IMP

Process View

Danio rerio

12 genes annotated in zebrafish

striated muscle contraction

A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "striated muscle contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "striated muscle contraction" (in gray)

Name	Description	Probability	Func Analog Organism
tnnc1b	troponin C type 1b (slow)	0.965
smyhc1	slow myosin heavy chain 1	0.868
acta1a	actin, alpha 1a, skeletal muscle	0.680
myf6	myogenic factor 6	0.599
myhz2	myosin, heavy polypeptide 2, fast muscle specific	0.536	Zebrafish
itgb1b.2	integrin, beta 1b.2	0.448	Worm
tnni1al	troponin I, skeletal, slow like	0.446
hsp90a.1	heat shock protein 90-alpha 1	0.420	Rat
smyd1b	SET and MYND domain containing 1b	0.400
mylz2	myosin, light polypeptide 2, skeletal muscle	0.399
smyhc2	slow myosin heavy chain 2	0.396
myl1	myosin, light chain 1, alkali; skeletal, fast	0.333	Rat
myhz1.1	myosin, heavy polypeptide 1.1, skeletal muscle	0.327	Zebrafish
zgc:66286	zgc:66286	0.314
pvalb4	parvalbumin 4	0.274
neb	nebulin	0.223
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.214
tnnt3b	troponin T3b, skeletal, fast	0.199	Human Zebrafish
nppa	natriuretic peptide precursor A	0.188
atp1b1b	ATPase, Na+/K+ transporting, beta 1b polypeptide	0.180
actc1a	actin, alpha, cardiac muscle 1a	0.176
ryr1b	ryanodine receptor 1b (skeletal)	0.176
ryr3	ryanodine receptor 3	0.160
casq2	calsequestrin 2	0.152	Mouse
ldb3a	LIM-domain binding factor 3a	0.140
tnni2a.4	troponin I, skeletal, fast 2a.4	0.131	Human
ckma	creatine kinase, muscle a	0.124
srl	sarcalumenin	0.118
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.116
cav3	caveolin 3	0.113
myog	myogenin	0.112
mybpc3	myosin binding protein C, cardiac	0.109
tpm3	tropomyosin 3	0.108	Zebrafish
tnni1b	troponin I, skeletal, slow b	0.105
scn12ab	sodium channel, voltage gated, type XII, alpha b	0.091
tnnc2	troponin C type 2 (fast)	0.088	Human Zebrafish
zgc:56376	zgc:56376	0.085
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.075	Human Rat
me2	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.073
musk	muscle, skeletal, receptor tyrosine kinase	0.071
actn2	actinin, alpha 2	0.068
aldocb	aldolase C, fructose-bisphosphate, b	0.067
fabp11a	fatty acid binding protein 11a	0.064
adrb2a	adrenergic receptor, beta 2a	0.061
xirp1	xin actin-binding repeat containing 1	0.060
atp6v1al	ATPase, H+ transporting, lysosomal V1 subunit A, like	0.058
itgb1a	integrin, beta 1a	0.056	Worm
tnnt3a	troponin T3a, skeletal, fast	0.054	Human Zebrafish
myl10	myosin, light chain 10, regulatory	0.054
synpo2lb	synaptopodin 2-like b	0.054
tnnc1a	troponin C type 1a (slow)	0.050
actc1b	actin, alpha, cardiac muscle 1b	0.049
unc45b	unc-45 homolog B (C. elegans)	0.048
ttna	titin a	0.044
actn3a	actinin alpha 3a	0.040
mef2ca	myocyte enhancer factor 2ca	0.040
rbm24a	RNA binding motif protein 24a	0.038
vmhcl	ventricular myosin heavy chain-like	0.037
itgb1b	integrin, beta 1b	0.037	Worm
slc25a4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	0.036
itgb1b.1	integrin, beta 1b.1	0.036	Worm
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.035	Mouse Rat
tpma	alpha-tropomyosin	0.035	Zebrafish Mouse
fhla	four and a half LIM domains a	0.035
cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.035	Worm
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.034
atp1a1a.4	ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide	0.034	Mouse Rat
atp1a3b	ATPase, Na+/K+ transporting, alpha 3b polypeptide	0.033
jup	junction plakoglobin	0.033
rabac1	Rab acceptor 1 (prenylated)	0.033
pygma	phosphorylase, glycogen (muscle) A	0.032
eya4	eyes absent homolog 4 (Drosophila)	0.031
pkm2a	pyruvate kinase, muscle, a	0.031
ryr1a	ryanodine receptor 1a (skeletal)	0.031
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.030
fxr2	fragile X mental retardation, autosomal homolog 2	0.030
hsp47	heat shock protein 47	0.029
lifrb	leukemia inhibitory factor receptor alpha b	0.029
zgc:113625	zgc:113625	0.028
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.028	Mouse
zgc:92806	zgc:92806	0.028
mylk3	myosin light chain kinase 3	0.028
tlr9	toll-like receptor 9	0.028
apobec2a	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a	0.027
ca2	carbonic anhydrase II	0.027
pvalb3	parvalbumin 3	0.027
tnnt2a	troponin T2a, cardiac	0.026
ca15a	carbonic anhydrase XV a	0.026
vmhc	ventricular myosin heavy chain	0.026
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.026
zgc:63947	zgc:63947	0.026
tnnt1	troponin T1, skeletal, slow	0.026	Zebrafish
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.025
itgb3b	integrin beta 3b	0.025	Worm
copeb	core promoter element binding protein	0.025
krt8	keratin 8	0.025
myl7	myosin, light polypeptide 7, regulatory	0.025
chrnd	cholinergic receptor, nicotinic, delta polypeptide	0.024	Rat
mfn2	mitofusin 2	0.024
dcn	decorin	0.024
hhatla	hedgehog acyltransferase-like, a	0.024
spry4	sprouty (Drosophila) homolog 4	0.023
flncb	filamin C, gamma b (actin binding protein 280)	0.023
anxa11a	annexin A11a	0.022
ckmb	creatine kinase, muscle b	0.022
LOC100149148	novel protein similar to myosin heavy chain 4 (myhc4)	0.022
chat	choline acetyltransferase	0.021
nrp1b	neuropilin 1b	0.021
cx36.7	connexin 36.7	0.021
stmn2b	stathmin-like 2b	0.020
lrrc10	leucine rich repeat containing 10	0.020
acvr1l	activin A receptor, type I like	0.020
ampd1	adenosine monophosphate deaminase 1 (isoform M)	0.020
atp2b1a	ATPase, Ca++ transporting, plasma membrane 1a	0.020
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.020	Worm
bcdo2l	beta-carotene 15, 15-dioxygenase 2, like	0.020
tmem38a	transmembrane protein 38A	0.020
syt4	synaptotagmin IV	0.020
il8	interleukin 8	0.019
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.019
cpne1	copine I	0.019
wnt11r	wingless-type MMTV integration site family, member 11, related	0.019
slc43a1a	solute carrier family 43, member 1a	0.019
zgc:92429	zgc:92429	0.019
ache	acetylcholinesterase	0.018
krt18	keratin 18	0.018
stc1l	stanniocalcin 1, like	0.018	Human
igfbp6b	insulin-like growth factor binding protein 6b	0.018
spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.018
trim3a	tripartite motif-containing 3a	0.018
ckmt2	creatine kinase, mitochondrial 2 (sarcomeric)	0.018
tcf12	transcription factor 12	0.018
cacnb2a	calcium channel, voltage-dependent, beta 2a	0.018
zgc:63734	zgc:63734	0.017	Zebrafish
pvalb2	parvalbumin 2	0.017
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.017
tpm2	tropomyosin 2 (beta)	0.017	Zebrafish
smyhc1l	slow myosin heavy chain 1, like	0.017
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.017
zgc:91870	zgc:91870	0.017
slc8a4a	solute carrier family 8 (sodium/calcium exchanger), member 4a	0.017
tdh	L-threonine dehydrogenase	0.016
igfbp5a	insulin-like growth factor binding protein 5a	0.016
actn3b	actinin alpha 3b	0.016
btg1	B-cell translocation gene 1	0.016
lims1	LIM and senescent cell antigen-like domains 1	0.016	Worm
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.016	Mouse
im:6896270	im:6896270	0.016
il1b	interleukin 1, beta and interleukin 1, beta	0.016
spag6	sperm associated antigen 6	0.016
itgav	integrin, alpha V	0.016	Worm
ankrd12	ankyrin repeat domain 12	0.015
cmlc1	cardiac myosin light chain-1	0.015	Rat
lama2	laminin, alpha 2	0.015
esrrd	estrogen-related receptor delta	0.015
kbtbd10b	kelch repeat and BTB (POZ) domain containing 10b	0.015
cd74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.015
rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.015
tagln2	transgelin 2	0.015
dusp2	dual specificity phosphatase 2	0.015
pth1a	parathyroid hormone 1a	0.015
lepr	leptin receptor	0.015
tgfb1a	transforming growth factor, beta 1a	0.014
flot1b	flotillin 1b	0.014
ilk	integrin linked kinase	0.014	Worm
jun	jun proto-oncogene	0.014
calm1b	calmodulin 1b	0.014
m17	IL-6 subfamily cytokine M17	0.014
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.014
snai1a	snail homolog 1a (Drosophila)	0.014
zgc:92061	zgc:92061	0.014
pomca	proopiomelanocortin a	0.014
LOC566040	protein notum homolog	0.014
hsd17b12a	hydroxysteroid (17-beta) dehydrogenase 12a	0.014
rhcgb	Rhesus blood group, C glycoprotein b	0.014
im:7137300	im:7137300	0.014
zgc:114164	zgc:114164	0.014	Human
crb2a	crumbs homolog 2a	0.014
zgc:86757	zgc:86757	0.014
tpm1	tropomyosin 1 (alpha)	0.013
scn4ba	sodium channel, voltage-gated, type IV, beta a	0.013
wu:fc31e07	wu:fc31e07	0.013
cnn2	calponin 2	0.013
zgc:165344	zgc:165344	0.013
dpysl4	dihydropyrimidinase-like 4	0.013
myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.013	Mouse
got2b	glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)	0.013
ATP8	ATP synthase 8	0.013
eno3	enolase 3, (beta, muscle)	0.013
actn1	actinin, alpha 1	0.013
pgam2	phosphoglycerate mutase 2 (muscle)	0.013
acta1b	actin, alpha 1b, skeletal muscle	0.013
smyhc3	slow myosin heavy chain 3	0.012	Human Zebrafish Mouse
sh3gl1b	SH3-domain GRB2-like 1b	0.012
zgc:66097	zgc:66097	0.012
myom1a	myomesin 1a (skelemin)	0.012
prmt1	protein arginine methyltransferase 1	0.012
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.012
anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.012
rtn3	reticulon 3	0.012
cdh15	cadherin 15, M-cadherin (myotubule)	0.012
im:6801444	im:6801444	0.012
card14	caspase recruitment domain family, member 14	0.012
sypl2b	synaptophysin-like 2b	0.012
cdh1	cadherin 1, epithelial	0.012
fabp7a	fatty acid binding protein 7, brain, a	0.012
igfbp6a	insulin-like growth factor binding protein 6a	0.012
myhc4	myosin heavy chain 4	0.012	Zebrafish
col5a2l	collagen, type V, alpha 2-like	0.012
zgc:91999	zgc:91999	0.012
pvalb8	parvalbumin 8	0.012
rbm24b	RNA binding motif protein 24b	0.012
sept2	septin 2	0.012
znf385b	zinc finger protein 385B	0.012
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.012	Human
kcnj13	potassium inwardly-rectifying channel, subfamily J, member 13	0.012
csrp3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.012	Human Mouse
ptbp1b	polypyrimidine tract binding protein 1b	0.012
hsp70l	heat shock cognate 70-kd protein, like	0.011
pvalb1	parvalbumin 1	0.011
txlnba	taxilin beta a	0.011
vgll2b	vestigial like 2b	0.011
atp1b3b	ATPase, Na+/K+ transporting, beta 3b polypeptide	0.011
esrra	estrogen-related receptor alpha	0.011
tpi1b	triosephosphate isomerase 1b	0.011
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.011
jam2a	junctional adhesion molecule 2a	0.011
zgc:136894	zgc:136894	0.011
im:6908257	im:6908257	0.011
crabp2b	cellular retinoic acid binding protein 2, b	0.011
vdac3	voltage-dependent anion channel 3	0.011
atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.011
zplxdc2	plexin domain containing 2	0.011
ucp2	uncoupling protein 2	0.011
ywhai	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide	0.011
ldb3b	LIM domain binding 3b	0.011
si:ch211-166a6.5	si:ch211-166a6.5	0.011
dsc2l	desmocollin 2 like	0.011
palm	paralemmin	0.011
sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.011
myhz1.2	myosin, heavy polypeptide 1.2, skeletal muscle	0.011
uap1l1	UDP-N-acteylglucosamine pyrophosphorylase 1, like 1	0.011
gsna	gelsolin a	0.011
ldha	lactate dehydrogenase A4	0.011
syt11a	synaptotagmin XIa	0.011
adrb2b	adrenergic receptor, beta 2b	0.011
tnni2a.2	troponin I, skeletal, fast 2a.2	0.011	Human
zgc:66156	zgc:66156	0.011	Human Zebrafish
stmn2a	stathmin-like 2a	0.011
p4ha2	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2	0.011
atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.010
wu:fb01h12	wu:fb01h12	0.010
igfbp1a	insulin-like growth factor binding protein 1a	0.010
krit1	KRIT1, ankyrin repeat containing	0.010
si:dkey-261h17.1	si:dkey-261h17.1	0.010
si:ch211-173b8.2	si:ch211-173b8.2	0.010
hspb8	heat shock protein, alpha-crystallin-related, b8	0.010
cldn8	claudin 8	0.010
zgc:112359	zgc:112359	0.010
dnase1l3	deoxyribonuclease I-like 3	0.010
gmds	GDP-mannose 4,6-dehydratase	0.010
tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.010
rhov	ras homolog gene family, member V	0.010
gnaia	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	0.010
tmx2a	thioredoxin-related transmembrane protein 2a	0.010