The network for 'immunoglobulin mediated immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

Danio rerio
Name Description Probability Func Analog Organism
grna granulin a 0.432
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.413
pcsk9 proprotein convertase subtilisin/kexin type 9 0.398
adipoql adiponectin, C1Q and collagen domain containing, like 0.256
nod1 nucleotide-binding oligomerization domain containing 1 0.197
adipoql2 adiponectin, C1Q and collagen domain containing, like 2 0.171
grn1 granulin 1 0.168
si:ch211-1n9.7 si:ch211-1n9.7 0.153
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.129
foxj1b forkhead box J1b 0.120
LOC566708 FL cytokine receptor-like 0.112
stat1b signal transducer and activator of transcription 1b 0.105
msh6 mutS homolog 6 (E. coli) 0.101
cacnb4a calcium channel, voltage-dependent, beta 4a subunit 0.101
adipor2 adiponectin receptor 2 0.100
pola1 polymerase (DNA directed), alpha 1 0.099
zgc:64051 zgc:64051 0.097
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.092
hirip3 HIRA interacting protein 3 0.088
msh2 mutS homolog 2 (E. coli) 0.084
ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 0.082
c1qc complement component 1, q subcomponent, C chain 0.081
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.080
adipor1b adiponectin receptor 1b 0.076
coro1a coronin, actin binding protein, 1A 0.075
mybl2 myeloblastosis oncogene-like 2 0.073
irf11 interferon regulatory factor 11 0.071
retsatl retinol saturase (all-trans-retinol 13,14-reductase) like 0.071
slc4a4b solute carrier family 4, sodium bicarbonate cotransporter, member 4b 0.069
zgc:154063 zgc:154063 0.067
eya2 eyes absent homolog 2 (Drosophila) 0.064
zgc:56197 zgc:56197 0.063
cps1 carbamoyl-phosphate synthase 1, mitochondrial 0.061
tlr3 toll-like receptor 3 0.060
tmprss4b transmembrane protease, serine 4b 0.058
zgc:174506 zgc:174506 0.058
LOC557072 caspase recruitment domain-containing protein 11-like 0.057
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.057
pole2 polymerase (DNA directed), epsilon 2 0.056
crb2a crumbs homolog 2a 0.056
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.056
s1pr3 sphingosine-1-phosphate receptor 3 0.055
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.054
cd40lg CD40 ligand 0.054
LOC100534776 toll-like receptor 7-like 0.054
zgc:113143 zgc:113143 0.053
calcr calcitonin receptor 0.052
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.052
LOC100004946 transient receptor potential cation channel subfamily M member 4-like 0.050
eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.049
zgc:66488 zgc:66488 0.049
cldn5a claudin 5a 0.048
cdc7 cell division cycle 7 homolog (S. cerevisiae) 0.046
chek2 CHK2 checkpoint homolog (S. pombe) 0.045
pcsk7 proprotein convertase subtilisin/kexin type 7 0.045
lrrc33 leucine rich repeat containing 33 0.045
mcm4 MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) 0.044
ren renin 0.044
rif1 RAP1 interacting factor homolog (yeast) 0.044
mbtps1 membrane-bound transcription factor protease, site 1 0.043
cxadr coxsackie virus and adenovirus receptor 0.042
hs3st1l2 heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2 0.042
c3b complement component c3b 0.041
pcsk1 proprotein convertase subtilisin/kexin type 1 0.040
tert telomerase reverse transcriptase 0.040
atxn7l2a ataxin 7-like 2a 0.039
adrb2a adrenergic receptor, beta 2a 0.039
zgc:55413 zgc:55413 0.038
lrrc42 leucine rich repeat containing 42 0.038
zgc:86870 zgc:86870 0.038
adipor1a adiponectin receptor 1a 0.038
rorca RAR-related orphan receptor C a 0.038
insrb insulin receptor b 0.038
illr1 immune-related, lectin-like receptor 1 0.037
nkd1 naked cuticle homolog 1 (Drosophila) 0.037
ticam1 toll-like receptor adaptor molecule 1 0.037
tbx21 T-box 21 0.037
stat6 signal transducer and activator of transcription 6, interleukin-4 induced 0.037
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.037
crfb7 cytokine receptor family member b7 0.037
vdrb vitamin D receptor b 0.036
rhag Rhesus blood group-associated glycoprotein 0.036
atp1b3b ATPase, Na+/K+ transporting, beta 3b polypeptide 0.036
gmfg glia maturation factor, gamma 0.036
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.035
LOC100149056 pannexin-3-like 0.035
nap1l1 nucleosome assembly protein 1, like 1 0.035
LOC100330224 fatty acid binding protein 1b-like 0.035
LOC795916 mucolipin-1-like 0.035
nos2a nitric oxide synthase 2a, inducible 0.035
lrrc6 leucine rich repeat containing 6 0.034
LOC100000934 hypothetical protein LOC100000934 0.034
cxc46 CXC chemokine 46 0.034
pold2 polymerase (DNA directed), delta 2, regulatory subunit 0.033
usp1 ubiquitin specific protease 1 0.033
c1qb complement component 1, q subcomponent, B chain 0.033
itgb1a integrin, beta 1a 0.033
zgc:123282 zgc:123282 0.033
ocrl oculocerebrorenal syndrome of Lowe 0.033
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.033
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IL4R interleukin 4 receptor 0.928
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.664
SYK spleen tyrosine kinase 0.645
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.592
HLA-DRA major histocompatibility complex, class II, DR alpha 0.533
HLA-DMB major histocompatibility complex, class II, DM beta 0.432
BRCA1 breast cancer 1, early onset 0.176
APLF aprataxin and PNKP like factor 0.169
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.158
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.149
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.110
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.105
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.085
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.081
GRAP2 GRB2-related adaptor protein 2 0.078
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.077
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.077
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.053
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.052
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.045
LAPTM5 lysosomal protein transmembrane 5 0.042
CARD11 caspase recruitment domain family, member 11 0.041
HLA-DMA major histocompatibility complex, class II, DM alpha 0.039
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.038
BCL3 B-cell CLL/lymphoma 3 0.037
MDC1 mediator of DNA-damage checkpoint 1 0.032
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.031
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.029
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.029
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.027
C1QB complement component 1, q subcomponent, B chain 0.027
C1QA complement component 1, q subcomponent, A chain 0.026
C1QC complement component 1, q subcomponent, C chain 0.025
CD22 CD22 molecule 0.024
THOC5 THO complex 5 0.024
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.023
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.022
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.021
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.021
IL2RG interleukin 2 receptor, gamma 0.021
MSH3 mutS homolog 3 (E. coli) 0.021
ENG endoglin 0.020
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.020
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.020
MSH6 mutS homolog 6 (E. coli) 0.019
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.018
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.017
LCK lymphocyte-specific protein tyrosine kinase 0.016
MYD88 myeloid differentiation primary response gene (88) 0.016
PVRL4 poliovirus receptor-related 4 0.016
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.016
LY96 lymphocyte antigen 96 0.015
TICAM2 toll-like receptor adaptor molecule 2 0.015
ZNF830 zinc finger protein 830 0.015
TRAF3 TNF receptor-associated factor 3 0.015
BLNK B-cell linker 0.014
IRAK2 interleukin-1 receptor-associated kinase 2 0.014
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.013
THOC2 THO complex 2 0.012
IRAK1 interleukin-1 receptor-associated kinase 1 0.012
CD80 CD80 molecule 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Igh immunoglobulin heavy chain complex 1.000
Ifng interferon gamma 1.000
Lyz2 lysozyme 2 1.000
Tnf tumor necrosis factor 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.999
Foxp3 forkhead box P3 0.998
Cd28 CD28 antigen 0.997
Cd40 CD40 antigen 0.997
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.996
Ccr1 chemokine (C-C motif) receptor 1 0.994
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.985
Socs1 suppressor of cytokine signaling 1 0.979
Il4 interleukin 4 0.972
Il10 interleukin 10 0.972
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.965
Cd19 CD19 antigen 0.962
Ikzf1 IKAROS family zinc finger 1 0.952
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.950
Il2 interleukin 2 0.946
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.946
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.946
Fas Fas (TNF receptor superfamily member 6) 0.930
H2-Aa histocompatibility 2, class II antigen A, alpha 0.923
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.918
Lta lymphotoxin A 0.910
Tcra T-cell receptor alpha chain 0.909
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.906
Tlr4 toll-like receptor 4 0.899
Ccl2 chemokine (C-C motif) ligand 2 0.894
Il2rg interleukin 2 receptor, gamma chain 0.889
Fcgr2b Fc receptor, IgG, low affinity IIb 0.876
Il6 interleukin 6 0.858
Batf basic leucine zipper transcription factor, ATF-like 0.857
Stat6 signal transducer and activator of transcription 6 0.851
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.848
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.828
C1qa complement component 1, q subcomponent, alpha polypeptide 0.827
Cd44 CD44 antigen 0.823
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.818
Fasl Fas ligand (TNF superfamily, member 6) 0.810
C1qb complement component 1, q subcomponent, beta polypeptide 0.808
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.807
Ccr7 chemokine (C-C motif) receptor 7 0.805
Bcl3 B-cell leukemia/lymphoma 3 0.796
Pten phosphatase and tensin homolog 0.772
Atm ataxia telangiectasia mutated homolog (human) 0.743
H2-Eb1 histocompatibility 2, class II antigen E beta 0.737
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.679
Prf1 perforin 1 (pore forming protein) 0.667
Pdcd1 programmed cell death 1 0.647
Lat linker for activation of T cells 0.626
Il1r1 interleukin 1 receptor, type I 0.602
C1qc complement component 1, q subcomponent, C chain 0.592
Clec4d C-type lectin domain family 4, member d 0.589
Fyn Fyn proto-oncogene 0.587
Birc3 baculoviral IAP repeat-containing 3 0.582
Cxcr5 chemokine (C-X-C motif) receptor 5 0.569
Cxcl13 chemokine (C-X-C motif) ligand 13 0.559
Il4ra interleukin 4 receptor, alpha 0.553
Folr2 folate receptor 2 (fetal) 0.538
Ccr2 chemokine (C-C motif) receptor 2 0.533
Ccl22 chemokine (C-C motif) ligand 22 0.530
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.519
Ifngr1 interferon gamma receptor 1 0.503
Irf1 interferon regulatory factor 1 0.497
Il1b interleukin 1 beta 0.496
Ccl6 chemokine (C-C motif) ligand 6 0.492
Casp1 caspase 1 0.468
Aif1 allograft inflammatory factor 1 0.461
Irf4 interferon regulatory factor 4 0.459
Sfpi1 SFFV proviral integration 1 0.439
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.437
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.433
Cxcl9 chemokine (C-X-C motif) ligand 9 0.430
Il27ra interleukin 27 receptor, alpha 0.423
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.415
Tlr2 toll-like receptor 2 0.409
Pax2 paired box gene 2 0.406
Stat5a signal transducer and activator of transcription 5A 0.405
Ccl8 chemokine (C-C motif) ligand 8 0.398
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.397
Socs3 suppressor of cytokine signaling 3 0.395
Itgb2 integrin beta 2 0.392
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.381
Stat5b signal transducer and activator of transcription 5B 0.371
Bcl6 B-cell leukemia/lymphoma 6 0.346
Mmp9 matrix metallopeptidase 9 0.338
Cd14 CD14 antigen 0.325
Sykb spleen tyrosine kinase 0.325
Xcl1 chemokine (C motif) ligand 1 0.324
Foxn1 forkhead box N1 0.324
Ccl9 chemokine (C-C motif) ligand 9 0.324
Traf1 TNF receptor-associated factor 1 0.313
Il6st interleukin 6 signal transducer 0.310
Unc93b1 unc-93 homolog B1 (C. elegans) 0.309
Ikbkb inhibitor of kappaB kinase beta 0.309
Ccl12 chemokine (C-C motif) ligand 12 0.308
Pax5 paired box gene 5 0.305
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.301
Il10ra interleukin 10 receptor, alpha 0.299
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Da RT1 class II, locus Da 0.900
RT1-Ba RT1 class II, locus Ba 0.888
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.809
RT1-Db1 RT1 class II, locus Db1 0.754
Cd37 CD37 molecule 0.468
LOC100359522 LRRGT00191-like 0.354
Il1b interleukin 1 beta 0.343
Hck hemopoietic cell kinase 0.303
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.298
Xdh xanthine dehydrogenase 0.265
Anpep alanyl (membrane) aminopeptidase 0.234
RT1-DMb RT1 class II, locus DMb 0.216
Plac8 placenta-specific 8 0.202
Slc15a3 solute carrier family 15, member 3 0.189
Fga fibrinogen alpha chain 0.155
Laptm5 lysosomal protein transmembrane 5 0.151
Sla src-like adaptor 0.126
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.120
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.117
Apol3 apolipoprotein L, 3 0.114
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.113
Lyz2 lysozyme 2 0.111
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.098
Icam1 intercellular adhesion molecule 1 0.091
Slfn2 schlafen 2 0.090
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.085
Ripk3 receptor-interacting serine-threonine kinase 3 0.084
Plcg2 phospholipase C, gamma 2 0.083
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.083
MGC112715 hypothetical protein LOC690899 0.080
Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 0.079
Bcl2l1 Bcl2-like 1 0.077
Ccl6 chemokine (C-C motif) ligand 6 0.076
Il17ra interleukin 17 receptor A 0.074
Cxcr4 chemokine (C-X-C motif) receptor 4 0.073
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.070
Myo1e myosin IE 0.070
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.069
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.069
C3 complement component 3 0.068
Nos3 nitric oxide synthase 3, endothelial cell 0.065
Ptprc protein tyrosine phosphatase, receptor type, C 0.065
C2 complement component 2 0.063
Cp ceruloplasmin 0.062
C1qb complement component 1, q subcomponent, B chain 0.060
Mmp8 matrix metallopeptidase 8 0.059
Gimap4 GTPase, IMAP family member 4 0.059
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.059
Kng1 kininogen 1 0.058
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.058
Inpp5d inositol polyphosphate-5-phosphatase D 0.058
Nckap1l NCK associated protein 1 like 0.058
Il2rg interleukin 2 receptor, gamma 0.058
Ctse cathepsin E 0.057
Accn5 amiloride-sensitive cation channel 5, intestinal 0.056
Eng endoglin 0.055
Alox5ap arachidonate 5-lipoxygenase activating protein 0.055
Hspa8 heat shock protein 8 0.055
Plek pleckstrin 0.055
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.054
Ctss cathepsin S 0.054
C9 complement component 9 0.053
Il2rb interleukin 2 receptor, beta 0.053
Syk spleen tyrosine kinase 0.052
Cfb complement factor B 0.052
Casp1 caspase 1 0.049
Fgg fibrinogen gamma chain 0.049
Ptafr platelet-activating factor receptor 0.049
Myh9 myosin, heavy chain 9, non-muscle 0.048
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.048
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.046
Cd53 Cd53 molecule 0.046
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.045
Il4ra interleukin 4 receptor, alpha 0.045
Ccl3 chemokine (C-C motif) ligand 3 0.044
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.044
Vcam1 vascular cell adhesion molecule 1 0.043
Reg3b regenerating islet-derived 3 beta 0.043
Sbno2 strawberry notch homolog 2 (Drosophila) 0.042
Psd4 pleckstrin and Sec7 domain containing 4 0.042
Ly6c Ly6-C antigen 0.042
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.042
Aif1 allograft inflammatory factor 1 0.042
Cd80 Cd80 molecule 0.041
ND4 NADH dehydrogenase subunit 4 0.041
Cd247 Cd247 molecule 0.041
Stat3 signal transducer and activator of transcription 3 0.041
Ncf4 neutrophil cytosolic factor 4 0.041
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.040
Arl5c ADP-ribosylation factor-like 5C 0.039
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.039
Cd3g CD3 molecule, gamma 0.039
Tgm1 transglutaminase 1, K polypeptide 0.039
RT1-Bb RT1 class II, locus Bb 0.039
Lcp2 lymphocyte cytosolic protein 2 0.039
Arhgap9 Rho GTPase activating protein 9 0.039
Rxra retinoid X receptor alpha 0.038
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.038
Tlr2 toll-like receptor 2 0.038
Epha2 Eph receptor A2 0.037
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism