The network for 'ventral spinal cord interneuron specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ventral spinal cord interneuron specification

The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.

Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pitx2 paired-like homeodomain transcription factor 2 0.999
Pax2 paired box gene 2 0.999
Pax6 paired box gene 6 0.998
Fgf8 fibroblast growth factor 8 0.998
Pax3 paired box gene 3 0.997
Emx2 empty spiracles homolog 2 (Drosophila) 0.990
Foxc2 forkhead box C2 0.989
Tbx1 T-box 1 0.987
Foxc1 forkhead box C1 0.986
Tcfap2a transcription factor AP-2, alpha 0.986
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.983
Sox9 SRY-box containing gene 9 0.976
Gbx2 gastrulation brain homeobox 2 0.966
Emx1 empty spiracles homolog 1 (Drosophila) 0.965
Lhx1 LIM homeobox protein 1 0.961
Rarg retinoic acid receptor, gamma 0.929
Isl1 ISL1 transcription factor, LIM/homeodomain 0.922
Eya1 eyes absent 1 homolog (Drosophila) 0.913
Otx1 orthodenticle homolog 1 (Drosophila) 0.906
Sox2 SRY-box containing gene 2 0.906
Hoxd3 homeobox D3 0.894
Msx1 homeobox, msh-like 1 0.894
Lhx3 LIM homeobox protein 3 0.883
Insm1 insulinoma-associated 1 0.859
Gli2 GLI-Kruppel family member GLI2 0.848
Foxg1 forkhead box G1 0.806
Hand2 heart and neural crest derivatives expressed transcript 2 0.777
Fgfr2 fibroblast growth factor receptor 2 0.730
Rarb retinoic acid receptor, beta 0.715
Lmx1b LIM homeobox transcription factor 1 beta 0.705
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.697
Hoxb3 homeobox B3 0.669
Lhx5 LIM homeobox protein 5 0.660
En1 engrailed 1 0.654
Phox2b paired-like homeobox 2b 0.647
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.647
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.622
Msx2 homeobox, msh-like 2 0.614
Hoxa1 homeobox A1 0.610
Hes5 hairy and enhancer of split 5 (Drosophila) 0.597
Dlx5 distal-less homeobox 5 0.594
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.549
Chrd chordin 0.545
Hoxa3 homeobox A3 0.517
Smo smoothened homolog (Drosophila) 0.497
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.490
Sall3 sal-like 3 (Drosophila) 0.481
Nodal nodal 0.478
Ednra endothelin receptor type A 0.474
Fgf10 fibroblast growth factor 10 0.450
Nkx6-1 NK6 homeobox 1 0.419
Gsc goosecoid homeobox 0.397
Wnt1 wingless-related MMTV integration site 1 0.393
Hoxd13 homeobox D13 0.377
Sox3 SRY-box containing gene 3 0.333
Hoxa2 homeobox A2 0.328
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.317
Hmx1 H6 homeobox 1 0.316
Bmp7 bone morphogenetic protein 7 0.308
Pou4f2 POU domain, class 4, transcription factor 2 0.301
Pax9 paired box gene 9 0.292
Rara retinoic acid receptor, alpha 0.287
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.284
Pitx1 paired-like homeodomain transcription factor 1 0.273
Hoxb1 homeobox B1 0.267
Hoxd11 homeobox D11 0.256
Uncx UNC homeobox 0.253
Nkx3-2 NK3 homeobox 2 0.245
Wnt3a wingless-related MMTV integration site 3A 0.242
Sox11 SRY-box containing gene 11 0.239
Hand1 heart and neural crest derivatives expressed transcript 1 0.224
Chd7 chromodomain helicase DNA binding protein 7 0.223
Atoh7 atonal homolog 7 (Drosophila) 0.220
Wt1 Wilms tumor 1 homolog 0.220
Neurod1 neurogenic differentiation 1 0.210
Neurog2 neurogenin 2 0.208
Lmx1a LIM homeobox transcription factor 1 alpha 0.191
Foxb1 forkhead box B1 0.184
Pdx1 pancreatic and duodenal homeobox 1 0.181
Nog noggin 0.172
Gdnf glial cell line derived neurotrophic factor 0.171
Twist2 twist homolog 2 (Drosophila) 0.165
Bmp4 bone morphogenetic protein 4 0.162
Lhx9 LIM homeobox protein 9 0.161
Dlx1 distal-less homeobox 1 0.159
Zic3 zinc finger protein of the cerebellum 3 0.158
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.150
Tlx3 T-cell leukemia, homeobox 3 0.149
Pax7 paired box gene 7 0.148
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.144
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.143
Zic2 zinc finger protein of the cerebellum 2 0.137
Fgf3 fibroblast growth factor 3 0.128
Tcfap2c transcription factor AP-2, gamma 0.126
Alx4 aristaless-like homeobox 4 0.126
Igfbpl1 insulin-like growth factor binding protein-like 1 0.124
Hoxd1 homeobox D1 0.121
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.999
pax2a paired box gene 2a 0.992
dla deltaA 0.970
nkx2.2a NK2 transcription factor related 2a 0.957
notch1a notch homolog 1a 0.757
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.692
gdf6a growth differentiation factor 6a 0.689
hoxb1a homeo box B1a 0.684
fgf8a fibroblast growth factor 8 a 0.619
six3b sine oculis homeobox homolog 3b 0.619
gli1 GLI-Kruppel family member 1 0.610
lamc1 laminin, gamma 1 0.593
gli2a GLI-Kruppel family member GLI2a 0.539
flh floating head 0.538
dbx1a developing brain homeobox 1a 0.510
tfap2a transcription factor AP-2 alpha 0.477
dzip1 DAZ interacting protein 1 0.467
disp1 dispatched homolog 1 (Drosophila) 0.442
mnx1 motor neuron and pancreas homeobox 1 0.439
apc adenomatosis polyposis coli 0.373
oep one-eyed pinhead 0.354
boc brother of CDO 0.320
prdm1a PR domain containing 1a, with ZNF domain 0.317
dld deltaD 0.313
tp53 tumor protein p53 0.305
mib mind bomb 0.296
cdh2 cadherin 2, neuronal 0.294
ptch1 patched 1 0.279
smo smoothened homolog (Drosophila) 0.273
otx1b orthodenticle homolog 1b 0.272
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.265
hnf1ba HNF1 homeobox Ba 0.252
neurog1 neurogenin 1 0.247
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.243
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.232
isl1 islet1 0.209
olig3 oligodendrocyte transcription factor 3 0.205
foxi1 forkhead box I1 0.202
ascl1a achaete-scute complex-like 1a (Drosophila) 0.197
ptch2 patched 2 0.197
foxa1 forkhead box A1 0.192
cdx4 caudal type homeo box transcription factor 4 0.190
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.187
olig2 oligodendrocyte lineage transcription factor 2 0.184
ndr2 nodal-related 2 0.167
neurod4 neurogenic differentiation 4 0.155
hoxb2a homeo box B2a 0.148
foxg1a forkhead box G1a 0.134
sox10 SRY-box containing gene 10 0.130
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.125
fezf2 FEZ family zinc finger 2 0.121
wnt11 wingless-type MMTV integration site family, member 11 0.115
neurod neurogenic differentiation 0.111
lhx2b LIM homeobox 2b 0.111
nkx6.2 NK6 transcription factor related, locus 2 0.110
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.106
hoxa4a homeo box A4a 0.104
vsx2 visual system homeobox 2 0.100
foxd3 forkhead box D3 0.098
hoxa2b homeo box A2b 0.091
met met proto-oncogene (hepatocyte growth factor receptor) 0.088
eng2a engrailed 2a 0.085
hlxb9la homeo box HB9 like a 0.082
tbx16 T-box gene 16 0.078
emx3 empty spiracles homeobox 3 0.077
dcc deleted in colorectal carcinoma 0.077
ntla no tail a 0.075
tpbgl trophoblast glycoprotein-like 0.074
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.073
chd chordin 0.072
rx3 retinal homeobox gene 3 0.070
otpb orthopedia homolog b 0.069
hoxa9a homeo box A9a 0.068
dbx1b developing brain homeobox 1b 0.065
sox1a SRY-box containing gene 1a 0.062
meis2.2 myeloid ecotropic viral integration site 2.2 0.061
crb2a crumbs homolog 2a 0.059
hoxb8a homeo box B8a 0.055
atoh7 atonal homolog 7 0.055
nkx2.2b NK2 transcription factor related 2b 0.049
hoxd4a homeo box D4a 0.049
tbx2b T-box 2b 0.047
hoxb1b homeo box B1b 0.047
hoxa10b homeo box A10b 0.047
smad5 MAD homolog 5 (Drosophila) 0.046
mab21l2 mab-21-like 2 0.045
lhx5 LIM homeobox 5 0.044
nkx2.1b NK2 homeobox 1b 0.044
gbx2 gastrulation brain homeo box 2 0.043
irx4a iroquois homeobox protein 4a 0.042
pax6a paired box gene 6a 0.042
nkx2.1a NK2 homeobox 1a 0.041
mitfa microphthalmia-associated transcription factor a 0.041
ascl1b achaete-scute complex-like 1b (Drosophila) 0.040
barhl2 BarH-like 2 0.040
lhx3 LIM homeobox 3 0.039
zic4 zic family member 4 0.038
vsx1 visual system homeobox 1 homolog, chx10-like 0.037
foxn4 forkhead box N4 0.037
jag1b jagged 1b 0.037
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Slc29a2 solute carrier family 29 (nucleoside transporters), member 2 0.046
Chrm1 cholinergic receptor, muscarinic 1 0.046
Pcdhga11 protocadherin gamma subfamily A, 11 0.035
Avpr1b arginine vasopressin receptor 1B 0.025
Rpl27 ribosomal protein L27 0.023
Fam65a family with sequence similarity 65, member A 0.023
C5ar1 complement component 5a receptor 1 0.021
Rps16 ribosomal protein S16 0.020
Rpl17 ribosomal protein L17 0.018
Gata6 GATA binding protein 6 0.015
Cox7c cytochrome c oxidase, subunit VIIc 0.015
Igh-6 immunoglobulin heavy chain 6 0.014
Rgs14 regulator of G-protein signaling 14 0.013
Chrna6 cholinergic receptor, nicotinic, alpha 6 0.013
Gjb5 gap junction protein, beta 5 0.013
Tomm7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.012
Polr2j polymerase (RNA) II (DNA directed) polypeptide J 0.012
Sell selectin L 0.010
Rps6 ribosomal protein S6 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism