IMP

Process View

Homo sapiens

2 genes annotated in human

Multi-species View

regulation of isotype switching

GO:0045191

Any process that modulates the frequency, rate or extent of isotype switching.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of isotype switching"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of isotype switching" (in gray)

Name	Description	Probability	Func Analog Organism
IL4R	interleukin 4 receptor	0.882
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.394
ENG	endoglin	0.163
TRAF3	TNF receptor-associated factor 3	0.152
GRAP2	GRB2-related adaptor protein 2	0.129
TP53BP1	tumor protein p53 binding protein 1	0.092
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.089
THOC5	THO complex 5	0.088
THOC2	THO complex 2	0.069
FSTL1	follistatin-like 1	0.067
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.063
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.059
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.057
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.056
TMEM173	transmembrane protein 173	0.042
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.041
IL2RG	interleukin 2 receptor, gamma	0.041
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.036
NCOR2	nuclear receptor corepressor 2	0.034
TGFBR1	transforming growth factor, beta receptor 1	0.034
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.031	Mouse
PCDH9	protocadherin 9	0.031
TRAF1	TNF receptor-associated factor 1	0.031
MDC1	mediator of DNA-damage checkpoint 1	0.030
THOC4	THO complex 4	0.030
SMC1A	structural maintenance of chromosomes 1A	0.027
TRAF2	TNF receptor-associated factor 2	0.026
TGFB3	transforming growth factor, beta 3	0.026
TRAF5	TNF receptor-associated factor 5	0.025
AR	androgen receptor	0.024
THBS1	thrombospondin 1	0.024
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.022
CD22	CD22 molecule	0.022
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.022
CHTOP	chromatin target of PRMT1	0.021
BIRC3	baculoviral IAP repeat containing 3	0.021
SUPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	0.020
CD80	CD80 molecule	0.020
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.020
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.019
NCOA6	nuclear receptor coactivator 6	0.019
HDAC9	histone deacetylase 9	0.019
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.019
NCAPD3	non-SMC condensin II complex, subunit D3	0.019
RIPK2	receptor-interacting serine-threonine kinase 2	0.018
NRP1	neuropilin 1	0.017
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.016
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.014
CD2	CD2 molecule	0.014
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.013
IRS1	insulin receptor substrate 1	0.013
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.013
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.013
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.013
MYST2	MYST histone acetyltransferase 2	0.012
SYK	spleen tyrosine kinase	0.012
C16orf53	chromosome 16 open reading frame 53	0.012
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.012
HDAC5	histone deacetylase 5	0.012
IL4	interleukin 4	0.012	Mouse
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
NXF1	nuclear RNA export factor 1	0.011
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.011
PPAP2B	phosphatidic acid phosphatase type 2B	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.011
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.011
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.011
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.010
KAT5	K(lysine) acetyltransferase 5	0.010
TRADD	TNFRSF1A-associated via death domain	0.010
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.010