The network for 'c21 steroid hormone biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

c21 steroid hormone biosynthetic process

The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.

Mus musculus
Name Description Probability Func Analog Organism
Mc2r melanocortin 2 receptor 0.949
Slc12a1 solute carrier family 12, member 1 0.875
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.755
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.605
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.538
Nanog Nanog homeobox 0.528
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.401
Bmp7 bone morphogenetic protein 7 0.323
Runx2 runt related transcription factor 2 0.321
Nostrin nitric oxide synthase trafficker 0.303
Lrp2 low density lipoprotein receptor-related protein 2 0.251
Mep1a meprin 1 alpha 0.236
Acsm2 acyl-CoA synthetase medium-chain family member 2 0.185
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.170
Akr1c21 aldo-keto reductase family 1, member C21 0.163
Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.147
Hoxa10 homeobox A10 0.141
Prrx1 paired related homeobox 1 0.135
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.119
Lypla1 lysophospholipase 1 0.114
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.114
Prrx2 paired related homeobox 2 0.109
Guca2a guanylate cyclase activator 2a (guanylin) 0.101
Itm2c integral membrane protein 2C 0.101
Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 0.100
Aldh6a1 aldehyde dehydrogenase family 6, subfamily A1 0.099
Timd2 T-cell immunoglobulin and mucin domain containing 2 0.097
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.094
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.089
Cat catalase 0.085
Ren1 renin 1 structural 0.082
Ednrb endothelin receptor type B 0.079
Tbx15 T-box 15 0.078
Htt huntingtin 0.077
Hand1 heart and neural crest derivatives expressed transcript 1 0.070
Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.068
Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.063
Miox myo-inositol oxygenase 0.060
Ihh Indian hedgehog 0.057
Ar androgen receptor 0.055
Agtr1a angiotensin II receptor, type 1a 0.055
Pik3c2g phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide 0.054
Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 0.054
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.053
Fgfr3 fibroblast growth factor receptor 3 0.053
Ddr2 discoidin domain receptor family, member 2 0.052
Hao2 hydroxyacid oxidase 2 0.050
Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 0.048
Bmp4 bone morphogenetic protein 4 0.048
Ctsk cathepsin K 0.047
F13b coagulation factor XIII, beta subunit 0.047
Itga8 integrin alpha 8 0.045
Pramel6 preferentially expressed antigen in melanoma like 6 0.044
Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 0.044
G6pc glucose-6-phosphatase, catalytic 0.043
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.043
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.042
Inhbc inhibin beta-C 0.042
Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 0.041
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.041
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.040
Phyh phytanoyl-CoA hydroxylase 0.040
Upp2 uridine phosphorylase 2 0.039
Smo smoothened homolog (Drosophila) 0.039
Umod uromodulin 0.037
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.037
Dmgdh dimethylglycine dehydrogenase precursor 0.037
Keg1 kidney expressed gene 1 0.037
Fshr follicle stimulating hormone receptor 0.037
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.036
Sox9 SRY-box containing gene 9 0.035
Wnk4 WNK lysine deficient protein kinase 4 0.034
Kl klotho 0.034
Pde8b phosphodiesterase 8B 0.034
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.034
Acadm acyl-Coenzyme A dehydrogenase, medium chain 0.033
Timp2 tissue inhibitor of metalloproteinase 2 0.033
Ctgf connective tissue growth factor 0.033
Clrn3 clarin 3 0.033
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.032
Pomc pro-opiomelanocortin-alpha 0.032
Hsd3b4 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 0.032
Star steroidogenic acute regulatory protein 0.032
Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.032
Aqp8 aquaporin 8 0.032
Zp2 zona pellucida glycoprotein 2 0.031
Hsdl2 hydroxysteroid dehydrogenase like 2 0.031
Kap kidney androgen regulated protein 0.031
Hand2 heart and neural crest derivatives expressed transcript 2 0.031
Alx1 ALX homeobox 1 0.030
Mertk c-mer proto-oncogene tyrosine kinase 0.030
Slc17a1 solute carrier family 17 (sodium phosphate), member 1 0.030
Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 0.030
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.029
Elk4 ELK4, member of ETS oncogene family 0.029
Khdc1b KH domain containing 1B 0.029
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.028
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.028
Clcnka chloride channel Ka 0.027
0610031J06Rik RIKEN cDNA 0610031J06 gene 0.027
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.950
bmp4 bone morphogenetic protein 4 0.594
bmp2a bone morphogenetic protein 2a 0.282
gdf6a growth differentiation factor 6a 0.070
dlx3b distal-less homeobox gene 3b 0.069
msxd muscle segment homeobox D 0.046
fgf24 fibroblast growth factor 24 0.041
gpr126 G protein-coupled receptor 126 0.033
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.032
sp7 Sp7 transcription factor 0.031
bmp7a bone morphogenetic protein 7a 0.029
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.027
msxb muscle segment homeobox B 0.023
st3gal2l ST3 beta-galactoside alpha-2,3-sialyltransferase 2, like 0.022
szl sizzled 0.021
inka1b induced in neural crest by AP2, 1b 0.020
fgf8a fibroblast growth factor 8 a 0.019
apoeb apolipoprotein Eb 0.017
sall4 sal-like 4 (Drosophila) 0.017
sdc2 syndecan 2 0.017
wnt5b wingless-type MMTV integration site family, member 5b 0.016
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.016
dlx4b distal-less homeobox gene 4b 0.015
lama5 laminin, alpha 5 0.014
mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 0.013
nkx2.3 NK2 transcription factor related 3 0.013
wu:fc18d04 wu:fc18d04 0.013
fn1b fibronectin 1b 0.013
tp63 tumor protein p63 0.012
msxe muscle segment homeobox E 0.012
hoxc8a homeo box C8a 0.011
spry4 sprouty (Drosophila) homolog 4 0.011
hoxb1b homeo box B1b 0.011
prdm1a PR domain containing 1a, with ZNF domain 0.011
ints6 integrator complex subunit 6 0.011
zgc:92765 zgc:92765 0.010
foxi1 forkhead box I1 0.010
mgp matrix Gla protein 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BMPR1A bone morphogenetic protein receptor, type IA 0.893
BMPR1B bone morphogenetic protein receptor, type IB 0.638
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.473
NOG noggin 0.121
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.068
ZFYVE9 zinc finger, FYVE domain containing 9 0.061
FSTL1 follistatin-like 1 0.055
MYO6 myosin VI 0.051
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.037
MAPK15 mitogen-activated protein kinase 15 0.036
LAMP2 lysosomal-associated membrane protein 2 0.034
FGF18 fibroblast growth factor 18 0.031
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 0.025
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.024
COL2A1 collagen, type II, alpha 1 0.023
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.021
FOXF2 forkhead box F2 0.021
FGF4 fibroblast growth factor 4 0.018
PHYH phytanoyl-CoA 2-hydroxylase 0.017
TGFB1 transforming growth factor, beta 1 0.016
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.016
SH3BGRL SH3 domain binding glutamic acid-rich protein like 0.015
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.015
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 0.015
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.015
KREMEN2 kringle containing transmembrane protein 2 0.015
ACAN aggrecan 0.014
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.014
BMP2 bone morphogenetic protein 2 0.013
FOXF1 forkhead box F1 0.013
WIF1 WNT inhibitory factor 1 0.012
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.012
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.012
FOXD3 forkhead box D3 0.011
PHKB phosphorylase kinase, beta 0.011
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.011
DLX4 distal-less homeobox 4 0.011
TG thyroglobulin 0.011
SOX21 SRY (sex determining region Y)-box 21 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Star steroidogenic acute regulatory protein 0.502
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.397
Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.377
Gabarapl2 GABA(A) receptor-associated protein like 2 0.358
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.293
Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 0.164
Hbg1 hemoglobin, gamma A 0.158
Clca4 chloride channel accessory 4 0.128
Prss3 protease, serine, 3 0.122
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.121
Fabp1 fatty acid binding protein 1, liver 0.114
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.100
Hipk3 homeodomain interacting protein kinase 3 0.092
Akr1c18 aldo-keto reductase family 1, member C18 0.090
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.090
LOC293989 cytochrome P450-like 0.084
Fbp1 fructose-1,6-bisphosphatase 1 0.077
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.072
Hrh2 histamine receptor H 2 0.069
LOC100366002 cytochrome P450 11B1, mitochondrial-like 0.061
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.059
Crisp2 cysteine-rich secretory protein 2 0.059
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.059
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.054
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.054
Fap fibroblast activation protein, alpha 0.054
Drd1a dopamine receptor D1A 0.051
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.049
Defb4 defensin beta 4 0.049
Tacr3 tachykinin receptor 3 0.049
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.047
Atxn1 ataxin 1 0.047
Hes2 hairy and enhancer of split 2 (Drosophila) 0.046
Ppard peroxisome proliferator-activated receptor delta 0.043
Pxmp2 peroxisomal membrane protein 2 0.043
A1i3 alpha-1-inhibitor III 0.042
Impg2 interphotoreceptor matrix proteoglycan 2 0.041
Slco4a1 solute carrier organic anion transporter family, member 4a1 0.040
Tacr2 tachykinin receptor 2 0.040
Hrh3 histamine receptor H3 0.040
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.040
Spink1 serine peptidase inhibitor, Kazal type 1 0.040
Ppp3r2 protein phosphatase 3, regulatory subunit B, beta isoform 0.037
Spt1 salivary protein 1 0.037
P22k15 cystatin related protein 2 0.036
Naglt1 Na+ dependent glucose transporter 1 0.035
Sycp3 synaptonemal complex protein 3 0.035
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.034
Col1a1 collagen, type I, alpha 1 0.034
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.034
Egr4 early growth response 4 0.034
Krt34 keratin 34 0.034
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.033
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.032
Olr1701 olfactory receptor 1701 0.032
Dnase1 deoxyribonuclease I 0.031
Syt13 synaptotagmin XIII 0.029
Cyb5a cytochrome b5 type A (microsomal) 0.029
Ces2c carboxylesterase 2C 0.028
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.028
Kcne1 potassium voltage-gated channel, Isk-related family, member 1 0.027
Pou3f1 POU class 3 homeobox 1 0.027
LOC100361547 Cytochrome P450, family 2, subfamily c, polypeptide 7-like 0.027
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.027
Abhd14b abhydrolase domain containing 14b 0.027
Gsta4 glutathione S-transferase alpha 4 0.026
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.026
Cmklr1 chemokine-like receptor 1 0.026
Pla2g5 phospholipase A2, group V 0.026
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.026
Cdcp1 CUB domain containing protein 1 0.025
Apob apolipoprotein B 0.025
Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 0.025
Grik3 glutamate receptor, ionotropic, kainate 3 0.025
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.025
Galnt5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) 0.025
G6pc glucose-6-phosphatase, catalytic subunit 0.025
LOC498222 similar to specifically androgen-regulated protein 0.024
Cd59 CD59 molecule, complement regulatory protein 0.024
Fndc3b fibronectin type III domain containing 3B 0.024
Oxtr oxytocin receptor 0.024
Cpa1 carboxypeptidase A1 0.023
Nudt8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 0.023
Grifin galectin-related inter-fiber protein 0.023
Omd osteomodulin 0.023
Tchh trichohyalin 0.023
Slc6a17 solute carrier family 6 (neurotransmitter transporter), member 17 0.022
Drd5 dopamine receptor D5 0.022
Rbpms RNA binding protein with multiple splicing 0.022
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.022
Kcnh4 potassium voltage-gated channel, subfamily H (eag-related), member 4 0.021
Col5a2 collagen, type V, alpha 2 0.021
Si sucrase-isomaltase (alpha-glucosidase) 0.021
Hibadh 3-hydroxyisobutyrate dehydrogenase 0.021
Lpar2 lysophosphatidic acid receptor 2 0.021
Itga1 integrin, alpha 1 0.020
Prss22 protease, serine, 22 0.020
Dpep1 dipeptidase 1 (renal) 0.020
Pla2g1b phospholipase A2, group IB, pancreas 0.020
Smad3 SMAD family member 3 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism