The network for 'endocardial cushion development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endocardial cushion development

The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 1.000
bmp4 bone morphogenetic protein 4 0.974
fgf8a fibroblast growth factor 8 a 0.710
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.631
myod1 myogenic differentiation 1 0.466
hand2 heart and neural crest derivatives expressed transcript 2 0.452
bmp2b bone morphogenetic protein 2b 0.423
wnt11r wingless-type MMTV integration site family, member 11, related 0.368
msxc muscle segment homeobox C 0.294
cdh2 cadherin 2, neuronal 0.285
wnt5b wingless-type MMTV integration site family, member 5b 0.273
ryk receptor-like tyrosine kinase 0.271
fgf3 fibroblast growth factor 3 0.254
mib mind bomb 0.248
shha sonic hedgehog a 0.223
hnf1ba HNF1 homeobox Ba 0.201
pax2a paired box gene 2a 0.161
eya1 eyes absent homolog 1 0.146
alcama activated leukocyte cell adhesion molecule a 0.119
lmo4a LIM domain only 4a 0.105
msxd muscle segment homeobox D 0.103
notch1b notch homolog 1b 0.099
ptch1 patched 1 0.097
tbx18 T-box 18 0.094
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.094
met met proto-oncogene (hepatocyte growth factor receptor) 0.086
notch2 notch homolog 2 0.081
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.077
myl7 myosin, light polypeptide 7, regulatory 0.072
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.069
hmx4 H6 family homeobox 4 0.067
kdrl kinase insert domain receptor like 0.064
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.064
twist1a twist1a 0.063
col1a1a collagen, type I, alpha 1a 0.059
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.057
oep one-eyed pinhead 0.056
nkx2.5 NK2 transcription factor related 5 0.056
dlx2a distal-less homeobox gene 2a 0.055
tnnc1a troponin C type 1a (slow) 0.054
edn1 endothelin 1 0.054
desma desmin a 0.054
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.053
bmp2a bone morphogenetic protein 2a 0.052
fgf10a fibroblast growth factor 10a 0.049
rest RE1-silencing transcription factor 0.048
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.047
gli2a GLI-Kruppel family member GLI2a 0.046
bactin1 bactin1 0.045
actc1a actin, alpha, cardiac muscle 1a 0.045
eng2b engrailed 2b 0.044
sox32 SRY-box containing gene 32 0.043
myf5 myogenic factor 5 0.042
wls wntless homolog (Drosophila) 0.042
prkci protein kinase C, iota 0.039
six2a sine oculis-related homeobox 2a 0.038
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.038
tnnt2a troponin T2a, cardiac 0.037
lef1 lymphocyte enhancer binding factor 1 0.036
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.036
dlx5a distal-less homeobox gene 5a 0.036
tbx16 T-box gene 16 0.035
aldoab aldolase a, fructose-bisphosphate, b 0.034
tmem2 transmembrane protein 2 0.032
zgc:172136 zgc:172136 0.031
wnt11 wingless-type MMTV integration site family, member 11 0.031
lft2 lefty2 0.031
hoxa2b homeo box A2b 0.030
fbn2b fibrillin 2b 0.030
sox11b SRY-box containing gene 11b 0.030
atoh1a atonal homolog 1a 0.030
nog1 noggin 1 0.029
vmhc ventricular myosin heavy chain 0.029
fsta follistatin a 0.029
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.028
ascl1a achaete-scute complex-like 1a (Drosophila) 0.028
gcga glucagon a and glucagon a-like 0.028
gsc goosecoid 0.028
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.027
gli1 GLI-Kruppel family member 1 0.027
zfand5a zinc finger, AN1-type domain 5a 0.027
wnt1 wingless-type MMTV integration site family, member 1 0.026
cx43 connexin 43 0.026
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.026
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.026
ntla no tail a 0.026
dlx3b distal-less homeobox gene 3b 0.026
dld deltaD 0.025
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.025
rhoab ras homolog gene family, member Ab 0.025
jag1b jagged 1b 0.024
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.024
crip2 cysteine-rich protein 2 0.024
plcg1 phospholipase C, gamma 1 0.024
tpma alpha-tropomyosin 0.023
ctgf connective tissue growth factor 0.023
chd chordin 0.023
myl10 myosin, light chain 10, regulatory 0.022
hsp47 heat shock protein 47 0.022
ptch2 patched 2 0.022
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TGFB1 transforming growth factor, beta 1 1.000
NOTCH1 notch 1 1.000
SKIL SKI-like oncogene 0.999
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.999
TAL1 T-cell acute lymphocytic leukemia 1 0.998
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.997
SMAD3 SMAD family member 3 0.997
ENG endoglin 0.996
BMPR1A bone morphogenetic protein receptor, type IA 0.996
BMP2 bone morphogenetic protein 2 0.992
JAG1 jagged 1 0.988
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.985
FKBP1A FK506 binding protein 1A, 12kDa 0.984
NOTCH3 notch 3 0.973
FSTL1 follistatin-like 1 0.955
TGFBR1 transforming growth factor, beta receptor 1 0.955
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.920
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.917
SMAD1 SMAD family member 1 0.893
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.788
SMAD4 SMAD family member 4 0.747
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.745
XIAP X-linked inhibitor of apoptosis 0.701
SMAD2 SMAD family member 2 0.692
ACVR1 activin A receptor, type I 0.654
MAML1 mastermind-like 1 (Drosophila) 0.628
CXXC5 CXXC finger protein 5 0.585
SETD8 SET domain containing (lysine methyltransferase) 8 0.572
TGFB3 transforming growth factor, beta 3 0.530
HIPK2 homeodomain interacting protein kinase 2 0.520
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.519
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.502
NOTCH2 notch 2 0.448
GATA4 GATA binding protein 4 0.394
PRKG1 protein kinase, cGMP-dependent, type I 0.337
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.325
MSX1 msh homeobox 1 0.314
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.279
EGR1 early growth response 1 0.262
SMAD7 SMAD family member 7 0.245
GATA2 GATA binding protein 2 0.232
ATXN1L ataxin 1-like 0.221
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.182
TBX5 T-box 5 0.175
PTK6 PTK6 protein tyrosine kinase 6 0.168
HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.166
SMAD9 SMAD family member 9 0.165
MSX2 msh homeobox 2 0.165
NRP1 neuropilin 1 0.160
SPEN spen homolog, transcriptional regulator (Drosophila) 0.151
FOXF1 forkhead box F1 0.146
SKI v-ski sarcoma viral oncogene homolog (avian) 0.125
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.114
TBX2 T-box 2 0.109
ANKRD13A ankyrin repeat domain 13A 0.108
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.104
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.104
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.099
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.094
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.094
EP300 E1A binding protein p300 0.081
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.078
FOXF2 forkhead box F2 0.077
RBPMS RNA binding protein with multiple splicing 0.071
FGF2 fibroblast growth factor 2 (basic) 0.069
JAG2 jagged 2 0.065
DLL1 delta-like 1 (Drosophila) 0.064
RUNX1 runt-related transcription factor 1 0.064
BMP4 bone morphogenetic protein 4 0.064
FGFR1 fibroblast growth factor receptor 1 0.060
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.059
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.058
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.057
FZD7 frizzled homolog 7 (Drosophila) 0.055
MAPK8 mitogen-activated protein kinase 8 0.055
ZFPM1 zinc finger protein, multitype 1 0.054
SP1 Sp1 transcription factor 0.053
SMAD6 SMAD family member 6 0.053
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.050
TGFB2 transforming growth factor, beta 2 0.049
RXRA retinoid X receptor, alpha 0.049
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.048
GRB7 growth factor receptor-bound protein 7 0.048
LAPTM5 lysosomal protein transmembrane 5 0.048
NCOR1 nuclear receptor corepressor 1 0.047
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.046
ARRDC3 arrestin domain containing 3 0.046
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.044
SOX17 SRY (sex determining region Y)-box 17 0.044
HEYL hairy/enhancer-of-split related with YRPW motif-like 0.042
NOG noggin 0.042
INHBB inhibin, beta B 0.040
NCOR2 nuclear receptor corepressor 2 0.039
TGFBR3 transforming growth factor, beta receptor III 0.039
HIPK1 homeodomain interacting protein kinase 1 0.038
SOX7 SRY (sex determining region Y)-box 7 0.036
BMPR1B bone morphogenetic protein receptor, type IB 0.035
ACVRL1 activin A receptor type II-like 1 0.035
APP amyloid beta (A4) precursor protein 0.035
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.034
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pitx2 paired-like homeodomain transcription factor 2 0.993
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.991
Gata4 GATA binding protein 4 0.986
Smad6 MAD homolog 6 (Drosophila) 0.986
Otx2 orthodenticle homolog 2 (Drosophila) 0.981
Notch1 Notch gene homolog 1 (Drosophila) 0.980
Hoxa1 homeobox A1 0.976
Jag1 jagged 1 0.975
Hand1 heart and neural crest derivatives expressed transcript 1 0.969
Hand2 heart and neural crest derivatives expressed transcript 2 0.968
Nodal nodal 0.964
Gli3 GLI-Kruppel family member GLI3 0.963
Fgf8 fibroblast growth factor 8 0.960
Fgfr2 fibroblast growth factor receptor 2 0.957
Bmp4 bone morphogenetic protein 4 0.957
Smad4 MAD homolog 4 (Drosophila) 0.945
Foxc1 forkhead box C1 0.937
Fgf10 fibroblast growth factor 10 0.936
Pax3 paired box gene 3 0.906
Efnb2 ephrin B2 0.864
Gata6 GATA binding protein 6 0.848
Meox2 mesenchyme homeobox 2 0.841
Tbx3 T-box 3 0.832
Hes1 hairy and enhancer of split 1 (Drosophila) 0.807
Ctnnb1 catenin (cadherin associated protein), beta 1 0.805
Isl1 ISL1 transcription factor, LIM/homeodomain 0.799
Smo smoothened homolog (Drosophila) 0.792
Dll4 delta-like 4 (Drosophila) 0.789
Emx1 empty spiracles homolog 1 (Drosophila) 0.763
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.759
Tgfb2 transforming growth factor, beta 2 0.741
Neurod1 neurogenic differentiation 1 0.724
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.704
Pax6 paired box gene 6 0.684
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.667
Foxc2 forkhead box C2 0.656
Prrx1 paired related homeobox 1 0.643
Tcfap2a transcription factor AP-2, alpha 0.638
Zic3 zinc finger protein of the cerebellum 3 0.612
Bmpr1a bone morphogenetic protein receptor, type 1A 0.601
Fgfr1 fibroblast growth factor receptor 1 0.598
Hoxa13 homeobox A13 0.589
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.584
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.569
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.565
Pax2 paired box gene 2 0.548
Prrx2 paired related homeobox 2 0.536
Sox2 SRY-box containing gene 2 0.517
Ntf3 neurotrophin 3 0.510
Gbx2 gastrulation brain homeobox 2 0.501
Nos3 nitric oxide synthase 3, endothelial cell 0.461
Lhx1 LIM homeobox protein 1 0.436
Smad1 MAD homolog 1 (Drosophila) 0.431
Pitx1 paired-like homeodomain transcription factor 1 0.429
Acvr1 activin A receptor, type 1 0.417
Snai1 snail homolog 1 (Drosophila) 0.405
Sox11 SRY-box containing gene 11 0.379
Neurog2 neurogenin 2 0.376
En1 engrailed 1 0.362
Foxh1 forkhead box H1 0.350
Chd7 chromodomain helicase DNA binding protein 7 0.347
Efna2 ephrin A2 0.329
Gdnf glial cell line derived neurotrophic factor 0.320
Pou5f1 POU domain, class 5, transcription factor 1 0.292
Msx2 homeobox, msh-like 2 0.279
Gsc goosecoid homeobox 0.272
Wt1 Wilms tumor 1 homolog 0.264
Eya1 eyes absent 1 homolog (Drosophila) 0.248
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.228
Hes5 hairy and enhancer of split 5 (Drosophila) 0.224
Rarg retinoic acid receptor, gamma 0.221
Nog noggin 0.213
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.208
She src homology 2 domain-containing transforming protein E 0.206
Tbx1 T-box 1 0.199
Klf3 Kruppel-like factor 3 (basic) 0.198
Alx4 aristaless-like homeobox 4 0.195
Chrd chordin 0.194
Lhx3 LIM homeobox protein 3 0.186
Sox7 SRY-box containing gene 7 0.180
Zfpm2 zinc finger protein, multitype 2 0.180
Pten phosphatase and tensin homolog 0.179
Tgfbr2 transforming growth factor, beta receptor II 0.177
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.173
Sox18 SRY-box containing gene 18 0.165
Runx2 runt related transcription factor 2 0.165
Ret ret proto-oncogene 0.162
Kiss1 KiSS-1 metastasis-suppressor 0.162
Vangl2 vang-like 2 (van gogh, Drosophila) 0.162
Foxg1 forkhead box G1 0.155
Grb10 growth factor receptor bound protein 10 0.153
Smad3 MAD homolog 3 (Drosophila) 0.152
Neurog3 neurogenin 3 0.150
Ptf1a pancreas specific transcription factor, 1a 0.150
Tbx5 T-box 5 0.142
Wnt3a wingless-related MMTV integration site 3A 0.140
Dlx5 distal-less homeobox 5 0.139
Wnt11 wingless-related MMTV integration site 11 0.136
Scn5a sodium channel, voltage-gated, type V, alpha 0.136
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Nfib nuclear factor I/B 0.072
Cav1 caveolin 1, caveolae protein 0.037
Galr2 galanin receptor 2 0.035
Muc1 mucin 1, cell surface associated 0.035
Glg1 golgi apparatus protein 1 0.033
Gata6 GATA binding protein 6 0.029
Cald1 caldesmon 1 0.027
Cast calpastatin 0.025
Il6st interleukin 6 signal transducer 0.025
Pou3f2 POU class 3 homeobox 2 0.023
Andpro androgen regulated protein 0.022
Maoa monoamine oxidase A 0.022
Fgf1 fibroblast growth factor 1 0.021
Jak1 Janus kinase 1 0.020
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.020
Pls3 plastin 3 (T-isoform) 0.020
Crhr1 corticotropin releasing hormone receptor 1 0.019
Igfbp5 insulin-like growth factor binding protein 5 0.018
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.016
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.016
Gja1 gap junction protein, alpha 1 0.016
Met met proto-oncogene 0.016
Acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.016
Lamc1 laminin, gamma 1 0.015
Nab1 Ngfi-A binding protein 1 0.015
Sp1 Sp1 transcription factor 0.015
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.015
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.014
Il1r1 interleukin 1 receptor, type I 0.014
Tcf12 transcription factor 12 0.014
Prkd3 protein kinase D3 0.014
Sbk1 SH3-binding domain kinase 1 0.014
Sox13 SRY (sex determining region Y)-box 13 0.013
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.013
Tcf21 transcription factor 21 0.013
Ireb2 iron responsive element binding protein 2 0.013
Capn8 calpain 8 0.013
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.013
Rasa1 RAS p21 protein activator (GTPase activating protein) 1 0.012
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.012
Ly6al lymphocyte antigen 6 complex, locus A-like 0.012
Fndc3b fibronectin type III domain containing 3B 0.012
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.012
Nckap1 NCK-associated protein 1 0.012
Adam18 ADAM metallopeptidase domain 18 0.012
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.011
Muc4 mucin 4, cell surface associated 0.011
Irs1 insulin receptor substrate 1 0.011
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.011
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.011
Taok1 TAO kinase 1 0.011
Adam10 ADAM metallopeptidase domain 10 0.011
Tcf4 transcription factor 4 0.011
Cdc25a cell division cycle 25 homolog A (S. pombe) 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism