The network for 'positive regulation of epithelial cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of epithelial cell differentiation

Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.

Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 0.999
gli1 GLI-Kruppel family member 1 0.975
pax6b paired box gene 6b 0.903
foxa2 forkhead box A2 0.838
ptf1a pancreas specific transcription factor, 1a 0.835
pax2a paired box gene 2a 0.746
ascl1a achaete-scute complex-like 1a (Drosophila) 0.684
shha sonic hedgehog a 0.681
wnt1 wingless-type MMTV integration site family, member 1 0.680
atoh1b atonal homolog 1b 0.665
hhex hematopoietically expressed homeobox 0.627
eng2a engrailed 2a 0.626
lhx1a LIM homeobox 1a 0.620
notch3 notch homolog 3 0.595
chd chordin 0.565
cdh2 cadherin 2, neuronal 0.559
atoh1a atonal homolog 1a 0.553
wt1a wilms tumor 1a 0.515
alcama activated leukocyte cell adhesion molecule a 0.501
dyx1c1 dyslexia susceptibility 1 candidate 1 0.494
prox1 prospero-related homeobox gene 1 0.476
notch1a notch homolog 1a 0.470
her5 hairy-related 5 0.460
jag1b jagged 1b 0.421
isl1 islet1 0.411
hlxb9la homeo box HB9 like a 0.364
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.349
dla deltaA 0.348
sox9b SRY-box containing gene 9b 0.335
gbx2 gastrulation brain homeo box 2 0.318
adipor2 adiponectin receptor 2 0.310
vsx2 visual system homeobox 2 0.301
sesn1 sestrin 1 0.296
hnf1ba HNF1 homeobox Ba 0.288
gata1a GATA binding protein 1a 0.282
mab21l2 mab-21-like 2 0.280
six4a sine oculis homeobox homolog 4a 0.279
dkk1b dickkopf 1b 0.275
foxa1 forkhead box A1 0.273
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.271
tbx24 T-box 24 0.258
fli1a friend leukemia integration 1a 0.247
lhx3 LIM homeobox 3 0.247
six4b sine oculis homeobox homolog 4b 0.246
hmx4 H6 family homeobox 4 0.244
nkx2.1a NK2 homeobox 1a 0.243
atoh1c atonal homolog 1c 0.232
osr2 odd-skipped related 2 (Drosophila) 0.230
tfe3b transcription factor binding to IGHM enhancer 3b 0.230
her1 hairy-related 1 0.223
twist1b twist1b 0.220
fgf8b fibroblast growth factor 8 b 0.220
chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 0.218
evx1 even-skipped homeobox 1 0.214
gata4 GATA-binding protein 4 0.211
dlc deltaC 0.201
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.200
irx4b iroquois homeobox protein 4b 0.197
nog1 noggin 1 0.193
vsx1 visual system homeobox 1 homolog, chx10-like 0.182
nkx2.7 NK2 transcription factor related 7 0.180
foxd5 forkhead box D5 0.179
neurod4 neurogenic differentiation 4 0.178
rnasel1 ribonuclease like 1 0.178
si:ch211-212m21.5 si:ch211-212m21.5 0.177
gata3 GATA-binding protein 3 0.175
wnt10a wingless-type MMTV integration site family, member 10a 0.171
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.170
pax6a paired box gene 6a 0.167
atoh7 atonal homolog 7 0.166
foxp2 forkhead box P2 0.165
sox9a SRY-box containing gene 9a 0.165
chrna2a cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal) 0.162
dld deltaD 0.157
nkx2.2a NK2 transcription factor related 2a 0.154
pglyrp2 peptidoglycan recognition protein 2 0.150
gdf6a growth differentiation factor 6a 0.148
cc2d2a coiled-coil and C2 domain containing 2A 0.142
notch1b notch homolog 1b 0.142
sepp1b selenoprotein P, plasma, 1b 0.137
bmper BMP binding endothelial regulator 0.137
hoxd4a homeo box D4a 0.135
nkx3.2 NK3 homeobox 2 0.133
sox10 SRY-box containing gene 10 0.130
wnt4a wingless-type MMTV integration site family, member 4a 0.130
st8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.129
shhb sonic hedgehog b 0.129
twist1a twist1a 0.129
etv2 ets variant gene 2 0.127
rx2 retinal homeobox gene 2 0.127
ins preproinsulin 0.127
adipoql adiponectin, C1Q and collagen domain containing, like 0.126
foxd3 forkhead box D3 0.126
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.125
gata2a GATA-binding protein 2a 0.125
wnt5b wingless-type MMTV integration site family, member 5b 0.122
aldoca aldolase C, fructose-bisphosphate, a 0.121
hoxa1a homeo box A1a 0.119
ednra endothelin receptor type A 0.116
pglyrp6 peptidoglycan recognition protein 6 0.113
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ey eyeless 0.734
pan pangolin 0.656
sens senseless 0.596
Ubx Ultrabithorax 0.591
hh hedgehog 0.531
pb proboscipedia 0.456
dpp decapentaplegic 0.416
wg wingless 0.321
Mad Mothers against dpp 0.302
eya eyes absent 0.286
amos absent MD neurons and olfactory sensilla 0.239
B-H2 BarH2 0.232
sli slit 0.229
rho rhomboid 0.218
Dl Delta 0.208
B-H1 BarH1 0.199
ro rough 0.178
toy twin of eyeless 0.157
Abd-B Abdominal B 0.142
hth homothorax 0.132
dib disembodied 0.116
rap retina aberrant in pattern 0.111
gsb gooseberry 0.109
spo spook 0.107
CG11055 CG11055 gene product from transcript CG11055-RB 0.106
so sine oculis 0.102
Su(H) Suppressor of Hairless 0.099
por porcupine 0.098
Syx1A Syntaxin 1A 0.098
klar klarsicht 0.097
en engrailed 0.096
Ser Serrate 0.093
danr distal antenna-related 0.092
spi spitz 0.088
oc ocelliless 0.087
dac dachshund 0.083
btd buttonhead 0.081
rn rotund 0.080
sog short gastrulation 0.079
Pkc98E Protein C kinase 98E 0.077
Psn Presenilin 0.077
elav embryonic lethal abnormal vision 0.076
E(spl) Enhancer of split 0.076
gbb glass bottom boat 0.076
tld tolloid 0.073
prd paired 0.064
crb crumbs 0.064
Med Medea 0.063
HLH54F CG5005 gene product from transcript CG5005-RA 0.061
CrebA Cyclic-AMP response element binding protein A 0.061
osk oskar 0.060
exu exuperantia 0.053
myoglianin CG1838 gene product from transcript CG1838-RD 0.053
eyg eyegone 0.050
sv shaven 0.049
byn brachyenteron 0.048
dy dusky 0.048
Wnt2 Wnt oncogene analog 2 0.047
Kr Kruppel 0.047
dan distal antenna 0.045
Poxn Pox neuro 0.044
Gug Grunge 0.043
eve even skipped 0.043
Ras85D Ras oncogene at 85D 0.042
insc inscuteable 0.042
rols rolling pebbles 0.042
Tom Twin of m4 0.040
tin tinman 0.040
Gef26 CG9491 gene product from transcript CG9491-RB 0.040
bin biniou 0.039
dsh dishevelled 0.039
Doc2 Dorsocross2 0.039
ara araucan 0.038
CG18806 CG18806 gene product from transcript CG18806-RA 0.037
Cby Chibby 0.036
InR Insulin-like receptor 0.036
dimm dimmed 0.036
Egfr Epidermal growth factor receptor 0.034
Mob2 CG11711 gene product from transcript CG11711-RC 0.034
spen split ends 0.034
Wnt4 Wnt oncogene analog 4 0.034
lz lozenge 0.034
Msi Male-specific insect derived growth factor 0.033
org-1 optomotor-blind-related-gene-1 0.032
abd-A abdominal A 0.031
fkh fork head 0.031
Six4 CG3871 gene product from transcript CG3871-RA 0.030
spdo sanpodo 0.030
shd shade 0.029
vvl ventral veins lacking 0.029
sd scalloped 0.028
Plc21C Phospholipase C at 21C 0.027
rempA reduced mechanoreceptor potential A 0.026
knrl knirps-like 0.026
dally division abnormally delayed 0.026
zfh2 Zn finger homeodomain 2 0.026
shn schnurri 0.026
Dfd Deformed 0.025
Lim1 CG11354 gene product from transcript CG11354-RA 0.025
opa odd paired 0.025
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Homo sapiens
Name Description Probability Func Analog Organism
NCOA1 nuclear receptor coactivator 1 0.846
RARA retinoic acid receptor, alpha 0.823
NCOR2 nuclear receptor corepressor 2 0.741
RXRA retinoid X receptor, alpha 0.728
BCL2L1 BCL2-like 1 0.687
CREBBP CREB binding protein 0.596
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.589
AR androgen receptor 0.577
NCOA2 nuclear receptor coactivator 2 0.411
BMPR1A bone morphogenetic protein receptor, type IA 0.352
EP300 E1A binding protein p300 0.345
RUNX1 runt-related transcription factor 1 0.224
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.197
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.182
ESR1 estrogen receptor 1 0.171
NCOA3 nuclear receptor coactivator 3 0.170
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.149
MED25 mediator complex subunit 25 0.144
JAG1 jagged 1 0.139
CNOT8 CCR4-NOT transcription complex, subunit 8 0.134
NCOR1 nuclear receptor corepressor 1 0.125
SUFU suppressor of fused homolog (Drosophila) 0.115
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.100
CCNE1 cyclin E1 0.098
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.096
HNF4A hepatocyte nuclear factor 4, alpha 0.090
ESR2 estrogen receptor 2 (ER beta) 0.063
HIPK2 homeodomain interacting protein kinase 2 0.063
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.060
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.056
E2F1 E2F transcription factor 1 0.054
NCOA6 nuclear receptor coactivator 6 0.053
NME4 non-metastatic cells 4, protein expressed in 0.048
STK36 serine/threonine kinase 36 0.047
FSTL1 follistatin-like 1 0.046
GATA2 GATA binding protein 2 0.042
NKX2-1 NK2 homeobox 1 0.041
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.040
FOXO1 forkhead box O1 0.036
NOTCH3 notch 3 0.033
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.033
ESRRG estrogen-related receptor gamma 0.032
SKI v-ski sarcoma viral oncogene homolog (avian) 0.031
FBXW7 F-box and WD repeat domain containing 7 0.029
CDK6 cyclin-dependent kinase 6 0.029
PNRC1 proline-rich nuclear receptor coactivator 1 0.028
NDP Norrie disease (pseudoglioma) 0.028
SMAD1 SMAD family member 1 0.028
KANK2 KN motif and ankyrin repeat domains 2 0.027
ZFYVE9 zinc finger, FYVE domain containing 9 0.026
VHL von Hippel-Lindau tumor suppressor 0.026
PRKCZ protein kinase C, zeta 0.024
SP1 Sp1 transcription factor 0.024
ELF5 E74-like factor 5 (ets domain transcription factor) 0.024
PGR progesterone receptor 0.023
SMAD3 SMAD family member 3 0.022
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.022
BCL6 B-cell CLL/lymphoma 6 0.021
WNT5A wingless-type MMTV integration site family, member 5A 0.019
SALL2 sal-like 2 (Drosophila) 0.019
PPARA peroxisome proliferator-activated receptor alpha 0.019
SMAD9 SMAD family member 9 0.019
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.018
TCF4 transcription factor 4 0.018
WNT3A wingless-type MMTV integration site family, member 3A 0.018
THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) 0.018
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.016
BBS10 Bardet-Biedl syndrome 10 0.016
TCF12 transcription factor 12 0.015
NME2 non-metastatic cells 2, protein (NM23B) expressed in 0.015
CCND3 cyclin D3 0.015
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.015
SIAH1 seven in absentia homolog 1 (Drosophila) 0.015
CCND1 cyclin D1 0.014
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.014
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.014
SFRP1 secreted frizzled-related protein 1 0.013
FZD7 frizzled homolog 7 (Drosophila) 0.013
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.013
HR hairless homolog (mouse) 0.013
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.012
PPARG peroxisome proliferator-activated receptor gamma 0.012
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.012
NOTCH2 notch 2 0.012
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.012
TGS1 trimethylguanosine synthase 1 0.012
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.011
LRP6 low density lipoprotein receptor-related protein 6 0.011
EHF ets homologous factor 0.011
CCDC115 coiled-coil domain containing 115 0.011
EPAS1 endothelial PAS domain protein 1 0.011
QKI quaking homolog, KH domain RNA binding (mouse) 0.010
CDK8 cyclin-dependent kinase 8 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Elk3 ELK3, ETS-domain protein 0.048
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.027
Foxe3 forkhead box E3 0.024
Emcn endomucin 0.021
Dchs1 dachsous 1 (Drosophila) 0.018
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.018
Mrgprf MAS-related GPR, member F 0.018
Fgf7 fibroblast growth factor 7 0.016
Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 0.014
Pdia6 protein disulfide isomerase family A, member 6 0.014
Ebf1 early B-cell factor 1 0.013
Foxd1 forkhead box D1 0.012
Hoxc4 homeo box C4 0.011
Pde5a phosphodiesterase 5A, cGMP-specific 0.011
Umod uromodulin 0.010
Unc5b unc-5 homolog B (C. elegans) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism