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Homo sapiens

33 genes annotated in human

skin disease

DOID:37

An integumentary system disease that is located in skin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "skin disease" (in gray)

Name	Description	Probability	Func Analog Organism
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.917
FLNB	filamin B, beta	0.625
B2M	beta-2-microglobulin	0.368
HLA-F	major histocompatibility complex, class I, F	0.324	Human
FLNA	filamin A, alpha	0.313
PSEN1	presenilin 1	0.308
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.300
PSEN2	presenilin 2 (Alzheimer disease 4)	0.278	Human
PKP4	plakophilin 4	0.159
NCSTN	nicastrin	0.150
TRAF6	TNF receptor-associated factor 6	0.108
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.079
LIPE	lipase, hormone-sensitive	0.061
HLA-B	major histocompatibility complex, class I, B	0.061
EHD2	EH-domain containing 2	0.060
LAMP1	lysosomal-associated membrane protein 1	0.056
IRS1	insulin receptor substrate 1	0.051
TRIM29	tripartite motif containing 29	0.047
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.044
TAGLN2	transgelin 2	0.035
FAF1	Fas (TNFRSF6) associated factor 1	0.035
KLK10	kallikrein-related peptidase 10	0.034
TGOLN2	trans-golgi network protein 2	0.031
IRAK2	interleukin-1 receptor-associated kinase 2	0.030
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.030
PIH1D1	PIH1 domain containing 1	0.030
HSPA13	heat shock protein 70kDa family, member 13	0.030
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.029
C1S	complement component 1, s subcomponent	0.029
KRT6B	keratin 6B	0.029	Human
UBC	ubiquitin C	0.028
TNIP1	TNFAIP3 interacting protein 1	0.027
PLEC	plectin	0.026
ITGB4	integrin, beta 4	0.025
USE1	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	0.025
CD151	CD151 molecule (Raph blood group)	0.024
TUBB6	tubulin, beta 6	0.024
BATF2	basic leucine zipper transcription factor, ATF-like 2	0.024
SPRR1A	small proline-rich protein 1A	0.024
IVL	involucrin	0.023
ESRRG	estrogen-related receptor gamma	0.023
NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.022
RB1CC1	RB1-inducible coiled-coil 1	0.022
HIST2H3C	histone cluster 2, H3c	0.022
TRAF2	TNF receptor-associated factor 2	0.022
EMD	emerin	0.022
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.021
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.021
DMAP1	DNA methyltransferase 1 associated protein 1	0.021
KRT4	keratin 4	0.021
KRT5	keratin 5	0.020	Human
KRT17	keratin 17	0.020	Human
TAPBP	TAP binding protein (tapasin)	0.019
MYL9	myosin, light chain 9, regulatory	0.019
CSE1L	CSE1 chromosome segregation 1-like (yeast)	0.019
GJB5	gap junction protein, beta 5, 31.1kDa	0.019	Human
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.019	Human
KRT13	keratin 13	0.019
MYO1C	myosin IC	0.019
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.019
ALB	albumin	0.018
PDLIM7	PDZ and LIM domain 7 (enigma)	0.018
FGFBP1	fibroblast growth factor binding protein 1	0.018
KRT16	keratin 16	0.018
AXL	AXL receptor tyrosine kinase	0.017
TP63	tumor protein p63	0.017
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.017
SSR1	signal sequence receptor, alpha	0.017
KRT9	keratin 9	0.017	Human
KRT6A	keratin 6A	0.016	Human
SPRR1B	small proline-rich protein 1B	0.016
PELI3	pellino homolog 3 (Drosophila)	0.016
DPCD	deleted in primary ciliary dyskinesia homolog (mouse)	0.016
PUS7	pseudouridylate synthase 7 homolog (S. cerevisiae)	0.016
LY6D	lymphocyte antigen 6 complex, locus D	0.016
GAB1	GRB2-associated binding protein 1	0.016
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.015
SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	0.015
KLF5	Kruppel-like factor 5 (intestinal)	0.015
LAD1	ladinin 1	0.015
SH3KBP1	SH3-domain kinase binding protein 1	0.015
SLURP1	secreted LY6/PLAUR domain containing 1	0.015
ALDH3A1	aldehyde dehydrogenase 3 family, member A1	0.015
OPA1	optic atrophy 1 (autosomal dominant)	0.015
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.014
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.014
KRT15	keratin 15	0.014	Human
CMIP	c-Maf-inducing protein	0.014
ZRANB1	zinc finger, RAN-binding domain containing 1	0.014
KRT14	keratin 14	0.014	Human
S100A14	S100 calcium binding protein A14	0.014
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.014
USP1	ubiquitin specific peptidase 1	0.014
IRAK1	interleukin-1 receptor-associated kinase 1	0.014
CEP170	centrosomal protein 170kDa	0.013
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.013
TSPAN4	tetraspanin 4	0.013
GOLGA2	golgin A2	0.013
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.013
UBQLN1	ubiquilin 1	0.013
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.013
HNF4A	hepatocyte nuclear factor 4, alpha	0.013
GJB3	gap junction protein, beta 3, 31kDa	0.013
TNS1	tensin 1	0.013
PI3	peptidase inhibitor 3, skin-derived	0.013
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.012
DSG3	desmoglein 3	0.012
HLA-G	major histocompatibility complex, class I, G	0.012	Human
IGFBP6	insulin-like growth factor binding protein 6	0.012
DSG1	desmoglein 1	0.012
XRN2	5'-3' exoribonuclease 2	0.012
ALOX12	arachidonate 12-lipoxygenase	0.012
USP25	ubiquitin specific peptidase 25	0.012
TFRC	transferrin receptor (p90, CD71)	0.012
TRIOBP	TRIO and F-actin binding protein	0.012
TMEM40	transmembrane protein 40	0.012
LY6G6C	lymphocyte antigen 6 complex, locus G6C	0.012
FBLIM1	filamin binding LIM protein 1	0.012
GAR1	GAR1 ribonucleoprotein homolog (yeast)	0.012
SLC10A3	solute carrier family 10 (sodium/bile acid cotransporter family), member 3	0.012
MUC4	mucin 4, cell surface associated	0.012
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.012
PRSS23	protease, serine, 23	0.012
MYH9	myosin, heavy chain 9, non-muscle	0.012
KLK11	kallikrein-related peptidase 11	0.012
SHARPIN	SHANK-associated RH domain interactor	0.012
CNN2	calponin 2	0.012
STK11	serine/threonine kinase 11	0.012
VGLL1	vestigial like 1 (Drosophila)	0.012
RNF31	ring finger protein 31	0.012
PAQR4	progestin and adipoQ receptor family member IV	0.012
SCEL	sciellin	0.012
SPRR3	small proline-rich protein 3	0.012
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.012
GABRP	gamma-aminobutyric acid (GABA) A receptor, pi	0.011
IL17RC	interleukin 17 receptor C	0.011
HLA-E	major histocompatibility complex, class I, E	0.011	Human
GAS2L1	growth arrest-specific 2 like 1	0.011
ALS2CL	ALS2 C-terminal like	0.011
CLN3	ceroid-lipofuscinosis, neuronal 3	0.011
SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	0.011
FTL	ferritin, light polypeptide	0.011
KRT19	keratin 19	0.011	Human
KRT1	keratin 1	0.011
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.011
RC3H2	ring finger and CCCH-type domains 2	0.011
UCHL5	ubiquitin carboxyl-terminal hydrolase L5	0.011
ATMIN	ATM interactor	0.011
ATRIP	ATR interacting protein	0.011
AZI2	5-azacytidine induced 2	0.011
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.011
S100A10	S100 calcium binding protein A10	0.011
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.011
C16orf59	chromosome 16 open reading frame 59	0.011
C9orf140	chromosome 9 open reading frame 140	0.011
CALML3	calmodulin-like 3	0.011
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.011
KTN1	kinectin 1 (kinesin receptor)	0.011
CANX	calnexin	0.011
LYPD3	LY6/PLAUR domain containing 3	0.010
KLK6	kallikrein-related peptidase 6	0.010
PKP3	plakophilin 3	0.010
NBL1	neuroblastoma, suppression of tumorigenicity 1	0.010
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.010
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.010
CD99	CD99 molecule	0.010
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.010
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.010
ODC1	ornithine decarboxylase 1	0.010
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.010
TBK1	TANK-binding kinase 1	0.010
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.010
RRAS	related RAS viral (r-ras) oncogene homolog	0.010
KRT75	keratin 75	0.010	Human
BSG	basigin (Ok blood group)	0.010
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.010
CDK5	cyclin-dependent kinase 5	0.010
PARP3	poly (ADP-ribose) polymerase family, member 3	0.010
C1orf116	chromosome 1 open reading frame 116	0.010
SRSF1	serine/arginine-rich splicing factor 1	0.010
PTRF	polymerase I and transcript release factor	0.009
LMNA	lamin A/C	0.007
KRT6C	keratin 6C	0.007
KRT10	keratin 10	0.006
PPP1R3A	protein phosphatase 1, regulatory (inhibitor) subunit 3A	0.006
PPARG	peroxisome proliferator-activated receptor gamma	0.005
TRAF3IP2	TRAF3 interacting protein 2	0.005
PLIN1	perilipin 1	0.005
IL23R	interleukin 23 receptor	0.005
DKC1	dyskeratosis congenita 1, dyskerin	0.005
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.004
HFE	hemochromatosis	0.004
BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	0.004
F12	coagulation factor XII (Hageman factor)	0.004
ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.003
CTSC	cathepsin C	0.003
GJB4	gap junction protein, beta 4, 30.3kDa	0.003
UROD	uroporphyrinogen decarboxylase	0.003
CARD14	caspase recruitment domain family, member 14	0.003
ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	0.003
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.002
RECQL4	RecQ protein-like 4	0.002
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.001
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.001
HLA-C	major histocompatibility complex, class I, C	0.000