IMP

Process View

Homo sapiens

3 genes annotated in human

negative regulation of transcription initiation from rna polymerase ii promoter

Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of transcription initiation from rna polymerase ii promoter"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of transcription initiation from rna polymerase ii promoter" (in gray)

Name	Description	Probability	Func Analog Organism
RXRA	retinoid X receptor, alpha	1.000
NCOA1	nuclear receptor coactivator 1	1.000
MED25	mediator complex subunit 25	1.000
CREBBP	CREB binding protein	1.000
HMGB2	high mobility group box 2	1.000	Human
HMGB1	high mobility group box 1	1.000
NCOR2	nuclear receptor corepressor 2	1.000
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.999
MED1	mediator complex subunit 1	0.998
NCOR1	nuclear receptor corepressor 1	0.998
SKIL	SKI-like oncogene	0.993
PTMA	prothymosin, alpha	0.989
ESR1	estrogen receptor 1	0.989
HMGN2	high mobility group nucleosomal binding domain 2	0.988
RARA	retinoic acid receptor, alpha	0.986	Human
CSNK1A1	casein kinase 1, alpha 1	0.986
RXRB	retinoid X receptor, beta	0.983
NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.983
HMGN1	high mobility group nucleosome binding domain 1	0.977
NCOA3	nuclear receptor coactivator 3	0.977
HMGA1	high mobility group AT-hook 1	0.973
SMAD9	SMAD family member 9	0.965
PPARA	peroxisome proliferator-activated receptor alpha	0.965
SP1	Sp1 transcription factor	0.963
SMAD3	SMAD family member 3	0.891
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.852
ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B	0.837
EP300	E1A binding protein p300	0.835
DUT	deoxyuridine triphosphatase	0.788
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.786
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.779
NCOA6	nuclear receptor coactivator 6	0.778
PRKD2	protein kinase D2	0.740
H2AFV	H2A histone family, member V	0.713
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.710
SET	SET nuclear oncogene	0.705
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.696
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.674
CXXC5	CXXC finger protein 5	0.645
KANK2	KN motif and ankyrin repeat domains 2	0.586
DCK	deoxycytidine kinase	0.540
PRMT6	protein arginine methyltransferase 6	0.516
LBR	lamin B receptor	0.431
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.393
ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.391
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.375
RXRG	retinoid X receptor, gamma	0.373
SORBS3	sorbin and SH3 domain containing 3	0.317
AR	androgen receptor	0.307
CBX5	chromobox homolog 5	0.295
ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.280
SMAD4	SMAD family member 4	0.262
SPOP	speckle-type POZ protein	0.213
KLHL24	kelch-like 24 (Drosophila)	0.190
BBX	bobby sox homolog (Drosophila)	0.187
LMNB1	lamin B1	0.185
PRC1	protein regulator of cytokinesis 1	0.172
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.167	Human
STMN1	stathmin 1	0.166
PML	promyelocytic leukemia	0.157
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.155
RAD21	RAD21 homolog (S. pombe)	0.143
PGR	progesterone receptor	0.137
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.131
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.130
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.123
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	0.101
HDAC3	histone deacetylase 3	0.101
C5orf41	chromosome 5 open reading frame 41	0.097
KAT2B	K(lysine) acetyltransferase 2B	0.096
CCNB2	cyclin B2	0.095
PIAS4	protein inhibitor of activated STAT, 4	0.086
SPIN1	spindlin 1	0.080
HIST1H4C	histone cluster 1, H4c	0.077
KIAA0101	KIAA0101	0.071
ARNT	aryl hydrocarbon receptor nuclear translocator	0.066
ZFYVE9	zinc finger, FYVE domain containing 9	0.065
NUSAP1	nucleolar and spindle associated protein 1	0.063
SUMO4	SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)	0.063
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.061
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.061	Human
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.061
CSNK1D	casein kinase 1, delta	0.055
DEK	DEK oncogene	0.055
PPARG	peroxisome proliferator-activated receptor gamma	0.054
RBPMS	RNA binding protein with multiple splicing	0.051
RBMX	RNA binding motif protein, X-linked	0.051
HIPK1	homeodomain interacting protein kinase 1	0.047
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.047
SIRT1	sirtuin 1	0.044
NRIP1	nuclear receptor interacting protein 1	0.044
SLC25A36	solute carrier family 25, member 36	0.041
LOC728026	hypothetical protein LOC728026	0.039
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.038
CBX1	chromobox homolog 1	0.037
CDK2	cyclin-dependent kinase 2	0.037
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.037
CDK19	cyclin-dependent kinase 19	0.035
GPSM2	G-protein signaling modulator 2	0.035
NR2F6	nuclear receptor subfamily 2, group F, member 6	0.035
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.034
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.034
EVC2	Ellis van Creveld syndrome 2	0.034
HDAC7	histone deacetylase 7	0.033
TFPI2	tissue factor pathway inhibitor 2	0.033
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.032
ERH	enhancer of rudimentary homolog (Drosophila)	0.032
PLCD3	phospholipase C, delta 3	0.031
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.031
C16orf53	chromosome 16 open reading frame 53	0.029
MED29	mediator complex subunit 29	0.029
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.028
CAMSAP1	calmodulin regulated spectrin-associated protein 1	0.025
ACVR1B	activin A receptor, type IB	0.025
CRMP1	collapsin response mediator protein 1	0.025
HMGB3	high mobility group box 3	0.025	Human
ING3	inhibitor of growth family, member 3	0.024
BCL6	B-cell CLL/lymphoma 6	0.024
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.024
NR1D1	nuclear receptor subfamily 1, group D, member 1	0.023	Human
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.023
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.023
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.023
PPIA	peptidylprolyl isomerase A (cyclophilin A)	0.023
H2AFZ	H2A histone family, member Z	0.022
ADAP1	ArfGAP with dual PH domains 1	0.021
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.021
MIS18BP1	MIS18 binding protein 1	0.020
RCC1	regulator of chromosome condensation 1	0.020
ASB2	ankyrin repeat and SOCS box containing 2	0.020
TADA3	transcriptional adaptor 3	0.020
HEY2	hairy/enhancer-of-split related with YRPW motif 2	0.020
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.020
HIPK3	homeodomain interacting protein kinase 3	0.020
ZBTB38	zinc finger and BTB domain containing 38	0.020
FOXO3	forkhead box O3	0.019
RBBP7	retinoblastoma binding protein 7	0.019
PSIP1	PC4 and SFRS1 interacting protein 1	0.019
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.019
ERF	Ets2 repressor factor	0.019
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.019
EPAS1	endothelial PAS domain protein 1	0.018
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.018
HR	hairless homolog (mouse)	0.018
ZBTB16	zinc finger and BTB domain containing 16	0.018
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.018
PPL	periplakin	0.017
MAN1C1	mannosidase, alpha, class 1C, member 1	0.017
SNRPG	small nuclear ribonucleoprotein polypeptide G	0.017
CDK1	cyclin-dependent kinase 1	0.017
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.016
RUNX1	runt-related transcription factor 1	0.016
NPAS2	neuronal PAS domain protein 2	0.016
ZNF576	zinc finger protein 576	0.016
FOXJ1	forkhead box J1	0.016
PPARD	peroxisome proliferator-activated receptor delta	0.016
NCOA2	nuclear receptor coactivator 2	0.016
HDAC5	histone deacetylase 5	0.016
JMY	junction mediating and regulatory protein, p53 cofactor	0.015
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.015
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.015
ZNF148	zinc finger protein 148	0.015
ATXN1L	ataxin 1-like	0.015
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.014
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.014	Human
RTKN	rhotekin	0.014
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.014
NAP1L1	nucleosome assembly protein 1-like 1	0.013
TRMT5	TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)	0.013
MBD1	methyl-CpG binding domain protein 1	0.013
TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)	0.013
DST	dystonin	0.013
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.013
THSD7A	thrombospondin, type I, domain containing 7A	0.013
UNC45A	unc-45 homolog A (C. elegans)	0.013
HES1	hairy and enhancer of split 1, (Drosophila)	0.013
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.013
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.012
HDAC4	histone deacetylase 4	0.012
PHF1	PHD finger protein 1	0.012
RARG	retinoic acid receptor, gamma	0.012	Human
HTT	huntingtin	0.012
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.012
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.012
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.012
HIP1	huntingtin interacting protein 1	0.012
H3F3B	H3 histone, family 3B (H3.3B)	0.012
TFDP1	transcription factor Dp-1	0.012
TRIM62	tripartite motif containing 62	0.012
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.012
SOCS7	suppressor of cytokine signaling 7	0.012
TUBA1C	tubulin, alpha 1c	0.012
THAP5	THAP domain containing 5	0.011
FOXO1	forkhead box O1	0.011
CRABP2	cellular retinoic acid binding protein 2	0.011
DEDD	death effector domain containing	0.011
MED10	mediator complex subunit 10	0.011
TINAGL1	tubulointerstitial nephritis antigen-like 1	0.011
MTMR10	myotubularin related protein 10	0.011
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.011
CACNB1	calcium channel, voltage-dependent, beta 1 subunit	0.011
EYA2	eyes absent homolog 2 (Drosophila)	0.011
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.011
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.011
TUBA1B	tubulin, alpha 1b	0.011
SMAD7	SMAD family member 7	0.011
DLG5	discs, large homolog 5 (Drosophila)	0.011
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.011
KIF9	kinesin family member 9	0.010
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.010
KIF3A	kinesin family member 3A	0.010
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.010