The network for 'ventral spinal cord interneuron fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ventral spinal cord interneuron fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.

Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Pax2 paired box gene 2 1.000
Shh sonic hedgehog 1.000
Fgf8 fibroblast growth factor 8 1.000
Rarg retinoic acid receptor, gamma 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Tbx1 T-box 1 0.998
Isl1 ISL1 transcription factor, LIM/homeodomain 0.997
Lhx3 LIM homeobox protein 3 0.997
Pax6 paired box gene 6 0.997
Emx2 empty spiracles homolog 2 (Drosophila) 0.993
Hoxd3 homeobox D3 0.992
Gbx2 gastrulation brain homeobox 2 0.992
Insm1 insulinoma-associated 1 0.985
Foxc2 forkhead box C2 0.982
Gli3 GLI-Kruppel family member GLI3 0.976
Pax3 paired box gene 3 0.974
Emx1 empty spiracles homolog 1 (Drosophila) 0.973
Hoxa1 homeobox A1 0.969
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.965
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.964
Nkx6-1 NK6 homeobox 1 0.961
Lmx1a LIM homeobox transcription factor 1 alpha 0.959
Sox2 SRY-box containing gene 2 0.951
Tcfap2a transcription factor AP-2, alpha 0.947
Sox3 SRY-box containing gene 3 0.946
Lhx1 LIM homeobox protein 1 0.940
Hand2 heart and neural crest derivatives expressed transcript 2 0.935
Lhx5 LIM homeobox protein 5 0.926
Eya1 eyes absent 1 homolog (Drosophila) 0.926
Foxc1 forkhead box C1 0.915
Otx1 orthodenticle homolog 1 (Drosophila) 0.900
Phox2b paired-like homeobox 2b 0.887
Fgf10 fibroblast growth factor 10 0.870
Sall3 sal-like 3 (Drosophila) 0.864
Hoxd13 homeobox D13 0.839
Msx1 homeobox, msh-like 1 0.833
Rarb retinoic acid receptor, beta 0.832
Neurog2 neurogenin 2 0.803
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.789
Nog noggin 0.786
Pax8 paired box gene 8 0.779
Foxg1 forkhead box G1 0.758
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.752
Tlx3 T-cell leukemia, homeobox 3 0.742
Lmx1b LIM homeobox transcription factor 1 beta 0.737
Neurod1 neurogenic differentiation 1 0.736
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.735
Neurog3 neurogenin 3 0.716
Hoxd11 homeobox D11 0.690
Nkx3-2 NK3 homeobox 2 0.689
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.676
Hoxb1 homeobox B1 0.672
Rara retinoic acid receptor, alpha 0.666
Gsc goosecoid homeobox 0.656
Foxb1 forkhead box B1 0.630
Pdx1 pancreatic and duodenal homeobox 1 0.626
Hoxa3 homeobox A3 0.619
Hes5 hairy and enhancer of split 5 (Drosophila) 0.615
En1 engrailed 1 0.608
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.593
Gli2 GLI-Kruppel family member GLI2 0.575
Nhlh1 nescient helix loop helix 1 0.571
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.543
Ren1 renin 1 structural 0.539
Ptf1a pancreas specific transcription factor, 1a 0.533
Vax1 ventral anterior homeobox containing gene 1 0.523
Hoxb3 homeobox B3 0.520
Hmx3 H6 homeobox 3 0.519
Hoxd1 homeobox D1 0.512
Igfbpl1 insulin-like growth factor binding protein-like 1 0.499
Hand1 heart and neural crest derivatives expressed transcript 1 0.483
Tcf15 transcription factor 15 0.459
Atoh7 atonal homolog 7 (Drosophila) 0.455
Sox9 SRY-box containing gene 9 0.452
Mesp1 mesoderm posterior 1 0.439
Hmx1 H6 homeobox 1 0.417
Sall4 sal-like 4 (Drosophila) 0.417
Pitx3 paired-like homeodomain transcription factor 3 0.414
Zic2 zinc finger protein of the cerebellum 2 0.387
Pax7 paired box gene 7 0.369
Hoxa4 homeobox A4 0.364
Chd7 chromodomain helicase DNA binding protein 7 0.363
Tlx2 T-cell leukemia, homeobox 2 0.363
Pou4f2 POU domain, class 4, transcription factor 2 0.362
Fgf3 fibroblast growth factor 3 0.350
Hoxa2 homeobox A2 0.348
Foxe3 forkhead box E3 0.341
Uncx UNC homeobox 0.326
Fgf15 fibroblast growth factor 15 0.326
Lhx9 LIM homeobox protein 9 0.324
Hes3 hairy and enhancer of split 3 (Drosophila) 0.323
Wnt3a wingless-related MMTV integration site 3A 0.318
Foxd3 forkhead box D3 0.311
Nodal nodal 0.299
Pou3f3 POU domain, class 3, transcription factor 3 0.286
Hoxa11 homeobox A11 0.282
Msx3 homeobox, msh-like 3 0.274
Nkx2-9 NK2 transcription factor related, locus 9 (Drosophila) 0.272
Pou3f4 POU domain, class 3, transcription factor 4 0.271
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nkx2.2a NK2 transcription factor related 2a 1.000
shha sonic hedgehog a 0.999
dla deltaA 0.998
pax2a paired box gene 2a 0.995
pax6a paired box gene 6a 0.990
isl1 islet1 0.966
dbx1a developing brain homeobox 1a 0.953
neurog1 neurogenin 1 0.929
ascl1b achaete-scute complex-like 1b (Drosophila) 0.929
neurod neurogenic differentiation 0.891
olig3 oligodendrocyte transcription factor 3 0.887
olig2 oligodendrocyte lineage transcription factor 2 0.833
notch1a notch homolog 1a 0.830
ascl1a achaete-scute complex-like 1a (Drosophila) 0.827
neurod4 neurogenic differentiation 4 0.783
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.694
otpb orthopedia homolog b 0.691
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.672
fgf8a fibroblast growth factor 8 a 0.661
dld deltaD 0.640
dlb deltaB 0.536
eng2a engrailed 2a 0.506
vsx2 visual system homeobox 2 0.477
barhl2 BarH-like 2 0.444
mnx1 motor neuron and pancreas homeobox 1 0.435
traf4a tnf receptor-associated factor 4a 0.365
gli2a GLI-Kruppel family member GLI2a 0.361
lhx1a LIM homeobox 1a 0.336
ptch2 patched 2 0.309
foxa2 forkhead box A2 0.298
irx4a iroquois homeobox protein 4a 0.290
pax6b paired box gene 6b 0.285
gdf6a growth differentiation factor 6a 0.285
tal1 T-cell acute lymphocytic leukemia 1 0.259
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.259
fezf2 FEZ family zinc finger 2 0.259
insm1b insulinoma-associated 1b 0.249
ptch1 patched 1 0.246
rad21 RAD21 homolog (S. pombe) 0.245
dcc deleted in colorectal carcinoma 0.242
ptf1a pancreas specific transcription factor, 1a 0.238
hoxb2a homeo box B2a 0.237
foxg1a forkhead box G1a 0.231
lhx5 LIM homeobox 5 0.218
prl prolactin 0.214
atoh7 atonal homolog 7 0.213
foxa1 forkhead box A1 0.209
hoxb1a homeo box B1a 0.201
prox1 prospero-related homeobox gene 1 0.199
cdh2 cadherin 2, neuronal 0.193
dzip1 DAZ interacting protein 1 0.189
rx3 retinal homeobox gene 3 0.184
sox10 SRY-box containing gene 10 0.183
irx3a iroquois homeobox protein 3a 0.182
flh floating head 0.175
meis2.2 myeloid ecotropic viral integration site 2.2 0.171
otx2 orthodenticle homolog 2 0.170
sox9b SRY-box containing gene 9b 0.160
vsx1 visual system homeobox 1 homolog, chx10-like 0.159
sox1a SRY-box containing gene 1a 0.144
hoxa4a homeo box A4a 0.137
foxn4 forkhead box N4 0.133
eng2b engrailed 2b 0.131
ek1 eph-like kinase 1 0.129
tac1 tachykinin 1 0.127
lamc1 laminin, gamma 1 0.118
zic4 zic family member 4 0.116
six3b sine oculis homeobox homolog 3b 0.112
tp53 tumor protein p53 0.112
nkx2.1b NK2 homeobox 1b 0.111
gfap glial fibrillary acidic protein 0.111
hoxa2b homeo box A2b 0.111
nkx2.2b NK2 transcription factor related 2b 0.105
pou3f3b POU class 3 homeobox 3b 0.104
dlc deltaC 0.103
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.098
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.098
tbx2b T-box 2b 0.096
mab21l2 mab-21-like 2 0.096
sfrp5 secreted frizzled-related protein 5 0.088
bhlhe22 basic helix-loop-helix family, member e22 0.086
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.085
lhx3 LIM homeobox 3 0.085
gbx1 gastrulation brain homeobox 1 0.084
gata2a GATA-binding protein 2a 0.082
evx1 even-skipped homeobox 1 0.081
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.076
met met proto-oncogene (hepatocyte growth factor receptor) 0.075
hhex hematopoietically expressed homeobox 0.075
hoxc4a homeo box C4a 0.071
jag1b jagged 1b 0.071
hlxb9la homeo box HB9 like a 0.069
epha4b eph receptor A4b 0.068
ccm2 cerebral cavernous malformation 2 0.067
cxcr4b chemokine (C-X-C motif), receptor 4b 0.066
lhx1b LIM homeobox 1b 0.066
hoxd4a homeo box D4a 0.066
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.065
meis3 myeloid ecotropic viral integration site 3 0.063
hoxb8a homeo box B8a 0.063
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.987
NOTCH1 notch 1 0.859
NOTCH3 notch 3 0.748
MID1IP1 MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) 0.567
PEX26 peroxisomal biogenesis factor 26 0.298
STK36 serine/threonine kinase 36 0.254
QPRT quinolinate phosphoribosyltransferase 0.118
VHL von Hippel-Lindau tumor suppressor 0.113
ZNF764 zinc finger protein 764 0.097
GFI1B growth factor independent 1B transcription repressor 0.092
NOTCH2 notch 2 0.079
GLIS3 GLIS family zinc finger 3 0.064
ZNF263 zinc finger protein 263 0.042
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.027
XIAP X-linked inhibitor of apoptosis 0.021
LMX1A LIM homeobox transcription factor 1, alpha 0.019
GLI3 GLI family zinc finger 3 0.018
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.018
DLL1 delta-like 1 (Drosophila) 0.017
TCF4 transcription factor 4 0.016
KRTAP4-12 keratin associated protein 4-12 0.015
JAG1 jagged 1 0.014
SKI v-ski sarcoma viral oncogene homolog (avian) 0.013
PDX1 pancreatic and duodenal homeobox 1 0.012
IPO13 importin 13 0.011
MAML1 mastermind-like 1 (Drosophila) 0.011
BHLHE23 basic helix-loop-helix family, member e23 0.010
FGF3 fibroblast growth factor 3 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rps26 ribosomal protein S26 0.045
Rpl27 ribosomal protein L27 0.034
Rps3 ribosomal protein S3 0.030
Rpl3 ribosomal protein L3 0.023
Rps15a ribosomal protein S15a 0.023
Rplp1 ribosomal protein, large, P1 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism