IMP

Process View

Homo sapiens

2 genes annotated in human

interleukin 8 mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
CCL5	chemokine (C-C motif) ligand 5	1.000
CCR2	chemokine (C-C motif) receptor 2	1.000	Human
CCR5	chemokine (C-C motif) receptor 5	0.998	Human
IL2RB	interleukin 2 receptor, beta	0.992
CCL22	chemokine (C-C motif) ligand 22	0.967
CXCL9	chemokine (C-X-C motif) ligand 9	0.935
IRF4	interferon regulatory factor 4	0.926
IFNG	interferon, gamma	0.914
CCR4	chemokine (C-C motif) receptor 4	0.911	Human
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.862
CXCR3	chemokine (C-X-C motif) receptor 3	0.832	Human
CCR7	chemokine (C-C motif) receptor 7	0.831	Human
CD40LG	CD40 ligand	0.733
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.617
CCL4	chemokine (C-C motif) ligand 4	0.608
CXCR6	chemokine (C-X-C motif) receptor 6	0.554	Human
SLAMF7	SLAM family member 7	0.552
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.525
CCR1	chemokine (C-C motif) receptor 1	0.505	Human
IL10	interleukin 10	0.435
IL10RA	interleukin 10 receptor, alpha	0.397
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.342
CD86	CD86 molecule	0.310
CCL3	chemokine (C-C motif) ligand 3	0.293
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.278
CXCL13	chemokine (C-X-C motif) ligand 13	0.273
CXCL11	chemokine (C-X-C motif) ligand 11	0.218
CXCR5	chemokine (C-X-C motif) receptor 5	0.215	Human
CLEC7A	C-type lectin domain family 7, member A	0.187
CXCL10	chemokine (C-X-C motif) ligand 10	0.182
CCR6	chemokine (C-C motif) receptor 6	0.157	Human
IL1R2	interleukin 1 receptor, type II	0.150
LAG3	lymphocyte-activation gene 3	0.146
CCL7	chemokine (C-C motif) ligand 7	0.139
CCL19	chemokine (C-C motif) ligand 19	0.129
CCL11	chemokine (C-C motif) ligand 11	0.121
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.103
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.098
GZMK	granzyme K (granzyme 3; tryptase II)	0.098
CLEC4A	C-type lectin domain family 4, member A	0.095
IL21R	interleukin 21 receptor	0.093
CD2	CD2 molecule	0.087
IL2RG	interleukin 2 receptor, gamma	0.086
TNF	tumor necrosis factor	0.085
CD1C	CD1c molecule	0.085
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.085
CCL8	chemokine (C-C motif) ligand 8	0.084
PRAF2	PRA1 domain family, member 2	0.082
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.082
LGALS2	lectin, galactoside-binding, soluble, 2	0.078
FASLG	Fas ligand (TNF superfamily, member 6)	0.075
CD80	CD80 molecule	0.074
CYBB	cytochrome b-245, beta polypeptide	0.074
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.073
CCR3	chemokine (C-C motif) receptor 3	0.072	Human
CD22	CD22 molecule	0.066
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.065
IL2RA	interleukin 2 receptor, alpha	0.057
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.055
IL18RAP	interleukin 18 receptor accessory protein	0.054
TLR2	toll-like receptor 2	0.051
CXCR2	chemokine (C-X-C motif) receptor 2	0.051
DPP4	dipeptidyl-peptidase 4	0.050
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.048
CLEC4E	C-type lectin domain family 4, member E	0.047
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.046
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.044
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.043
FGL2	fibrinogen-like 2	0.041
CD28	CD28 molecule	0.040
IGSF6	immunoglobulin superfamily, member 6	0.040
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.039
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.039
EVI2B	ecotropic viral integration site 2B	0.037
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.037
CD48	CD48 molecule	0.036
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.035
CCR8	chemokine (C-C motif) receptor 8	0.034	Human
AQP9	aquaporin 9	0.034
IL4	interleukin 4	0.033
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.033
ADAMDEC1	ADAM-like, decysin 1	0.033
IL1RN	interleukin 1 receptor antagonist	0.032
ITK	IL2-inducible T-cell kinase	0.032
CD93	CD93 molecule	0.032
RGS1	regulator of G-protein signaling 1	0.032
CLEC5A	C-type lectin domain family 5, member A	0.031
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.031
SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	0.031
CD19	CD19 molecule	0.030
GPR18	G protein-coupled receptor 18	0.030
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.030
BIN2	bridging integrator 2	0.029
CCL20	chemokine (C-C motif) ligand 20	0.028
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.028
IL1B	interleukin 1, beta	0.027
SASH3	SAM and SH3 domain containing 3	0.027
LAX1	lymphocyte transmembrane adaptor 1	0.027
CCL13	chemokine (C-C motif) ligand 13	0.026
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.026
SIT1	signaling threshold regulating transmembrane adaptor 1	0.026
SELL	selectin L	0.026
TRAF1	TNF receptor-associated factor 1	0.026
CCR9	chemokine (C-C motif) receptor 9	0.026	Human
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.026
IL1A	interleukin 1, alpha	0.025
MSR1	macrophage scavenger receptor 1	0.025
IL6R	interleukin 6 receptor	0.025
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.025
LAMP3	lysosomal-associated membrane protein 3	0.025
GIMAP4	GTPase, IMAP family member 4	0.024
TBX21	T-box 21	0.023
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.023
UBASH3A	ubiquitin associated and SH3 domain containing A	0.022
AOAH	acyloxyacyl hydrolase (neutrophil)	0.022
XCR1	chemokine (C motif) receptor 1	0.022	Human
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.021
CD6	CD6 molecule	0.021
TLR7	toll-like receptor 7	0.020
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.020
CLC	Charcot-Leyden crystal protein	0.019
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.019
RNASE6	ribonuclease, RNase A family, k6	0.019
CD160	CD160 molecule	0.019
SLAMF1	signaling lymphocytic activation molecule family member 1	0.018
C3AR1	complement component 3a receptor 1	0.018
RUNX3	runt-related transcription factor 3	0.017
CLEC10A	C-type lectin domain family 10, member A	0.017
FPR2	formyl peptide receptor 2	0.017
NCR3	natural cytotoxicity triggering receptor 3	0.017
PDCD1LG2	programmed cell death 1 ligand 2	0.016
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.016
EBI3	Epstein-Barr virus induced 3	0.016
CD1A	CD1a molecule	0.016
CD163	CD163 molecule	0.016
IL17A	interleukin 17A	0.016
BATF	basic leucine zipper transcription factor, ATF-like	0.015
CD4	CD4 molecule	0.015
IDO1	indoleamine 2,3-dioxygenase 1	0.015
IL18R1	interleukin 18 receptor 1	0.015
TDRD12	tudor domain containing 12	0.015
FAIM3	Fas apoptotic inhibitory molecule 3	0.015
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.015
PTAFR	platelet-activating factor receptor	0.015
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	0.014
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.014
ITGB7	integrin, beta 7	0.014
GPR109B	G protein-coupled receptor 109B	0.014
FFAR2	free fatty acid receptor 2	0.014
XCL2	chemokine (C motif) ligand 2	0.014
SIRPB1	signal-regulatory protein beta 1	0.014
SLAMF6	SLAM family member 6	0.014
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.013
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.013
GPR171	G protein-coupled receptor 171	0.013
KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	0.013
NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	0.013
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.013
CCL23	chemokine (C-C motif) ligand 23	0.013
CD83	CD83 molecule	0.013
GPA33	glycoprotein A33 (transmembrane)	0.013
CLEC1A	C-type lectin domain family 1, member A	0.013
S100A12	S100 calcium binding protein A12	0.012
CD1E	CD1e molecule	0.012
IL12RB1	interleukin 12 receptor, beta 1	0.012
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.012
CCL2	chemokine (C-C motif) ligand 2	0.012
ADORA3	adenosine A3 receptor	0.012
ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.012
C2	complement component 2	0.012
FPR1	formyl peptide receptor 1	0.011
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.011
GRAP2	GRB2-related adaptor protein 2	0.011
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.011
FPR3	formyl peptide receptor 3	0.011
PRDM1	PR domain containing 1, with ZNF domain	0.011
ZBED2	zinc finger, BED-type containing 2	0.011
IRF8	interferon regulatory factor 8	0.011
LY9	lymphocyte antigen 9	0.011
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.011
CNR2	cannabinoid receptor 2 (macrophage)	0.011
AIM2	absent in melanoma 2	0.011
HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	0.011
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.011
ZBP1	Z-DNA binding protein 1	0.011
HAL	histidine ammonia-lyase	0.010
CSF1R	colony stimulating factor 1 receptor	0.010
LY86	lymphocyte antigen 86	0.010
STAT4	signal transducer and activator of transcription 4	0.010
VPREB3	pre-B lymphocyte 3	0.010
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.010
MARCO	macrophage receptor with collagenous structure	0.010
RNASE3	ribonuclease, RNase A family, 3	0.010
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.010
CPVL	carboxypeptidase, vitellogenic-like	0.010
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.010
ASGR2	asialoglycoprotein receptor 2	0.010