IMP
Process View
nik nf kappab signaling
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "nik nf kappab signaling"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1.000 | Mouse | |
| MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | 0.995 | ||
| TRAF3 | TNF receptor-associated factor 3 | 0.992 | Human | |
| TRAF6 | TNF receptor-associated factor 6 | 0.988 | ||
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.972 | Human | |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.962 | Mouse | |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.804 | Mouse | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.673 | ||
| BIRC3 | baculoviral IAP repeat containing 3 | 0.532 | ||
| BCL10 | B-cell CLL/lymphoma 10 | 0.385 | ||
| MYD88 | myeloid differentiation primary response gene (88) | 0.275 | ||
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.245 | ||
| CHUK | conserved helix-loop-helix ubiquitous kinase | 0.240 | Human | |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.222 | ||
| TBK1 | TANK-binding kinase 1 | 0.211 | Human | |
| ZMYND11 | zinc finger, MYND-type containing 11 | 0.210 | ||
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.196 | ||
| TNFRSF14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.191 | ||
| IL1R1 | interleukin 1 receptor, type I | 0.188 | ||
| TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | 0.181 | ||
| PELI3 | pellino homolog 3 (Drosophila) | 0.169 | ||
| ANGPT2 | angiopoietin 2 | 0.146 | ||
| GFER | growth factor, augmenter of liver regeneration | 0.142 | ||
| COPS4 | COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) | 0.139 | ||
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.135 | ||
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.131 | ||
| SQSTM1 | sequestosome 1 | 0.125 | ||
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.108 | ||
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.099 | ||
| COPS2 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | 0.085 | ||
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.080 | ||
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.077 | Human | |
| NUMBL | numb homolog (Drosophila)-like | 0.064 | ||
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.048 | ||
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.042 | ||
| TRAF5 | TNF receptor-associated factor 5 | 0.039 | Human | |
| ANGPT1 | angiopoietin 1 | 0.038 | ||
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 0.031 | ||
| TNFRSF1B | tumor necrosis factor receptor superfamily, member 1B | 0.030 | ||
| COPS3 | COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) | 0.029 | ||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.027 | ||
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.025 | ||
| ADAM15 | ADAM metallopeptidase domain 15 | 0.023 | ||
| C1orf93 | chromosome 1 open reading frame 93 | 0.022 | ||
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.022 | ||
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.020 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.018 | ||
| MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | 0.018 | ||
| TANK | TRAF family member-associated NFKB activator | 0.017 | ||
| COPS5 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) | 0.017 | ||
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.016 | ||
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.016 | ||
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.015 | ||
| CARD11 | caspase recruitment domain family, member 11 | 0.014 | Human | |
| TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | 0.013 | ||
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.013 | ||
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.012 | ||
| TUBA3C | tubulin, alpha 3c | 0.012 | ||
| ZBTB8A | zinc finger and BTB domain containing 8A | 0.011 | ||
| PRKRA | protein kinase, interferon-inducible double stranded RNA dependent activator | 0.011 | ||
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.011 | ||
| CD14 | CD14 molecule | 0.011 | ||
| BCL3 | B-cell CLL/lymphoma 3 | 0.011 | ||
| BBS10 | Bardet-Biedl syndrome 10 | 0.011 | ||
| CLTC | clathrin, heavy chain (Hc) | 0.011 | ||
| ZNF512B | zinc finger protein 512B | 0.010 |