IMP

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Danio rerio

12 genes annotated in zebrafish

regulation of lyase activity

Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of lyase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of lyase activity" (in gray)

Name	Description	Probability	Func Analog Organism
drd2a	dopamine receptor D2a	0.835	Human Rat
adra2c	adrenergic, alpha-2C-, receptor	0.802
avpl	arginine vasopressin-like	0.583
uts1	urotensin 1	0.529
drd3	dopamine receptor D3	0.512	Human Rat
LOC559201	similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)	0.506
adra2da	adrenergic, alpha-2D-, receptor a	0.479
dbh	dopamine beta hydroxylase	0.328
drd2b	dopamine receptor D2b	0.284	Human Rat
nf1b	neurofibromin 1b	0.270	Mouse Fly
adra2b	adrenergic, alpha-2B-, receptor	0.244
drd2l	dopamine receptor D2 like	0.209
hcrtr2	hypocretin (orexin) receptor 2	0.164
ext2	exostoses (multiple) 2	0.156
cpla2	cytosolic phospholipase a2	0.151
nf1a	neurofibromin 1a	0.151	Mouse Fly
plp1b	proteolipid protein 1b	0.141
oprd1a	opioid receptor, delta 1a	0.129
sncgb	synuclein, gamma b (breast cancer-specific protein 1)	0.115
calm1a	calmodulin 1a	0.112
LOC569642	hypothetical protein LOC569642	0.108
hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.108
mc2r	melanocortin 2 receptor	0.105
cx52.6	connexin 52.6	0.098
si:ch211-14k19.8	si:ch211-14k19.8	0.098
sst3	somatostatin 3	0.090
nlgn4a	neuroligin 4a	0.083
grk7a	G-protein-coupled receptor kinase 7a	0.080
nlgn1	neuroligin 1	0.077
npb	neuropeptide B	0.073
vamp2	vesicle-associated membrane protein 2	0.067
calcrla	calcitonin receptor-like a	0.067
zgc:103663	zgc:103663	0.066
ptp4a1	protein tyrosine phosphatase type IVA, member 1	0.064
pcp4a	Purkinje cell protein 4a	0.064
ncam2	neural cell adhesion molecule 2	0.060
oxtl	oxytocin-like	0.060
pyya	peptide YYa	0.058
ucn3l	urocortin 3, like	0.057
th2	tyrosine hydroxylase 2	0.055
rap1b	RAS related protein 1b	0.054
gap43	growth associated protein 43	0.054
LOC569128	hypothetical protein LOC569128	0.052
dclk2	doublecortin-like kinase 2	0.050
mpp5b	membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)	0.049
esrrga	estrogen-related receptor gamma a	0.049
si:ch211-209p5.2	si:ch211-209p5.2	0.046
penka	proenkephalin a	0.044
rag1	recombination activating gene 1	0.044
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.043
rtn1a	reticulon 1a	0.043
paqr8	progestin and adipoQ receptor family member VIII	0.043
nrl	neural retina leucine zipper	0.042
pp	pyrophosphatase (inorganic)	0.042
fshr	follicle stimulating hormone receptor	0.040
klf7l	Kruppel-like factor 7 (ubiquitous), like	0.039
si:dkey-228g21.4	si:dkey-228g21.4	0.038
LOC100006249	carbohydrate sulfotransferase 2-like	0.037
mchr1b	melanin-concentrating hormone receptor 1b	0.037
dio2	deiodinase, iodothyronine, type II	0.035
adra2db	adrenergic, alpha-2D-, receptor b	0.034
zgc:65851	zgc:65851	0.033
prdx4	peroxiredoxin 4	0.033
cx55.5	connexin 55.5	0.032
LOC100001008	prepro-urotensin II-related peptide	0.032
eno2	enolase 2	0.031
rln3a	relaxin 3a	0.030
mc4r	melanocortin 4 receptor	0.030
nadl1.2	neural adhesion molecule L1.2	0.029
gucy2f	guanylate cyclase 2F, retinal	0.029
ppp3cb	protein phosphatase 3, catalytic subunit, beta isozyme	0.029
nras	neuroblastoma RAS viral (v-ras) oncogene homolog	0.029
flj13639	flj13639	0.029
LOC555482	tachykinin receptor 3-like	0.027
slc1a2a	solute carrier family 1 (glial high affinity glutamate transporter), member 2a	0.027
zgc:162213	zgc:162213	0.027
esrrb	estrogen-related receptor beta	0.027
ttc39c	tetratricopeptide repeat domain 39C	0.027
crb2b	crumbs homolog 2b	0.027
LOC555504	novel protocadherin protein	0.027
adora2aa	adenosine A2a receptor a	0.026	Human
palm	paralemmin	0.026	Mouse
vegfab	vascular endothelial growth factor Ab	0.026
cldn2	claudin 2	0.025
hdc	histidine decarboxylase	0.025
bsk146	brain specific kinase 146	0.025
ptpra	protein tyrosine phosphatase, receptor type, A	0.024
cox4i2	cytochrome c oxidase subunit IV isoform 2	0.024
gnrh2	gonadotropin-releasing hormone 2	0.023
tspan7b	tetraspanin 7b	0.023
zgc:56548	zgc:56548	0.022
zgc:91860	zgc:91860	0.022
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.022
LOC799274	kinesin heavy chain isoform 5A-like	0.022
saga	S-antigen; retina and pineal gland (arrestin) a	0.022
aqp8a.2	aquaporin 8a, tandem duplicate 2	0.022
ryr2a	ryanodine receptor 2a (cardiac)	0.021
inha	inhibin, alpha	0.021
slc18a3b	solute carrier family 18 (vesicular acetylcholine), member 3b	0.021
aqp11	aquaporin 11	0.021
ahrrb	aryl-hydrocarbon receptor repressor b	0.021
aqp10b	aquaporin 10b	0.020
pvalb6	parvalbumin 6	0.020
mapk6	mitogen-activated protein kinase 6	0.020
vwf	von Willebrand factor	0.019
si:dkeyp-72g9.4	si:dkeyp-72g9.4	0.019
neurog3	neurogenin 3	0.019
slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.019
zgc:91926	zgc:91926	0.019
htr1bd	5-hydroxytryptamine (serotonin) receptor 1bd	0.019	Zebrafish
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.019
drd4a	dopamine receptor D4a	0.018	Human
gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.018
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.018
mmd2	progestin and adipoQ receptor 10	0.018
LOC100332193	growth hormone secretagogue receptor type 1-like	0.018
pmch	pro-melanin concentrating hormone	0.017
rhoaa	ras homolog gene family, member Aa	0.017
adora2b	adenosine A2b receptor	0.017	Mouse
gulp1	GULP, engulfment adaptor PTB domain containing 1	0.016
uts2a	urotensin 2, alpha	0.016
cry1a	cryptochrome 1a	0.016
pdca	phosducin a	0.016
thrb	thyroid hormone receptor beta	0.016
efemp2	EGF-containing fibulin-like extracellular matrix protein 2	0.016
zgc:77060	zgc:77060	0.016
lasp1	LIM and SH3 protein 1	0.016
si:dkey-49m19.7	si:dkey-49m19.7	0.016
cnr1	cannabinoid receptor 1	0.016
si:dkey-24h22.4	si:dkey-24h22.4	0.016
bhlha15	basic helix-loop-helix family, member a15	0.016
sst1.1	somatostatin 1, tandem duplicate 1	0.016
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.016
pppde2a	PPPDE peptidase domain containing 2a	0.016
chrm2a	cholinergic receptor, muscarinic 2a	0.016
slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.015
rag2	recombination activating gene 2	0.015
adcyap1a	adenylate cyclase activating polypeptide 1a	0.015	Human Mouse
pdlim3a	PDZ and LIM domain 3a	0.015
hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit	0.014
arf1	ADP-ribosylation factor 1	0.014
vdac3	voltage-dependent anion channel 3	0.014
zgc:63633	zgc:63633	0.014
arfip2a	ADP-ribosylation factor interacting protein 2a	0.014
fgf13a	fibroblast growth factor 13a	0.014
crh	corticotropin releasing hormone	0.014
tm9sf2	transmembrane 9 superfamily member 2	0.014
prkca	protein kinase C, alpha	0.014
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.014
si:dkey-15j16.2	si:dkey-15j16.2	0.013
prdm15	PR domain containing 15	0.013
zgc:110124	zgc:110124	0.013
kif5c	kinesin family member 5C	0.013
adam10a	a disintegrin and metalloprotease domain 10a	0.013
grk7b	G protein-coupled receptor kinase 7b	0.013
kiss1rb	KISS1 receptor b	0.013
si:dkey-3d4.3	si:dkey-3d4.3	0.013
oprl1	opiate receptor-like 1	0.012
cyb5r4	cytochrome b5 reductase 4	0.012
cd99l2	CD99 antigen-like 2	0.012
ehd1	EH-domain containing 1	0.012
grk1b	G protein-coupled receptor kinase 1 b	0.012
ywhag1	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1	0.012
tert	telomerase reverse transcriptase	0.012
gdnf	glial cell derived neurotrophic factor	0.012
lepb	leptin b	0.012
spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.011
ndufa4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4	0.011
slc6a17	solute carrier family 6, member 17	0.011
sagb	S-antigen; retina and pineal gland (arrestin) b	0.011
si:ch73-56f16.1	si:ch73-56f16.1	0.011
uchl1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.011
adrb2b	adrenergic receptor, beta 2b	0.011
lrrfip1a	leucine rich repeat (in FLII) interacting protein 1a	0.011
gnb3a	guanine nucleotide binding protein (G protein), beta polypeptide 3a	0.011
pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	0.011
fshb	follicle stimulating hormone, beta polypeptide	0.011
zgc:112359	zgc:112359	0.011
mstnb	myostatin b	0.011
crygs2	crystallin, gamma S2	0.011
hint2	histidine triad nucleotide binding protein 2	0.011
pnocb	prepronociceptin b	0.011
zgc:63587	zgc:63587	0.011
stmn4l	stathmin-like 4, like	0.011
abcb3l1	ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1	0.011
fam84b	family with sequence similarity 84, member B	0.011
gpd2	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	0.011
si:ch211-191i18.3	si:ch211-191i18.3	0.011
LOC566040	protein notum homolog	0.010
id2b	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, b	0.010
pnrc2	proline-rich nuclear receptor coactivator 2	0.010
grk1a	G protein-coupled receptor kinase 1 a	0.010
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.010
inhbab	inhibin, beta Ab	0.010
flnca	filamin C, gamma a (actin binding protein 280)	0.010
fermt2	fermitin family homolog 2 (Drosophila)	0.010
xgb	x globin	0.010
crb1	crumbs homolog 1 (Drosophila)	0.010
ppardb	peroxisome proliferator-activated receptor delta b	0.010
zgc:77051	zgc:77051	0.010
atf3	activating transcription factor 3	0.010
im:6895682	im:6895682	0.010
gc3	guanylyl cyclase 3	0.010
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.010