The network for 'negative regulation of cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.

Drosophila melanogaster
Name Description Probability Func Analog Organism
ci cubitus interruptus 0.996
so sine oculis 0.995
dap dacapo 0.992
Ras85D Ras oncogene at 85D 0.991
Dl Delta 0.985
Mad Mothers against dpp 0.979
brat brain tumor 0.975
emc extra macrochaetae 0.972
en engrailed 0.966
N Notch 0.964
Egfr Epidermal growth factor receptor 0.940
sd scalloped 0.920
Stat92E Signal-transducer and activator of transcription protein at 92E 0.920
E(spl) Enhancer of split 0.917
tkv thickveins 0.916
Su(H) Suppressor of Hairless 0.916
hh hedgehog 0.916
bsk basket 0.915
Gap1 GTPase-activating protein 1 0.890
eff effete 0.881
ato atonal 0.846
ph-p polyhomeotic proximal 0.822
rl rolled 0.812
eya eyes absent 0.808
MED4 Mediator complex subunit 4 0.786
hep hemipterous 0.777
yki yorkie 0.764
nkd naked cuticle 0.762
slp1 sloppy paired 1 0.747
sax saxophone 0.739
shn schnurri 0.725
Wnt4 Wnt oncogene analog 4 0.721
gro groucho 0.706
arm armadillo 0.705
shi shibire 0.703
da daughterless 0.699
Tao-1 CG14217 gene product from transcript CG14217-RF 0.683
CkIIalpha Casein kinase II alpha subunit 0.683
Akt1 CG4006 gene product from transcript CG4006-RA 0.677
smo smoothened 0.660
stwl stonewall 0.659
usp ultraspiracle 0.656
G-oalpha47A G protein oalpha 47A 0.654
slmb supernumerary limbs 0.653
ovo CG6824 gene product from transcript CG6824-RE 0.644
NetB Netrin-B 0.640
ap apterous 0.637
Moe Moesin 0.600
tup tailup 0.594
wg wingless 0.593
dm diminutive 0.581
spen split ends 0.581
MED11 Mediator complex subunit 11 0.580
rin rasputin 0.575
ex expanded 0.570
Ser Serrate 0.570
HLHm7 E(spl) region transcript m7 0.568
dally division abnormally delayed 0.566
CtBP C-terminal Binding Protein 0.562
tws twins 0.551
nub nubbin 0.548
MED6 Mediator complex subunit 6 0.539
kn knot 0.527
MED27 Mediator complex subunit 27 0.523
elav embryonic lethal abnormal vision 0.517
rho rhomboid 0.513
slp2 sloppy paired 2 0.510
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.510
tin tinman 0.509
G-salpha60A G protein salpha 60A 0.503
nmo nemo 0.503
gig gigas 0.500
Gp150 CG5820 gene product from transcript CG5820-RA 0.498
Ubqn Ubiquilin 0.492
lbl ladybird late 0.491
MED31 Mediator complex subunit 31 0.486
ac achaete 0.483
dpn deadpan 0.482
ds dachsous 0.480
BicD Bicaudal D 0.477
gsb gooseberry 0.470
pyd polychaetoid 0.466
os outstretched 0.449
CG5794 CG5794 gene product from transcript CG5794-RB 0.448
pnr pannier 0.448
Dad Daughters against dpp 0.444
rap retina aberrant in pattern 0.441
bowl brother of odd with entrails limited 0.431
CdsA CDP diglyceride synthetase 0.428
Snoo Sno oncogene 0.419
Ubx Ultrabithorax 0.415
Ptp69D Protein tyrosine phosphatase 69D 0.406
drpr draper 0.406
fng fringe 0.405
Pak PAK-kinase 0.403
chico CG5686 gene product from transcript CG5686-RB 0.402
sno strawberry notch 0.396
Ten-a Tenascin accessory 0.392
Lam Lamin 0.390
ab abrupt 0.390
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.049
bar-1 Protein BAR-1 0.012
nhr-67 Protein NHR-67 0.011
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Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.923
tal1 T-cell acute lymphocytic leukemia 1 0.789
tbx16 T-box gene 16 0.721
dlc deltaC 0.655
ascl1a achaete-scute complex-like 1a (Drosophila) 0.633
ndr2 nodal-related 2 0.605
foxa2 forkhead box A2 0.553
wnt5b wingless-type MMTV integration site family, member 5b 0.540
foxi1 forkhead box I1 0.530
hmx3 homeo box (H6 family) 3 0.511
gata1a GATA binding protein 1a 0.479
twist3 twist3 0.467
fgf8a fibroblast growth factor 8 a 0.427
pcdh8 protocadherin 8 0.403
notch1a notch homolog 1a 0.390
six4b sine oculis homeobox homolog 4b 0.389
fn1 fibronectin 1 0.377
tbx2b T-box 2b 0.375
bmp2b bone morphogenetic protein 2b 0.358
gli1 GLI-Kruppel family member 1 0.353
sox1a SRY-box containing gene 1a 0.352
myod1 myogenic differentiation 1 0.349
cxcr4b chemokine (C-X-C motif), receptor 4b 0.348
pax7a paired box gene 7a 0.344
cdh1 cadherin 1, epithelial 0.339
dlx4b distal-less homeobox gene 4b 0.338
bmp2a bone morphogenetic protein 2a 0.337
sox7 SRY-box containing gene 7 0.336
nog1 noggin 1 0.335
fzd8a frizzled homolog 8a 0.326
mecom MDS1 and EVI1 complex locus 0.317
fzd7a frizzled homolog 7a 0.315
wnt11r wingless-type MMTV integration site family, member 11, related 0.287
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.284
alcama activated leukocyte cell adhesion molecule a 0.278
wnt4a wingless-type MMTV integration site family, member 4a 0.277
atoh8 atonal homolog 8 0.270
sox2 SRY-box containing gene 2 0.267
hlxb9la homeo box HB9 like a 0.267
gdf6a growth differentiation factor 6a 0.264
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.263
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.260
sox17 SRY-box containing gene 17 0.260
pax6a paired box gene 6a 0.260
isl1 islet1 0.259
rdh10a retinol dehydrogenase 10a 0.258
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.253
jag2 jagged 2 0.253
tp53 tumor protein p53 0.248
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.248
sox19a SRY-box containing gene 19a 0.247
spry4 sprouty (Drosophila) homolog 4 0.246
nkx2.2a NK2 transcription factor related 2a 0.245
dkk1b dickkopf 1b 0.238
foxd3 forkhead box D3 0.229
foxd5 forkhead box D5 0.213
fgfr3 fibroblast growth factor receptor 3 0.212
her7 hairy and enhancer of split related-7 0.209
hoxb3a homeo box B3a 0.207
tbx6 T-box gene 6 0.203
foxa3 forkhead box A3 0.203
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.201
neurod4 neurogenic differentiation 4 0.198
her12 hairy-related 12 0.193
cdx4 caudal type homeo box transcription factor 4 0.192
fzd10 frizzled homolog 10 0.192
lhx1a LIM homeobox 1a 0.191
dlx2a distal-less homeobox gene 2a 0.187
lfng lunatic fringe homolog 0.187
robo2 roundabout homolog 2 0.182
egr2b early growth response 2b 0.180
flh floating head 0.179
her6 hairy-related 6 0.178
mespa mesoderm posterior a 0.173
nkx2.2b NK2 transcription factor related 2b 0.171
cxcr4a chemokine (C-X-C motif) receptor 4a 0.169
hoxa2b homeo box A2b 0.163
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.162
sox3 SRY-box containing gene 3 0.161
phox2a paired-like homeobox 2a 0.158
lef1 lymphocyte enhancer binding factor 1 0.158
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.158
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.154
tia1 cytotoxic granule-associated RNA binding protein 1 0.152
etv2 ets variant gene 2 0.152
rarab retinoic acid receptor, alpha b 0.150
foxj1b forkhead box J1b 0.146
pkd2 polycystic kidney disease 2 0.145
atoh1a atonal homolog 1a 0.144
sox9b SRY-box containing gene 9b 0.144
hoxb1b homeo box B1b 0.144
itgb1a integrin, beta 1a 0.142
gsna gelsolin a 0.141
slit3 slit (Drosophila) homolog 3 0.141
barhl2 BarH-like 2 0.141
otpb orthopedia homolog b 0.140
cntn2 contactin 2 0.139
ccnd1 cyclin D1 0.137
notch3 notch homolog 3 0.136
vsx2 visual system homeobox 2 0.134
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Homo sapiens
Name Description Probability Func Analog Organism
JUN jun proto-oncogene 1.000
SMAD4 SMAD family member 4 1.000
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.000
SMAD3 SMAD family member 3 0.999
CREBBP CREB binding protein 0.998
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.998
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.997
AR androgen receptor 0.997
EGFR epidermal growth factor receptor 0.992
TAL1 T-cell acute lymphocytic leukemia 1 0.989
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.986
SMAD1 SMAD family member 1 0.985
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.982
NCOR2 nuclear receptor corepressor 2 0.977
IL4R interleukin 4 receptor 0.972
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.972
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.964
FOS FBJ murine osteosarcoma viral oncogene homolog 0.960
ZNF43 zinc finger protein 43 0.957
SMAD7 SMAD family member 7 0.957
SMAD2 SMAD family member 2 0.954
CAV1 caveolin 1, caveolae protein, 22kDa 0.952
ESR1 estrogen receptor 1 0.951
ATF2 activating transcription factor 2 0.938
ATF3 activating transcription factor 3 0.924
YAP1 Yes-associated protein 1 0.919
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.916
NCOA1 nuclear receptor coactivator 1 0.908
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.905
ZNF273 zinc finger protein 273 0.883
FN1 fibronectin 1 0.881
JAG1 jagged 1 0.881
HNRPDL heterogeneous nuclear ribonucleoprotein D-like 0.877
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.874
C1QA complement component 1, q subcomponent, A chain 0.864
JUNB jun B proto-oncogene 0.859
MED15 mediator complex subunit 15 0.851
HLA-B major histocompatibility complex, class I, B 0.850
PDX1 pancreatic and duodenal homeobox 1 0.848
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.844
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.838
AXIN1 axin 1 0.837
B2M beta-2-microglobulin 0.836
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.826
SP1 Sp1 transcription factor 0.824
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.822
HOXB5 homeobox B5 0.821
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.818
BCAR1 breast cancer anti-estrogen resistance 1 0.814
FHL2 four and a half LIM domains 2 0.802
CXCL2 chemokine (C-X-C motif) ligand 2 0.799
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.797
TP73 tumor protein p73 0.796
DDIT3 DNA-damage-inducible transcript 3 0.795
SMN1 survival of motor neuron 1, telomeric 0.793
DICER1 dicer 1, ribonuclease type III 0.792
SFRP1 secreted frizzled-related protein 1 0.784
MED10 mediator complex subunit 10 0.769
LTBP2 latent transforming growth factor beta binding protein 2 0.765
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.755
BMP2 bone morphogenetic protein 2 0.746
ATN1 atrophin 1 0.744
IL8 interleukin 8 0.740
GSK3B glycogen synthase kinase 3 beta 0.734
NOTCH1 notch 1 0.733
RAD21 RAD21 homolog (S. pombe) 0.730
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.728
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.721
CCND1 cyclin D1 0.718
HMGA1 high mobility group AT-hook 1 0.712
GATA2 GATA binding protein 2 0.712
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.704
NCOR1 nuclear receptor corepressor 1 0.702
FGF1 fibroblast growth factor 1 (acidic) 0.701
TP53 tumor protein p53 0.700
DUSP1 dual specificity phosphatase 1 0.697
RBBP4 retinoblastoma binding protein 4 0.693
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.684
SETDB1 SET domain, bifurcated 1 0.684
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.682
FBLN1 fibulin 1 0.680
CDK8 cyclin-dependent kinase 8 0.672
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.665
HNF4A hepatocyte nuclear factor 4, alpha 0.661
COL1A1 collagen, type I, alpha 1 0.660
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.659
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.659
SOX2 SRY (sex determining region Y)-box 2 0.655
TMSB4X thymosin beta 4, X-linked 0.647
APP amyloid beta (A4) precursor protein 0.646
PAX3 paired box 3 0.646
SOX11 SRY (sex determining region Y)-box 11 0.641
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.640
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.635
PSG9 pregnancy specific beta-1-glycoprotein 9 0.634
ENG endoglin 0.627
SMAD6 SMAD family member 6 0.621
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.611
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.609
MED6 mediator complex subunit 6 0.602
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
S100a6 S100 calcium binding protein A6 0.693
Fgfr2 fibroblast growth factor receptor 2 0.624
Rara retinoic acid receptor, alpha 0.459
Cd9 CD9 molecule 0.420
S100a9 S100 calcium binding protein A9 0.375
Otx1 orthodenticle homeobox 1 0.371
S100a8 S100 calcium binding protein A8 0.354
Anxa2 annexin A2 0.319
Foxq1 forkhead box Q1 0.307
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.295
Jak1 Janus kinase 1 0.288
S100a10 S100 calcium binding protein A10 0.278
Lgals5 lectin, galactose binding, soluble 5 0.274
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.269
Gna15 guanine nucleotide binding protein, alpha 15 0.247
Marcks myristoylated alanine rich protein kinase C substrate 0.244
Ager advanced glycosylation end product-specific receptor 0.243
Egr1 early growth response 1 0.242
Aqp4 aquaporin 4 0.240
Calcrl calcitonin receptor-like 0.233
Acvr1 activin A receptor, type I 0.220
Tcfe2a transcription factor E2a 0.216
Ednrb endothelin receptor type B 0.209
Igfbp5 insulin-like growth factor binding protein 5 0.205
Nptn neuroplastin 0.203
Sorbs3 sorbin and SH3 domain containing 3 0.196
Galr3 galanin receptor 3 0.188
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.186
Cd4 Cd4 molecule 0.178
Gata3 GATA binding protein 3 0.172
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.169
S100a4 S100 calcium-binding protein A4 0.167
Ifitm3 interferon induced transmembrane protein 3 0.163
Ptprd protein tyrosine phosphatase, receptor type, D 0.162
Gata6 GATA binding protein 6 0.156
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.150
Twist2 twist homolog 2 (Drosophila) 0.148
Anxa5 annexin A5 0.144
Nrarp Notch-regulated ankyrin repeat protein 0.144
Irs1 insulin receptor substrate 1 0.143
Lgals3 lectin, galactoside-binding, soluble, 3 0.143
Ahnak AHNAK nucleoprotein 0.142
Foxs1 forkhead box S1 0.141
Rxra retinoid X receptor alpha 0.140
Adcy6 adenylate cyclase 6 0.140
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.139
Cd5 Cd5 molecule 0.138
Zfp36 zinc finger protein 36 0.138
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.137
S100a11 S100 calcium binding protein A11 (calizzarin) 0.135
Anxa1 annexin A1 0.135
Mybpc2 myosin binding protein C, fast-type 0.133
Rest RE1-silencing transcription factor 0.131
Reln reelin 0.130
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.130
Il12b interleukin 12B 0.129
Ralgds ral guanine nucleotide dissociation stimulator 0.126
Oxtr oxytocin receptor 0.125
Pld1 phospholipase D1 0.125
Myo1c myosin IC 0.124
Gja1 gap junction protein, alpha 1 0.121
Scarb1 scavenger receptor class B, member 1 0.120
Phox2a paired-like homeobox 2a 0.120
Hes1 hairy and enhancer of split 1 (Drosophila) 0.119
Sf1 splicing factor 1 0.118
Mgp matrix Gla protein 0.117
Mtpn myotrophin 0.115
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.114
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.113
Cdk2 cyclin dependent kinase 2 0.111
Fut2 fucosyltransferase 2 (secretor status included) 0.111
Capn2 calpain 2 0.110
Prkcd protein kinase C, delta 0.110
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.108
Triobp TRIO and F-actin binding protein 0.108
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.108
Klf4 Kruppel-like factor 4 (gut) 0.108
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.102
Gpx3 glutathione peroxidase 3 0.102
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.102
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.101
Ece1 endothelin converting enzyme 1 0.100
Gja6 gap junction protein, alpha 6 0.100
Syt6 synaptotagmin VI 0.098
RGD1310262 hypothetical LOC304650 0.098
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.096
Crip cysteine-rich intestinal protein 0.095
Myh9 myosin, heavy chain 9, non-muscle 0.095
Ddr1 discoidin domain receptor tyrosine kinase 1 0.094
Dll1 delta-like 1 (Drosophila) 0.094
Stat6 signal transducer and activator of transcription 6 0.094
Ccnd1 cyclin D1 0.094
Ifitm1 interferon induced transmembrane protein 1 0.094
Pls3 plastin 3 (T-isoform) 0.093
Pld2 phospholipase D2 0.093
Gpc1 glypican 1 0.093
Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 0.093
Nos2 nitric oxide synthase 2, inducible 0.093
Prss22 protease, serine, 22 0.091
Notch3 Notch homolog 3 (Drosophila) 0.091
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
IRA1 Ira1p 0.017
RAS2 Ras2p 0.016
PSD2 Psd2p 0.015
PIR1 Pir1p 0.015
PCL9 Pcl9p 0.013
KDX1 Kdx1p 0.012
PTM1 Ptm1p 0.012
MSG5 Msg5p 0.011
FUS3 Fus3p 0.011
CDC25 Cdc25p 0.010
CYR1 Cyr1p 0.010