The network for 'catecholamine secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

catecholamine secretion

The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.

Mus musculus
Name Description Probability Func Analog Organism
Drd2 dopamine receptor D2 1.000
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.998
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.988
Ren1 renin 1 structural 0.618
Lepr leptin receptor 0.594
Oprm1 opioid receptor, mu 1 0.521
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.516
Nos1 nitric oxide synthase 1, neuronal 0.515
Ache acetylcholinesterase 0.475
Emx1 empty spiracles homolog 1 (Drosophila) 0.431
Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 0.319
Pomc pro-opiomelanocortin-alpha 0.315
Pitx3 paired-like homeodomain transcription factor 3 0.313
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.312
Agtr1a angiotensin II receptor, type 1a 0.298
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.274
Lhx3 LIM homeobox protein 3 0.238
Pcsk2 proprotein convertase subtilisin/kexin type 2 0.230
Wwox WW domain-containing oxidoreductase 0.223
Drd1a dopamine receptor D1A 0.218
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.203
Gabbr2 gamma-aminobutyric acid (GABA) B receptor, 2 0.188
Slc12a1 solute carrier family 12, member 1 0.185
Pgr progesterone receptor 0.177
Psapl1 prosaposin-like 1 0.164
Rit2 Ras-like without CAAX 2 0.151
Adora2a adenosine A2a receptor 0.135
Mb myoglobin 0.131
Gckr glucokinase regulatory protein 0.117
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.110
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.106
Krt6a keratin 6A 0.106
Agtr2 angiotensin II receptor, type 2 0.103
Cdk5r2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 0.097
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.096
Insr insulin receptor 0.093
Vdr vitamin D receptor 0.088
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.086
Smyd1 SET and MYND domain containing 1 0.085
Grm2 glutamate receptor, metabotropic 2 0.084
Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 0.078
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.078
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.077
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.075
Egln3 EGL nine homolog 3 (C. elegans) 0.075
Drd4 dopamine receptor D4 0.074
Kl klotho 0.073
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.070
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.069
App amyloid beta (A4) precursor protein 0.068
Kcnk4 potassium channel, subfamily K, member 4 0.067
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.066
Musk muscle, skeletal, receptor tyrosine kinase 0.066
Has1 hyaluronan synthase1 0.065
Krtap5-1 keratin associated protein 5-1 0.064
Nos2 nitric oxide synthase 2, inducible 0.064
Plat plasminogen activator, tissue 0.062
Th tyrosine hydroxylase 0.062
Prop1 paired like homeodomain factor 1 0.062
Esr1 estrogen receptor 1 (alpha) 0.060
Gad2 glutamic acid decarboxylase 2 0.059
Lpar5 lysophosphatidic acid receptor 5 0.059
Gjd2 gap junction protein, delta 2 0.058
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.057
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.054
Npy2r neuropeptide Y receptor Y2 0.054
Mpl myeloproliferative leukemia virus oncogene 0.052
Cox8c cytochrome c oxidase, subunit VIIIc 0.051
Cyp2b19 cytochrome P450, family 2, subfamily b, polypeptide 19 0.051
Mas1 MAS1 oncogene 0.050
Chrne cholinergic receptor, nicotinic, epsilon polypeptide 0.049
Prkch protein kinase C, eta 0.047
Fshr follicle stimulating hormone receptor 0.044
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) 0.043
Dync1i1 dynein cytoplasmic 1 intermediate chain 1 0.043
Mc3r melanocortin 3 receptor 0.042
Ppyr1 pancreatic polypeptide receptor 1 0.042
Rapsn receptor-associated protein of the synapse 0.041
Ptgs2 prostaglandin-endoperoxide synthase 2 0.040
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.040
Vip vasoactive intestinal polypeptide 0.039
Cryaa crystallin, alpha A 0.039
Gzmm granzyme M (lymphocyte met-ase 1) 0.038
Rgs8 regulator of G-protein signaling 8 0.038
Sprr1a small proline-rich protein 1A 0.038
Rs1 retinoschisis (X-linked, juvenile) 1 (human) 0.038
Tshr thyroid stimulating hormone receptor 0.037
Thrb thyroid hormone receptor beta 0.037
2310002J15Rik RIKEN cDNA 2310002J15 gene 0.037
Ctrb1 chymotrypsinogen B1 0.037
Nos3 nitric oxide synthase 3, endothelial cell 0.036
Syt1 synaptotagmin I 0.035
Lcn8 lipocalin 8 0.035
Sim1 single-minded homolog 1 (Drosophila) 0.034
Gpr27 G protein-coupled receptor 27 0.034
Pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha 0.033
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.033
Mmp24 matrix metallopeptidase 24 0.033
Dcx doublecortin 0.032
Pitx1 paired-like homeodomain transcription factor 1 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
DRD2 dopamine receptor D2 1.000
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.991
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.973
ADORA2A adenosine A2a receptor 0.916
CRHR1 corticotropin releasing hormone receptor 1 0.878
CRH corticotropin releasing hormone 0.820
NAMPT nicotinamide phosphoribosyltransferase 0.770
HDAC6 histone deacetylase 6 0.669
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.492
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.422
FBXO7 F-box protein 7 0.382
NECAB2 N-terminal EF-hand calcium binding protein 2 0.347
HIPK2 homeodomain interacting protein kinase 2 0.333
SNCAIP synuclein, alpha interacting protein 0.151
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.120
MAPT microtubule-associated protein tau 0.117
ADORA1 adenosine A1 receptor 0.107
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.094
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.082
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.080
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.075
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.075
CHD3 chromodomain helicase DNA binding protein 3 0.067
TPPP tubulin polymerization promoting protein 0.058
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 0.051
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.045
SPTBN1 spectrin, beta, non-erythrocytic 1 0.044
NSF N-ethylmaleimide-sensitive factor 0.042
SIRT2 sirtuin 2 0.039
BHLHE23 basic helix-loop-helix family, member e23 0.038
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.037
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.035
SIN3B SIN3 homolog B, transcription regulator (yeast) 0.035
SLC9A3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.034
FTL ferritin, light polypeptide 0.032
HRH3 histamine receptor H3 0.032
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.032
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.031
DOCK7 dedicator of cytokinesis 7 0.031
FABP4 fatty acid binding protein 4, adipocyte 0.029
AVPR1B arginine vasopressin receptor 1B 0.029
FEZF2 FEZ family zinc finger 2 0.029
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.028
SYN1 synapsin I 0.027
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 0.026
SGSM2 small G protein signaling modulator 2 0.026
FOXN4 forkhead box N4 0.024
GALR3 galanin receptor 3 0.024
APLP1 amyloid beta (A4) precursor-like protein 1 0.024
ADD1 adducin 1 (alpha) 0.024
NCS1 neuronal calcium sensor 1 0.023
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.023
HCRT hypocretin (orexin) neuropeptide precursor 0.023
SEZ6L seizure related 6 homolog (mouse)-like 0.022
SSTR4 somatostatin receptor 4 0.022
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.022
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.021
FHL1 four and a half LIM domains 1 0.021
KCNK9 potassium channel, subfamily K, member 9 0.021
GPR6 G protein-coupled receptor 6 0.021
SQSTM1 sequestosome 1 0.021
WDTC1 WD and tetratricopeptide repeats 1 0.020
ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 0.020
SKI v-ski sarcoma viral oncogene homolog (avian) 0.020
LBX1 ladybird homeobox 1 0.020
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 0.020
SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.020
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.020
KCNC3 potassium voltage-gated channel, Shaw-related subfamily, member 3 0.020
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.020
FAM134A family with sequence similarity 134, member A 0.019
HNF4A hepatocyte nuclear factor 4, alpha 0.019
MAN2A2 mannosidase, alpha, class 2A, member 2 0.019
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.019
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.019
REN renin 0.018
PRLH prolactin releasing hormone 0.018
APP amyloid beta (A4) precursor protein 0.018
SLC6A7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.018
PAX7 paired box 7 0.018
ZMYM3 zinc finger, MYM-type 3 0.017
IFI6 interferon, alpha-inducible protein 6 0.017
OPTN optineurin 0.017
TBC1D10A TBC1 domain family, member 10A 0.017
COL20A1 collagen, type XX, alpha 1 0.017
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.017
RHO rhodopsin 0.017
SLC22A14 solute carrier family 22, member 14 0.017
SLC5A5 solute carrier family 5 (sodium iodide symporter), member 5 0.017
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 0.017
ND1 NADH dehydrogenase, subunit 1 (complex I) 0.016
NPPC natriuretic peptide C 0.016
TPSG1 tryptase gamma 1 0.016
GJD2 gap junction protein, delta 2, 36kDa 0.016
KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.016
CLDN6 claudin 6 0.016
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.016
ADRBK2 adrenergic, beta, receptor kinase 2 0.016
PAX8 paired box 8 0.016
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.864
Adora1 adenosine A1 receptor 0.539
Fev FEV (ETS oncogene family) 0.374
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.296
Alb albumin 0.283
Olr1361 olfactory receptor 1361 0.268
Strn striatin, calmodulin binding protein 0.255
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.188
Chrne cholinergic receptor, nicotinic, epsilon 0.182
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.180
Csf3 colony stimulating factor 3 (granulocyte) 0.162
Mchr1 melanin-concentrating hormone receptor 1 0.160
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.155
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.134
Olr1641 olfactory receptor 1641 0.132
Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 0.129
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.124
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.118
Uncx UNC homeobox 0.114
Olr416 olfactory receptor 416 0.104
Acrv1 acrosomal vesicle protein 1 0.100
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.097
Apcs amyloid P component, serum 0.095
Spp2 secreted phosphoprotein 2 0.094
Grm6 glutamate receptor, metabotropic 6 0.092
Hpca hippocalcin 0.087
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.085
Prlhr prolactin releasing hormone receptor 0.084
Crhr2 corticotropin releasing hormone receptor 2 0.082
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.081
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.079
Drd2 dopamine receptor D2 0.079
Slc6a18 solute carrier family 6, member 18 0.078
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.074
Dcc deleted in colorectal carcinoma 0.073
Pnmt phenylethanolamine-N-methyltransferase 0.073
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.070
Pax6 paired box 6 0.069
LOC286987 hemiferrin, transferrin-like protein 0.069
Atxn1 ataxin 1 0.068
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.067
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.067
Mcpt2 mast cell protease 2 0.066
Gzmk granzyme K 0.065
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.064
Grik3 glutamate receptor, ionotropic, kainate 3 0.063
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.061
Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 0.061
Aqp4 aquaporin 4 0.060
Oprk1 opioid receptor, kappa 1 0.060
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.060
Hcrt hypocretin 0.060
Gja6 gap junction protein, alpha 6 0.059
Prss1 protease, serine, 1 (trypsin 1) 0.059
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.059
Neurog3 neurogenin 3 0.058
Agxt2 alanine-glyoxylate aminotransferase 2 0.058
Pomc proopiomelanocortin 0.057
Cpne9 copine family member IX 0.056
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.056
Igfals insulin-like growth factor binding protein, acid labile subunit 0.056
Mc5r melanocortin 5 receptor 0.056
Aqp2 aquaporin 2 (collecting duct) 0.055
Igfl3 IGF-like family member 3 0.053
Apoa5 apolipoprotein A-V 0.052
Grm2 glutamate receptor, metabotropic 2 0.052
Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.051
Chrna2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.050
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.050
Mmp7 matrix metallopeptidase 7 0.050
Olr1082 olfactory receptor 1082 0.050
Vom2r27 vomeronasal 2 receptor, 27 0.050
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.049
Gcm1 glial cells missing homolog 1 (Drosophila) 0.049
Psg19 pregnancy specific glycoprotein 19 0.049
Nmbr neuromedin B receptor 0.048
Grk1 G protein-coupled receptor kinase 1 0.048
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.047
Avp arginine vasopressin 0.047
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.047
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.047
Tff1 trefoil factor 1 0.047
Olr442 olfactory receptor 442 0.047
Mag myelin-associated glycoprotein 0.046
Edn2 endothelin 2 0.045
Clstn3 calsyntenin 3 0.045
Cd4 Cd4 molecule 0.044
N5 DNA binding protein N5 0.044
Ghrl ghrelin/obestatin prepropeptide 0.044
Smad3 SMAD family member 3 0.043
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.043
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.042
Rup2 urinary protein 2 0.042
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.042
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.042
Neurod1 neurogenic differentiation 1 0.041
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.040
Smgb neonatal submandibular gland protein B 0.040
LOC246267 resection-induced TPI (rs11) 0.040
Iapp islet amyloid polypeptide 0.040
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism