The network for 'morphogenesis of an epithelium' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of an epithelium

The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.

Danio rerio
Name Description Probability Func Analog Organism
hnf1ba HNF1 homeobox Ba 0.996
notch1a notch homolog 1a 0.994
tbx1 T-box 1 0.988
sulf1 sulfatase 1 0.987
foxa2 forkhead box A2 0.987
chd chordin 0.986
cdh1 cadherin 1, epithelial 0.984
six3b sine oculis homeobox homolog 3b 0.978
kdrl kinase insert domain receptor like 0.978
shha sonic hedgehog a 0.976
tp53 tumor protein p53 0.972
dlx2a distal-less homeobox gene 2a 0.967
mdka midkine-related growth factor 0.959
jag1b jagged 1b 0.958
gli2a GLI-Kruppel family member GLI2a 0.958
bmp2b bone morphogenetic protein 2b 0.956
crabp2a cellular retinoic acid binding protein 2, a 0.952
ndr2 nodal-related 2 0.952
six4b sine oculis homeobox homolog 4b 0.951
ttna titin a 0.949
dla deltaA 0.948
otpb orthopedia homolog b 0.941
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.933
foxn4 forkhead box N4 0.932
pax8 paired box gene 8 0.932
flh floating head 0.930
foxc1a forkhead box C1a 0.928
twist1a twist1a 0.913
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.909
dlx5a distal-less homeobox gene 5a 0.909
fgf3 fibroblast growth factor 3 0.909
traf4a tnf receptor-associated factor 4a 0.908
etv5b ets variant 5b 0.902
col15a1b collagen, type XV, alpha 1b 0.901
notch3 notch homolog 3 0.901
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.901
wnt11 wingless-type MMTV integration site family, member 11 0.897
ift88 intraflagellar transport 88 homolog 0.896
arl13b ADP-ribosylation factor-like 13b 0.892
foxd3 forkhead box D3 0.887
fgfr4 fibroblast growth factor receptor 4 0.885
tbx20 T-box 20 0.884
pkd2 polycystic kidney disease 2 0.883
lft1 lefty1 0.881
fgf8a fibroblast growth factor 8 a 0.877
shhb sonic hedgehog b 0.875
hhex hematopoietically expressed homeobox 0.871
plcg1 phospholipase C, gamma 1 0.869
nrp2b neuropilin 2b 0.859
lamb1a laminin, beta 1a 0.846
tfap2a transcription factor AP-2 alpha 0.845
irx4b iroquois homeobox protein 4b 0.840
efnb2a ephrin B2a 0.840
rarga retinoic acid receptor gamma a 0.840
jag2 jagged 2 0.840
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.837
gpr126 G protein-coupled receptor 126 0.835
wnt11r wingless-type MMTV integration site family, member 11, related 0.831
si:ch73-60e21.1 si:ch73-60e21.1 0.830
sox9a SRY-box containing gene 9a 0.828
pou3f3b POU class 3 homeobox 3b 0.827
lcp1 lymphocyte cytosolic plastin 1 0.827
fzd10 frizzled homolog 10 0.820
foxi1 forkhead box I1 0.818
tgfb2 transforming growth factor, beta 2 0.816
sox32 SRY-box containing gene 32 0.816
osr2 odd-skipped related 2 (Drosophila) 0.816
slit3 slit (Drosophila) homolog 3 0.815
egr2b early growth response 2b 0.810
tmem2 transmembrane protein 2 0.808
gata5 GATA-binding protein 5 0.802
gata3 GATA-binding protein 3 0.799
tbx16 T-box gene 16 0.797
wls wntless homolog (Drosophila) 0.794
hapln1a hyaluronan and proteoglycan link protein 1a 0.787
tp63 tumor protein p63 0.786
fgfr2 fibroblast growth factor receptor 2 0.784
pitx3 paired-like homeodomain transcription factor 3 0.784
tpm4 tropomyosin 4 0.783
hlx1 H2.0-like homeo box 1 (Drosophila) 0.775
mych myelocytomatosis oncogene homolog 0.770
hand2 heart and neural crest derivatives expressed transcript 2 0.770
hhip hedgehog interacting protein 0.765
pcdh18b protocadherin 18b 0.761
acvr1l activin A receptor, type I like 0.759
hoxa13b homeo box A13b 0.756
eya1 eyes absent homolog 1 0.755
sb:cb81 sb:cb81 0.749
sox19a SRY-box containing gene 19a 0.746
fli1a friend leukemia integration 1a 0.745
twist2 twist2 0.743
fgf10a fibroblast growth factor 10a 0.739
fgfr3 fibroblast growth factor receptor 3 0.739
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.738
col2a1a collagen type II, alpha-1a 0.735
dlx4b distal-less homeobox gene 4b 0.733
oep one-eyed pinhead 0.731
fzd7b frizzled homolog 7b 0.729
gata2a GATA-binding protein 2a 0.723
lfng lunatic fringe homolog 0.717
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
N Notch 1.000
Ras85D Ras oncogene at 85D 1.000
Rac1 CG2248 gene product from transcript CG2248-RA 1.000
ed echinoid 0.999
wg wingless 0.999
dsh dishevelled 0.999
msn misshapen 0.999
Rho1 CG8416 gene product from transcript CG8416-RB 0.998
hep hemipterous 0.997
E(spl) Enhancer of split 0.997
fz2 frizzled 2 0.996
shi shibire 0.996
bsk basket 0.995
Cdc42 CG12530 gene product from transcript CG12530-RA 0.995
tkv thickveins 0.994
ato atonal 0.994
aPKC atypical protein kinase C 0.993
rok Rho-kinase 0.993
pyd polychaetoid 0.993
baz bazooka 0.993
Egfr Epidermal growth factor receptor 0.991
Vang Van Gogh 0.990
shg shotgun 0.984
Nrx-IV Neurexin IV 0.983
argos CG4531 gene product from transcript CG4531-RA 0.982
zip zipper 0.980
kay kayak 0.980
btl breathless 0.980
pnt pointed 0.980
babo baboon 0.978
dpp decapentaplegic 0.972
pk prickle 0.972
rhea CG6831 gene product from transcript CG6831-RA 0.970
lin lines 0.970
arm armadillo 0.967
Dad Daughters against dpp 0.965
chic chickadee 0.964
G-oalpha47A G protein oalpha 47A 0.962
stumps CG31317 gene product from transcript CG31317-RC 0.962
par-1 CG8201 gene product from transcript CG8201-RA 0.962
Ubx Ultrabithorax 0.958
Jra Jun-related antigen 0.956
crb crumbs 0.955
BicD Bicaudal D 0.952
ovo CG6824 gene product from transcript CG6824-RE 0.951
p120ctn Adherens junction protein p120 0.950
Sra-1 specifically Rac1-associated protein 1 0.948
Wnt4 Wnt oncogene analog 4 0.946
nmo nemo 0.939
EcR Ecdysone receptor 0.936
Mad Mothers against dpp 0.936
put punt 0.935
E2f2 E2F transcription factor 2 0.935
lola longitudinals lacking 0.934
Mcr Macroglobulin complement-related 0.930
ci cubitus interruptus 0.929
sli slit 0.927
stan starry night 0.922
Moe Moesin 0.921
fng fringe 0.919
cindr CIN85 and CD2AP orthologue 0.913
shn schnurri 0.907
spi spitz 0.903
mirr mirror 0.897
aop anterior open 0.896
kel kelch 0.895
tgo tango 0.893
vg vestigial 0.893
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.890
CycA Cyclin A 0.882
caup caupolican 0.881
rib ribbon 0.880
Appl beta amyloid protein precursor-like 0.879
raw CG12437 gene product from transcript CG12437-RB 0.871
HLHm5 E(spl) region transcript m5 0.866
eyg eyegone 0.866
rin rasputin 0.863
yki yorkie 0.862
vvl ventral veins lacking 0.862
Src42A Src oncogene at 42A 0.860
dgo diego 0.859
rho rhomboid 0.858
gbb glass bottom boat 0.856
sim single-minded 0.855
pbl pebble 0.850
Rala Ras-related protein 0.850
brk brinker 0.849
Akt1 CG4006 gene product from transcript CG4006-RA 0.849
mys myospheroid 0.848
Pkn Protein kinase related to protein kinase N 0.847
cbt cabut 0.847
LanB2 Laminin B2 0.847
tutl turtle 0.829
cora coracle 0.825
kni knirps 0.823
mew multiple edematous wings 0.821
emc extra macrochaetae 0.819
tup tailup 0.813
Sema-1b CG6446 gene product from transcript CG6446-RA 0.813
spas spastin 0.811
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.999
FN1 fibronectin 1 0.994
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.986
FGFR2 fibroblast growth factor receptor 2 0.976
NOTCH1 notch 1 0.975
JAG1 jagged 1 0.968
ESR1 estrogen receptor 1 0.964
RHOA ras homolog gene family, member A 0.963
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.961
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.936
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.924
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.916
THBS1 thrombospondin 1 0.892
COL1A1 collagen, type I, alpha 1 0.884
TP53 tumor protein p53 0.879
SFN stratifin 0.869
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.839
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.838
PXN paxillin 0.827
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.827
CREBBP CREB binding protein 0.825
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.804
SMAD2 SMAD family member 2 0.803
NCOR2 nuclear receptor corepressor 2 0.772
BBS10 Bardet-Biedl syndrome 10 0.754
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.753
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.752
SP1 Sp1 transcription factor 0.744
SMAD3 SMAD family member 3 0.741
TP63 tumor protein p63 0.735
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.704
NOTCH3 notch 3 0.700
MSN moesin 0.697
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.689
CTGF connective tissue growth factor 0.686
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.686
NCOR1 nuclear receptor corepressor 1 0.652
BMP1 bone morphogenetic protein 1 0.650
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.645
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.640
VEGFA vascular endothelial growth factor A 0.637
EGR1 early growth response 1 0.629
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.621
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.616
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.614
EP300 E1A binding protein p300 0.592
COL1A2 collagen, type I, alpha 2 0.583
FGF1 fibroblast growth factor 1 (acidic) 0.571
TIMP3 TIMP metallopeptidase inhibitor 3 0.566
MET met proto-oncogene (hepatocyte growth factor receptor) 0.565
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.564
FHL2 four and a half LIM domains 2 0.561
COL4A1 collagen, type IV, alpha 1 0.560
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.547
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.545
EPS8 epidermal growth factor receptor pathway substrate 8 0.542
PRKCZ protein kinase C, zeta 0.541
FLNA filamin A, alpha 0.538
SMAD7 SMAD family member 7 0.534
GSK3B glycogen synthase kinase 3 beta 0.531
SMAD4 SMAD family member 4 0.509
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.507
KRT17 keratin 17 0.507
COL5A1 collagen, type V, alpha 1 0.472
COL3A1 collagen, type III, alpha 1 0.468
BMP7 bone morphogenetic protein 7 0.468
ARHGAP1 Rho GTPase activating protein 1 0.463
RARA retinoic acid receptor, alpha 0.461
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.461
RXRA retinoid X receptor, alpha 0.458
ITGB4 integrin, beta 4 0.453
KLK10 kallikrein-related peptidase 10 0.448
ERBB2IP erbb2 interacting protein 0.444
KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4 0.442
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.428
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.416
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.413
PTK2 PTK2 protein tyrosine kinase 2 0.410
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.400
APC adenomatous polyposis coli 0.396
AXIN1 axin 1 0.394
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.388
PBX1 pre-B-cell leukemia homeobox 1 0.376
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.375
SOCS3 suppressor of cytokine signaling 3 0.370
COL2A1 collagen, type II, alpha 1 0.366
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.360
SQSTM1 sequestosome 1 0.352
FOXF2 forkhead box F2 0.350
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.345
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.341
ENG endoglin 0.334
EPAS1 endothelial PAS domain protein 1 0.318
GATA4 GATA binding protein 4 0.307
TGFB1 transforming growth factor, beta 1 0.305
FGFR1 fibroblast growth factor receptor 1 0.303
TRIP6 thyroid hormone receptor interactor 6 0.300
FNBP1L formin binding protein 1-like 0.292
SIRT1 sirtuin 1 0.292
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Col12a1 collagen, type XII, alpha 1 0.425
Prrx1 paired related homeobox 1 0.340
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.326
Fgfr2 fibroblast growth factor receptor 2 0.174
Golph3 golgi phosphoprotein 3 (coat-protein) 0.171
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.159
Arnt aryl hydrocarbon receptor nuclear translocator 0.155
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.134
Creb1 cAMP responsive element binding protein 1 0.132
Syt4 synaptotagmin IV 0.117
Vim vimentin 0.111
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.110
Unc5b unc-5 homolog B (C. elegans) 0.100
Lamc1 laminin, gamma 1 0.096
Lims1 LIM and senescent cell antigen-like domains 1 0.094
Dmd dystrophin 0.094
Tacr1 tachykinin receptor 1 0.093
Dchs1 dachsous 1 (Drosophila) 0.091
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.089
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.089
Myh9 myosin, heavy chain 9, non-muscle 0.085
Ednrb endothelin receptor type B 0.081
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.080
Dab2 disabled homolog 2 (Drosophila) 0.080
Jak1 Janus kinase 1 0.078
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.077
Bdkrb2 bradykinin receptor B2 0.077
Foxe3 forkhead box E3 0.077
Stat5b signal transducer and activator of transcription 5B 0.077
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.073
Pou3f2 POU class 3 homeobox 2 0.072
Dcaf17 DDB1 and CUL4 associated factor 17 0.068
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.068
Bcl2 B-cell CLL/lymphoma 2 0.067
Calcrl calcitonin receptor-like 0.065
Il1r1 interleukin 1 receptor, type I 0.063
Lig3 ligase III, DNA, ATP-dependent 0.063
Tcf4 transcription factor 4 0.062
Nfia nuclear factor I/A 0.058
Grm7 glutamate receptor, metabotropic 7 0.058
Shox2 short stature homeobox 2 0.056
Dlg1 discs, large homolog 1 (Drosophila) 0.056
Itgb1 integrin, beta 1 0.055
Irs1 insulin receptor substrate 1 0.055
Gata6 GATA binding protein 6 0.054
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.052
Utrn utrophin 0.050
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.049
Igfbp5 insulin-like growth factor binding protein 5 0.049
Flt1 FMS-related tyrosine kinase 1 0.049
Tnc tenascin C 0.049
Pfn1 profilin 1 0.048
Igfbp3 insulin-like growth factor binding protein 3 0.048
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.047
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.047
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.047
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.047
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.047
Fgfr1 Fibroblast growth factor receptor 1 0.046
Prkar2a protein kinase, cAMP dependent regulatory, type II alpha 0.045
Nos3 nitric oxide synthase 3, endothelial cell 0.045
Gpc1 glypican 1 0.044
Cpa3 carboxypeptidase A3, mast cell 0.044
Tcf12 transcription factor 12 0.044
Csnk1g1 casein kinase 1, gamma 1 0.044
Slc30a2 solute carrier family 30 (zinc transporter), member 2 0.043
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.043
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.043
Trhr2 thyrotropin releasing hormone receptor 2 0.043
Tgfbr2 transforming growth factor, beta receptor II 0.042
Casp3 caspase 3 0.042
Mycs myc-like oncogene, s-myc protein 0.042
Taok1 TAO kinase 1 0.041
Nab1 Ngfi-A binding protein 1 0.041
Crtap cartilage associated protein 0.041
Capn6 calpain 6 0.041
Baiap2 BAI1-associated protein 2 0.040
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.040
Cpxm2 carboxypeptidase X (M14 family), member 2 0.040
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.039
Lphn2 latrophilin 2 0.039
Scarf2 scavenger receptor class F, member 2 0.038
Actb actin, beta 0.038
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.038
Synrg synergin, gamma 0.037
Ddr1 discoidin domain receptor tyrosine kinase 1 0.036
Bgn biglycan 0.036
Timp2 TIMP metallopeptidase inhibitor 2 0.036
Cd80 Cd80 molecule 0.036
Aebp1 AE binding protein 1 0.036
Cga glycoprotein hormones, alpha polypeptide 0.036
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.036
Vcan versican 0.035
LOC100365106 rCG32755-like 0.034
Bmp7 bone morphogenetic protein 7 0.034
Il1rl1 interleukin 1 receptor-like 1 0.034
Tgfbr3 transforming growth factor, beta receptor III 0.034
Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.033
Mcam melanoma cell adhesion molecule 0.033
B2m beta-2 microglobulin 0.032
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism