IMP

Process View

Homo sapiens

13 genes annotated in human

response to glucocorticoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to glucocorticoid"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to glucocorticoid" (in gray)

Name	Description	Probability	Func Analog Organism
IL8	interleukin 8	0.759
ESR1	estrogen receptor 1	0.533
JUN	jun proto-oncogene	0.511
RNF144B	ring finger protein 144B	0.439
IL1R1	interleukin 1 receptor, type I	0.376
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.363
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.355	Rat
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	0.352	Rat
EGFR	epidermal growth factor receptor	0.297
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0.295	Rat
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.278	Rat
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.213	Rat
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	0.176	Rat
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.175
BCL2L1	BCL2-like 1	0.164
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.160	Mouse
APAF1	apoptotic peptidase activating factor 1	0.150
ANXA1	annexin A1	0.145
PLAU	plasminogen activator, urokinase	0.134
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.127
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.120
PLAUR	plasminogen activator, urokinase receptor	0.114
CXCL2	chemokine (C-X-C motif) ligand 2	0.097	Rat
JUNB	jun B proto-oncogene	0.086
NRP1	neuropilin 1	0.086
RB1	retinoblastoma 1	0.084
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.082
ATF3	activating transcription factor 3	0.079
IL6	interleukin 6 (interferon, beta 2)	0.076
S100A10	S100 calcium binding protein A10	0.076
MAPK8	mitogen-activated protein kinase 8	0.074
NOSTRIN	nitric oxide synthase trafficker	0.073
XIAP	X-linked inhibitor of apoptosis	0.073
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.072	Rat
THBS1	thrombospondin 1	0.069
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.068
VIM	vimentin	0.065
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.062
IER3	immediate early response 3	0.055
DUSP1	dual specificity phosphatase 1	0.054	Rat
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.054
CDK2	cyclin-dependent kinase 2	0.051
CRHR1	corticotropin releasing hormone receptor 1	0.050	Human
NRIP1	nuclear receptor interacting protein 1	0.049
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.048
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.043	Rat
NCOA1	nuclear receptor coactivator 1	0.041
ANXA5	annexin A5	0.040	Human
CRH	corticotropin releasing hormone	0.039	Rat
RPL18A	ribosomal protein L18a	0.037
IQGAP1	IQ motif containing GTPase activating protein 1	0.035
CCL20	chemokine (C-C motif) ligand 20	0.034
JAK2	Janus kinase 2	0.033	Mouse
IL22RA2	interleukin 22 receptor, alpha 2	0.031
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.031
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.029
RICTOR	RPTOR independent companion of MTOR, complex 2	0.028
CCR5	chemokine (C-C motif) receptor 5	0.027
CXCL3	chemokine (C-X-C motif) ligand 3	0.027	Rat
LAT	linker for activation of T cells	0.027
PTPRB	protein tyrosine phosphatase, receptor type, B	0.027
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.027
CREBBP	CREB binding protein	0.027
EMP1	epithelial membrane protein 1	0.027
CCL2	chemokine (C-C motif) ligand 2	0.026
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.026
APOA1	apolipoprotein A-I	0.026
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.025
SCP2	sterol carrier protein 2	0.025
IGF1R	insulin-like growth factor 1 receptor	0.024
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.024
ARRDC3	arrestin domain containing 3	0.024
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.023
STAT5A	signal transducer and activator of transcription 5A	0.023
MAPK3	mitogen-activated protein kinase 3	0.022
RARA	retinoic acid receptor, alpha	0.022
BCL2	B-cell CLL/lymphoma 2	0.022	Mouse Rat
PGF	placental growth factor	0.021
BID	BH3 interacting domain death agonist	0.021
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.021
FSTL1	follistatin-like 1	0.021
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.021
FOSL1	FOS-like antigen 1	0.020	Rat
C16orf53	chromosome 16 open reading frame 53	0.020
MAPT	microtubule-associated protein tau	0.020
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.020
C1QA	complement component 1, q subcomponent, A chain	0.019
SMAD3	SMAD family member 3	0.019
LY96	lymphocyte antigen 96	0.019
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.019
KLF4	Kruppel-like factor 4 (gut)	0.018
PLAT	plasminogen activator, tissue	0.018	Rat
PML	promyelocytic leukemia	0.018
IFNGR1	interferon gamma receptor 1	0.018
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.018
CCND3	cyclin D3	0.018
DUSP5	dual specificity phosphatase 5	0.017
KLF6	Kruppel-like factor 6	0.017
AHR	aryl hydrocarbon receptor	0.017	Rat
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.017
PPP5C	protein phosphatase 5, catalytic subunit	0.017
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.017
CFLAR	CASP8 and FADD-like apoptosis regulator	0.017
BAD	BCL2-associated agonist of cell death	0.016
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.016
SMN1	survival of motor neuron 1, telomeric	0.016
S100A11	S100 calcium binding protein A11	0.016
IRS1	insulin receptor substrate 1	0.016
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.016
IL22RA1	interleukin 22 receptor, alpha 1	0.016
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.016
EPOR	erythropoietin receptor	0.015
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.015
SOCS1	suppressor of cytokine signaling 1	0.014
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.014
ITGB5	integrin, beta 5	0.014
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.014
SOCS3	suppressor of cytokine signaling 3	0.014	Rat
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.013
FOSL2	FOS-like antigen 2	0.013
BCAR1	breast cancer anti-estrogen resistance 1	0.013
MAPK14	mitogen-activated protein kinase 14	0.013
SMAD9	SMAD family member 9	0.013
PRKCA	protein kinase C, alpha	0.013
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.013
NEB	nebulin	0.013
ATF2	activating transcription factor 2	0.012
TMSB10	thymosin beta 10	0.012
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.012
BCL3	B-cell CLL/lymphoma 3	0.012
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
BAG1	BCL2-associated athanogene	0.012
ENG	endoglin	0.012
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.012
TTN	titin	0.012
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.012	Zebrafish Mouse Rat
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.012
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.011
IER2	immediate early response 2	0.011
MED25	mediator complex subunit 25	0.011
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.011
BCL2A1	BCL2-related protein A1	0.011
S100A2	S100 calcium binding protein A2	0.011
CTTN	cortactin	0.011
HBEGF	heparin-binding EGF-like growth factor	0.011
MYD88	myeloid differentiation primary response gene (88)	0.011
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.011
COL1A2	collagen, type I, alpha 2	0.011
S100A4	S100 calcium binding protein A4	0.011
IL1RAP	interleukin 1 receptor accessory protein	0.010
BAK1	BCL2-antagonist/killer 1	0.010
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.010
EPAS1	endothelial PAS domain protein 1	0.010
DUSP6	dual specificity phosphatase 6	0.010