The network for 'regulation of protein binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein binding

Any process that modulates the frequency, rate or extent of protein binding.

Danio rerio
Name Description Probability Func Analog Organism
smyhc1 slow myosin heavy chain 1 0.634
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.487
robo3 roundabout homolog 3 0.484
alcama activated leukocyte cell adhesion molecule a 0.410
mapk1 mitogen-activated protein kinase 1 0.402
bmp2b bone morphogenetic protein 2b 0.385
tnnt2a troponin T2a, cardiac 0.383
mef2ca myocyte enhancer factor 2ca 0.378
hsp90a.1 heat shock protein 90-alpha 1 0.271
mapk12 mitogen-activated protein kinase 12 0.268
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.260
col7a1l collagen type VII alpha 1-like 0.252
nrg2a neuregulin 2a 0.245
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.244
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.243
smad9 MAD homolog 9 (Drosophila) 0.236
mapk4 mitogen-activated protein kinase 4 0.233
fbn2b fibrillin 2b 0.226
fbln4 fibulin 4 0.221
tp53 tumor protein p53 0.217
wnt11r wingless-type MMTV integration site family, member 11, related 0.214
ptf1a pancreas specific transcription factor, 1a 0.202
ruvbl2 RuvB-like 2 (E. coli) 0.184
mapk6 mitogen-activated protein kinase 6 0.181
sox11b SRY-box containing gene 11b 0.178
cdh2 cadherin 2, neuronal 0.178
mapk7 mitogen-activated protein kinase 7 0.160
efnb2a ephrin B2a 0.159
actc1b actin, alpha, cardiac muscle 1b 0.159
sh3gl1b SH3-domain GRB2-like 1b 0.156
neurod neurogenic differentiation 0.156
spna2 spectrin alpha 2 0.155
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.154
ctnnb1 catenin (cadherin-associated protein), beta 1 0.154
rbpms2 RNA binding protein with multiple splicing 2 0.153
ntn2 netrin 2 0.151
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.151
nrg1 neuregulin 1 0.147
hs3st3b1a heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a 0.144
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.142
ptena phosphatase and tensin homolog A 0.138
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.135
hspa12b heat shock protein 12B 0.134
hsp90a.2 heat shock protein 90-alpha 2 0.127
flot1b flotillin 1b 0.127
tnnc1b troponin C type 1b (slow) 0.124
fabp7a fatty acid binding protein 7, brain, a 0.119
ndrg4 N-myc downstream regulated gene 4 0.116
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.114
gdf6a growth differentiation factor 6a 0.109
tfe3a transcription factor binding to IGHM enhancer 3a 0.109
crip2 cysteine-rich protein 2 0.107
hlxb9la homeo box HB9 like a 0.107
bmp4 bone morphogenetic protein 4 0.107
ube2i2 ubiquitin-conjugating enzyme E2I2 0.105
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.101
dusp6 dual specificity phosphatase 6 0.100
svil supervillin 0.100
hs3st1l1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like1 0.098
mfn2 mitofusin 2 0.097
prom1a prominin 1a 0.097
appa amyloid beta (A4) precursor protein a 0.097
bcl2 B-cell leukemia/lymphoma 2 0.096
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.095
foxd3 forkhead box D3 0.095
myog myogenin 0.093
gle1 GLE1 RNA export mediator homolog (yeast) 0.091
itga3b integrin, alpha 3b 0.088
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.088
foxo3b forkhead box O3b 0.088
ahctf1 AT hook containing transcription factor 1 0.087
epha4a eph receptor A4a 0.087
flr fleer 0.086
igfbp5a insulin-like growth factor binding protein 5a 0.083
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.083
atp1b2a ATPase, Na+/K+ transporting, beta 2a polypeptide 0.083
neo1 neogenin 1 0.083
clic4 chloride intracellular channel 4 0.081
mapk3 mitogen-activated protein kinase 3 0.081
dkk1b dickkopf 1b 0.080
eif3c eukaryotic translation initiation factor 3, subunit C 0.080
pcdh10b protocadherin 10b 0.079
smad5 MAD homolog 5 (Drosophila) 0.079
ntn1a netrin 1a 0.078
cpsf1 cleavage and polyadenylation specific factor 1 0.078
extl3 exostoses (multiple)-like 3 0.078
cadm3 cell adhesion molecule 3 0.077
hspb1 heat shock protein, alpha-crystallin-related, 1 0.076
frem3 Fras1 related extracellular matrix 3 0.075
wnt10a wingless-type MMTV integration site family, member 10a 0.074
prox1 prospero-related homeobox gene 1 0.074
sec13 SEC13 homolog (S. cerevisiae) 0.074
pdx1 pancreatic and duodenal homeobox 1 0.074
wars tryptophanyl-tRNA synthetase 0.073
mycl1b v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b 0.073
hmgb3a high-mobility group box 3a 0.073
stac3 SH3 and cysteine rich domain 3 0.073
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.072
crx cone-rod homeobox 0.072
pabpc1a poly A binding protein, cytoplasmic 1 a 0.072
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
hep hemipterous 0.011
crb crumbs 0.011
CaMKII Calcium/calmodulin-dependent protein kinase II 0.011
rok Rho-kinase 0.010
PICK1 CG6167 gene product from transcript CG6167-RA 0.010
nej nejire 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.999
FHL2 four and a half LIM domains 2 0.955
PSEN1 presenilin 1 0.911
BCL2L1 BCL2-like 1 0.902
C1QA complement component 1, q subcomponent, A chain 0.875
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.830
ARRB1 arrestin, beta 1 0.794
FLNA filamin A, alpha 0.761
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.649
NCOR2 nuclear receptor corepressor 2 0.625
TP53 tumor protein p53 0.581
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.538
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.533
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.498
CCR5 chemokine (C-C motif) receptor 5 0.496
FN1 fibronectin 1 0.490
MPDZ multiple PDZ domain protein 0.448
TRAF1 TNF receptor-associated factor 1 0.447
ENG endoglin 0.434
MAPK8 mitogen-activated protein kinase 8 0.429
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.427
ZMYND11 zinc finger, MYND-type containing 11 0.385
CREBBP CREB binding protein 0.379
ESR1 estrogen receptor 1 0.374
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.368
TRAF2 TNF receptor-associated factor 2 0.368
PDIA3 protein disulfide isomerase family A, member 3 0.361
LRP6 low density lipoprotein receptor-related protein 6 0.340
APP amyloid beta (A4) precursor protein 0.337
CBX5 chromobox homolog 5 0.321
BTBD2 BTB (POZ) domain containing 2 0.298
CSNK1E casein kinase 1, epsilon 0.290
FLNB filamin B, beta 0.272
TGFB1 transforming growth factor, beta 1 0.271
AR androgen receptor 0.267
CCL4 chemokine (C-C motif) ligand 4 0.267
MAP2K4 mitogen-activated protein kinase kinase 4 0.265
ABI2 abl-interactor 2 0.264
CD40 CD40 molecule, TNF receptor superfamily member 5 0.255
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.246
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.240
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.230
TRAF3 TNF receptor-associated factor 3 0.229
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.219
BAD BCL2-associated agonist of cell death 0.218
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.215
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.215
BMPR1A bone morphogenetic protein receptor, type IA 0.214
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.211
TPM1 tropomyosin 1 (alpha) 0.209
TCF4 transcription factor 4 0.209
VCAM1 vascular cell adhesion molecule 1 0.207
EPS8 epidermal growth factor receptor pathway substrate 8 0.207
FAS Fas (TNF receptor superfamily, member 6) 0.206
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.206
CXCL9 chemokine (C-X-C motif) ligand 9 0.201
PTEN phosphatase and tensin homolog 0.201
C1QC complement component 1, q subcomponent, C chain 0.201
ATF2 activating transcription factor 2 0.189
MAPK1 mitogen-activated protein kinase 1 0.181
SMAD7 SMAD family member 7 0.173
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.173
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.166
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.163
THBS1 thrombospondin 1 0.160
IRAK2 interleukin-1 receptor-associated kinase 2 0.160
SPTBN1 spectrin, beta, non-erythrocytic 1 0.157
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.149
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.144
C1QB complement component 1, q subcomponent, B chain 0.141
PSEN2 presenilin 2 (Alzheimer disease 4) 0.139
TPM2 tropomyosin 2 (beta) 0.138
MEF2A myocyte enhancer factor 2A 0.137
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.137
CCL8 chemokine (C-C motif) ligand 8 0.136
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.135
CORO1C coronin, actin binding protein, 1C 0.134
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.130
IRAK1 interleukin-1 receptor-associated kinase 1 0.129
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.126
CXCL10 chemokine (C-X-C motif) ligand 10 0.125
ATXN1 ataxin 1 0.122
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.120
INCENP inner centromere protein antigens 135/155kDa 0.119
STK4 serine/threonine kinase 4 0.117
MAPK14 mitogen-activated protein kinase 14 0.113
SPTB spectrin, beta, erythrocytic 0.112
ZNF512B zinc finger protein 512B 0.111
GSK3B glycogen synthase kinase 3 beta 0.111
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.111
CCL7 chemokine (C-C motif) ligand 7 0.111
CCL2 chemokine (C-C motif) ligand 2 0.106
ITGB5 integrin, beta 5 0.106
SOCS3 suppressor of cytokine signaling 3 0.105
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.102
CCL20 chemokine (C-C motif) ligand 20 0.099
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.099
AXIN1 axin 1 0.099
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.099
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.098
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Mus musculus
Name Description Probability Func Analog Organism
Mef2d myocyte enhancer factor 2D 0.952
Pten phosphatase and tensin homolog 0.831
Arrb1 arrestin, beta 1 0.769
Meox2 mesenchyme homeobox 2 0.701
Src Rous sarcoma oncogene 0.679
Tlr4 toll-like receptor 4 0.673
Mstn myostatin 0.660
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.613
Axin1 axin 1 0.596
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.586
Pax3 paired box gene 3 0.570
Ncoa3 nuclear receptor coactivator 3 0.564
Klc1 kinesin light chain 1 0.555
Tgfbr2 transforming growth factor, beta receptor II 0.542
Psen1 presenilin 1 0.522
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.514
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.496
Smad3 MAD homolog 3 (Drosophila) 0.494
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.483
Gsk3b glycogen synthase kinase 3 beta 0.476
Thra thyroid hormone receptor alpha 0.453
Fyn Fyn proto-oncogene 0.418
Smad4 MAD homolog 4 (Drosophila) 0.408
Ctnnb1 catenin (cadherin associated protein), beta 1 0.364
Mapk8 mitogen-activated protein kinase 8 0.360
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.354
Pea15a phosphoprotein enriched in astrocytes 15A 0.324
Myd88 myeloid differentiation primary response gene 88 0.318
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.317
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.309
Fgfr2 fibroblast growth factor receptor 2 0.276
Ncoa2 nuclear receptor coactivator 2 0.268
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.267
Tgfbr3 transforming growth factor, beta receptor III 0.261
Apc adenomatosis polyposis coli 0.258
Arrb2 arrestin, beta 2 0.256
Stk3 serine/threonine kinase 3 (Ste20, yeast homolog) 0.246
Cbl Casitas B-lineage lymphoma 0.246
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.238
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.230
Ednra endothelin receptor type A 0.229
Trp53 transformation related protein 53 0.227
Cdh5 cadherin 5 0.223
Tcf7 transcription factor 7, T-cell specific 0.222
Gm5806 predicted gene 5806 0.221
Prkce protein kinase C, epsilon 0.216
Bptf bromodomain PHD finger transcription factor 0.216
Pkd1 polycystic kidney disease 1 homolog 0.213
Notch2 Notch gene homolog 2 (Drosophila) 0.213
Atf4 activating transcription factor 4 0.213
Epor erythropoietin receptor 0.213
Rarg retinoic acid receptor, gamma 0.212
Rxra retinoid X receptor alpha 0.209
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.205
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.204
Sox9 SRY-box containing gene 9 0.200
Hdac7 histone deacetylase 7 0.200
App amyloid beta (A4) precursor protein 0.199
Ncstn nicastrin 0.196
Cd19 CD19 antigen 0.194
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.193
Pitx2 paired-like homeodomain transcription factor 2 0.189
Gli2 GLI-Kruppel family member GLI2 0.185
Hdac5 histone deacetylase 5 0.182
Clstn1 calsyntenin 1 0.182
Gata1 GATA binding protein 1 0.179
Gata6 GATA binding protein 6 0.178
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.175
Inpp5d inositol polyphosphate-5-phosphatase D 0.174
Gata4 GATA binding protein 4 0.173
Kit kit oncogene 0.173
Mprip myosin phosphatase Rho interacting protein 0.171
Ephb2 Eph receptor B2 0.168
Tgfb2 transforming growth factor, beta 2 0.168
Was Wiskott-Aldrich syndrome homolog (human) 0.166
Spnb1 spectrin beta 1 0.165
Mef2c myocyte enhancer factor 2C 0.165
Spnb2 spectrin beta 2 0.158
Dag1 dystroglycan 1 0.158
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.155
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.154
Csf1 colony stimulating factor 1 (macrophage) 0.154
Fbn1 fibrillin 1 0.153
Plxna1 plexin A1 0.149
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.149
Vangl2 vang-like 2 (van gogh, Drosophila) 0.148
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.145
Mrc1 mannose receptor, C type 1 0.143
Ikzf1 IKAROS family zinc finger 1 0.143
Igf1r insulin-like growth factor I receptor 0.143
St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.142
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.141
Notch1 Notch gene homolog 1 (Drosophila) 0.140
Tcfcp2l1 transcription factor CP2-like 1 0.140
Mapk3 mitogen-activated protein kinase 3 0.137
Nf1 neurofibromatosis 1 0.136
Phldb1 pleckstrin homology-like domain, family B, member 1 0.135
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.135
Cd14 CD14 antigen 0.131
Rac1 RAS-related C3 botulinum substrate 1 0.130
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Rattus norvegicus
Name Description Probability Func Analog Organism
Canx calnexin 0.021
St13 suppression of tumorigenicity 13 0.019
Eif4h eukaryotic translation initiation factor 4H 0.016
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.012
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.011
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.011
Stip1 stress-induced phosphoprotein 1 0.010
Zmym2 zinc finger, MYM-type 2 0.010
Hspd1 heat shock protein 1 (chaperonin) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
UBI4 Ubi4p 0.138
SSB1 Ssb1p 0.019
MRPL16 Mrpl16p 0.015
RIM11 Rim11p 0.014
BEM1 Bem1p 0.013
BRE1 Bre1p 0.013
RVS167 Rvs167p 0.013
SSD1 Ssd1p 0.012
FMC1 Fmc1p 0.012
ATG3 Atg3p 0.012
DCS1 Dcs1p 0.012
SAC3 Sac3p 0.012
ARX1 Arx1p 0.012
MRPL38 Mrpl38p 0.011
MRPL10 Mrpl10p 0.011
MRPL24 Mrpl24p 0.011
MRPL9 Mrpl9p 0.011
MHR1 Mhr1p 0.011
RPF2 Rpf2p 0.010
ISA2 Isa2p 0.010
PET100 Pet100p 0.010
MRPS12 Mrps12p 0.010