The network for 'multicellular organismal metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

multicellular organismal metabolic process

The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required.

Danio rerio
Name Description Probability Func Analog Organism
itgb1b integrin, beta 1b 0.891
itgb1b.2 integrin, beta 1b.2 0.793
col1a2 collagen, type I, alpha 2 0.780
spry4 sprouty (Drosophila) homolog 4 0.759
col12a1 collagen, type XII, alpha 1 0.732
cdx1b caudal type homeobox 1 b 0.690
sparc secreted acidic cysteine rich glycoprotein 0.609
jag1b jagged 1b 0.552
ctsk cathepsin K 0.534
prrx1a paired related homeobox 1a 0.529
adrb2a adrenergic receptor, beta 2a 0.505
il6st interleukin 6 signal transducer 0.471
col27a1a collagen, type XXVII, alpha 1a 0.452
itgb1a integrin, beta 1a 0.437
zgc:77714 zgc:77714 0.416
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.402
si:ch211-212m21.5 si:ch211-212m21.5 0.399
gcm2 glial cells missing homolog 2 (Drosophila) 0.397
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.382
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.354
ghrb growth hormone receptor b 0.349
itgb1b.1 integrin, beta 1b.1 0.344
ghra growth hormone receptor a 0.335
mc3r melanocortin 3 receptor 0.332
col1a1a collagen, type I, alpha 1a 0.308
LOC569128 hypothetical protein LOC569128 0.272
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.269
ahr2 aryl hydrocarbon receptor 2 0.264
col5a1 procollagen, type V, alpha 1 0.262
angptl2 angiopoietin-like 2 0.261
col2a1a collagen type II, alpha-1a 0.255
mmp2 matrix metalloproteinase 2 0.248
timp2a tissue inhibitor of metalloproteinase 2a 0.243
ntd5 ntl-dependent gene 5 0.235
matn4 matrilin 4 0.232
psap prosaposin 0.232
hsp47 heat shock protein 47 0.216
col11a1a collagen, type XI, alpha 1a 0.215
fn1b fibronectin 1b 0.208
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.200
lifrb leukemia inhibitory factor receptor alpha b 0.200
igf2b insulin-like growth factor 2b 0.198
apoeb apolipoprotein Eb 0.196
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.195
cpn1 carboxypeptidase N, polypeptide 1 0.192
rbp4 retinol binding protein 4, plasma 0.189
zgc:55891 zgc:55891 0.185
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.184
col5a2l collagen, type V, alpha 2-like 0.181
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.181
rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.181
tgfb2 transforming growth factor, beta 2 0.179
hapln1a hyaluronan and proteoglycan link protein 1a 0.178
fbn2b fibrillin 2b 0.176
sox9a SRY-box containing gene 9a 0.172
igfbp6b insulin-like growth factor binding protein 6b 0.172
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.171
lpar1 lysophosphatidic acid receptor 1 0.169
satb2 SATB homeobox 2 0.167
pparg peroxisome proliferator activated receptor gamma 0.164
csnk1a1 casein kinase 1, alpha 1 0.156
etv5b ets variant 5b 0.151
wls wntless homolog (Drosophila) 0.151
spon2a spondin 2a, extracellular matrix protein 0.150
cfdl complement factor D (adipsin) like 0.148
tbx18 T-box 18 0.146
dcn decorin 0.145
mmp13a matrix metalloproteinase 13a 0.140
postn periostin, osteoblast specific factor 0.138
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.136
fzd2 frizzled homolog 2 0.128
bhmt betaine-homocysteine methyltransferase 0.122
xbp1 X-box binding protein 1 0.122
hspa5 heat shock protein 5 0.120
tgfbi transforming growth factor, beta-induced 0.118
ctsl1a cathepsin L, 1 a 0.115
p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 0.114
wnt11r wingless-type MMTV integration site family, member 11, related 0.113
ncf1 neutrophil cytosolic factor 1 0.112
pmp22a peripheral myelin protein 22a 0.112
tpm4 tropomyosin 4 0.110
rbp1a retinol binding protein 1a, cellular 0.109
gpd1b glycerol-3-phosphate dehydrogenase 1b 0.108
vcanb versican b 0.108
pea3 ETS-domain transcription factor pea3 0.107
LOC100534776 toll-like receptor 7-like 0.106
ctsba cathepsin B, a 0.106
mxra8a matrix-remodelling associated 8a 0.106
wu:fv91b12 wu:fv91b12 0.106
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.104
irf8 interferon regulatory factor 8 0.103
mpx myeloid-specific peroxidase 0.102
duox dual oxidase 0.102
adrb2b adrenergic receptor, beta 2b 0.101
tlr3 toll-like receptor 3 0.100
asb8 ankyrin repeat and SOCS box-containing 8 0.100
bmp2b bone morphogenetic protein 2b 0.099
mtp microsomal triglyceride transfer protein 0.099
col10a1 collagen, type X, alpha 1 0.096
adipoql adiponectin, C1Q and collagen domain containing, like 0.096
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ci cubitus interruptus 0.034
mew multiple edematous wings 0.023
Mmp1 Matrix metalloproteinase 1 0.022
bsk basket 0.021
Df31 Decondensation factor 31 0.017
Egfr Epidermal growth factor receptor 0.017
if inflated 0.016
loqs loquacious 0.016
ap apterous 0.016
cora coracle 0.016
Med Medea 0.015
stck steamer duck 0.013
shn schnurri 0.013
hipk homeodomain interacting protein kinase 0.013
Cg25C Collagen type IV 0.012
CG9510 CG9510 gene product from transcript CG9510-RC 0.012
Cdk5alpha Cdk5 activator-like protein 0.012
hig hikaru genki 0.012
Dad Daughters against dpp 0.012
AcCoAS Acetyl Coenzyme A synthase 0.011
Ctr1A Copper transporter 1A 0.011
zetaTry zetaTrypsin 0.011
Ser7 CG2045 gene product from transcript CG2045-RA 0.011
gbb glass bottom boat 0.011
CG30427 CG30427 gene product from transcript CG30427-RC 0.011
sd scalloped 0.010
CG7526 CG7526 gene product from transcript CG7526-RC 0.010
dpp decapentaplegic 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.992
COL3A1 collagen, type III, alpha 1 0.987
COL6A1 collagen, type VI, alpha 1 0.986
TEK TEK tyrosine kinase, endothelial 0.980
FGA fibrinogen alpha chain 0.963
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.940
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.933
COL4A1 collagen, type IV, alpha 1 0.918
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.903
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.893
COL1A2 collagen, type I, alpha 2 0.880
ELN elastin 0.868
THBS1 thrombospondin 1 0.843
TGFB1 transforming growth factor, beta 1 0.828
FN1 fibronectin 1 0.812
BMPR1A bone morphogenetic protein receptor, type IA 0.809
LOX lysyl oxidase 0.808
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.803
FBN1 fibrillin 1 0.801
DDR2 discoidin domain receptor tyrosine kinase 2 0.801
TIMP1 TIMP metallopeptidase inhibitor 1 0.744
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.715
COL6A2 collagen, type VI, alpha 2 0.669
ALB albumin 0.656
BGN biglycan 0.633
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.598
FSTL1 follistatin-like 1 0.590
COL5A2 collagen, type V, alpha 2 0.571
COL18A1 collagen, type XVIII, alpha 1 0.568
PXDN peroxidasin homolog (Drosophila) 0.532
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.528
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.503
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.481
COL4A2 collagen, type IV, alpha 2 0.468
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.459
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.457
BMP1 bone morphogenetic protein 1 0.449
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.441
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.427
POSTN periostin, osteoblast specific factor 0.420
COL5A1 collagen, type V, alpha 1 0.399
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.396
CYR61 cysteine-rich, angiogenic inducer, 61 0.333
TIMP2 TIMP metallopeptidase inhibitor 2 0.304
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.300
LTBP2 latent transforming growth factor beta binding protein 2 0.294
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.284
PTPRB protein tyrosine phosphatase, receptor type, B 0.276
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.220
TNXB tenascin XB 0.213
LAMB1 laminin, beta 1 0.201
THBS2 thrombospondin 2 0.196
HSPG2 heparan sulfate proteoglycan 2 0.187
BMPR1B bone morphogenetic protein receptor, type IB 0.186
IL6R interleukin 6 receptor 0.182
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.178
FGG fibrinogen gamma chain 0.176
CAV1 caveolin 1, caveolae protein, 22kDa 0.174
IGFBP3 insulin-like growth factor binding protein 3 0.171
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.170
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.168
IL6 interleukin 6 (interferon, beta 2) 0.167
CXCL12 chemokine (C-X-C motif) ligand 12 0.165
NNMT nicotinamide N-methyltransferase 0.163
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.160
FKBP10 FK506 binding protein 10, 65 kDa 0.156
PTEN phosphatase and tensin homolog 0.153
FAP fibroblast activation protein, alpha 0.149
C1S complement component 1, s subcomponent 0.148
ITGB5 integrin, beta 5 0.148
LOXL2 lysyl oxidase-like 2 0.146
MRC2 mannose receptor, C type 2 0.145
WISP1 WNT1 inducible signaling pathway protein 1 0.143
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.142
PCOLCE procollagen C-endopeptidase enhancer 0.142
NID2 nidogen 2 (osteonidogen) 0.136
NRP1 neuropilin 1 0.135
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 0.135
ANGPT2 angiopoietin 2 0.132
FLNB filamin B, beta 0.130
NCF4 neutrophil cytosolic factor 4, 40kDa 0.130
MFAP2 microfibrillar-associated protein 2 0.129
THY1 Thy-1 cell surface antigen 0.129
TNC tenascin C 0.127
CDCP1 CUB domain containing protein 1 0.125
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.124
CUL2 cullin 2 0.117
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.116
CYTH1 cytohesin 1 0.113
OSMR oncostatin M receptor 0.109
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.107
CALD1 caldesmon 1 0.107
BCAR1 breast cancer anti-estrogen resistance 1 0.105
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.103
COL6A3 collagen, type VI, alpha 3 0.101
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.099
APOA1 apolipoprotein A-I 0.099
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.097
FBLN2 fibulin 2 0.096
COL7A1 collagen, type VII, alpha 1 0.096
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.663
Pnpla2 patatin-like phospholipase domain containing 2 0.603
Col2a1 collagen, type II, alpha 1 0.461
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.421
Id1 inhibitor of DNA binding 1 0.384
Fgf18 fibroblast growth factor 18 0.361
Pten phosphatase and tensin homolog 0.357
Lep leptin 0.344
Pdx1 pancreatic and duodenal homeobox 1 0.338
Id3 inhibitor of DNA binding 3 0.334
Kl klotho 0.308
Nos3 nitric oxide synthase 3, endothelial cell 0.273
Pparg peroxisome proliferator activated receptor gamma 0.241
Csf1 colony stimulating factor 1 (macrophage) 0.240
Neurog2 neurogenin 2 0.215
Nkx3-2 NK3 homeobox 2 0.204
Msx1 homeobox, msh-like 1 0.194
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.188
Bmp4 bone morphogenetic protein 4 0.177
Otx2 orthodenticle homolog 2 (Drosophila) 0.169
Hif1a hypoxia inducible factor 1, alpha subunit 0.164
Npr2 natriuretic peptide receptor 2 0.161
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.160
Col1a1 collagen, type I, alpha 1 0.147
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.138
Adrb1 adrenergic receptor, beta 1 0.137
Acvrl1 activin A receptor, type II-like 1 0.134
Gli2 GLI-Kruppel family member GLI2 0.133
Neurog3 neurogenin 3 0.130
Gata1 GATA binding protein 1 0.124
Gli3 GLI-Kruppel family member GLI3 0.114
Smo smoothened homolog (Drosophila) 0.108
Il6st interleukin 6 signal transducer 0.100
Ptger1 prostaglandin E receptor 1 (subtype EP1) 0.097
Apoe apolipoprotein E 0.097
Gata6 GATA binding protein 6 0.097
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.091
Shh sonic hedgehog 0.089
Hic1 hypermethylated in cancer 1 0.086
Irx2 Iroquois related homeobox 2 (Drosophila) 0.086
Hand2 heart and neural crest derivatives expressed transcript 2 0.083
Pthlh parathyroid hormone-like peptide 0.081
Irx1 Iroquois related homeobox 1 (Drosophila) 0.080
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.080
Ddah2 dimethylarginine dimethylaminohydrolase 2 0.078
Zeb1 zinc finger E-box binding homeobox 1 0.078
Ctsd cathepsin D 0.078
Ptgs2 prostaglandin-endoperoxide synthase 2 0.074
Foxd2 forkhead box D2 0.074
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.071
Fgf15 fibroblast growth factor 15 0.071
Fgfr3 fibroblast growth factor receptor 3 0.070
Foxc1 forkhead box C1 0.070
Bdkrb2 bradykinin receptor, beta 2 0.070
Hoxd13 homeobox D13 0.069
Fgf4 fibroblast growth factor 4 0.069
Il6 interleukin 6 0.069
Tlr4 toll-like receptor 4 0.069
Plau plasminogen activator, urokinase 0.067
Stat3 signal transducer and activator of transcription 3 0.066
Sox9 SRY-box containing gene 9 0.066
Gata4 GATA binding protein 4 0.065
Olfr70 olfactory receptor 70 0.063
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.062
Mmp9 matrix metallopeptidase 9 0.061
Onecut1 one cut domain, family member 1 0.061
Icam1 intercellular adhesion molecule 1 0.060
Prrx1 paired related homeobox 1 0.059
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.058
Cldn2 claudin 2 0.058
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.058
Fgf8 fibroblast growth factor 8 0.058
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.057
Gpr50 G-protein-coupled receptor 50 0.057
Adrb3 adrenergic receptor, beta 3 0.056
Cav1 caveolin 1, caveolae protein 0.055
Foxf1a forkhead box F1a 0.054
Hmx1 H6 homeobox 1 0.054
Itgb3 integrin beta 3 0.053
Mrc2 mannose receptor, C type 2 0.053
Adra2b adrenergic receptor, alpha 2b 0.053
Pax6 paired box gene 6 0.052
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.052
Lyz2 lysozyme 2 0.051
Bgn biglycan 0.050
Pax3 paired box gene 3 0.049
Nos1 nitric oxide synthase 1, neuronal 0.049
Fgf9 fibroblast growth factor 9 0.048
Gja1 gap junction protein, alpha 1 0.048
Kcnk3 potassium channel, subfamily K, member 3 0.047
Gdf3 growth differentiation factor 3 0.047
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.046
En1 engrailed 1 0.046
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.045
Elane elastase, neutrophil expressed 0.045
Pkd1 polycystic kidney disease 1 homolog 0.045
Tcf3 transcription factor 3 0.044
Plg plasminogen 0.043
Il1r1 interleukin 1 receptor, type I 0.043
Bmp7 bone morphogenetic protein 7 0.042
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col12a1 collagen, type XII, alpha 1 0.040
Aebp1 AE binding protein 1 0.031
Bgn biglycan 0.023
Mmp3 matrix metallopeptidase 3 0.021
Eln elastin 0.020
Col1a2 collagen, type I, alpha 2 0.019
Loxl1 lysyl oxidase-like 1 0.019
Col5a1 collagen, type V, alpha 1 0.019
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.017
Plau plasminogen activator, urokinase 0.017
Cd4 Cd4 molecule 0.017
Col1a1 collagen, type I, alpha 1 0.016
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.015
Fgfr1 Fibroblast growth factor receptor 1 0.014
Calcb calcitonin-related polypeptide, beta 0.014
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.013
Lamc1 laminin, gamma 1 0.013
Stat6 signal transducer and activator of transcription 6 0.012
Ecm1 extracellular matrix protein 1 0.012
Olfml2b olfactomedin-like 2B 0.012
Il7r interleukin 7 receptor 0.012
Col3a1 collagen, type III, alpha 1 0.011
Fstl1 follistatin-like 1 0.011
Anxa4 annexin A4 0.011
Hr hairless 0.011
Gzmb granzyme B 0.011
Edn1 endothelin 1 0.011
Fn1 fibronectin 1 0.011
Cela1 chymotrypsin-like elastase family, member 1 0.010
Rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.010
Tacr1 tachykinin receptor 1 0.010
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.010
Col4a1 collagen, type IV, alpha 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism