The network for 'serotonin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

serotonin receptor signaling pathway

The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.

Mus musculus
Name Description Probability Func Analog Organism
Pnpla2 patatin-like phospholipase domain containing 2 0.883
Drd2 dopamine receptor D2 0.818
Adrb1 adrenergic receptor, beta 1 0.806
Cckbr cholecystokinin B receptor 0.791
Sstr4 somatostatin receptor 4 0.641
Kl klotho 0.620
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.582
Pparg peroxisome proliferator activated receptor gamma 0.521
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.479
Grid1 glutamate receptor, ionotropic, delta 1 0.421
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 0.343
ND6 NADH dehydrogenase subunit 6 0.336
Htr4 5 hydroxytryptamine (serotonin) receptor 4 0.332
Crhr1 corticotropin releasing hormone receptor 1 0.304
Adra2c adrenergic receptor, alpha 2c 0.289
Cav1 caveolin 1, caveolae protein 0.278
Oprm1 opioid receptor, mu 1 0.268
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.263
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.241
Sstr1 somatostatin receptor 1 0.205
Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) 0.203
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.190
Shc3 src homology 2 domain-containing transforming protein C3 0.185
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.178
Otog otogelin 0.152
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.150
Sstr3 somatostatin receptor 3 0.150
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.132
Epha6 Eph receptor A6 0.117
Pgr progesterone receptor 0.113
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.112
Gsx1 GS homeobox 1 0.109
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.104
Lhx6 LIM homeobox protein 6 0.100
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.088
Adrb2 adrenergic receptor, beta 2 0.085
Krt2 keratin 2 0.083
Foxd2 forkhead box D2 0.082
Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 0.079
Thra thyroid hormone receptor alpha 0.078
Hrh1 histamine receptor H1 0.078
Syn2 synapsin II 0.074
Gpr12 G-protein coupled receptor 12 0.074
Oprd1 opioid receptor, delta 1 0.069
Npy2r neuropeptide Y receptor Y2 0.069
Col4a3 collagen, type IV, alpha 3 0.068
Wnt7a wingless-related MMTV integration site 7A 0.067
Adrb3 adrenergic receptor, beta 3 0.065
Fgf5 fibroblast growth factor 5 0.064
Cbl Casitas B-lineage lymphoma 0.062
Npy5r neuropeptide Y receptor Y5 0.061
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.060
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.060
Glycam1 glycosylation dependent cell adhesion molecule 1 0.060
Lep leptin 0.058
Enam enamelin 0.058
Htr1f 5-hydroxytryptamine (serotonin) receptor 1F 0.058
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.057
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.056
Krt86 keratin 86 0.054
Lepr leptin receptor 0.053
Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 0.052
Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 0.050
Adra2b adrenergic receptor, alpha 2b 0.049
Tgfbr3 transforming growth factor, beta receptor III 0.048
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.048
Gast gastrin 0.047
Sebox SEBOX homeobox 0.047
Slc6a18 solute carrier family 6 (neurotransmitter transporter), member 18 0.047
Cnr1 cannabinoid receptor 1 (brain) 0.047
Glra1 glycine receptor, alpha 1 subunit 0.046
Zfr2 zinc finger RNA binding protein 2 0.045
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.045
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.045
Fndc7 fibronectin type III domain containing 7 0.045
Kcnk4 potassium channel, subfamily K, member 4 0.044
Nrg3 neuregulin 3 0.044
Nxph1 neurexophilin 1 0.044
Trpc5 transient receptor potential cation channel, subfamily C, member 5 0.040
Sox1 SRY-box containing gene 1 0.040
Mc3r melanocortin 3 receptor 0.040
Il12b interleukin 12b 0.039
Chia chitinase, acidic 0.039
Tacr1 tachykinin receptor 1 0.039
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.037
Oprk1 opioid receptor, kappa 1 0.037
Runx2 runt related transcription factor 2 0.037
Gucy2e guanylate cyclase 2e 0.036
Pspn persephin 0.035
Ids iduronate 2-sulfatase 0.034
Thrb thyroid hormone receptor beta 0.034
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.034
Cntn3 contactin 3 0.034
Fgf4 fibroblast growth factor 4 0.034
Cntn4 contactin 4 0.033
Fam164c family with sequence similarity 164, member C 0.033
Btn1a1 butyrophilin, subfamily 1, member A1 0.033
Gjd2 gap junction protein, delta 2 0.032
Lmx1b LIM homeobox transcription factor 1 beta 0.032
Gabrd gamma-aminobutyric acid (GABA) A receptor, subunit delta 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
gpb-1 Protein GPB-1 0.022
CELE_H12D21.9 Protein H12D21.9 0.015
cmd-1 Protein CMD-1 0.015
egl-5 Protein EGL-5 0.014
F55A4.7 Protein F55A4.7 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
fas faint sausage 0.084
rdgC retinal degeneration C 0.053
cac cacophony 0.042
norpA no receptor potential A 0.041
klg klingon 0.041
CG42629 CG42629 gene product from transcript CG42629-RB 0.028
gsb-n gooseberry-neuro 0.023
Glut1 Glucose transporter 1 0.020
hug hugin 0.018
Phm Peptidylglycine-alpha-hydroxylating monooxygenase 0.017
Rdl Resistant to dieldrin 0.017
dpr10 CG32057 gene product from transcript CG32057-RB 0.016
Hs3st-A Heparan sulfate 3-O sulfotransferase-A 0.015
GABA-B-R3 metabotropic GABA-B receptor subtype 3 0.015
Nmnat Nicotinamide mononucleotide adenylyltransferase 0.013
onecut CG1922 gene product from transcript CG1922-RA 0.012
rtv retroactive 0.012
Hey Hairy/E(spl)-related with YRPW motif 0.012
Gef64C Guanine nucleotide exchange factor GEF64C 0.012
CG16778 CG16778 gene product from transcript CG16778-RA 0.011
skl sickle 0.011
dpr15 CG10095 gene product from transcript CG10095-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MPDZ multiple PDZ domain protein 1.000
ARRB1 arrestin, beta 1 0.999
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.992
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.971
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.816
ARRDC3 arrestin domain containing 3 0.426
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.378
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.273
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.231
PTEN phosphatase and tensin homolog 0.193
SSTR3 somatostatin receptor 3 0.162
CHRND cholinergic receptor, nicotinic, delta 0.141
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 0.129
HTR4 5-hydroxytryptamine (serotonin) receptor 4 0.114
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.105
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.104
ADRA2B adrenergic, alpha-2B-, receptor 0.099
BAI1 brain-specific angiogenesis inhibitor 1 0.072
TBC1D10A TBC1 domain family, member 10A 0.067
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.063
DRD2 dopamine receptor D2 0.059
CHRNG cholinergic receptor, nicotinic, gamma 0.059
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.052
CNTFR ciliary neurotrophic factor receptor 0.052
AFF2 AF4/FMR2 family, member 2 0.047
PPT1 palmitoyl-protein thioesterase 1 0.046
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B 0.042
TSHR thyroid stimulating hormone receptor 0.040
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.038
GPR6 G protein-coupled receptor 6 0.036
SLC5A5 solute carrier family 5 (sodium iodide symporter), member 5 0.034
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.033
AQP2 aquaporin 2 (collecting duct) 0.031
DRD1 dopamine receptor D1 0.030
ADRB3 adrenergic, beta-3-, receptor 0.030
COPG2 coatomer protein complex, subunit gamma 2 0.029
HRH3 histamine receptor H3 0.029
P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 0.029
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A 0.027
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.027
AVPR1B arginine vasopressin receptor 1B 0.027
KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.025
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.025
DSCAML1 Down syndrome cell adhesion molecule like 1 0.024
KRT9 keratin 9 0.024
CHRNE cholinergic receptor, nicotinic, epsilon 0.024
GRM5 glutamate receptor, metabotropic 5 0.022
MAPK10 mitogen-activated protein kinase 10 0.021
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.020
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 0.020
OPRK1 opioid receptor, kappa 1 0.019
EZR ezrin 0.019
NTSR1 neurotensin receptor 1 (high affinity) 0.019
CHRNB4 cholinergic receptor, nicotinic, beta 4 0.019
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.019
GHRHR growth hormone releasing hormone receptor 0.018
CHRM5 cholinergic receptor, muscarinic 5 0.018
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.018
MLN motilin 0.018
CALCA calcitonin-related polypeptide alpha 0.018
AQP7 aquaporin 7 0.017
CCKBR cholecystokinin B receptor 0.017
OR2H1 olfactory receptor, family 2, subfamily H, member 1 0.017
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 0.017
GRPR gastrin-releasing peptide receptor 0.017
PAX8 paired box 8 0.017
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D 0.017
TACR3 tachykinin receptor 3 0.017
LBX1 ladybird homeobox 1 0.016
KRT33B keratin 33B 0.016
CALCR calcitonin receptor 0.016
SLC16A8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.016
PRODH2 proline dehydrogenase (oxidase) 2 0.016
YAP1 Yes-associated protein 1 0.016
PADI4 peptidyl arginine deiminase, type IV 0.016
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.015
SCRT1 scratch homolog 1, zinc finger protein (Drosophila) 0.015
SCTR secretin receptor 0.015
SMR3A submaxillary gland androgen regulated protein 3A 0.014
KCNJ1 potassium inwardly-rectifying channel, subfamily J, member 1 0.014
TFF2 trefoil factor 2 0.014
FGF4 fibroblast growth factor 4 0.014
HNF1A HNF1 homeobox A 0.014
GRIK1 glutamate receptor, ionotropic, kainate 1 0.014
ODF1 outer dense fiber of sperm tails 1 0.014
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.014
TBX5 T-box 5 0.014
NELL1 NEL-like 1 (chicken) 0.013
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.013
PYY peptide YY 0.013
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 0.013
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 0.013
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.013
PNLIPRP1 pancreatic lipase-related protein 1 0.013
TBXA2R thromboxane A2 receptor 0.013
ALPPL2 alkaline phosphatase, placental-like 2 0.013
HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 0.013
NPY2R neuropeptide Y receptor Y2 0.013
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.013
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
Chrne cholinergic receptor, nicotinic, epsilon 0.436
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.380
Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.202
Aif1l allograft inflammatory factor 1-like 0.185
Chrna6 cholinergic receptor, nicotinic, alpha 6 0.145
Fgf14 fibroblast growth factor 14 0.136
Gcm1 glial cells missing homolog 1 (Drosophila) 0.136
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.134
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.125
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.121
Grik3 glutamate receptor, ionotropic, kainate 3 0.114
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.106
Mc5r melanocortin 5 receptor 0.105
Olr416 olfactory receptor 416 0.105
Svs3a seminal vesicle secretory protein 3A 0.098
Lim2 lens intrinsic membrane protein 2 0.095
Grik1 glutamate receptor, ionotropic, kainate 1 0.092
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.091
Gabbr1 gamma-aminobutyric acid (GABA) B receptor 1 0.084
Cntn2 contactin 2 (axonal) 0.083
Rin1 Ras and Rab interactor 1 0.081
Syt8 synaptotagmin VIII 0.079
Sstr5 somatostatin receptor 5 0.078
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.078
Ar androgen receptor 0.077
Ccbp2 chemokine binding protein 2 0.073
Cacng1 calcium channel, voltage-dependent, gamma subunit 1 0.070
Avpr1b arginine vasopressin receptor 1B 0.067
Vom2r27 vomeronasal 2 receptor, 27 0.067
Vom2r53 vomeronasal 2 receptor, 53 0.066
Zp1 zona pellucida glycoprotein 1 (sperm receptor) 0.065
Olr1500 olfactory receptor 1500 0.063
Trpc4 transient receptor potential cation channel, subfamily C, member 4 0.062
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.062
Gja3 gap junction protein, alpha 3 0.061
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.059
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.057
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.057
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.055
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.055
Plcd4 phospholipase C, delta 4 0.055
Oprl1 opiate receptor-like 1 0.051
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.050
Phkg1 phosphorylase kinase, gamma 1 0.047
Npy5r neuropeptide Y receptor Y5 0.046
Tacr2 tachykinin receptor 2 0.046
Mmp13 matrix metallopeptidase 13 0.046
Cckar cholecystokinin A receptor 0.045
Spt1 salivary protein 1 0.045
Ddn dendrin 0.044
RGD1559748 similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) 0.042
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.041
Colq collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.041
Tore trispanning orphan 0.039
Uncx UNC homeobox 0.039
Smad3 SMAD family member 3 0.037
Atxn1 ataxin 1 0.036
Oprk1 opioid receptor, kappa 1 0.036
Kl Klotho 0.036
Svs1 seminal vesicle secretory protein 1 0.036
Chrnb1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.035
Il13 interleukin 13 0.035
Crisp1 cysteine-rich secretory protein 1 0.035
Krt4 keratin 4 0.035
Odf4 outer dense fiber of sperm tails 4 0.034
Cpne9 copine family member IX 0.034
Crx cone-rod homeobox 0.034
Grm6 glutamate receptor, metabotropic 6 0.034
Omp olfactory marker protein 0.034
Prp15 proline-rich protein 15 0.034
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.033
Vom1r93 vomeronasal 1 receptor 93 0.033
Ifnb1 interferon beta 1, fibroblast 0.032
Chrng cholinergic receptor, nicotinic, gamma 0.032
Pth parathyroid hormone 0.032
Il2ra interleukin 2 receptor, alpha 0.031
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.031
Fgf7 fibroblast growth factor 7 0.031
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.031
Pomc proopiomelanocortin 0.030
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.030
Rgs8 regulator of G-protein signaling 8 0.030
Grid2 glutamate receptor, ionotropic, delta 2 0.029
Ncan neurocan 0.028
Gfra2 GDNF family receptor alpha 2 0.028
Grm2 glutamate receptor, metabotropic 2 0.028
Cyss cystatin S 0.027
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.027
Mr1 major histocompatibility complex, class I-related 0.027
Cnga2 cyclic nucleotide gated channel alpha 2 0.027
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.027
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.026
Isl2 ISL LIM homeobox 2 0.026
Npy1r neuropeptide Y receptor Y1 0.026
Olr1082 olfactory receptor 1082 0.026
Drd2 dopamine receptor D2 0.026
Prl prolactin 0.026
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.026
Syt4 synaptotagmin IV 0.026
Cacnb4 calcium channel, voltage-dependent, beta 4 subunit 0.026
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism