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Homo sapiens

3 genes annotated in human

Multi-species View

aortic valve morphogenesis

GO:0003180

The process in which the structure of the aortic valve is generated and organized.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "aortic valve morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "aortic valve morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
JAG1	jagged 1	1.000
NOTCH1	notch 1	0.981
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.974
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.949
NOTCH3	notch 3	0.919	Human
SETD8	SET domain containing (lysine methyltransferase) 8	0.754
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.672
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.549
GATA2	GATA binding protein 2	0.491
TAL1	T-cell acute lymphocytic leukemia 1	0.432	Human
DLL1	delta-like 1 (Drosophila)	0.361
GATA4	GATA binding protein 4	0.330
RUNX1	runt-related transcription factor 1	0.320
MAML1	mastermind-like 1 (Drosophila)	0.245
JAG2	jagged 2	0.237
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.237
XIAP	X-linked inhibitor of apoptosis	0.231
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.115
TCF12	transcription factor 12	0.097
MYOD1	myogenic differentiation 1	0.081
EGFL7	EGF-like-domain, multiple 7	0.081
LMO2	LIM domain only 2 (rhombotin-like 1)	0.062
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.057
TBX5	T-box 5	0.054	Human
GATA3	GATA binding protein 3	0.052	Mouse
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.048
SOX18	SRY (sex determining region Y)-box 18	0.048
PHOX2A	paired-like homeobox 2a	0.040
DLL4	delta-like 4 (Drosophila)	0.039
NOTCH2NL	notch 2 N-terminal like	0.037
FGF3	fibroblast growth factor 3	0.037
LRRN2	leucine rich repeat neuronal 2	0.036
HIPK2	homeodomain interacting protein kinase 2	0.034
LMO1	LIM domain only 1 (rhombotin 1)	0.034
SMAD1	SMAD family member 1	0.033
SIX6	SIX homeobox 6	0.032
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.030
FOXF2	forkhead box F2	0.029
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.029
MSX1	msh homeobox 1	0.028
RUNX3	runt-related transcription factor 3	0.028
SOX1	SRY (sex determining region Y)-box 1	0.026
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.026
GFI1B	growth factor independent 1B transcription repressor	0.026
TBX21	T-box 21	0.026	Human
HAND2	heart and neural crest derivatives expressed 2	0.025	Human
POU4F2	POU class 4 homeobox 2	0.025
HOXD11	homeobox D11	0.024
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.024
ACAN	aggrecan	0.024
PML	promyelocytic leukemia	0.023
HOXD12	homeobox D12	0.023
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.023
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.022
WNT6	wingless-type MMTV integration site family, member 6	0.022
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.022	Mouse
LTK	leukocyte receptor tyrosine kinase	0.022
NKG7	natural killer cell group 7 sequence	0.022
FEV	FEV (ETS oncogene family)	0.021
ATXN1L	ataxin 1-like	0.020
HOXB9	homeobox B9	0.020
ELF4	E74-like factor 4 (ets domain transcription factor)	0.020
FOXF1	forkhead box F1	0.020
LHX5	LIM homeobox 5	0.020
GLP1R	glucagon-like peptide 1 receptor	0.019
PKNOX2	PBX/knotted 1 homeobox 2	0.019
HOXD13	homeobox D13	0.019
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.019
FGF8	fibroblast growth factor 8 (androgen-induced)	0.019
HOXC11	homeobox C11	0.019
HOXD9	homeobox D9	0.019
TBX2	T-box 2	0.019	Human
HOXA3	homeobox A3	0.019
TBX1	T-box 1	0.018	Human
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.018
FBLN1	fibulin 1	0.018
S1PR4	sphingosine-1-phosphate receptor 4	0.018
NEUROG2	neurogenin 2	0.018	Human
GATA5	GATA binding protein 5	0.018
SFRP5	secreted frizzled-related protein 5	0.018
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.017
LHX3	LIM homeobox 3	0.017
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.017
FOXB1	forkhead box B1	0.017
BMP6	bone morphogenetic protein 6	0.017
SMAD6	SMAD family member 6	0.017
POU2F2	POU class 2 homeobox 2	0.017
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.017
PHOX2B	paired-like homeobox 2b	0.017
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.017
SLITRK3	SLIT and NTRK-like family, member 3	0.017
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.017
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.017
TLX1	T-cell leukemia homeobox 1	0.016
MAGED1	melanoma antigen family D, 1	0.016
OAF	OAF homolog (Drosophila)	0.016
CXCR6	chemokine (C-X-C motif) receptor 6	0.016
HAP1	huntingtin-associated protein 1	0.016
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.016
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.016
COL2A1	collagen, type II, alpha 1	0.015
SCARF2	scavenger receptor class F, member 2	0.015
FOXA2	forkhead box A2	0.015
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.015
FLT4	fms-related tyrosine kinase 4	0.015
PITX2	paired-like homeodomain 2	0.015
SHOX2	short stature homeobox 2	0.015
FOXG1	forkhead box G1	0.015
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.015
HOXA5	homeobox A5	0.015
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.015
HOXA4	homeobox A4	0.015
A4GALT	alpha 1,4-galactosyltransferase	0.015
FOXE3	forkhead box E3	0.015
SSTR2	somatostatin receptor 2	0.015
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.015
CDX2	caudal type homeobox 2	0.015
MNX1	motor neuron and pancreas homeobox 1	0.015
MYT1	myelin transcription factor 1	0.015
NEUROG1	neurogenin 1	0.015	Human
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.015
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.015
HOXB13	homeobox B13	0.015
GSC2	goosecoid homeobox 2	0.015
POU3F4	POU class 3 homeobox 4	0.014
PAX5	paired box 5	0.014
EVX1	even-skipped homeobox 1	0.014
MMD2	monocyte to macrophage differentiation-associated 2	0.014
IL3RA	interleukin 3 receptor, alpha (low affinity)	0.014
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.014
LYL1	lymphoblastic leukemia derived sequence 1	0.014	Human
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.014
PAX9	paired box 9	0.014
COMP	cartilage oligomeric matrix protein	0.014
NPAS1	neuronal PAS domain protein 1	0.014
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.014
HOXB8	homeobox B8	0.014
CALCR	calcitonin receptor	0.014
LMX1A	LIM homeobox transcription factor 1, alpha	0.014
GCM2	glial cells missing homolog 2 (Drosophila)	0.014
LBX1	ladybird homeobox 1	0.014
BARHL1	BarH-like homeobox 1	0.014
DCC	deleted in colorectal carcinoma	0.014
VSX1	visual system homeobox 1	0.014
POU4F3	POU class 4 homeobox 3	0.014
BNC1	basonuclin 1	0.013
RGS9BP	regulator of G protein signaling 9 binding protein	0.013
ESPN	espin	0.013
NKX3-2	NK3 homeobox 2	0.013
HOXD3	homeobox D3	0.013
VAX2	ventral anterior homeobox 2	0.013
ARX	aristaless related homeobox	0.013
NHLH2	nescient helix loop helix 2	0.013	Human
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.013
HCRTR1	hypocretin (orexin) receptor 1	0.013
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.013
HTRA3	HtrA serine peptidase 3	0.013
NKX2-8	NK2 homeobox 8	0.013
MAPK4	mitogen-activated protein kinase 4	0.013
MRC2	mannose receptor, C type 2	0.013
AMN	amnionless homolog (mouse)	0.013
FOXC1	forkhead box C1	0.013
FOXL1	forkhead box L1	0.013
PHLDB1	pleckstrin homology-like domain, family B, member 1	0.013
IRX4	iroquois homeobox 4	0.013
ISL1	ISL LIM homeobox 1	0.013
PAX2	paired box 2	0.013
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.013
BHLHE23	basic helix-loop-helix family, member e23	0.013
TNNT3	troponin T type 3 (skeletal, fast)	0.013
GBX1	gastrulation brain homeobox 1	0.013
SCT	secretin	0.013
PRDM13	PR domain containing 13	0.013
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.013
GGN	gametogenetin	0.013
CADPS	Ca++-dependent secretion activator	0.013
TCF15	transcription factor 15 (basic helix-loop-helix)	0.013	Human
GRM6	glutamate receptor, metabotropic 6	0.012
HOXA2	homeobox A2	0.012
ELSPBP1	epididymal sperm binding protein 1	0.012
SOX14	SRY (sex determining region Y)-box 14	0.012
INSM1	insulinoma-associated 1	0.012
PRPH	peripherin	0.012
PAX1	paired box 1	0.012
SNAI1	snail homolog 1 (Drosophila)	0.012
IAPP	islet amyloid polypeptide	0.012
CBLN1	cerebellin 1 precursor	0.012
TBXA2R	thromboxane A2 receptor	0.012
PYY	peptide YY	0.012
GPR4	G protein-coupled receptor 4	0.012
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.012
FOXD3	forkhead box D3	0.012
HOXA11	homeobox A11	0.012
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
DLX5	distal-less homeobox 5	0.012
NGB	neuroglobin	0.012
EFNB2	ephrin-B2	0.012
EFNB3	ephrin-B3	0.012
EMILIN1	elastin microfibril interfacer 1	0.012
TNXB	tenascin XB	0.012
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.012
AFF2	AF4/FMR2 family, member 2	0.012
SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5	0.012
KCNIP2	Kv channel interacting protein 2	0.012
CD248	CD248 molecule, endosialin	0.012
POU4F1	POU class 4 homeobox 1	0.012
CLEC14A	C-type lectin domain family 14, member A	0.012
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.012
VAX1	ventral anterior homeobox 1	0.012
CLDN5	claudin 5	0.012
GJD2	gap junction protein, delta 2, 36kDa	0.012
INA	internexin neuronal intermediate filament protein, alpha	0.012
CD7	CD7 molecule	0.012
SORCS1	sortilin-related VPS10 domain containing receptor 1	0.012
PRDM12	PR domain containing 12	0.012
SCGN	secretagogin, EF-hand calcium binding protein	0.012
OTOP2	otopetrin 2	0.012
PTF1A	pancreas specific transcription factor, 1a	0.012	Human
GRM8	glutamate receptor, metabotropic 8	0.012
C2orf55	chromosome 2 open reading frame 55	0.012
FOXD2	forkhead box D2	0.012
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.012
IRX5	iroquois homeobox 5	0.012
NOV	nephroblastoma overexpressed gene	0.012
PRMT8	protein arginine methyltransferase 8	0.012
ATP2A3	ATPase, Ca++ transporting, ubiquitous	0.012
TWIST2	twist homolog 2 (Drosophila)	0.012
NEUROD2	neurogenic differentiation 2	0.012	Human
MCHR2	melanin-concentrating hormone receptor 2	0.012
NEURL	neuralized homolog (Drosophila)	0.011
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.011
TPSD1	tryptase delta 1	0.011
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.011
CSPG4	chondroitin sulfate proteoglycan 4	0.011
ECEL1	endothelin converting enzyme-like 1	0.011
GAS1	growth arrest-specific 1	0.011
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.011
FOXL2	forkhead box L2	0.011
BHLHE22	basic helix-loop-helix family, member e22	0.011
PAX6	paired box 6	0.011
HOXA13	homeobox A13	0.011
PAX3	paired box 3	0.011
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.011
HOXA7	homeobox A7	0.011
CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.011
HBQ1	hemoglobin, theta 1	0.011
EGR1	early growth response 1	0.011
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.011
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.011
KHDRBS2	KH domain containing, RNA binding, signal transduction associated 2	0.011
PDX1	pancreatic and duodenal homeobox 1	0.011
NKX6-1	NK6 homeobox 1	0.011
ATOH1	atonal homolog 1 (Drosophila)	0.011	Human
SIX2	SIX homeobox 2	0.011
ELN	elastin	0.011
MEOX2	mesenchyme homeobox 2	0.011
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.011
EN2	engrailed homeobox 2	0.011
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
DMRT3	doublesex and mab-3 related transcription factor 3	0.011
KANK3	KN motif and ankyrin repeat domains 3	0.011
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.011
EFNB1	ephrin-B1	0.011
HES2	hairy and enhancer of split 2 (Drosophila)	0.011
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.011
TLX2	T-cell leukemia homeobox 2	0.011
CYP26C1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.011
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.011
FGF20	fibroblast growth factor 20	0.011
HOXC8	homeobox C8	0.011
NES	nestin	0.011
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.011
NRG2	neuregulin 2	0.011
C4orf6	chromosome 4 open reading frame 6	0.011
HOXB5	homeobox B5	0.011
TCF4	transcription factor 4	0.011
UNC5B	unc-5 homolog B (C. elegans)	0.011
HOXD1	homeobox D1	0.011
MYL7	myosin, light chain 7, regulatory	0.011
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.011
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.011
ARID3C	AT rich interactive domain 3C (BRIGHT-like)	0.011
SIM2	single-minded homolog 2 (Drosophila)	0.011
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.011
SIX3	SIX homeobox 3	0.011
OLIG3	oligodendrocyte transcription factor 3	0.011
PLVAP	plasmalemma vesicle associated protein	0.011
PLXDC1	plexin domain containing 1	0.011
CD79B	CD79b molecule, immunoglobulin-associated beta	0.011
MAB21L1	mab-21-like 1 (C. elegans)	0.011
KCNS2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	0.011
ALX3	ALX homeobox 3	0.011
ADRA2B	adrenergic, alpha-2B-, receptor	0.011
CXCR5	chemokine (C-X-C motif) receptor 5	0.011
GLRA2	glycine receptor, alpha 2	0.011
HOXA6	homeobox A6	0.011
ETV2	ets variant 2	0.011
POU3F3	POU class 3 homeobox 3	0.011
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.011
JSRP1	junctional sarcoplasmic reticulum protein 1	0.011
KCNH6	potassium voltage-gated channel, subfamily H (eag-related), member 6	0.010
VSTM2B	V-set and transmembrane domain containing 2B	0.010
MYF6	myogenic factor 6 (herculin)	0.010
GJA3	gap junction protein, alpha 3, 46kDa	0.010
POU6F1	POU class 6 homeobox 1	0.010
HIC1	hypermethylated in cancer 1	0.010
SP5	Sp5 transcription factor	0.010
PDE4A	phosphodiesterase 4A, cAMP-specific	0.010
PROX1	prospero homeobox 1	0.010
GALR2	galanin receptor 2	0.010
LAMA5	laminin, alpha 5	0.010
ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.010
GLI1	GLI family zinc finger 1	0.010
COL18A1	collagen, type XVIII, alpha 1	0.010
ST18	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	0.010
TP73	tumor protein p73	0.010
SHE	Src homology 2 domain containing E	0.010
MADCAM1	mucosal vascular addressin cell adhesion molecule 1	0.010
MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.010
TLX3	T-cell leukemia homeobox 3	0.010
HOXD10	homeobox D10	0.010
CRHR2	corticotropin releasing hormone receptor 2	0.010
TWIST1	twist homolog 1 (Drosophila)	0.010
HSPA12B	heat shock 70kD protein 12B	0.010
MCOLN2	mucolipin 2	0.010
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.010
BFSP2	beaded filament structural protein 2, phakinin	0.010
LHX6	LIM homeobox 6	0.010
PRRX2	paired related homeobox 2	0.010
C7orf16	chromosome 7 open reading frame 16	0.010
SLIT2	slit homolog 2 (Drosophila)	0.010
NYX	nyctalopin	0.010
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E	0.010
TEAD2	TEA domain family member 2	0.010
P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	0.010
FIBCD1	fibrinogen C domain containing 1	0.010
KRT31	keratin 31	0.010
GJA4	gap junction protein, alpha 4, 37kDa	0.010
NPR3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	0.010