IMP

Process View

Homo sapiens

3 genes annotated in human

protein heterotetramerization

The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein heterotetramerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein heterotetramerization" (in gray)

Name	Description	Probability	Func Analog Organism
S100A6	S100 calcium binding protein A6	1.000	Human
S100B	S100 calcium binding protein B	1.000	Human
S100A10	S100 calcium binding protein A10	0.999
ANXA1	annexin A1	0.997	Human
ANXA2	annexin A2	0.996
S100A11	S100 calcium binding protein A11	0.989	Human
S100A1	S100 calcium binding protein A1	0.986	Human
TK1	thymidine kinase 1, soluble	0.966
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.960
S100A4	S100 calcium binding protein A4	0.954	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.930
FKBP4	FK506 binding protein 4, 59kDa	0.878
EGFR	epidermal growth factor receptor	0.793
LGALS1	lectin, galactoside-binding, soluble, 1	0.781
IGF1R	insulin-like growth factor 1 receptor	0.773	Human
ANXA5	annexin A5	0.699	Human
TMSB10	thymosin beta 10	0.576
LGALS3	lectin, galactoside-binding, soluble, 3	0.510
INSR	insulin receptor	0.495
EMP3	epithelial membrane protein 3	0.490
AREG	amphiregulin	0.442
FN1	fibronectin 1	0.409
IRS1	insulin receptor substrate 1	0.348
AGER	advanced glycosylation end product-specific receptor	0.326
GRB10	growth factor receptor-bound protein 10	0.318
S100A2	S100 calcium binding protein A2	0.299	Human
S100A9	S100 calcium binding protein A9	0.267	Human
ANXA4	annexin A4	0.265	Human
DLG4	discs, large homolog 4 (Drosophila)	0.236
CTSB	cathepsin B	0.232
SMN1	survival of motor neuron 1, telomeric	0.164
S100A12	S100 calcium binding protein A12	0.164	Human
S100A8	S100 calcium binding protein A8	0.162	Human
S100P	S100 calcium binding protein P	0.158	Human
IRS2	insulin receptor substrate 2	0.157
PDCD6	programmed cell death 6	0.145
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.141
EMP1	epithelial membrane protein 1	0.115
AHNAK	AHNAK nucleoprotein	0.113
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.107
RPS27L	ribosomal protein S27-like	0.082
CAV1	caveolin 1, caveolae protein, 22kDa	0.079
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.077
APP	amyloid beta (A4) precursor protein	0.057
ITGB5	integrin, beta 5	0.055
LCN2	lipocalin 2	0.055
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.055
S100A13	S100 calcium binding protein A13	0.054	Human
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.053
ARF4	ADP-ribosylation factor 4	0.048
MYOF	myoferlin	0.046
IGSF21	immunoglobin superfamily, member 21	0.045
ANXA3	annexin A3	0.042
IQGAP1	IQ motif containing GTPase activating protein 1	0.042
PI3	peptidase inhibitor 3, skin-derived	0.039
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.039
RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	0.036
MVP	major vault protein	0.034
TSC22D1	TSC22 domain family, member 1	0.034
TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.034
CSTA	cystatin A (stefin A)	0.033
TGFBI	transforming growth factor, beta-induced, 68kDa	0.033
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.031
LMNA	lamin A/C	0.030
CAPN2	calpain 2, (m/II) large subunit	0.030
CAST	calpastatin	0.029
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.029
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.029
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.029
GHR	growth hormone receptor	0.027
TUBB6	tubulin, beta 6	0.026
RRAS	related RAS viral (r-ras) oncogene homolog	0.025
SFN	stratifin	0.025
CRIP1	cysteine-rich protein 1 (intestinal)	0.024
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.023
JAK2	Janus kinase 2	0.022
DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.022
CD63	CD63 molecule	0.022
VIM	vimentin	0.021
MCM6	minichromosome maintenance complex component 6	0.020
EXO1	exonuclease 1	0.020
RIF1	RAP1 interacting factor homolog (yeast)	0.020
FRS2	fibroblast growth factor receptor substrate 2	0.020
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.020
CAV2	caveolin 2	0.020
STAT5B	signal transducer and activator of transcription 5B	0.019
MYL12B	myosin, light chain 12B, regulatory	0.019
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.019
GAB2	GRB2-associated binding protein 2	0.018
KRT23	keratin 23 (histone deacetylase inducible)	0.018
GRB14	growth factor receptor-bound protein 14	0.018
SLPI	secretory leukocyte peptidase inhibitor	0.017
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.017
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.017
CSTB	cystatin B (stefin B)	0.017
PARP4	poly (ADP-ribose) polymerase family, member 4	0.016
BCAR1	breast cancer anti-estrogen resistance 1	0.016
FKBP3	FK506 binding protein 3, 25kDa	0.016
ADAM9	ADAM metallopeptidase domain 9	0.015
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.015
EPOR	erythropoietin receptor	0.015
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.015
S100A3	S100 calcium binding protein A3	0.015	Human
C11orf66	chromosome 11 open reading frame 66	0.015
RBBP7	retinoblastoma binding protein 7	0.015
NMT2	N-myristoyltransferase 2	0.015
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.015
IL13RA1	interleukin 13 receptor, alpha 1	0.014
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.014
ACOT9	acyl-CoA thioesterase 9	0.014
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.014
TREM1	triggering receptor expressed on myeloid cells 1	0.014
ACTG1	actin, gamma 1	0.014
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.014
PLB1	phospholipase B1	0.014
CAMP	cathelicidin antimicrobial peptide	0.014
HMGN2	high mobility group nucleosomal binding domain 2	0.014
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.013
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.013
KLF4	Kruppel-like factor 4 (gut)	0.013
ENO2	enolase 2 (gamma, neuronal)	0.013
RRM2	ribonucleotide reductase M2	0.013	Mouse
PYGL	phosphorylase, glycogen, liver	0.013
PF4	platelet factor 4	0.013
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.013
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.012
NQO1	NAD(P)H dehydrogenase, quinone 1	0.012
STEAP4	STEAP family member 4	0.012
ALG2	asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)	0.012
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.012
CAPG	capping protein (actin filament), gelsolin-like	0.012
CP110	CP110 protein	0.012
BTC	betacellulin	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
CCNA2	cyclin A2	0.012
TJP1	tight junction protein 1 (zona occludens 1)	0.012
TM4SF1	transmembrane 4 L six family member 1	0.012
IL1RN	interleukin 1 receptor antagonist	0.012
NCAPG2	non-SMC condensin II complex, subunit G2	0.012
CSRP1	cysteine and glycine-rich protein 1	0.012
TRIOBP	TRIO and F-actin binding protein	0.011
IL1R2	interleukin 1 receptor, type II	0.011
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.011
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.011
LAT	linker for activation of T cells	0.011
SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	0.011
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.011
DFNB31	deafness, autosomal recessive 31	0.011
ECM1	extracellular matrix protein 1	0.011
MYO1C	myosin IC	0.011
CXCR2	chemokine (C-X-C motif) receptor 2	0.011
CDA	cytidine deaminase	0.011
MLF1IP	MLF1 interacting protein	0.011
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.011
FADS1	fatty acid desaturase 1	0.011
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.011
CD58	CD58 molecule	0.011
LMTK2	lemur tyrosine kinase 2	0.011
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.011
PTTG1IP	pituitary tumor-transforming 1 interacting protein	0.011
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.010
KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	0.010
PRPS2	phosphoribosyl pyrophosphate synthetase 2	0.010
GIGYF1	GRB10 interacting GYF protein 1	0.010
NOS1	nitric oxide synthase 1 (neuronal)	0.010
NPC2	Niemann-Pick disease, type C2	0.010
LAMC2	laminin, gamma 2	0.010
CCNF	cyclin F	0.010
TP53I3	tumor protein p53 inducible protein 3	0.010
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.010
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.010