IMP

Process View

Danio rerio

2 genes annotated in zebrafish

ectodermal cell fate specification

The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ectodermal cell fate specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ectodermal cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
alas2	aminolevulinate, delta-, synthetase 2	0.642
krt8	keratin 8	0.606
tagln2	transgelin 2	0.352
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.335
krt4	keratin 4	0.327
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.299
foxa3	forkhead box A3	0.233
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.180
perp	PERP, TP53 apoptosis effector	0.168
jun	jun proto-oncogene	0.162
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.155
hspb1	heat shock protein, alpha-crystallin-related, 1	0.155
cdh1	cadherin 1, epithelial	0.143
slc4a1a	solute carrier family 4, anion exchanger, member 1a	0.143
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.133
tp63	tumor protein p63	0.121
klf2a	Kruppel-like factor 2a	0.112
krt5	keratin 5	0.095
sdprb	serum deprivation response b	0.094
anxa5b	annexin A5b	0.090
acvr1b	activin A receptor, type IB	0.084
sfrp1a	secreted frizzled-related protein 1a	0.083
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.080
hspa5	heat shock protein 5	0.079
gata2a	GATA-binding protein 2a	0.077
drl	draculin	0.074
aldocb	aldolase C, fructose-bisphosphate, b	0.073
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.073
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.065
fzd7a	frizzled homolog 7a	0.064
rhov	ras homolog gene family, member V	0.063
rasl11b	RAS-like, family 11, member B	0.062
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.060
amotl2a	angiomotin like 2a	0.058
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.057
btg2	B-cell translocation gene 2	0.057
klf4	Kruppel-like factor 4	0.057	Zebrafish
dspa	desmoplakin a	0.057
mych	myelocytomatosis oncogene homolog	0.056
pea3	ETS-domain transcription factor pea3	0.055
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.055
blf	bloody fingers	0.053
bmper	BMP binding endothelial regulator	0.052
zfand5a	zinc finger, AN1-type domain 5a	0.051
klf2b	Kruppel-like factor 2b	0.050
wif1	wnt inhibitory factor 1	0.049
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.049
krt18	keratin 18	0.046
irf6	interferon regulatory factor 6	0.045
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.042
dlx3b	distal-less homeobox gene 3b	0.041
celsr1a	cadherin EGF LAG seven-pass G-type receptor 1a	0.039
wu:fc24e06	wu:fc24e06	0.038
socs3a	suppressor of cytokine signaling 3a	0.036
apoeb	apolipoprotein Eb	0.035
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.035
anxa1a	annexin A1a	0.035
mmp2	matrix metalloproteinase 2	0.034
jup	junction plakoglobin	0.034
id1	inhibitor of DNA binding 1	0.034
gata3	GATA-binding protein 3	0.033
aplnrb	apelin receptor b	0.033
stat3	signal transduction and activation of transcription 3	0.033
zgc:91870	zgc:91870	0.033
cahz	carbonic anhydrase	0.032
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.031
junbl	jun B proto-oncogene, like	0.031
gata1a	GATA binding protein 1a	0.031
urod	uroporphyrinogen decarboxylase	0.030
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.029
aqp1a.1	aquaporin 1a, tandem duplicate 1	0.028
foxb1.2	forkhead box B1.2	0.028
mvp	major vault protein	0.027
pabpc1b	poly A binding protein, cytoplasmic 1 b	0.027
alcamb	activated leukocyte cell adhesion molecule b	0.026
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.026
junb	jun B proto-oncogene	0.026
fzd7b	frizzled homolog 7b	0.026	Human
sox3	SRY-box containing gene 3	0.026
sptb	spectrin, beta, erythrocytic	0.026
dsc2l	desmocollin 2 like	0.024
dusp5	dual specificity phosphatase 5	0.024
pdlim1	PDZ and LIM domain 1 (elfin)	0.024
zgc:55813	zgc:55813	0.023
gmds	GDP-mannose 4,6-dehydratase	0.023
tal1	T-cell acute lymphocytic leukemia 1	0.022
bhlhe40	basic helix-loop-helix family, member e40	0.022
dusp2	dual specificity phosphatase 2	0.022
brd2a	bromodomain-containing 2a	0.022
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.021
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.021
gsna	gelsolin a	0.020
si:ch211-166a6.5	si:ch211-166a6.5	0.020
appa	amyloid beta (A4) precursor protein a	0.020
pfn1	profilin 1	0.020
inka1a	induced in neural crest by AP2, 1a	0.020
ctsl1b	cathepsin L, 1 b	0.019
calm1a	calmodulin 1a	0.018
her6	hairy-related 6	0.018
nrarpa	notch-regulated ankyrin repeat protein a	0.018
notch3	notch homolog 3	0.018
cldne	claudin e	0.017
lnx2b	ligand of numb-protein X 2b	0.017
arl4ab	ADP-ribosylation factor-like 4ab	0.017
notch2	notch homolog 2	0.017
eya1	eyes absent homolog 1	0.016
zgc:110340	zgc:110340	0.016
zfp36l1b	zinc finger protein 36, C3H type-like 1b	0.016
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.016
cast	calpastatin	0.016
cd9b	CD9 antigen, b	0.016
zgc:101000	zgc:101000	0.015
irf2bp2b	interferon regulatory factor 2 binding protein 2b	0.015
six1b	sine oculis homeobox homolog 1b	0.015
hbae3	hemoglobin alpha embryonic-3	0.015
tfr1a	transferrin receptor 1a	0.015
hbbe2	hemoglobin beta embryonic-2	0.015
met	met proto-oncogene (hepatocyte growth factor receptor)	0.014
slc20a1a	solute carrier family 20, member 1a	0.014
id3	inhibitor of DNA binding 3	0.014
lmo4a	LIM domain only 4a	0.014
rnd1l	Rho family GTPase 1 like	0.014
bactin1	bactin1	0.014
zgc:113210	zgc:113210	0.014
aplp2	amyloid beta (A4) precursor-like protein 2	0.014
anxa2a	annexin A2a	0.014
LOC572344	hypothetical protein LOC572344	0.013
zgc:92061	zgc:92061	0.013
ef1	ETS-related factor1	0.013
foxo3b	forkhead box O3b	0.013
stmn2b	stathmin-like 2b	0.013
ptprb	protein tyrosine phosphatase, receptor type, b	0.013
six4b	sine oculis homeobox homolog 4b	0.013
coro2a	coronin, actin binding protein, 2A	0.013
tmod4	tropomodulin 4 (muscle)	0.013
zgc:66433	zgc:66433	0.013
atf3	activating transcription factor 3	0.013
hdr	hematopoietic death receptor	0.013
ptgs1	prostaglandin-endoperoxide synthase 1	0.013
mapk3	mitogen-activated protein kinase 3	0.013
cnn2	calponin 2	0.012
zgc:153997	zgc:153997	0.012
cldnb	claudin b	0.012
evpl	envoplakin	0.012
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.012
sox2	SRY-box containing gene 2	0.012
nr4a1	nuclear receptor subfamily 4, group A, member 1	0.012
gsc	goosecoid	0.012
epcam	epithelial cell adhesion molecule	0.012
pak1	p21/Cdc42/Rac1-activated kinase 1	0.012
tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.012
socs3b	suppressor of cytokine signaling 3b	0.012
znfl2a	zinc finger-like gene 2a	0.012
zgc:85975	zgc:85975	0.011
rtn1a	reticulon 1a	0.011
zgc:92242	zgc:92242	0.011
tgfbr2	transforming growth factor, beta receptor II	0.011
si:dkeyp-66d7.2	si:dkeyp-66d7.2	0.011
foxc1b	forkhead box C1b	0.011
s100a10b	S100 calcium binding protein A10b	0.011
sb:cb81	sb:cb81	0.011
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.011
glulb	glutamate-ammonia ligase (glutamine synthase) b	0.011
foxc1a	forkhead box C1a	0.011
plcd1b	phospholipase C, delta 1b	0.011
ppl	periplakin	0.010
brd2b	bromodomain containing 2b	0.010
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.010
si:ch211-173o4.2	si:ch211-173o4.2	0.010
igfbp1a	insulin-like growth factor binding protein 1a	0.010
fgf10a	fibroblast growth factor 10a	0.010
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.010
snai2	snail homolog 2 (Drosophila)	0.010