IMP
Process View
The network for 'substantia nigra development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
substantia nigra development
The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 0.933 | |
| Rac1 | RAS-related C3 botulinum substrate 1 | 0.900 | |
| Pax3 | paired box gene 3 | 0.838 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.768 | |
| Pax2 | paired box gene 2 | 0.743 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.689 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.535 | |
| Pgk1 | phosphoglycerate kinase 1 | 0.526 | |
| Fgf10 | fibroblast growth factor 10 | 0.496 | |
| Prrx1 | paired related homeobox 1 | 0.464 | |
| Mtor | mechanistic target of rapamycin (serine/threonine kinase) | 0.398 | |
| Tbx1 | T-box 1 | 0.360 | |
| Foxc1 | forkhead box C1 | 0.340 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.322 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.318 | |
| Foxg1 | forkhead box G1 | 0.308 | |
| Bmp4 | bone morphogenetic protein 4 | 0.304 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.290 | |
| Nog | noggin | 0.264 | |
| Sox9 | SRY-box containing gene 9 | 0.260 | |
| Aldoa | aldolase A, fructose-bisphosphate | 0.236 | |
| Chrd | chordin | 0.224 | |
| Tpi1 | triosephosphate isomerase 1 | 0.220 | |
| Calm1 | calmodulin 1 | 0.216 | |
| Sox2 | SRY-box containing gene 2 | 0.208 | |
| Gapdh | glyceraldehyde-3-phosphate dehydrogenase | 0.199 | |
| Gm6788 | predicted gene 6788 | 0.187 | |
| Fgf8 | fibroblast growth factor 8 | 0.175 | |
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.170 | |
| Hoxa1 | homeobox A1 | 0.160 | |
| Pkm2 | pyruvate kinase, muscle | 0.152 | |
| Iqcb1 | IQ calmodulin-binding motif containing 1 | 0.151 | |
| Dlx5 | distal-less homeobox 5 | 0.151 | |
| Gsc | goosecoid homeobox | 0.147 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.145 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.140 | |
| Rarb | retinoic acid receptor, beta | 0.136 | |
| Hsp90b1 | heat shock protein 90, beta (Grp94), member 1 | 0.134 | |
| Atp5a1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 | 0.132 | |
| Tbx10 | T-box 10 | 0.131 | |
| Lrrk2 | leucine-rich repeat kinase 2 | 0.126 | |
| Jag1 | jagged 1 | 0.116 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.116 | |
| Tbx15 | T-box 15 | 0.110 | |
| Rpgrip1l | Rpgrip1-like | 0.109 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.107 | |
| Sin3a | transcriptional regulator, SIN3A (yeast) | 0.100 | |
| Manf | mesencephalic astrocyte-derived neurotrophic factor | 0.099 | |
| Kcna1 | potassium voltage-gated channel, shaker-related subfamily, member 1 | 0.098 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.094 | |
| Msx1 | homeobox, msh-like 1 | 0.092 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.091 | |
| Bmp5 | bone morphogenetic protein 5 | 0.088 | |
| Prrx2 | paired related homeobox 2 | 0.087 | |
| Morf4l2 | mortality factor 4 like 2 | 0.087 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.086 | |
| Sin3b | transcriptional regulator, SIN3B (yeast) | 0.085 | |
| Nkx2-1 | NK2 homeobox 1 | 0.083 | |
| Hoxd11 | homeobox D11 | 0.080 | |
| Nde1 | nuclear distribution gene E homolog 1 (A nidulans) | 0.080 | |
| Kcnma1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 0.077 | |
| Tcf21 | transcription factor 21 | 0.077 | |
| Sdf2l1 | stromal cell-derived factor 2-like 1 | 0.074 | |
| Actr3 | ARP3 actin-related protein 3 homolog (yeast) | 0.074 | |
| Srcin1 | SRC kinase signaling inhibitor 1 | 0.073 | |
| Meox2 | mesenchyme homeobox 2 | 0.072 | |
| Creld2 | cysteine-rich with EGF-like domains 2 | 0.070 | |
| Hoxa11 | homeobox A11 | 0.069 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.069 | |
| Hmx3 | H6 homeobox 3 | 0.067 | |
| Ret | ret proto-oncogene | 0.067 | |
| Msx2 | homeobox, msh-like 2 | 0.067 | |
| Tbx3 | T-box 3 | 0.066 | |
| Gm5506 | predicted gene 5506 | 0.064 | |
| Nefl | neurofilament, light polypeptide | 0.064 | |
| Runx2 | runt related transcription factor 2 | 0.063 | |
| Npr2 | natriuretic peptide receptor 2 | 0.062 | |
| Syt5 | synaptotagmin V | 0.062 | |
| Pak1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.062 | |
| Fgf9 | fibroblast growth factor 9 | 0.061 | |
| Bdnf | brain derived neurotrophic factor | 0.060 | |
| Gata3 | GATA binding protein 3 | 0.060 | |
| Foxc2 | forkhead box C2 | 0.060 | |
| Ednra | endothelin receptor type A | 0.060 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.059 | |
| Ywhah | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.057 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.057 | |
| Fgfrl1 | fibroblast growth factor receptor-like 1 | 0.057 | |
| Dnajb11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.057 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.056 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.056 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.056 | |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.056 | |
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.056 | |
| Hpca | hippocalcin | 0.055 | |
| Rtn4r | reticulon 4 receptor | 0.055 | |
| Marcksl1 | MARCKS-like 1 | 0.054 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.053 | |
| Actg1 | actin, gamma, cytoplasmic 1 | 0.053 | |
| Pdia3 | protein disulfide isomerase associated 3 | 0.052 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.997 | |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.956 | |
| FGFR2 | fibroblast growth factor receptor 2 | 0.946 | |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.932 | |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.925 | |
| ZNF43 | zinc finger protein 43 | 0.916 | |
| S100A6 | S100 calcium binding protein A6 | 0.824 | |
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.806 | |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.783 | |
| ZNF273 | zinc finger protein 273 | 0.750 | |
| TRIM63 | tripartite motif containing 63 | 0.711 | |
| ZNF253 | zinc finger protein 253 | 0.658 | |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.656 | |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.610 | |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 0.600 | |
| S100A8 | S100 calcium binding protein A8 | 0.545 | |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 0.519 | |
| S100A9 | S100 calcium binding protein A9 | 0.498 | |
| ZNF675 | zinc finger protein 675 | 0.444 | |
| XIAP | X-linked inhibitor of apoptosis | 0.394 | |
| S100A16 | S100 calcium binding protein A16 | 0.371 | |
| ZNF91 | zinc finger protein 91 | 0.333 | |
| SFN | stratifin | 0.305 | |
| ANXA2 | annexin A2 | 0.302 | |
| ANXA7 | annexin A7 | 0.292 | |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.284 | |
| LDHA | lactate dehydrogenase A | 0.280 | |
| ZNF117 | zinc finger protein 117 | 0.279 | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.266 | |
| S100B | S100 calcium binding protein B | 0.232 | |
| CFL1 | cofilin 1 (non-muscle) | 0.201 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.201 | |
| ZNF680 | zinc finger protein 680 | 0.166 | |
| VIM | vimentin | 0.158 | |
| MDH1 | malate dehydrogenase 1, NAD (soluble) | 0.157 | |
| RHOA | ras homolog gene family, member A | 0.155 | |
| ZNF85 | zinc finger protein 85 | 0.154 | |
| ZNF93 | zinc finger protein 93 | 0.148 | |
| ACTB | actin, beta | 0.144 | |
| S100A1 | S100 calcium binding protein A1 | 0.142 | |
| S100A11 | S100 calcium binding protein A11 | 0.140 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.138 | |
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.137 | |
| ZNF708 | zinc finger protein 708 | 0.129 | |
| ZNF430 | zinc finger protein 430 | 0.129 | |
| TMSB10 | thymosin beta 10 | 0.125 | |
| ATP5L | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G | 0.121 | |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.120 | |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.117 | |
| ATP5O | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit | 0.116 | |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.114 | |
| FGFR1 | fibroblast growth factor receptor 1 | 0.099 | |
| SH3BGRL3 | SH3 domain binding glutamic acid-rich protein like 3 | 0.097 | |
| ZNF254 | zinc finger protein 254 | 0.094 | |
| VDAC3 | voltage-dependent anion channel 3 | 0.090 | |
| TMSB4X | thymosin beta 4, X-linked | 0.089 | |
| S100A4 | S100 calcium binding protein A4 | 0.084 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.083 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.078 | |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.074 | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.074 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.074 | |
| FGF10 | fibroblast growth factor 10 | 0.072 | |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.072 | |
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.065 | |
| S100A10 | S100 calcium binding protein A10 | 0.062 | |
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.060 | |
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) | 0.059 | |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.058 | |
| ZNF92 | zinc finger protein 92 | 0.056 | |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.055 | |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.054 | |
| NDRG1 | N-myc downstream regulated 1 | 0.048 | |
| ATP5J2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 | 0.047 | |
| ZNF136 | zinc finger protein 136 | 0.047 | |
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.046 | |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.046 | |
| ARHGAP1 | Rho GTPase activating protein 1 | 0.046 | |
| CAPNS1 | calpain, small subunit 1 | 0.045 | |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.045 | |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.044 | |
| ZNF682 | zinc finger protein 682 | 0.043 | |
| OTUB1 | OTU domain, ubiquitin aldehyde binding 1 | 0.040 | |
| CDC14B | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | 0.040 | |
| EMP3 | epithelial membrane protein 3 | 0.039 | |
| DSTN | destrin (actin depolymerizing factor) | 0.039 | |
| EZR | ezrin | 0.039 | |
| ACTG1 | actin, gamma 1 | 0.039 | |
| SUDS3 | suppressor of defective silencing 3 homolog (S. cerevisiae) | 0.037 | |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.037 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.037 | |
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 0.035 | |
| HSPA8 | heat shock 70kDa protein 8 | 0.035 | |
| CFL2 | cofilin 2 (muscle) | 0.034 | |
| MYO10 | myosin X | 0.034 | |
| GSN | gelsolin | 0.033 | |
| NCF2 | neutrophil cytosolic factor 2 | 0.033 | |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 0.033 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.033 | |
| ZNF107 | zinc finger protein 107 | 0.032 |