The network for 'protein kinase c activating g protein coupled receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein kinase c activating g protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).

Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.993
Kl klotho 0.968
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.960
Pnpla2 patatin-like phospholipase domain containing 2 0.947
Hoxa3 homeobox A3 0.810
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.798
Jak2 Janus kinase 2 0.793
Ece1 endothelin converting enzyme 1 0.731
ND6 NADH dehydrogenase subunit 6 0.705
Cckbr cholecystokinin B receptor 0.673
Socs2 suppressor of cytokine signaling 2 0.653
Adrb2 adrenergic receptor, beta 2 0.631
Sstr4 somatostatin receptor 4 0.625
Lhx6 LIM homeobox protein 6 0.615
Fgf8 fibroblast growth factor 8 0.584
Npy2r neuropeptide Y receptor Y2 0.580
Prrx1 paired related homeobox 1 0.570
Col4a3 collagen, type IV, alpha 3 0.542
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.535
Cish cytokine inducible SH2-containing protein 0.533
Pparg peroxisome proliferator activated receptor gamma 0.518
Npy5r neuropeptide Y receptor Y5 0.483
Htr4 5 hydroxytryptamine (serotonin) receptor 4 0.445
Vegfa vascular endothelial growth factor A 0.423
Fgf4 fibroblast growth factor 4 0.405
Vip vasoactive intestinal polypeptide 0.386
Nrp1 neuropilin 1 0.369
Cul5 cullin 5 0.364
Adrb1 adrenergic receptor, beta 1 0.342
Acvr1 activin A receptor, type 1 0.313
Grid1 glutamate receptor, ionotropic, delta 1 0.309
Plcg1 phospholipase C, gamma 1 0.302
Hcrt hypocretin 0.295
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.292
Sstr1 somatostatin receptor 1 0.279
Il6st interleukin 6 signal transducer 0.275
Crhr1 corticotropin releasing hormone receptor 1 0.266
Shc3 src homology 2 domain-containing transforming protein C3 0.256
Drd4 dopamine receptor D4 0.246
Prss32 protease, serine, 32 0.233
Hrh1 histamine receptor H1 0.230
Opn1sw opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) 0.228
Mas1 MAS1 oncogene 0.223
Drd2 dopamine receptor D2 0.216
Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) 0.209
Pim1 proviral integration site 1 0.208
Foxd2 forkhead box D2 0.206
Ednrb endothelin receptor type B 0.206
Bdkrb2 bradykinin receptor, beta 2 0.198
Edn1 endothelin 1 0.191
Krt86 keratin 86 0.191
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.181
Pdcd1 programmed cell death 1 0.177
Lag3 lymphocyte-activation gene 3 0.176
Sst somatostatin 0.176
Fosb FBJ osteosarcoma oncogene B 0.175
Slc16a8 solute carrier family 16 (monocarboxylic acid transporters), member 8 0.174
Upp2 uridine phosphorylase 2 0.173
Syt6 synaptotagmin VI 0.169
Mkl2 MKL/myocardin-like 2 0.163
Mc3r melanocortin 3 receptor 0.158
Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like 0.156
Lrp1b low density lipoprotein-related protein 1B (deleted in tumors) 0.155
C1qtnf1 C1q and tumor necrosis factor related protein 1 0.152
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.150
Gast gastrin 0.150
Kcnk4 potassium channel, subfamily K, member 4 0.145
Fosl2 fos-like antigen 2 0.143
Npy1r neuropeptide Y receptor Y1 0.142
Grm2 glutamate receptor, metabotropic 2 0.140
Nppb natriuretic peptide type B 0.138
Cdh6 cadherin 6 0.137
Fgf5 fibroblast growth factor 5 0.136
Accn1 amiloride-sensitive cation channel 1, neuronal (degenerin) 0.135
Foxn1 forkhead box N1 0.134
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.134
F11r F11 receptor 0.128
Pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha 0.127
Otog otogelin 0.127
Rcvrn recoverin 0.125
Gzmm granzyme M (lymphocyte met-ase 1) 0.123
Chia chitinase, acidic 0.123
Sult4a1 sulfotransferase family 4A, member 1 0.122
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.122
Csmd1 CUB and Sushi multiple domains 1 0.121
Msx1 homeobox, msh-like 1 0.120
Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 0.119
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.117
Hand1 heart and neural crest derivatives expressed transcript 1 0.117
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.116
Nptx2 neuronal pentraxin 2 0.116
Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 0.115
Ido1 indoleamine 2,3-dioxygenase 1 0.115
Ptafr platelet-activating factor receptor 0.115
Fndc7 fibronectin type III domain containing 7 0.114
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.114
Galr2 galanin receptor 2 0.114
Stat5a signal transducer and activator of transcription 5A 0.113
Itga1 integrin alpha 1 0.113
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.113
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
DRD2 dopamine receptor D2 1.000
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.999
CAV1 caveolin 1, caveolae protein, 22kDa 0.995
PRLHR prolactin releasing hormone receptor 0.936
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.886
CAV2 caveolin 2 0.859
PRKCG protein kinase C, gamma 0.827
NECAB2 N-terminal EF-hand calcium binding protein 2 0.720
ACCN2 amiloride-sensitive cation channel 2, neuronal 0.533
ATXN7L3 ataxin 7-like 3 0.517
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.474
ADORA1 adenosine A1 receptor 0.382
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.315
CCKBR cholecystokinin B receptor 0.223
PCDHB5 protocadherin beta 5 0.163
CYTH2 cytohesin 2 0.146
EDN1 endothelin 1 0.097
CNR1 cannabinoid receptor 1 (brain) 0.077
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.071
EPOR erythropoietin receptor 0.070
PTPRF protein tyrosine phosphatase, receptor type, F 0.069
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.068
CYR61 cysteine-rich, angiogenic inducer, 61 0.059
ERP27 endoplasmic reticulum protein 27 0.056
SCG5 secretogranin V (7B2 protein) 0.054
EDNRA endothelin receptor type A 0.051
GJA1 gap junction protein, alpha 1, 43kDa 0.049
CTGF connective tissue growth factor 0.046
BDKRB2 bradykinin receptor B2 0.044
CALCRL calcitonin receptor-like 0.041
ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.040
PCDH8 protocadherin 8 0.040
SDPR serum deprivation response 0.040
PTEN phosphatase and tensin homolog 0.038
CIC capicua homolog (Drosophila) 0.037
TRAF5 TNF receptor-associated factor 5 0.036
BFSP2 beaded filament structural protein 2, phakinin 0.036
SPRR2A small proline-rich protein 2A 0.035
FKBP2 FK506 binding protein 2, 13kDa 0.034
EDNRB endothelin receptor type B 0.033
NID2 nidogen 2 (osteonidogen) 0.032
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.031
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.030
NOXA1 NADPH oxidase activator 1 0.029
DLC1 deleted in liver cancer 1 0.029
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.028
TXNRD1 thioredoxin reductase 1 0.027
PRKCDBP protein kinase C, delta binding protein 0.026
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.024
COL4A2 collagen, type IV, alpha 2 0.024
POSTN periostin, osteoblast specific factor 0.024
STX1A syntaxin 1A (brain) 0.023
ASPN asporin 0.023
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.022
COL4A1 collagen, type IV, alpha 1 0.022
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.022
CPA3 carboxypeptidase A3 (mast cell) 0.022
COL8A1 collagen, type VIII, alpha 1 0.022
COL3A1 collagen, type III, alpha 1 0.021
ELTD1 EGF, latrophilin and seven transmembrane domain containing 1 0.021
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.021
IGSF21 immunoglobin superfamily, member 21 0.020
NPHP1 nephronophthisis 1 (juvenile) 0.020
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.020
CNN3 calponin 3, acidic 0.020
KRT31 keratin 31 0.019
SOX17 SRY (sex determining region Y)-box 17 0.019
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.019
EGF epidermal growth factor 0.019
TM4SF1 transmembrane 4 L six family member 1 0.019
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 0.019
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.019
ARL4C ADP-ribosylation factor-like 4C 0.019
PCDH17 protocadherin 17 0.018
GCM1 glial cells missing homolog 1 (Drosophila) 0.018
SULF1 sulfatase 1 0.018
LHB luteinizing hormone beta polypeptide 0.018
GRIA4 glutamate receptor, ionotrophic, AMPA 4 0.018
SNAI2 snail homolog 2 (Drosophila) 0.018
KRT14 keratin 14 0.018
GPR6 G protein-coupled receptor 6 0.018
SPP1 secreted phosphoprotein 1 0.018
PRRX1 paired related homeobox 1 0.018
CALD1 caldesmon 1 0.017
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.017
GUCA1A guanylate cyclase activator 1A (retina) 0.017
GFI1 growth factor independent 1 transcription repressor 0.017
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 0.017
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.017
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.017
MUC1 mucin 1, cell surface associated 0.016
F2RL2 coagulation factor II (thrombin) receptor-like 2 0.016
NTM neurotrimin 0.016
GNG11 guanine nucleotide binding protein (G protein), gamma 11 0.016
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.016
DDR2 discoidin domain receptor tyrosine kinase 2 0.016
BMP2 bone morphogenetic protein 2 0.015
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.015
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.015
ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 0.015
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.364
Adora2a adenosine A2a receptor 0.239
Csf1 colony stimulating factor 1 (macrophage) 0.229
Mag myelin-associated glycoprotein 0.165
Dspp dentin sialophosphoprotein 0.163
Ciita class II, major histocompatibility complex, transactivator 0.150
Ucn urocortin 0.141
Chrm2 cholinergic receptor, muscarinic 2 0.137
Dio2 deiodinase, iodothyronine, type II 0.136
Lims1 LIM and senescent cell antigen-like domains 1 0.135
C5ar1 complement component 5a receptor 1 0.131
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.129
Rftn2 raftlin family member 2 0.112
Mog myelin oligodendrocyte glycoprotein 0.089
Il9r interleukin 9 receptor 0.087
Hpca hippocalcin 0.084
Rgs9 regulator of G-protein signaling 9 0.082
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.081
St6galnac3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.078
Pax6 paired box 6 0.076
Prkg2 protein kinase, cGMP-dependent, type II 0.075
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.074
Itgam integrin, alpha M 0.071
Nmbr neuromedin B receptor 0.069
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.067
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.065
Oprk1 opioid receptor, kappa 1 0.065
Fgb fibrinogen beta chain 0.064
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.063
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.063
Cxcr3 chemokine (C-X-C motif) receptor 3 0.062
Mobp myelin-associated oligodendrocyte basic protein 0.059
Ar androgen receptor 0.058
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.056
Tbxas1 thromboxane A synthase 1, platelet 0.054
Il1a interleukin 1 alpha 0.054
Ednra endothelin receptor type A 0.051
Hcrt hypocretin 0.050
S1pr2 sphingosine-1-phosphate receptor 2 0.049
Grm6 glutamate receptor, metabotropic 6 0.049
Hand1 heart and neural crest derivatives expressed 1 0.047
Grip2 glutamate receptor interacting protein 2 0.045
Cybb cytochrome b-245, beta polypeptide 0.044
Drd2 dopamine receptor D2 0.044
Lep leptin 0.043
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.042
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.041
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.041
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive 0.040
Adora1 adenosine A1 receptor 0.040
Adora3 adenosine A3 receptor 0.040
Bcl2 B-cell CLL/lymphoma 2 0.040
Cpa3 carboxypeptidase A3, mast cell 0.036
Gja6 gap junction protein, alpha 6 0.036
Gzmk granzyme K 0.036
Ptafr platelet-activating factor receptor 0.033
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.033
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.033
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.032
Grip1 glutamate receptor interacting protein 1 0.031
Pla2g2c phospholipase A2, group IIC 0.031
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.031
Cnga4 cyclic nucleotide gated channel alpha 4 0.031
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.031
Nrg1 neuregulin 1 0.030
Grm7 glutamate receptor, metabotropic 7 0.030
Trhr thyrotropin releasing hormone receptor 0.030
Folh1 folate hydrolase 1 0.029
Ctsj cathepsin J 0.028
Mchr1 melanin-concentrating hormone receptor 1 0.028
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.027
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.026
Tlr7 toll-like receptor 7 0.026
LOC286987 hemiferrin, transferrin-like protein 0.025
Dcc deleted in colorectal carcinoma 0.025
Nfasc neurofascin 0.024
Tlr4 toll-like receptor 4 0.024
Hcrtr2 hypocretin (orexin) receptor 2 0.024
Vipr2 vasoactive intestinal peptide receptor 2 0.024
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.023
Sell selectin L 0.022
Gria2 glutamate receptor, ionotropic, AMPA 2 0.022
Tacr1 tachykinin receptor 1 0.022
Folr2 folate receptor 2 (fetal) 0.022
Igsf1 immunoglobulin superfamily, member 1 0.022
Iapp islet amyloid polypeptide 0.022
Acrv1 acrosomal vesicle protein 1 0.022
Fgf14 fibroblast growth factor 14 0.022
Mmp12 matrix metallopeptidase 12 0.021
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.021
Socs3 suppressor of cytokine signaling 3 0.021
Znf483 zinc finger protein 483 0.021
Hpgds hematopoietic prostaglandin D synthase 0.021
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.021
Galr2 galanin receptor 2 0.021
Cd38 CD38 molecule 0.020
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.019
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.019
Olr1078 olfactory receptor 1078 0.019
Cckar cholecystokinin A receptor 0.019
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism