IMP

Process View

Homo sapiens

1 genes annotated in human

Multi-species View

specification of axis polarity

GO:0065001

The pattern specification process in which the polarity of a body or organ axis is established and maintained.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "specification of axis polarity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "specification of axis polarity" (in gray)

Name	Description	Probability	Func Analog Organism
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.999	Worm
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.993	Worm
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.977	Worm
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.940	Worm
PRKCZ	protein kinase C, zeta	0.904
PALB2	partner and localizer of BRCA2	0.830
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.776	Fly
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.747
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.633
PRKCI	protein kinase C, iota	0.571
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.395	Fly
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.349
CDH5	cadherin 5, type 2 (vascular endothelium)	0.333
C19orf39	chromosome 19 open reading frame 39	0.303
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.286	Worm
WDYHV1	WDYHV motif containing 1	0.266
APC	adenomatous polyposis coli	0.258
CTNNBIP1	catenin, beta interacting protein 1	0.256
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.193	Worm
BRCA2	breast cancer 2, early onset	0.162
KDM2B	lysine (K)-specific demethylase 2B	0.136
PCGF1	polycomb group ring finger 1	0.123
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.108
IQGAP1	IQ motif containing GTPase activating protein 1	0.105
ACTN1	actinin, alpha 1	0.090
JUP	junction plakoglobin	0.081	Worm
ANAPC5	anaphase promoting complex subunit 5	0.077
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.076	Worm
RAD52	RAD52 homolog (S. cerevisiae)	0.068
F11R	F11 receptor	0.066
TCF4	transcription factor 4	0.065
RAD51C	RAD51 homolog C (S. cerevisiae)	0.060	Fly
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.060
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.054	Worm
ANAPC7	anaphase promoting complex subunit 7	0.053
BTRC	beta-transducin repeat containing	0.053
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.048
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.047	Worm
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.044
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.043
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.043
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.040
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.036
HIC1	hypermethylated in cancer 1	0.035
GLIS2	GLIS family zinc finger 2	0.035
TRPM7	transient receptor potential cation channel, subfamily M, member 7	0.034
JAM3	junctional adhesion molecule 3	0.034
MARK2	MAP/microtubule affinity-regulating kinase 2	0.033
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.031
SFN	stratifin	0.030
DSP	desmoplakin	0.029
TP53BP1	tumor protein p53 binding protein 1	0.028
DSG2	desmoglein 2	0.028
JAM2	junctional adhesion molecule 2	0.028
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.025
AXIN1	axin 1	0.023
HDAC4	histone deacetylase 4	0.022
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.021
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.020
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.020
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.020
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.020
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.019
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.019
PBX1	pre-B-cell leukemia homeobox 1	0.019
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.019
FLNB	filamin B, beta	0.019
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.019
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.019
MDC1	mediator of DNA-damage checkpoint 1	0.018
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.018
CAMKK1	calcium/calmodulin-dependent protein kinase kinase 1, alpha	0.017
RNF2	ring finger protein 2	0.017
ASCC2	activating signal cointegrator 1 complex subunit 2	0.016
PSEN1	presenilin 1	0.016
ING1	inhibitor of growth family, member 1	0.016
CLTC	clathrin, heavy chain (Hc)	0.015
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.014
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.014
FZD1	frizzled homolog 1 (Drosophila)	0.013
EMD	emerin	0.013
ITSN1	intersectin 1 (SH3 domain protein)	0.012
LEF1	lymphoid enhancer-binding factor 1	0.012	Worm
PFN1	profilin 1	0.012
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.012
FANCD2	Fanconi anemia, complementation group D2	0.011
VCL	vinculin	0.011
C17orf63	chromosome 17 open reading frame 63	0.011
ZNF512B	zinc finger protein 512B	0.011
ARRB1	arrestin, beta 1	0.011
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.010
NCF2	neutrophil cytosolic factor 2	0.010
SP1	Sp1 transcription factor	0.010