IMP

Process View

Homo sapiens

22 genes annotated in human

positive regulation of pathway restricted smad protein phosphorylation

Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of pathway restricted smad protein phosphorylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of pathway restricted smad protein phosphorylation" (in gray)

Name	Description	Probability	Func Analog Organism
TGFB1	transforming growth factor, beta 1	1.000
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	1.000	Human
ENG	endoglin	1.000
TGFB3	transforming growth factor, beta 3	1.000	Mouse
FSTL1	follistatin-like 1	1.000
TGFBR1	transforming growth factor, beta receptor 1	1.000
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	1.000
FKBP1A	FK506 binding protein 1A, 12kDa	0.999
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.996
BMPR1B	bone morphogenetic protein receptor, type IB	0.996	Human
SMAD7	SMAD family member 7	0.993
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.982
NRP1	neuropilin 1	0.979
BMPR1A	bone morphogenetic protein receptor, type IA	0.975
GDF5	growth differentiation factor 5	0.971	Human
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.956
BMP2	bone morphogenetic protein 2	0.877
ACVR1	activin A receptor, type I	0.810
ZFYVE9	zinc finger, FYVE domain containing 9	0.775
ACVR2B	activin A receptor, type IIB	0.651	Human
BMP4	bone morphogenetic protein 4	0.616
NOG	noggin	0.573
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.527
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.463
ACVR1B	activin A receptor, type IB	0.450	Human Rat Fly
PRKG1	protein kinase, cGMP-dependent, type I	0.436
SMAD2	SMAD family member 2	0.255
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.232
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.162
FST	follistatin	0.158
SMAD6	SMAD family member 6	0.155
GRB7	growth factor receptor-bound protein 7	0.146
THBS1	thrombospondin 1	0.130
RXRA	retinoid X receptor, alpha	0.127
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.125
MAPK8	mitogen-activated protein kinase 8	0.123
TGFBR3	transforming growth factor, beta receptor III	0.116	Human
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.115
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.111
RHOXF2	Rhox homeobox family, member 2	0.094
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.094
TGFB2	transforming growth factor, beta 2	0.089	Human
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.087
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.070
SMAD1	SMAD family member 1	0.069
APP	amyloid beta (A4) precursor protein	0.067
MYO6	myosin VI	0.060
COL2A1	collagen, type II, alpha 1	0.056
QKI	quaking homolog, KH domain RNA binding (mouse)	0.053
FNDC3B	fibronectin type III domain containing 3B	0.053
RBMS3	RNA binding motif, single stranded interacting protein 3	0.045
BMP8B	bone morphogenetic protein 8b	0.040	Human Mouse
ZMYND11	zinc finger, MYND-type containing 11	0.040
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.039
SMAD5	SMAD family member 5	0.039
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.039
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.038
EYA2	eyes absent homolog 2 (Drosophila)	0.036
NRP2	neuropilin 2	0.036
PDLIM4	PDZ and LIM domain 4	0.034
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.033
SMAD3	SMAD family member 3	0.032
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.030
SOX7	SRY (sex determining region Y)-box 7	0.030
LRP6	low density lipoprotein receptor-related protein 6	0.027
ACVR2A	activin A receptor, type IIA	0.026
SKIL	SKI-like oncogene	0.026
BMP7	bone morphogenetic protein 7	0.024
LRP2	low density lipoprotein receptor-related protein 2	0.024
RARA	retinoic acid receptor, alpha	0.024
GDF11	growth differentiation factor 11	0.023	Human
ATXN1	ataxin 1	0.023
ACVRL1	activin A receptor type II-like 1	0.023
ZC3H10	zinc finger CCCH-type containing 10	0.021
TACC1	transforming, acidic coiled-coil containing protein 1	0.021
CLU	clusterin	0.021
PITX1	paired-like homeodomain 1	0.021
INHBB	inhibin, beta B	0.020	Human
FOXC1	forkhead box C1	0.020
PDGFC	platelet derived growth factor C	0.019
FZD7	frizzled homolog 7 (Drosophila)	0.018
IGSF1	immunoglobulin superfamily, member 1	0.018
FOXF1	forkhead box F1	0.018
BMP3	bone morphogenetic protein 3	0.018	Human
WT1	Wilms tumor 1	0.017
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.017
MED25	mediator complex subunit 25	0.016
PMEPA1	prostate transmembrane protein, androgen induced 1	0.015
EFNB3	ephrin-B3	0.015
FOXF2	forkhead box F2	0.015
FN1	fibronectin 1	0.015
FGF4	fibroblast growth factor 4	0.015
USP15	ubiquitin specific peptidase 15	0.014
PHF1	PHD finger protein 1	0.014
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.014
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.014
BMP5	bone morphogenetic protein 5	0.014
SOD3	superoxide dismutase 3, extracellular	0.014
WNT11	wingless-type MMTV integration site family, member 11	0.014
HOXB9	homeobox B9	0.013
VTN	vitronectin	0.013
FZD10	frizzled homolog 10 (Drosophila)	0.013
IQGAP1	IQ motif containing GTPase activating protein 1	0.013
APLP1	amyloid beta (A4) precursor-like protein 1	0.012
FOXS1	forkhead box S1	0.012
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.012
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
GDNF	glial cell derived neurotrophic factor	0.012
PITX2	paired-like homeodomain 2	0.012
FZD4	frizzled homolog 4 (Drosophila)	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
AHR	aryl hydrocarbon receptor	0.012
SOSTDC1	sclerostin domain containing 1	0.012
VEGFC	vascular endothelial growth factor C	0.012
TDGF1	teratocarcinoma-derived growth factor 1	0.012
SLIT2	slit homolog 2 (Drosophila)	0.012
ZNF581	zinc finger protein 581	0.012
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.012
FILIP1L	filamin A interacting protein 1-like	0.012
SOX21	SRY (sex determining region Y)-box 21	0.011
VEGFA	vascular endothelial growth factor A	0.011
ATF7IP	activating transcription factor 7 interacting protein	0.011
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.011
NLK	nemo-like kinase	0.011
VASN	vasorin	0.011
C9orf100	chromosome 9 open reading frame 100	0.011
C2orf51	chromosome 2 open reading frame 51	0.011
SOX13	SRY (sex determining region Y)-box 13	0.011
DACH1	dachshund homolog 1 (Drosophila)	0.011
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.011
ANTXR2	anthrax toxin receptor 2	0.011
PRPH	peripherin	0.011
STC1	stanniocalcin 1	0.011
CXXC5	CXXC finger protein 5	0.011
CER1	cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)	0.011
PRPH2	peripherin 2 (retinal degeneration, slow)	0.011
PTCH1	patched 1	0.010
DLX4	distal-less homeobox 4	0.010
PRNP	prion protein	0.010
GJA4	gap junction protein, alpha 4, 37kDa	0.010
EDN1	endothelin 1	0.010
GLI3	GLI family zinc finger 3	0.010
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.010