IMP
Process View
negative regulation of purine nucleotide metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of purine nucleotide metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.465 | ||
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.298 | ||
| GUCY2C | guanylate cyclase 2C (heat stable enterotoxin receptor) | 0.273 | ||
| MPDZ | multiple PDZ domain protein | 0.261 | ||
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.259 | ||
| HAP1 | huntingtin-associated protein 1 | 0.248 | ||
| SNTB2 | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | 0.180 | ||
| TNNC1 | troponin C type 1 (slow) | 0.156 | ||
| RND1 | Rho family GTPase 1 | 0.145 | ||
| TBC1D10A | TBC1 domain family, member 10A | 0.126 | ||
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.117 | Human | |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.115 | Human | |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.096 | ||
| GOPC | golgi-associated PDZ and coiled-coil motif containing | 0.087 | ||
| ARRB1 | arrestin, beta 1 | 0.082 | ||
| TRIM63 | tripartite motif containing 63 | 0.080 | ||
| PCDHA4 | protocadherin alpha 4 | 0.069 | ||
| AMOTL1 | angiomotin like 1 | 0.067 | ||
| LMAN1 | lectin, mannose-binding, 1 | 0.064 | ||
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.054 | ||
| SSRP1 | structure specific recognition protein 1 | 0.048 | ||
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.043 | ||
| TBCD | tubulin folding cofactor D | 0.043 | ||
| YAP1 | Yes-associated protein 1 | 0.041 | ||
| UNC119 | unc-119 homolog (C. elegans) | 0.040 | ||
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.039 | ||
| CANX | calnexin | 0.033 | ||
| BCR | breakpoint cluster region | 0.032 | ||
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.032 | ||
| THOC5 | THO complex 5 | 0.031 | ||
| RALGDS | ral guanine nucleotide dissociation stimulator | 0.031 | ||
| PTEN | phosphatase and tensin homolog | 0.031 | ||
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.029 | ||
| SLC9A3R2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.028 | Human | |
| DNM2 | dynamin 2 | 0.027 | ||
| BBS10 | Bardet-Biedl syndrome 10 | 0.026 | ||
| SURF4 | surfeit 4 | 0.026 | ||
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.025 | ||
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) | 0.024 | ||
| ADORA2A | adenosine A2a receptor | 0.024 | ||
| NSF | N-ethylmaleimide-sensitive factor | 0.023 | ||
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.023 | ||
| GRPEL1 | GrpE-like 1, mitochondrial (E. coli) | 0.023 | ||
| QARS | glutaminyl-tRNA synthetase | 0.022 | ||
| DDX39A | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A | 0.022 | ||
| TFRC | transferrin receptor (p90, CD71) | 0.022 | ||
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.021 | ||
| WNT3A | wingless-type MMTV integration site family, member 3A | 0.021 | ||
| PDZK1 | PDZ domain containing 1 | 0.020 | Human | |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.020 | ||
| DES | desmin | 0.020 | ||
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.020 | ||
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.019 | ||
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | 0.019 | ||
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.019 | ||
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.019 | ||
| CYR61 | cysteine-rich, angiogenic inducer, 61 | 0.019 | ||
| STX12 | syntaxin 12 | 0.018 | ||
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.018 | ||
| SH3GL3 | SH3-domain GRB2-like 3 | 0.018 | ||
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.018 | Human | |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.017 | Human | |
| RIN1 | Ras and Rab interactor 1 | 0.017 | ||
| ARRDC3 | arrestin domain containing 3 | 0.017 | ||
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.017 | ||
| PPP1R9B | protein phosphatase 1, regulatory (inhibitor) subunit 9B | 0.016 | ||
| ACTA1 | actin, alpha 1, skeletal muscle | 0.016 | ||
| GAD2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 0.016 | ||
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.016 | ||
| PAWR | PRKC, apoptosis, WT1, regulator | 0.016 | ||
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.015 | ||
| EPAS1 | endothelial PAS domain protein 1 | 0.015 | ||
| TNNI2 | troponin I type 2 (skeletal, fast) | 0.015 | Human | |
| ARAP1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 0.015 | ||
| TRAM1 | translocation associated membrane protein 1 | 0.015 | ||
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.015 | ||
| GPR6 | G protein-coupled receptor 6 | 0.015 | ||
| ELF5 | E74-like factor 5 (ets domain transcription factor) | 0.014 | ||
| LDB3 | LIM domain binding 3 | 0.014 | ||
| COX6A2 | cytochrome c oxidase subunit VIa polypeptide 2 | 0.014 | ||
| MPP3 | membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) | 0.014 | ||
| NDP | Norrie disease (pseudoglioma) | 0.014 | ||
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.014 | ||
| OR2AG1 | olfactory receptor, family 2, subfamily AG, member 1 | 0.014 | ||
| FKBP8 | FK506 binding protein 8, 38kDa | 0.014 | ||
| TNNI1 | troponin I type 1 (skeletal, slow) | 0.014 | Human | |
| MST1R | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | 0.014 | ||
| RALB | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | 0.013 | Human | |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.013 | ||
| TTN | titin | 0.013 | ||
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.013 | ||
| ROD1 | ROD1 regulator of differentiation 1 (S. pombe) | 0.013 | ||
| SEP15 | 15 kDa selenoprotein | 0.013 | ||
| COL6A2 | collagen, type VI, alpha 2 | 0.013 | ||
| GOLT1B | golgi transport 1B | 0.013 | ||
| SNF8 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) | 0.013 | ||
| SSTR3 | somatostatin receptor 3 | 0.013 | ||
| MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | 0.012 | ||
| CD34 | CD34 molecule | 0.012 | ||
| FAM18B1 | family with sequence similarity 18, member B1 | 0.012 | ||
| TWF1 | twinfilin, actin-binding protein, homolog 1 (Drosophila) | 0.012 | ||
| SLC26A3 | solute carrier family 26, member 3 | 0.012 | ||
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.012 | ||
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.012 | ||
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 0.012 | ||
| KCNA1 | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 0.012 | ||
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.012 | ||
| TNNI3K | TNNI3 interacting kinase | 0.012 | ||
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.012 | ||
| CDV3 | CDV3 homolog (mouse) | 0.011 | ||
| MCFD2 | multiple coagulation factor deficiency 2 | 0.011 | ||
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | 0.011 | Mouse | |
| HDGF | hepatoma-derived growth factor | 0.011 | ||
| ACHE | acetylcholinesterase | 0.011 | ||
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | 0.011 | ||
| MRPL41 | mitochondrial ribosomal protein L41 | 0.011 | ||
| ADORA1 | adenosine A1 receptor | 0.011 | ||
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.011 | ||
| AMOTL2 | angiomotin like 2 | 0.011 | ||
| SSR1 | signal sequence receptor, alpha | 0.011 | ||
| GMPR2 | guanosine monophosphate reductase 2 | 0.011 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.011 | ||
| MYO10 | myosin X | 0.011 | ||
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 0.011 | ||
| AIP | aryl hydrocarbon receptor interacting protein | 0.011 | ||
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.011 | ||
| SAMD4A | sterile alpha motif domain containing 4A | 0.011 | ||
| GDF10 | growth differentiation factor 10 | 0.011 | ||
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.011 | ||
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | 0.011 | ||
| ADRB2 | adrenergic, beta-2-, receptor, surface | 0.010 | Human | |
| DVL3 | dishevelled, dsh homolog 3 (Drosophila) | 0.010 | ||
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 0.010 | ||
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.010 | ||
| CLIC4 | chloride intracellular channel 4 | 0.010 |