IMP

Process View

Homo sapiens

14 genes annotated in human

columnar cuboidal epithelial cell differentiation

GO:0002065

The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "columnar cuboidal epithelial cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "columnar cuboidal epithelial cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
TAL1	T-cell acute lymphocytic leukemia 1	0.991
HNF4A	hepatocyte nuclear factor 4, alpha	0.755
HDAC2	histone deacetylase 2	0.753
EP300	E1A binding protein p300	0.672
RUNX1	runt-related transcription factor 1	0.588
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.574
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.517
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.461	Fly
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.460	Fly
TSC2	tuberous sclerosis 2	0.398
PAX3	paired box 3	0.390
PSEN1	presenilin 1	0.342	Zebrafish
TP53	tumor protein p53	0.272
PDX1	pancreatic and duodenal homeobox 1	0.247
FGF1	fibroblast growth factor 1 (acidic)	0.212
BMPR1A	bone morphogenetic protein receptor, type IA	0.189	Fly
POU3F2	POU class 3 homeobox 2	0.176
POU5F1	POU class 5 homeobox 1	0.165
MED25	mediator complex subunit 25	0.155
SFN	stratifin	0.150
RAB27A	RAB27A, member RAS oncogene family	0.144	Mouse
CREBBP	CREB binding protein	0.131
ESR1	estrogen receptor 1	0.123
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.120	Fly
MLPH	melanophilin	0.117	Mouse
NCOA1	nuclear receptor coactivator 1	0.115
TCF4	transcription factor 4	0.107	Fly
JAG1	jagged 1	0.103
TNRC6B	trinucleotide repeat containing 6B	0.097
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.082
CLOCK	clock homolog (mouse)	0.081	Mouse
STK3	serine/threonine kinase 3	0.081
FGFR1	fibroblast growth factor receptor 1	0.077	Fly
RARA	retinoic acid receptor, alpha	0.077	Mouse
BCL2L1	BCL2-like 1	0.073
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.072
FLNB	filamin B, beta	0.068	Fly
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.067
HNF1A	HNF1 homeobox A	0.063
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.063	Mouse
NCOA3	nuclear receptor coactivator 3	0.062
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.060
HIPK2	homeodomain interacting protein kinase 2	0.060	Zebrafish
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.059
BMPR1B	bone morphogenetic protein receptor, type IB	0.058	Fly
NKX3-1	NK3 homeobox 1	0.056
FGF10	fibroblast growth factor 10	0.054
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.054
NOTCH3	notch 3	0.052	Fly
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.051
CTNND1	catenin (cadherin-associated protein), delta 1	0.051
APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.049
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.048	Zebrafish
AR	androgen receptor	0.048
ARRB1	arrestin, beta 1	0.043
CCND1	cyclin D1	0.039
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.038
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.038
GRB7	growth factor receptor-bound protein 7	0.037
EPAS1	endothelial PAS domain protein 1	0.037
NCSTN	nicastrin	0.036
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.034
KAT2B	K(lysine) acetyltransferase 2B	0.033
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.032	Human
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.032
SOX2	SRY (sex determining region Y)-box 2	0.031
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.031
ONECUT1	one cut homeobox 1	0.030
FOXA2	forkhead box A2	0.028	Fly
CDX2	caudal type homeobox 2	0.028
ZFYVE9	zinc finger, FYVE domain containing 9	0.027
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.027
MTA3	metastasis associated 1 family, member 3	0.025
GATA2	GATA binding protein 2	0.025	Human
AHR	aryl hydrocarbon receptor	0.024
ZFPM1	zinc finger protein, multitype 1	0.024
HIC1	hypermethylated in cancer 1	0.023
RAX	retina and anterior neural fold homeobox	0.023
NOG	noggin	0.023
FGF8	fibroblast growth factor 8 (androgen-induced)	0.022
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.022
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.021
PML	promyelocytic leukemia	0.021
HOXD12	homeobox D12	0.021	Fly
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.020
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.020
MEOX2	mesenchyme homeobox 2	0.020
SATB2	SATB homeobox 2	0.019
SIRT1	sirtuin 1	0.019
PROX1	prospero homeobox 1	0.018	Mouse
MYOD1	myogenic differentiation 1	0.018
STRADA	STE20-related kinase adaptor alpha	0.018
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.018
EGLN1	egl nine homolog 1 (C. elegans)	0.018
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.018
TBX5	T-box 5	0.018
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.018
BMP4	bone morphogenetic protein 4	0.017
SFRP5	secreted frizzled-related protein 5	0.017
TNRC6A	trinucleotide repeat containing 6A	0.016
PYY	peptide YY	0.016
FGF18	fibroblast growth factor 18	0.016	Human
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.016
OTP	orthopedia homeobox	0.016
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.016	Fly
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.016
NEUROD1	neurogenic differentiation 1	0.015	Mouse
GSK3B	glycogen synthase kinase 3 beta	0.015	Fly
TRIM33	tripartite motif containing 33	0.015
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.015	Fly
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.015
TGIF1	TGFB-induced factor homeobox 1	0.014
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.014
SOX1	SRY (sex determining region Y)-box 1	0.014
MNX1	motor neuron and pancreas homeobox 1	0.014	Zebrafish Fly
FERMT2	fermitin family member 2	0.014
QKI	quaking homolog, KH domain RNA binding (mouse)	0.014
TCF12	transcription factor 12	0.014	Fly
CABLES1	Cdk5 and Abl enzyme substrate 1	0.014
COL2A1	collagen, type II, alpha 1	0.014
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.014
MTA2	metastasis associated 1 family, member 2	0.013
HNF1B	HNF1 homeobox B	0.013	Zebrafish
GATA4	GATA binding protein 4	0.013
FGF3	fibroblast growth factor 3	0.013
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.013
CIB1	calcium and integrin binding 1 (calmyrin)	0.013
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.013	Human
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.013
SOX21	SRY (sex determining region Y)-box 21	0.013
BHLHE23	basic helix-loop-helix family, member e23	0.012
WNT1	wingless-type MMTV integration site family, member 1	0.012	Human Fly
FHL2	four and a half LIM domains 2	0.012
NKX2-2	NK2 homeobox 2	0.012	Mouse
ALX4	ALX homeobox 4	0.012
FOXA1	forkhead box A1	0.012	Mouse Fly
FGF7	fibroblast growth factor 7	0.012
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.011
MYO5A	myosin VA (heavy chain 12, myoxin)	0.011	Mouse
STK4	serine/threonine kinase 4	0.011
MEF2A	myocyte enhancer factor 2A	0.011
MYT1	myelin transcription factor 1	0.011
LBX1	ladybird homeobox 1	0.011
LEF1	lymphoid enhancer-binding factor 1	0.010
HES2	hairy and enhancer of split 2 (Drosophila)	0.010
SOX9	SRY (sex determining region Y)-box 9	0.010
FGF4	fibroblast growth factor 4	0.010
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.010
SMAD4	SMAD family member 4	0.010	Fly
FEV	FEV (ETS oncogene family)	0.010
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.010
SFRP1	secreted frizzled-related protein 1	0.010
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.010
HOXA10	homeobox A10	0.010
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.010
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.010	Fly
EFNB3	ephrin-B3	0.010