The network for 'negative regulation of protein import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

Danio rerio
Name Description Probability Func Analog Organism
lef1 lymphocyte enhancer binding factor 1 0.318
nf1a neurofibromin 1a 0.311
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.171
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.166
cdc20 cell division cycle 20 homolog 0.131
igf1rb insulin-like growth factor 1b receptor 0.110
plk1 polo-like kinase 1 (Drosophila) 0.107
ptgs1 prostaglandin-endoperoxide synthase 1 0.106
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.106
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.097
insrb insulin receptor b 0.096
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.094
mapk3 mitogen-activated protein kinase 3 0.093
atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.088
acvr1b activin A receptor, type IB 0.088
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.079
cdh1 cadherin 1, epithelial 0.075
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.071
capns1a calpain, small subunit 1 a 0.069
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.068
nrg1 neuregulin 1 0.068
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.068
thraa thyroid hormone receptor alpha a 0.066
zgc:101761 zgc:101761 0.065
ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.064
flh floating head 0.063
mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.061
zgc:162965 zgc:162965 0.060
tp53bp2 tumor protein p53 binding protein, 2 0.058
extl3 exostoses (multiple)-like 3 0.057
gdf6a growth differentiation factor 6a 0.056
wars tryptophanyl-tRNA synthetase 0.056
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.053
akt2 v-akt murine thymoma viral oncogene homolog 2 0.052
ptges prostaglandin E synthase 0.051
nf1b neurofibromin 1b 0.051
wls wntless homolog (Drosophila) 0.050
mcl1a myeloid cell leukemia sequence 1a 0.049
ptpra protein tyrosine phosphatase, receptor type, A 0.048
fbn2b fibrillin 2b 0.048
rnf128a ring finger protein 128a 0.046
zgc:153047 zgc:153047 0.046
atp6v1g1 ATPase, H+ transporting, V1 subunit G isoform 1 0.046
cyp51 cytochrome P450, family 51 0.046
ppp2r5d protein phosphatase 2, regulatory subunit B', delta 0.046
si:ch211-197n10.2 si:ch211-197n10.2 0.045
furinb furin (paired basic amino acid cleaving enzyme) b 0.044
pppde1 PPPDE peptidase domain containing 1 0.043
zgc:56200 zgc:56200 0.043
ccr6a chemokine (C-C motif) receptor 6a 0.042
scn1lab sodium channel, voltage-gated, type I like, alpha b 0.041
mapk6 mitogen-activated protein kinase 6 0.041
pld1a phospholipase D1a 0.041
clk4a CDC-like kinase 4a 0.040
zgc:86764 zgc:86764 0.040
nuf2 NUF2, NDC80 kinetochore complex component, homolog 0.040
rarga retinoic acid receptor gamma a 0.039
zgc:73328 zgc:73328 0.039
birc5a baculoviral IAP repeat-containing 5a 0.038
tmem161b transmembrane protein 161B 0.038
jag2 jagged 2 0.038
ntn2 netrin 2 0.037
gro2 groucho 2 0.037
mcl1b myeloid cell leukemia sequence 1b 0.037
lpp LIM domain containing preferred translocation partner in lipoma 0.036
klhl11 kelch-like 11 (Drosophila) 0.036
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.035
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.035
uspl1 ubiquitin specific peptidase like 1 0.034
lsm1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.034
zbtb4 zinc finger and BTB domain containing 4 0.033
vgll4l vestigial like 4 like 0.033
ankrd13c ankyrin repeat domain 13C 0.033
bmpr1ab bone morphogenetic protein receptor, type 1ab 0.032
col7a1l collagen type VII alpha 1-like 0.032
ptpn11b protein tyrosine phosphatase, non-receptor type 11, b 0.032
grem1a gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) 0.031
stau2 staufen, RNA binding protein, homolog 2 (Drosophila) 0.031
litaf lipopolysaccharide-induced TNF factor 0.031
tk2 thymidine kinase 2, mitochondrial 0.030
sb:cb166 sb:cb166 0.030
ip6k2 inositol hexaphosphate kinase 2 0.030
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.030
mapk12 mitogen-activated protein kinase 12 0.029
anxa13 annexin A13 0.029
ptk2.1 protein tyrosine kinase 2a 0.029
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.029
pdcd6ip programmed cell death 6 interacting protein 0.029
LOC793701 growth arrest-specific protein 7-like 0.029
sec24c SEC24 family, member C (S. cerevisiae) 0.029
zgc:64114 zgc:64114 0.029
cish cytokine inducible SH2-containing protein 0.029
cyp1a cytochrome P450, family 1, subfamily A 0.028
mkln1 muskelin 1, intracellular mediator containing kelch motifs 0.028
mycbp2 MYC binding protein 2 0.028
smc4 structural maintenance of chromosomes 4 0.028
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.028
gins2 GINS complex subunit 2 0.028
LOC100000332 e3 ubiquitin-protein ligase RNF182-like 0.028
aplnra apelin receptor a 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.022
Akt1 CG4006 gene product from transcript CG4006-RA 0.015
l(2)gl lethal (2) giant larvae 0.013
mub mushroom-body expressed 0.012
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Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.942
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.907
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.848
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.730
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.613
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.600
GSK3B glycogen synthase kinase 3 beta 0.547
BTRC beta-transducin repeat containing 0.451
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.451
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.394
FAS Fas (TNF receptor superfamily, member 6) 0.348
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.333
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.275
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.268
FBXW11 F-box and WD repeat domain containing 11 0.229
CHUK conserved helix-loop-helix ubiquitous kinase 0.227
FADD Fas (TNFRSF6)-associated via death domain 0.196
AXIN1 axin 1 0.176
DTX3L deltex 3-like (Drosophila) 0.142
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.140
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.130
SKP1 S-phase kinase-associated protein 1 0.123
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.111
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.108
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.105
CREBBP CREB binding protein 0.103
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.102
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.100
PARP14 poly (ADP-ribose) polymerase family, member 14 0.089
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.087
PML promyelocytic leukemia 0.081
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.078
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.077
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.076
HIPK3 homeodomain interacting protein kinase 3 0.074
CFLAR CASP8 and FADD-like apoptosis regulator 0.070
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.062
CUL1 cullin 1 0.061
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.060
ERBB2IP erbb2 interacting protein 0.060
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.056
IGF1R insulin-like growth factor 1 receptor 0.054
PARP9 poly (ADP-ribose) polymerase family, member 9 0.050
PROX1 prospero homeobox 1 0.048
MAP2K5 mitogen-activated protein kinase kinase 5 0.047
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.047
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.044
RARA retinoic acid receptor, alpha 0.044
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.042
CKAP5 cytoskeleton associated protein 5 0.041
AXL AXL receptor tyrosine kinase 0.040
TEK TEK tyrosine kinase, endothelial 0.040
RANBP3 RAN binding protein 3 0.037
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.036
MAPK3 mitogen-activated protein kinase 3 0.036
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.035
STRN3 striatin, calmodulin binding protein 3 0.034
TCF4 transcription factor 4 0.031
BCL3 B-cell CLL/lymphoma 3 0.031
IRS1 insulin receptor substrate 1 0.030
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.030
CALD1 caldesmon 1 0.030
GLIS2 GLIS family zinc finger 2 0.030
LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.029
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 0.029
RPTOR regulatory associated protein of MTOR, complex 1 0.028
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.027
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.027
SNAI1 snail homolog 1 (Drosophila) 0.026
YAP1 Yes-associated protein 1 0.025
IRS2 insulin receptor substrate 2 0.025
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.024
PRKCZ protein kinase C, zeta 0.024
LMO4 LIM domain only 4 0.024
SOCS1 suppressor of cytokine signaling 1 0.023
INSR insulin receptor 0.022
C3orf15 chromosome 3 open reading frame 15 0.022
BBS10 Bardet-Biedl syndrome 10 0.022
ZNF260 zinc finger protein 260 0.021
GLI1 GLI family zinc finger 1 0.020
PSEN2 presenilin 2 (Alzheimer disease 4) 0.020
JUB jub, ajuba homolog (Xenopus laevis) 0.020
ZNF84 zinc finger protein 84 0.020
GRB10 growth factor receptor-bound protein 10 0.020
MAPK14 mitogen-activated protein kinase 14 0.020
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.020
C19orf46 chromosome 19 open reading frame 46 0.020
EMD emerin 0.019
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.019
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.019
PEX26 peroxisomal biogenesis factor 26 0.019
TJP2 tight junction protein 2 (zona occludens 2) 0.019
APC adenomatous polyposis coli 0.018
AMOTL1 angiomotin like 1 0.018
SETD7 SET domain containing (lysine methyltransferase) 7 0.018
AMOTL2 angiomotin like 2 0.018
PRKCA protein kinase C, alpha 0.018
LZTS2 leucine zipper, putative tumor suppressor 2 0.018
NOG noggin 0.018
SMAD3 SMAD family member 3 0.018
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Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.957
Trp53 transformation related protein 53 0.953
Pten phosphatase and tensin homolog 0.716
Apc adenomatosis polyposis coli 0.684
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.627
Gli3 GLI-Kruppel family member GLI3 0.448
Fgfr2 fibroblast growth factor receptor 2 0.382
Trp63 transformation related protein 63 0.381
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.352
Grb10 growth factor receptor bound protein 10 0.286
Rara retinoic acid receptor, alpha 0.280
Fgfr1 fibroblast growth factor receptor 1 0.272
Casp1 caspase 1 0.270
Gopc golgi associated PDZ and coiled-coil motif containing 0.253
Smad3 MAD homolog 3 (Drosophila) 0.152
Yap1 yes-associated protein 1 0.147
Pbx1 pre B-cell leukemia transcription factor 1 0.127
Bcl2 B-cell leukemia/lymphoma 2 0.124
Iigp1 interferon inducible GTPase 1 0.121
Pycard PYD and CARD domain containing 0.108
Gli2 GLI-Kruppel family member GLI2 0.100
Aim2 absent in melanoma 2 0.079
Smo smoothened homolog (Drosophila) 0.077
Rxra retinoid X receptor alpha 0.076
Pax8 paired box gene 8 0.064
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.054
Htt huntingtin 0.053
Gbp2 guanylate binding protein 2 0.051
Wnt5a wingless-related MMTV integration site 5A 0.051
Ghr growth hormone receptor 0.050
Ifit2 interferon-induced protein with tetratricopeptide repeats 2 0.049
Gbp3 guanylate binding protein 3 0.049
Fzd1 frizzled homolog 1 (Drosophila) 0.048
Sox9 SRY-box containing gene 9 0.046
Irgm2 immunity-related GTPase family M member 2 0.044
Sap18 Sin3-associated polypeptide 18 0.044
Meox2 mesenchyme homeobox 2 0.043
Prrx1 paired related homeobox 1 0.041
Axin1 axin 1 0.040
Stat6 signal transducer and activator of transcription 6 0.040
Il6st interleukin 6 signal transducer 0.039
Rnh1 ribonuclease/angiogenin inhibitor 1 0.039
Ptk7 PTK7 protein tyrosine kinase 7 0.039
Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 0.038
Rb1 retinoblastoma 1 0.035
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.034
Per2 period homolog 2 (Drosophila) 0.034
Bmp4 bone morphogenetic protein 4 0.034
Bmpr1a bone morphogenetic protein receptor, type 1A 0.034
Fzd8 frizzled homolog 8 (Drosophila) 0.033
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.033
Ncoa3 nuclear receptor coactivator 3 0.033
Notch2 Notch gene homolog 2 (Drosophila) 0.031
Kitl kit ligand 0.030
Hoxa2 homeobox A2 0.030
F2r coagulation factor II (thrombin) receptor 0.030
Shh sonic hedgehog 0.029
Dlg2 discs, large homolog 2 (Drosophila) 0.028
Rarg retinoic acid receptor, gamma 0.028
Ikbkb inhibitor of kappaB kinase beta 0.027
Bicc1 bicaudal C homolog 1 (Drosophila) 0.027
Tef thyrotroph embryonic factor 0.026
Casp12 caspase 12 0.026
Bcl3 B-cell leukemia/lymphoma 3 0.026
Ifi203 interferon activated gene 203 0.025
Rnf115 ring finger protein 115 0.025
Bmp5 bone morphogenetic protein 5 0.024
Dlg4 discs, large homolog 4 (Drosophila) 0.024
Eya1 eyes absent 1 homolog (Drosophila) 0.024
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.024
Ar androgen receptor 0.024
Mapkap1 mitogen-activated protein kinase associated protein 1 0.024
Tbx3 T-box 3 0.024
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.023
Mdm2 transformed mouse 3T3 cell double minute 2 0.023
Phldb2 pleckstrin homology-like domain, family B, member 2 0.023
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.023
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.023
Btbd3 BTB (POZ) domain containing 3 0.022
Ptch1 patched homolog 1 0.022
Rptor regulatory associated protein of MTOR, complex 1 0.022
Gbp7 guanylate binding protein 7 0.022
Pax2 paired box gene 2 0.022
Lepr leptin receptor 0.022
Hr hairless 0.021
Hoxb3 homeobox B3 0.021
Gbp6 guanylate binding protein 6 0.021
Tsc1 tuberous sclerosis 1 0.021
Per1 period homolog 1 (Drosophila) 0.021
Mpdz multiple PDZ domain protein 0.020
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.020
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.020
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.020
Per3 period homolog 3 (Drosophila) 0.020
Igbp1 immunoglobulin (CD79A) binding protein 1 0.020
Zfp358 zinc finger protein 358 0.020
Col4a5 collagen, type IV, alpha 5 0.020
Vhl von Hippel-Lindau tumor suppressor 0.020
Rhoq ras homolog gene family, member Q 0.020
Wnt9b wingless-type MMTV integration site 9B 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rraga Ras-related GTP binding A 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism