The network for 'negative regulation of cell morphogenesis involved in differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell morphogenesis involved in differentiation

Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.996
Ephb2 Eph receptor B2 0.995
Gli3 GLI-Kruppel family member GLI3 0.995
Epha4 Eph receptor A4 0.993
Efnb2 ephrin B2 0.977
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.956
Robo1 roundabout homolog 1 (Drosophila) 0.910
Psen1 presenilin 1 0.905
Ctnnb1 catenin (cadherin associated protein), beta 1 0.885
Slit3 slit homolog 3 (Drosophila) 0.813
Shh sonic hedgehog 0.773
Ephb3 Eph receptor B3 0.757
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.718
Wnt3a wingless-related MMTV integration site 3A 0.717
Tyro3 TYRO3 protein tyrosine kinase 3 0.685
Pou3f3 POU domain, class 3, transcription factor 3 0.679
Axl AXL receptor tyrosine kinase 0.658
Ptk2 PTK2 protein tyrosine kinase 2 0.645
Gli2 GLI-Kruppel family member GLI2 0.635
Notch1 Notch gene homolog 1 (Drosophila) 0.617
Nog noggin 0.591
Fgf8 fibroblast growth factor 8 0.583
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.575
Fzd1 frizzled homolog 1 (Drosophila) 0.573
Wnt5a wingless-related MMTV integration site 5A 0.569
Foxa2 forkhead box A2 0.533
Rarb retinoic acid receptor, beta 0.529
Tbx3 T-box 3 0.527
Sall4 sal-like 4 (Drosophila) 0.516
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.491
Gab1 growth factor receptor bound protein 2-associated protein 1 0.481
Apc2 adenomatosis polyposis coli 2 0.476
Zfpm2 zinc finger protein, multitype 2 0.475
Nrp1 neuropilin 1 0.410
Foxc1 forkhead box C1 0.408
Rarg retinoic acid receptor, gamma 0.402
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.395
Plcg1 phospholipase C, gamma 1 0.360
Pten phosphatase and tensin homolog 0.355
Axin1 axin 1 0.354
Fgf18 fibroblast growth factor 18 0.347
Tnks1bp1 tankyrase 1 binding protein 1 0.334
Mmp15 matrix metallopeptidase 15 0.334
Sfrp1 secreted frizzled-related protein 1 0.326
Hoxd11 homeobox D11 0.319
Sfrp2 secreted frizzled-related protein 2 0.314
Sox2 SRY-box containing gene 2 0.297
Pax2 paired box gene 2 0.297
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.293
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.289
Lhx1 LIM homeobox protein 1 0.277
Fgfr1 fibroblast growth factor receptor 1 0.277
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.236
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.234
Pcdh12 protocadherin 12 0.232
Axin2 axin2 0.227
Emx1 empty spiracles homolog 1 (Drosophila) 0.225
Fgf3 fibroblast growth factor 3 0.224
L1cam L1 cell adhesion molecule 0.220
Dll1 delta-like 1 (Drosophila) 0.218
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.216
Dll4 delta-like 4 (Drosophila) 0.215
Vangl2 vang-like 2 (van gogh, Drosophila) 0.213
Pax8 paired box gene 8 0.210
Fzd8 frizzled homolog 8 (Drosophila) 0.208
Bmp5 bone morphogenetic protein 5 0.196
Hoxa13 homeobox A13 0.194
Nrp2 neuropilin 2 0.193
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.192
Wnt3 wingless-related MMTV integration site 3 0.187
Chd7 chromodomain helicase DNA binding protein 7 0.187
Sall1 sal-like 1 (Drosophila) 0.186
Bmp1 bone morphogenetic protein 1 0.185
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.185
Grid1 glutamate receptor, ionotropic, delta 1 0.182
Pthlh parathyroid hormone-like peptide 0.181
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.173
Mertk c-mer proto-oncogene tyrosine kinase 0.171
Pbx1 pre B-cell leukemia transcription factor 1 0.170
Hes1 hairy and enhancer of split 1 (Drosophila) 0.169
Pou3f2 POU domain, class 3, transcription factor 2 0.165
Unc5c unc-5 homolog C (C. elegans) 0.162
Dock1 dedicator of cytokinesis 1 0.161
Efna2 ephrin A2 0.160
Trp63 transformation related protein 63 0.155
Zdhhc17 zinc finger, DHHC domain containing 17 0.154
Wnt2b wingless related MMTV integration site 2b 0.152
Dlx5 distal-less homeobox 5 0.152
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.152
Adam11 a disintegrin and metallopeptidase domain 11 0.150
Efs embryonal Fyn-associated substrate 0.149
Magix MAGI family member, X-linked 0.149
Grb10 growth factor receptor bound protein 10 0.149
App amyloid beta (A4) precursor protein 0.148
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.146
Src Rous sarcoma oncogene 0.145
Chrd chordin 0.144
Pax3 paired box gene 3 0.141
Gli1 GLI-Kruppel family member GLI1 0.141
Rnf208 ring finger protein 208 0.139
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
sel-12 Protein SEL-12 0.082
bar-1 Protein BAR-1 0.069
egl-18 Protein EGL-18 0.062
pry-1 Protein PRY-1 0.060
madf-5 Protein MADF-5 0.056
R10E12.2 Protein R10E12.2 0.054
sax-3 Protein SAX-3 0.044
unc-104 Protein UNC-104 0.044
lir-1 Protein LIR-1 0.041
unc-9 Protein UNC-9 0.038
F28E10.1 Protein F28E10.1 0.037
sur-2 Protein SUR-2 0.036
sem-4 Protein SEM-4 0.035
axl-1 Protein AXL-1 0.035
tbb-4 Protein TBB-4 0.034
lin-17 Protein LIN-17 0.034
cdh-3 Protein CDH-3 0.032
cam-1 Protein CAM-1 0.029
ten-1 Protein TEN-1 0.028
cfz-2 Protein CFZ-2 0.027
snt-4 Protein SNT-4 0.026
pcp-3 Protein PCP-3 0.025
nhr-66 Protein NHR-66 0.025
paa-1 Protein PAA-1 0.025
set-16 Protein SET-16 0.025
soc-2 Protein SOC-2 0.025
B0198.3 Protein B0198.3 0.023
ccb-1 Protein CCB-1 0.023
hbl-1 Protein HBL-1 0.023
pop-1 Protein POP-1 0.023
unc-129 Protein UNC-129 0.023
T28B11.1 Protein T28B11.1 0.023
unc-42 Protein UNC-42 0.023
ptp-3 Protein PTP-3 0.022
lin-12 Protein LIN-12 0.022
cec-1 Protein CEC-1 0.022
zfp-1 Protein ZFP-1 0.022
F52D10.6 Protein F52D10.6 0.022
xpc-1 Protein XPC-1 0.021
smp-1 Protein SMP-1 0.021
nhr-67 Protein NHR-67 0.021
CELE_T13H5.1 Protein T13H5.1 0.021
let-60 Protein LET-60 0.021
hhat-2 Protein HHAT-2 0.021
kal-1 Protein KAL-1 0.020
daf-12 Protein DAF-12 0.019
zoo-1 Protein ZOO-1 0.019
rig-6 Protein RIG-6 0.019
syg-2 Protein SYG-2 0.019
W02B8.1 Protein W02B8.1 0.019
rpy-1 Protein RPY-1 0.019
F53B3.5 Protein F53B3.5 0.018
F36D4.5 Protein F36D4.5 0.018
jac-1 Protein JAC-1 0.018
ife-4 Protein IFE-4 0.018
dpy-19 Protein DPY-19 0.018
hlh-30 Protein HLH-30 0.018
hmr-1 Protein HMR-1 0.018
DH11.5 Protein DH11.5 0.018
fmi-1 Protein FMI-1 0.018
ima-3 Protein IMA-3 0.018
lit-1 Protein LIT-1 0.018
bet-2 Protein BET-2 0.018
cnt-2 Protein CNT-2 0.017
lin-36 Protein LIN-36 0.017
mrck-1 Protein MRCK-1 0.017
pha-4 Protein PHA-4 0.017
dhs-27 Protein DHS-27 0.017
ceh-6 Protein CEH-6 0.017
elt-6 Protein ELT-6 0.017
lev-1 Protein LEV-1 0.017
mef-2 Protein MEF-2 0.017
B0432.8 Protein B0432.8 0.017
exp-2 Protein EXP-2 0.016
clh-5 Protein CLH-5 0.016
met-1 Protein MET-1 0.016
F09C3.2 Protein F09C3.2 0.016
igcm-3 Protein IGCM-3 0.016
CELE_F47G4.4 Protein F47G4.4 0.016
jmjd-2 Protein JMJD-2 0.015
pde-1 Protein PDE-1 0.015
eor-2 Protein EOR-2 0.015
cdc-42 Protein CDC-42 0.015
hmp-1 Protein HMP-1 0.015
F11A10.5 Protein F11A10.5 0.015
tmc-2 Protein TMC-2 0.015
arl-3 Protein ARL-3 0.015
egl-30 Protein EGL-30 0.015
dmd-9 Protein DMD-9 0.015
plx-2 Protein PLX-2 0.015
egl-46 Protein EGL-46 0.015
pqn-87 Protein PQN-87 0.015
CELE_F07A5.4 Protein F07A5.4 0.015
inx-7 Protein INX-7 0.015
csnk-1 Protein CSNK-1 0.015
hrp-1 Protein HRP-1 0.015
eor-1 Protein EOR-1 0.015
unc-1 Protein UNC-1 0.015
cit-1.1 Protein CIT-1.1 0.014
rgl-1 Protein RGL-1 0.014
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Danio rerio
Name Description Probability Func Analog Organism
foxa1 forkhead box A1 0.774
fgfr3 fibroblast growth factor receptor 3 0.409
boc brother of CDO 0.239
tfec transcription factor EC 0.182
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.170
fzd7a frizzled homolog 7a 0.148
notum3 notum 3 0.111
rdh10a retinol dehydrogenase 10a 0.108
lhx2b LIM homeobox 2b 0.108
irx2a iroquois homeobox protein 2, a 0.096
robo2 roundabout homolog 2 0.092
gro1 groucho 1 0.086
rdh8 retinol dehydrogenase 8 0.086
col7a1l collagen type VII alpha 1-like 0.084
efnb3b ephrin B3b 0.081
dlc deltaC 0.074
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.068
alcama activated leukocyte cell adhesion molecule a 0.065
ntn2 netrin 2 0.063
ntn1b netrin 1b 0.062
tnc tenascin C 0.061
epb4.1l4 erythrocyte protein band 4.1-like 4 0.061
ntn1a netrin 1a 0.060
sema3d semaphorin 3d 0.058
efnb2a ephrin B2a 0.054
sp8a sp8 transcription factor a 0.053
slit1a slit homolog 1a (Drosophila) 0.051
cdh2 cadherin 2, neuronal 0.050
crabp1b cellular retinoic acid binding protein 1b 0.050
fstl1b follistatin-like 1b 0.049
igf1rb insulin-like growth factor 1b receptor 0.048
kal1a Kallmann syndrome 1a sequence 0.047
irx5a iroquois homeobox protein 5a 0.047
igf2a insulin-like growth factor 2a 0.047
ptpra protein tyrosine phosphatase, receptor type, A 0.045
pxn paxillin 0.044
evx1 even-skipped homeobox 1 0.041
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.040
loxl2b lysyl oxidase-like 2b 0.039
barhl2 BarH-like 2 0.038
olfm2 olfactomedin 2 0.038
esrra estrogen-related receptor alpha 0.038
zdhhc8b zinc finger, DHHC-type containing 8b 0.038
gsna gelsolin a 0.038
foxa3 forkhead box A3 0.037
dab1a disabled homolog 1a (Drosophila) 0.036
bmp2a bone morphogenetic protein 2a 0.035
met met proto-oncogene (hepatocyte growth factor receptor) 0.034
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.032
irx5b iroquois homeobox protein 5b 0.031
ret1 receptor tyrosine kinase 0.031
traf4a tnf receptor-associated factor 4a 0.031
smoc1 SPARC related modular calcium binding 1 0.030
sox1a SRY-box containing gene 1a 0.030
gro2 groucho 2 0.029
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.029
fzd5 frizzled homolog 5 0.028
lama1 laminin, alpha 1 0.028
epha7 eph receptor A7 0.028
slit1b slit homolog 1b (Drosophila) 0.028
sema3fb semaphorin 3fb 0.027
rxrga retinoid x receptor, gamma a 0.027
neurod4 neurogenic differentiation 4 0.027
phox2a paired-like homeobox 2a 0.027
tbx2a T-box gene 2a 0.025
epha4a eph receptor A4a 0.025
ebf3 early B-cell factor 3 0.024
cntn2 contactin 2 0.023
mapk14a mitogen-activated protein kinase 14a 0.023
nrp1a neuropilin 1a 0.023
angptl2 angiopoietin-like 2 0.022
col12a1 collagen, type XII, alpha 1 0.021
sema3aa semaphorin 3aa 0.021
nog1 noggin 1 0.021
ascl1a achaete-scute complex-like 1a (Drosophila) 0.020
slit3 slit (Drosophila) homolog 3 0.020
unc5b unc-5 homolog B (C. elegans) 0.020
sema6dl sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like 0.020
frem3 Fras1 related extracellular matrix 3 0.020
insm1a insulinoma-associated 1a 0.019
flncb filamin C, gamma b (actin binding protein 280) 0.019
pou3f3a POU class 3 homeobox 3a 0.019
hoxb2a homeo box B2a 0.019
gap43 growth associated protein 43 0.019
nav3 neuron navigator 3 0.018
metrn meteorin, glial cell differentiation regulator 0.018
hgfa hepatocyte growth factor a 0.018
nrp2a neuropilin 2a 0.018
raraa retinoic acid receptor, alpha a 0.018
foxi3b forkhead box I3b 0.018
pea3 ETS-domain transcription factor pea3 0.018
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.018
foxd3 forkhead box D3 0.017
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.017
im:7137555 im:7137555 0.017
sfrp1a secreted frizzled-related protein 1a 0.017
dbx1a developing brain homeobox 1a 0.016
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.016
ephb4b eph receptor B4b 0.016
bhmt betaine-homocysteine methyltransferase 0.016
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC1 histone deacetylase 1 0.998
HDAC2 histone deacetylase 2 0.989
FGF1 fibroblast growth factor 1 (acidic) 0.809
TBX5 T-box 5 0.245
POU5F1 POU class 5 homeobox 1 0.160
RB1CC1 RB1-inducible coiled-coil 1 0.142
NCOA1 nuclear receptor coactivator 1 0.139
VEGFA vascular endothelial growth factor A 0.124
GRB7 growth factor receptor-bound protein 7 0.124
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.123
PCDHA4 protocadherin alpha 4 0.107
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.093
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.075
IMMT inner membrane protein, mitochondrial 0.067
RBBP4 retinoblastoma binding protein 4 0.064
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.060
GOLGA2 golgin A2 0.052
SMN1 survival of motor neuron 1, telomeric 0.052
CLDN4 claudin 4 0.051
FAF1 Fas (TNFRSF6) associated factor 1 0.050
WDYHV1 WDYHV motif containing 1 0.048
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.046
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.045
TGFB3 transforming growth factor, beta 3 0.045
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.038
SLC25A36 solute carrier family 25, member 36 0.037
REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast) 0.036
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.036
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.035
CHD4 chromodomain helicase DNA binding protein 4 0.033
MTA3 metastasis associated 1 family, member 3 0.033
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.033
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.032
TTR transthyretin 0.031
FZD1 frizzled homolog 1 (Drosophila) 0.031
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.030
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.030
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.030
GABARAP GABA(A) receptor-associated protein 0.028
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.027
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.027
RTN4 reticulon 4 0.025
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.025
RAP1A RAP1A, member of RAS oncogene family 0.025
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.024
CPE carboxypeptidase E 0.024
FAM160A2 family with sequence similarity 160, member A2 0.024
FZD8 frizzled homolog 8 (Drosophila) 0.024
PAX8 paired box 8 0.024
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.023
RXRA retinoid X receptor, alpha 0.023
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.023
RAB2A RAB2A, member RAS oncogene family 0.022
AP1M1 adaptor-related protein complex 1, mu 1 subunit 0.022
MBD2 methyl-CpG binding domain protein 2 0.022
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.021
COL1A1 collagen, type I, alpha 1 0.021
GAST gastrin 0.020
AR androgen receptor 0.020
SOX2 SRY (sex determining region Y)-box 2 0.020
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.020
TBK1 TANK-binding kinase 1 0.019
LRP6 low density lipoprotein receptor-related protein 6 0.019
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.019
MOBKL3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.019
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.018
GATA4 GATA binding protein 4 0.018
DCC deleted in colorectal carcinoma 0.018
MTA1 metastasis associated 1 0.018
KCNRG potassium channel regulator 0.018
CREBBP CREB binding protein 0.018
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.018
CDK6 cyclin-dependent kinase 6 0.018
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.017
FGF10 fibroblast growth factor 10 0.017
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.017
SCAMP1 secretory carrier membrane protein 1 0.017
FXR1 fragile X mental retardation, autosomal homolog 1 0.016
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.016
ATN1 atrophin 1 0.016
GATAD2A GATA zinc finger domain containing 2A 0.016
SESN2 sestrin 2 0.015
GEMIN6 gem (nuclear organelle) associated protein 6 0.015
FGFR1 fibroblast growth factor receptor 1 0.015
LBX1 ladybird homeobox 1 0.015
WFDC2 WAP four-disulfide core domain 2 0.015
FXYD3 FXYD domain containing ion transport regulator 3 0.015
BBS10 Bardet-Biedl syndrome 10 0.014
MTA2 metastasis associated 1 family, member 2 0.014
ATP8 ATP synthase F0 subunit 8 0.014
FGF8 fibroblast growth factor 8 (androgen-induced) 0.014
KDM1A lysine (K)-specific demethylase 1A 0.014
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.014
UBE3A ubiquitin protein ligase E3A 0.013
CSNK2B casein kinase 2, beta polypeptide 0.013
RCOR1 REST corepressor 1 0.013
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.013
CDX2 caudal type homeobox 2 0.013
WBP2 WW domain binding protein 2 0.013
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism