IMP

Process View

Homo sapiens

14 genes annotated in human

non canonical wnt signaling pathway

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "non canonical wnt signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "non canonical wnt signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.999
AFF1	AF4/FMR2 family, member 1	0.980
WNT3A	wingless-type MMTV integration site family, member 3A	0.900	Human
CSNK1E	casein kinase 1, epsilon	0.861
AXIN1	axin 1	0.819
GSK3B	glycogen synthase kinase 3 beta	0.757	Worm
FZD1	frizzled homolog 1 (Drosophila)	0.755	Human Mouse
LRRK2	leucine-rich repeat kinase 2	0.719
LRP6	low density lipoprotein receptor-related protein 6	0.599	Mouse
GIPC1	GIPC PDZ domain containing family, member 1	0.588
JAM2	junctional adhesion molecule 2	0.525
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.424
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.289
FBLN1	fibulin 1	0.277
SFN	stratifin	0.260
PRKCI	protein kinase C, iota	0.234
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.228
BBS10	Bardet-Biedl syndrome 10	0.226
RHOA	ras homolog gene family, member A	0.220
AKAP8L	A kinase (PRKA) anchor protein 8-like	0.195
MED29	mediator complex subunit 29	0.181
SMAD2	SMAD family member 2	0.177
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.161
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.129
RIN1	Ras and Rab interactor 1	0.128
CSNK1D	casein kinase 1, delta	0.101
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.098
MYO6	myosin VI	0.090
AXIN2	axin 2	0.082
FZD8	frizzled homolog 8 (Drosophila)	0.081	Human
EGFR	epidermal growth factor receptor	0.070
WNT5A	wingless-type MMTV integration site family, member 5A	0.065
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.064
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.064
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.064
TSG101	tumor susceptibility gene 101	0.061
CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon	0.055
AFF4	AF4/FMR2 family, member 4	0.053
SFRP1	secreted frizzled-related protein 1	0.052
GRB7	growth factor receptor-bound protein 7	0.052
F11R	F11 receptor	0.050
PRKCZ	protein kinase C, zeta	0.043
GDF10	growth differentiation factor 10	0.042
MED24	mediator complex subunit 24	0.042
WIF1	WNT inhibitory factor 1	0.042
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.041
NCKAP1	NCK-associated protein 1	0.040
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.039
NDP	Norrie disease (pseudoglioma)	0.039
ELF5	E74-like factor 5 (ets domain transcription factor)	0.037
FGF18	fibroblast growth factor 18	0.037
TNS4	tensin 4	0.035
CDH5	cadherin 5, type 2 (vascular endothelium)	0.034
APC	adenomatous polyposis coli	0.032
ARID1A	AT rich interactive domain 1A (SWI-like)	0.032
SOS1	son of sevenless homolog 1 (Drosophila)	0.031
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.031
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.030	Mouse Fly
ARHGAP1	Rho GTPase activating protein 1	0.029
ZFYVE9	zinc finger, FYVE domain containing 9	0.029
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.027
ITM2B	integral membrane protein 2B	0.026
APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	0.025
WT1	Wilms tumor 1	0.025
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.025
PTK6	PTK6 protein tyrosine kinase 6	0.024
ARL8B	ADP-ribosylation factor-like 8B	0.024
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.024
IHH	Indian hedgehog	0.023
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.023
WNT1	wingless-type MMTV integration site family, member 1	0.022	Human Fly
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.022
ZMYND11	zinc finger, MYND-type containing 11	0.022
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.022
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.022
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.022
GLIS2	GLIS family zinc finger 2	0.021
PTN	pleiotrophin	0.021
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.021
JAM3	junctional adhesion molecule 3	0.021
BMP4	bone morphogenetic protein 4	0.021
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.021
NKD2	naked cuticle homolog 2 (Drosophila)	0.020
CEP164	centrosomal protein 164kDa	0.020
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.020
JUB	jub, ajuba homolog (Xenopus laevis)	0.020
DLG1	discs, large homolog 1 (Drosophila)	0.020
THBS2	thrombospondin 2	0.020
NCK1	NCK adaptor protein 1	0.020
TGFBR1	transforming growth factor, beta receptor 1	0.020
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.019
TRRAP	transformation/transcription domain-associated protein	0.018
TP73	tumor protein p73	0.018
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.018
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.018
FZD10	frizzled homolog 10 (Drosophila)	0.017
MED16	mediator complex subunit 16	0.017
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.017
BMP7	bone morphogenetic protein 7	0.017
FZD6	frizzled homolog 6 (Drosophila)	0.017
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.016
FOXF2	forkhead box F2	0.016
PITX1	paired-like homeodomain 1	0.015
FGF3	fibroblast growth factor 3	0.015
FZD7	frizzled homolog 7 (Drosophila)	0.015
PDGFC	platelet derived growth factor C	0.015
GFI1	growth factor independent 1 transcription repressor	0.015
SFRP4	secreted frizzled-related protein 4	0.015	Human
ITIH5	inter-alpha (globulin) inhibitor H5	0.014
EHF	ets homologous factor	0.014
MAPT	microtubule-associated protein tau	0.014
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.014
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.013
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.013
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.013
WNT3	wingless-type MMTV integration site family, member 3	0.013	Human
TGFB3	transforming growth factor, beta 3	0.013
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.013
PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	0.013
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.013
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.013
WNT5B	wingless-type MMTV integration site family, member 5B	0.012	Human
FGF8	fibroblast growth factor 8 (androgen-induced)	0.012
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.012
LRP2	low density lipoprotein receptor-related protein 2	0.012
WASF1	WAS protein family, member 1	0.012
ZNF512B	zinc finger protein 512B	0.011
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
GPC4	glypican 4	0.011
MUC1	mucin 1, cell surface associated	0.011
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.011
ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	0.011
AGPAT1	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	0.011
TNK1	tyrosine kinase, non-receptor, 1	0.011
FGF4	fibroblast growth factor 4	0.011
MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	0.011
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.011
FOXF1	forkhead box F1	0.011
CREBBP	CREB binding protein	0.011
COL12A1	collagen, type XII, alpha 1	0.011
SH2D3A	SH2 domain containing 3A	0.011
VAV3	vav 3 guanine nucleotide exchange factor	0.010
OMD	osteomodulin	0.010
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.010
LBX1	ladybird homeobox 1	0.010
FGFR1	fibroblast growth factor receptor 1	0.010
PDCD6IP	programmed cell death 6 interacting protein	0.010
ZBTB8A	zinc finger and BTB domain containing 8A	0.010
CXCL14	chemokine (C-X-C motif) ligand 14	0.010