	0.011
rlbp1a	retinaldehyde binding protein 1a	0.011
mbnl2	muscleblind-like 2 (Drosophila)	0.011
hoxb5a	homeo box B5a	0.011
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.011
sox9b	SRY-box containing gene 9b	0.011
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.010
kal1a	Kallmann syndrome 1a sequence	0.010
hoxa4a	homeo box A4a	0.010
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.010
gata3	GATA-binding protein 3	0.010
zgc:101606	zgc:101606	0.010