The network for 'positive regulation of extrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of extrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.

Danio rerio
Name Description Probability Func Analog Organism
acvr2a activin receptor IIa 0.578
nrp1a neuropilin 1a 0.547
frem3 Fras1 related extracellular matrix 3 0.262
il7r interleukin 7 receptor 0.211
six1b sine oculis homeobox homolog 1b 0.185
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.184
ildr1b immunoglobulin-like domain containing receptor 1b 0.179
hsp90b1 heat shock protein 90, beta (grp94), member 1 0.165
zgc:92360 zgc:92360 0.163
nf1b neurofibromin 1b 0.155
notch2 notch homolog 2 0.147
uba1 ubiquitin-like modifier activating enzyme 1 0.144
sox7 SRY-box containing gene 7 0.135
caspa caspase a 0.127
zgc:66382 zgc:66382 0.124
hsp47 heat shock protein 47 0.117
plxnb2a plexin b2a 0.116
wu:fb80a07 wu:fb80a07 0.115
tp63 tumor protein p63 0.113
tagln2 transgelin 2 0.111
sulf2l sulfatase 2, like 0.108
inha inhibin, alpha 0.108
igf3 insulin-like growth factor 3 0.107
igf1 insulin-like growth factor 1 0.106
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.101
ptgs1 prostaglandin-endoperoxide synthase 1 0.096
stat3 signal transduction and activation of transcription 3 0.096
calrl calreticulin like 0.093
tcf21 transcription factor 21 0.092
psen1 presenilin 1 0.090
inhbaa inhibin, beta Aa 0.089
il6st interleukin 6 signal transducer 0.086
mpx myeloid-specific peroxidase 0.084
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.081
mxa myxovirus (influenza) resistance A 0.080
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.079
cnn2 calponin 2 0.078
tardbp TAR DNA binding protein 0.078
hug HuG 0.078
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.077
ubin ataxin-1 ubiquitin-like interacting protein 0.076
sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.075
nf1a neurofibromin 1a 0.074
zgc:55886 zgc:55886 0.073
acvr2b activin receptor IIb 0.072
star steroidogenic acute regulatory protein 0.070
igfbp1b insulin-like growth factor binding protein 1b 0.067
cldni claudin i 0.067
yrk Yes-related kinase 0.066
zgc:101724 zgc:101724 0.065
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.065
rag1 recombination activating gene 1 0.064
cpsf6 cleavage and polyadenylation specific factor 6 0.064
ryk receptor-like tyrosine kinase 0.064
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.063
mmp13a matrix metalloproteinase 13a 0.062
naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.062
sdcbp syndecan binding protein (syntenin) 0.062
bbc3 BCL2 binding component 3 0.061
fstl1b follistatin-like 1b 0.061
rpn2 ribophorin II 0.061
cnih cornichon homolog (Drosophila) 0.060
plg plasminogen 0.060
capns1a calpain, small subunit 1 a 0.060
ewsr1a Ewing sarcoma breakpoint region 1a 0.060
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.058
timp2b tissue inhibitor of metalloproteinase 2b 0.058
lpp LIM domain containing preferred translocation partner in lipoma 0.058
gdf9 growth differentiation factor 9 0.057
calm3b calmodulin 3b (phosphorylase kinase, delta) 0.056
rhoab ras homolog gene family, member Ab 0.056
plxnd1 plexin D1 0.054
trpc6 transient receptor potential cation channel, subfamily C, member 6 0.054
baxa bcl2-associated X protein, a 0.054
ck2b casein kinase 2 beta 0.054
arf2 ADP-ribosylation factor 2 0.053
ext1b exostoses (multiple) 1b 0.053
ptena phosphatase and tensin homolog A 0.053
fadd Fas (tnfrsf6)-associated via death domain 0.052
tgfbi transforming growth factor, beta-induced 0.051
nkx2.3 NK2 transcription factor related 3 0.051
cflar CASP8 and FADD-like apoptosis regulator 0.051
rarga retinoic acid receptor gamma a 0.051
cald1 caldesmon 1 0.051
adipor2 adiponectin receptor 2 0.051
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.051
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.050
ednra endothelin receptor type A 0.050
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.049
caprin1a cell cycle associated protein 1a 0.049
tgfb3 transforming growth factor, beta 3 0.048
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.048
il1b interleukin 1, beta and interleukin 1, beta 0.047
dlx4a distal-less homeobox gene 4a 0.047
scinlb scinderin like b 0.047
fbxl14b F-box and leucine-rich repeat protein 14b 0.047
bcl2l1 bcl2-like 1 0.045
agr2 anterior gradient homolog 2 (Xenopus laevis) 0.045
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.045
vegfab vascular endothelial growth factor Ab 0.045
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.000
TRAF1 TNF receptor-associated factor 1 1.000
TRAF2 TNF receptor-associated factor 2 1.000
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.000
BIRC3 baculoviral IAP repeat containing 3 0.999
CFLAR CASP8 and FADD-like apoptosis regulator 0.993
FADD Fas (TNFRSF6)-associated via death domain 0.992
FAS Fas (TNF receptor superfamily, member 6) 0.981
TRAF3 TNF receptor-associated factor 3 0.938
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.926
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.924
BIRC2 baculoviral IAP repeat containing 2 0.924
TRADD TNFRSF1A-associated via death domain 0.921
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.912
SMAD3 SMAD family member 3 0.894
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.889
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.887
RIPK2 receptor-interacting serine-threonine kinase 2 0.882
TRAF5 TNF receptor-associated factor 5 0.835
CAV1 caveolin 1, caveolae protein, 22kDa 0.826
BCL2L1 BCL2-like 1 0.804
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.792
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.756
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.708
SQSTM1 sequestosome 1 0.701
XIAP X-linked inhibitor of apoptosis 0.651
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.580
BAX BCL2-associated X protein 0.570
TANK TRAF family member-associated NFKB activator 0.543
BCL2 B-cell CLL/lymphoma 2 0.533
BID BH3 interacting domain death agonist 0.518
MAPK1 mitogen-activated protein kinase 1 0.511
STK4 serine/threonine kinase 4 0.489
PSEN1 presenilin 1 0.481
BAK1 BCL2-antagonist/killer 1 0.443
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.425
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.415
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.410
APP amyloid beta (A4) precursor protein 0.405
RNF31 ring finger protein 31 0.359
CD40 CD40 molecule, TNF receptor superfamily member 5 0.351
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.338
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.292
TNF tumor necrosis factor 0.270
STK3 serine/threonine kinase 3 0.268
ZMYND11 zinc finger, MYND-type containing 11 0.251
RLN3 relaxin 3 0.239
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.212
NLRC4 NLR family, CARD domain containing 4 0.192
TIMP3 TIMP metallopeptidase inhibitor 3 0.180
BAD BCL2-associated agonist of cell death 0.164
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.160
CARD11 caspase recruitment domain family, member 11 0.148
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.140
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.139
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.126
RNF144B ring finger protein 144B 0.123
DUSP3 dual specificity phosphatase 3 0.114
FASLG Fas ligand (TNF superfamily, member 6) 0.112
TUBA1A tubulin, alpha 1a 0.111
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.107
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.097
BIK BCL2-interacting killer (apoptosis-inducing) 0.094
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.093
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.090
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.089
LRRK2 leucine-rich repeat kinase 2 0.088
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.088
PDPK1 3-phosphoinositide dependent protein kinase-1 0.088
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.087
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.086
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.085
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.085
C9orf89 chromosome 9 open reading frame 89 0.084
TP53BP2 tumor protein p53 binding protein, 2 0.075
CD14 CD14 molecule 0.074
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.071
MEFV Mediterranean fever 0.070
ERO1L ERO1-like (S. cerevisiae) 0.070
PTPRJ protein tyrosine phosphatase, receptor type, J 0.068
CD22 CD22 molecule 0.067
SPHK1 sphingosine kinase 1 0.066
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.062
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.062
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.060
FLNB filamin B, beta 0.058
TRAF6 TNF receptor-associated factor 6 0.058
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.057
BBC3 BCL2 binding component 3 0.057
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.056
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.055
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.055
EGFR epidermal growth factor receptor 0.055
TGIF1 TGFB-induced factor homeobox 1 0.053
BECN1 beclin 1, autophagy related 0.052
FHL2 four and a half LIM domains 2 0.051
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.051
DIABLO diablo, IAP-binding mitochondrial protein 0.050
CTTNBP2NL CTTNBP2 N-terminal like 0.050
NUMBL numb homolog (Drosophila)-like 0.048
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Pten phosphatase and tensin homolog 0.998
Tgfb1 transforming growth factor, beta 1 0.994
Tgfbr2 transforming growth factor, beta receptor II 0.931
Casp8 caspase 8 0.920
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.895
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.883
Lepr leptin receptor 0.842
Bax BCL2-associated X protein 0.804
Psen1 presenilin 1 0.802
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.782
Ctnnb1 catenin (cadherin associated protein), beta 1 0.764
Fgfr2 fibroblast growth factor receptor 2 0.753
Col1a1 collagen, type I, alpha 1 0.741
Hsp90b1 heat shock protein 90, beta (Grp94), member 1 0.731
Cd19 CD19 antigen 0.718
Hif1a hypoxia inducible factor 1, alpha subunit 0.717
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.704
Bcl2 B-cell leukemia/lymphoma 2 0.692
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.665
Notch1 Notch gene homolog 1 (Drosophila) 0.657
Fyn Fyn proto-oncogene 0.650
Foxc1 forkhead box C1 0.637
Apc adenomatosis polyposis coli 0.614
Fas Fas (TNF receptor superfamily member 6) 0.611
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.588
Cd44 CD44 antigen 0.560
Esr1 estrogen receptor 1 (alpha) 0.559
Il6st interleukin 6 signal transducer 0.544
Lyz2 lysozyme 2 0.539
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.507
Tnf tumor necrosis factor 0.506
Kit kit oncogene 0.466
Gbp5 guanylate binding protein 5 0.459
Stat3 signal transducer and activator of transcription 3 0.440
Csf1 colony stimulating factor 1 (macrophage) 0.416
Ikzf1 IKAROS family zinc finger 1 0.414
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.413
Rb1 retinoblastoma 1 0.408
Vegfa vascular endothelial growth factor A 0.400
Mdm2 transformed mouse 3T3 cell double minute 2 0.383
Tlr4 toll-like receptor 4 0.380
Tgfbr1 transforming growth factor, beta receptor I 0.341
Fadd Fas (TNFRSF6)-associated via death domain 0.320
Fst follistatin 0.319
Rxra retinoid X receptor alpha 0.312
Nos3 nitric oxide synthase 3, endothelial cell 0.306
Ren1 renin 1 structural 0.300
Apaf1 apoptotic peptidase activating factor 1 0.298
Rara retinoic acid receptor, alpha 0.297
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.289
Agtr1a angiotensin II receptor, type 1a 0.278
Notch2 Notch gene homolog 2 (Drosophila) 0.278
Ptgs2 prostaglandin-endoperoxide synthase 2 0.273
Cdk4 cyclin-dependent kinase 4 0.271
Vav2 vav 2 oncogene 0.270
Il2rg interleukin 2 receptor, gamma chain 0.268
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.261
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.256
Bmpr1a bone morphogenetic protein receptor, type 1A 0.251
Smad3 MAD homolog 3 (Drosophila) 0.238
Mcl1 myeloid cell leukemia sequence 1 0.221
Inpp5d inositol polyphosphate-5-phosphatase D 0.215
Casp1 caspase 1 0.213
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.211
Il1r1 interleukin 1 receptor, type I 0.211
Ahr aryl-hydrocarbon receptor 0.198
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.194
Igh immunoglobulin heavy chain complex 0.193
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.191
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.190
Nf1 neurofibromatosis 1 0.189
Braf Braf transforming gene 0.188
Vdr vitamin D receptor 0.186
Fshr follicle stimulating hormone receptor 0.182
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.182
Fbn1 fibrillin 1 0.177
Stk3 serine/threonine kinase 3 (Ste20, yeast homolog) 0.163
Shc1 src homology 2 domain-containing transforming protein C1 0.155
Adam17 a disintegrin and metallopeptidase domain 17 0.155
Nos2 nitric oxide synthase 2, inducible 0.151
Vhl von Hippel-Lindau tumor suppressor 0.151
Casp3 caspase 3 0.145
Dok1 docking protein 1 0.140
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.139
Rnf31 ring finger protein 31 0.135
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.134
Myd88 myeloid differentiation primary response gene 88 0.133
Itgav integrin alpha V 0.132
Hspa5 heat shock protein 5 0.131
Mstn myostatin 0.129
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.128
Rbl1 retinoblastoma-like 1 (p107) 0.127
Klf6 Kruppel-like factor 6 0.122
Myc myelocytomatosis oncogene 0.120
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.118
Hr hairless 0.117
Birc3 baculoviral IAP repeat-containing 3 0.112
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.107
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.106
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pdia6 protein disulfide isomerase family A, member 6 0.016
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.010
Ccdc124 coiled-coil domain containing 124 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism