IMP

Process View

Homo sapiens

1 genes annotated in human

negative regulation of cd4 positive alpha beta t cell activation

GO:2000515

Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cd4 positive alpha beta t cell activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cd4 positive alpha beta t cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	0.999
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.995
CCL4	chemokine (C-C motif) ligand 4	0.946	Human
IL8	interleukin 8	0.896
IL2RG	interleukin 2 receptor, gamma	0.881
CCL2	chemokine (C-C motif) ligand 2	0.730	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.725
CCL13	chemokine (C-C motif) ligand 13	0.588	Human
DPP4	dipeptidyl-peptidase 4	0.498
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.460	Human
IL1B	interleukin 1, beta	0.388
IDE	insulin-degrading enzyme	0.382
CCR7	chemokine (C-C motif) receptor 7	0.382
CCL8	chemokine (C-C motif) ligand 8	0.340	Human
CCL22	chemokine (C-C motif) ligand 22	0.227	Human
CCL5	chemokine (C-C motif) ligand 5	0.227	Human
IL7R	interleukin 7 receptor	0.206
CCR1	chemokine (C-C motif) receptor 1	0.192
IL6	interleukin 6 (interferon, beta 2)	0.186
CXCL2	chemokine (C-X-C motif) ligand 2	0.163
CXCL10	chemokine (C-X-C motif) ligand 10	0.160
CCR4	chemokine (C-C motif) receptor 4	0.148
CXCL3	chemokine (C-X-C motif) ligand 3	0.134
CCL11	chemokine (C-C motif) ligand 11	0.129	Human
CXCL13	chemokine (C-X-C motif) ligand 13	0.124
CCL3	chemokine (C-C motif) ligand 3	0.121	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.117
CCL7	chemokine (C-C motif) ligand 7	0.107	Human
SOCS3	suppressor of cytokine signaling 3	0.094
VCAM1	vascular cell adhesion molecule 1	0.089
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.082
CCL19	chemokine (C-C motif) ligand 19	0.080	Human
PCDH9	protocadherin 9	0.078
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.076
SELE	selectin E	0.073
TNF	tumor necrosis factor	0.065
CD40	CD40 molecule, TNF receptor superfamily member 5	0.061
CD83	CD83 molecule	0.060
RGS1	regulator of G-protein signaling 1	0.060
ICAM1	intercellular adhesion molecule 1	0.059
NCOR2	nuclear receptor corepressor 2	0.058
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.056
FPR3	formyl peptide receptor 3	0.055
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.053
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.052
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.052
IL10	interleukin 10	0.049
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.047
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.046
CH25H	cholesterol 25-hydroxylase	0.045
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.044
IFNG	interferon, gamma	0.042
DARC	Duffy blood group, chemokine receptor	0.041
EBI3	Epstein-Barr virus induced 3	0.041
ARRB1	arrestin, beta 1	0.041
IL1RN	interleukin 1 receptor antagonist	0.040
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.039
HDAC9	histone deacetylase 9	0.039
IL13	interleukin 13	0.038
IRF4	interferon regulatory factor 4	0.038
EPOR	erythropoietin receptor	0.037
CXCL5	chemokine (C-X-C motif) ligand 5	0.037
IL18RAP	interleukin 18 receptor accessory protein	0.036
CCR3	chemokine (C-C motif) receptor 3	0.033
IL2RB	interleukin 2 receptor, beta	0.032
HDAC5	histone deacetylase 5	0.032
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.031
CCL21	chemokine (C-C motif) ligand 21	0.030
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.030
INHBA	inhibin, beta A	0.029
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.029
MSC	musculin	0.028
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.027
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.027
CCL17	chemokine (C-C motif) ligand 17	0.026	Human
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.026
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.026
ZC3H12A	zinc finger CCCH-type containing 12A	0.025
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.024
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.024
XCL2	chemokine (C motif) ligand 2	0.024	Human
CSF1	colony stimulating factor 1 (macrophage)	0.023
XCL1	chemokine (C motif) ligand 1	0.023
CD69	CD69 molecule	0.023
KDM2A	lysine (K)-specific demethylase 2A	0.023
STAT4	signal transducer and activator of transcription 4	0.022
IL1R2	interleukin 1 receptor, type II	0.022
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.021
LAMP3	lysosomal-associated membrane protein 3	0.021
UBD	ubiquitin D	0.020
IDO1	indoleamine 2,3-dioxygenase 1	0.020
BATF	basic leucine zipper transcription factor, ATF-like	0.020
CCL1	chemokine (C-C motif) ligand 1	0.020	Human
CCL20	chemokine (C-C motif) ligand 20	0.019	Human
NNMT	nicotinamide N-methyltransferase	0.018
BCL2A1	BCL2-related protein A1	0.018
RGS16	regulator of G-protein signaling 16	0.018
DDX6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.017
SLAMF8	SLAM family member 8	0.017
GADD45B	growth arrest and DNA-damage-inducible, beta	0.017
CCL23	chemokine (C-C motif) ligand 23	0.017	Human
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.017
CRMP1	collapsin response mediator protein 1	0.017
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.017
OASL	2'-5'-oligoadenylate synthetase-like	0.017
IL32	interleukin 32	0.017
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.016
ADAMDEC1	ADAM-like, decysin 1	0.016
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.016
CCBP2	chemokine binding protein 2	0.016
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.016
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.015
IL1R1	interleukin 1 receptor, type I	0.015
IL1A	interleukin 1, alpha	0.015
LRRC32	leucine rich repeat containing 32	0.015
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.015
TM7SF4	transmembrane 7 superfamily member 4	0.014
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.014
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.014
IL11	interleukin 11	0.014
IL21R	interleukin 21 receptor	0.014
SOD2	superoxide dismutase 2, mitochondrial	0.014
C2	complement component 2	0.013
ZNF280D	zinc finger protein 280D	0.013
C5AR1	complement component 5a receptor 1	0.013
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.013
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.013
APOC1	apolipoprotein C-I	0.013
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.013
TSPYL4	TSPY-like 4	0.013
CCRL2	chemokine (C-C motif) receptor-like 2	0.013
EBF1	early B-cell factor 1	0.013
ARIH2	ariadne homolog 2 (Drosophila)	0.013
CHIT1	chitinase 1 (chitotriosidase)	0.013
BTG2	BTG family, member 2	0.013
NKG7	natural killer cell group 7 sequence	0.013
CLEC10A	C-type lectin domain family 10, member A	0.012
TPSB2	tryptase beta 2 (gene/pseudogene)	0.012
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.012
SCARF1	scavenger receptor class F, member 1	0.012
PLEK	pleckstrin	0.012
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.012
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.012
IL4	interleukin 4	0.012	Mouse
CD209	CD209 molecule	0.012
DNASE1L3	deoxyribonuclease I-like 3	0.012
CXCR5	chemokine (C-X-C motif) receptor 5	0.012
STAT5A	signal transducer and activator of transcription 5A	0.012
PI3	peptidase inhibitor 3, skin-derived	0.011
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.011
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.011
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.011
GPR109B	G protein-coupled receptor 109B	0.011
CXCR3	chemokine (C-X-C motif) receptor 3	0.011
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.011
GNLY	granulysin	0.011
CXCR6	chemokine (C-X-C motif) receptor 6	0.011
OSMR	oncostatin M receptor	0.011
IL4I1	interleukin 4 induced 1	0.011
IL18R1	interleukin 18 receptor 1	0.011
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.011
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.011
SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.011
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.011
RGL1	ral guanine nucleotide dissociation stimulator-like 1	0.011
IL12RB2	interleukin 12 receptor, beta 2	0.011
NACC1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.011
IL13RA1	interleukin 13 receptor, alpha 1	0.011
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.010
HDAC4	histone deacetylase 4	0.010
IFNB1	interferon, beta 1, fibroblast	0.010
RUNX3	runt-related transcription factor 3	0.010
CCIN	calicin	0.010
CAMSAP1L1	calmodulin regulated spectrin-associated protein 1-like 1	0.010
CX3CL1	chemokine (C-X3-C motif) ligand 1	0.010
SAP30L	SAP30-like	0.010
PTGES	prostaglandin E synthase	0.010
IL2	interleukin 2	0.010
CD160	CD160 molecule	0.010
AQP9	aquaporin 9	0.010
BDKRB1	bradykinin receptor B1	0.010
OSM	oncostatin M	0.010
SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	0.010
PTK6	PTK6 protein tyrosine kinase 6	0.010
IL1F5	interleukin 1 family, member 5 (delta)	0.010