IMP

Process View

Homo sapiens

2 genes annotated in human

establishment of t cell polarity

The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of t cell polarity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment of t cell polarity" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
CCL4	chemokine (C-C motif) ligand 4	0.993	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.985
CCL2	chemokine (C-C motif) ligand 2	0.972	Human
IL1B	interleukin 1, beta	0.879
IDE	insulin-degrading enzyme	0.858
IL8	interleukin 8	0.814
CCL5	chemokine (C-C motif) ligand 5	0.805	Human
CCR7	chemokine (C-C motif) receptor 7	0.777
DPP4	dipeptidyl-peptidase 4	0.720
CCL19	chemokine (C-C motif) ligand 19	0.669
CCL8	chemokine (C-C motif) ligand 8	0.657	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.556	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.555
CXCL10	chemokine (C-X-C motif) ligand 10	0.455
CXCL3	chemokine (C-X-C motif) ligand 3	0.397
CCL22	chemokine (C-C motif) ligand 22	0.363	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.350
IL6	interleukin 6 (interferon, beta 2)	0.348
CCL13	chemokine (C-C motif) ligand 13	0.308	Human
CCL3	chemokine (C-C motif) ligand 3	0.291	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.287
IFNG	interferon, gamma	0.267
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.253
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.231
CXCL13	chemokine (C-X-C motif) ligand 13	0.216
TNF	tumor necrosis factor	0.165
MYL9	myosin, light chain 9, regulatory	0.156
VCAM1	vascular cell adhesion molecule 1	0.151
CXCL5	chemokine (C-X-C motif) ligand 5	0.147
CCR4	chemokine (C-C motif) receptor 4	0.147
RGS1	regulator of G-protein signaling 1	0.134
CD83	CD83 molecule	0.133
IL10	interleukin 10	0.111
SELE	selectin E	0.105
DARC	Duffy blood group, chemokine receptor	0.104
CCR1	chemokine (C-C motif) receptor 1	0.099
CCL7	chemokine (C-C motif) ligand 7	0.092	Human
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.091
IL7R	interleukin 7 receptor	0.086
IL2RB	interleukin 2 receptor, beta	0.080
IL2RG	interleukin 2 receptor, gamma	0.074
ASCC2	activating signal cointegrator 1 complex subunit 2	0.073
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.068
ICAM1	intercellular adhesion molecule 1	0.064
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.063
FPR3	formyl peptide receptor 3	0.061
IL32	interleukin 32	0.059
CH25H	cholesterol 25-hydroxylase	0.056
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.049
ARRB1	arrestin, beta 1	0.048
EBI3	Epstein-Barr virus induced 3	0.046
SLAMF8	SLAM family member 8	0.045
MEN1	multiple endocrine neoplasia I	0.045
FLNA	filamin A, alpha	0.044
UBD	ubiquitin D	0.043
CCL11	chemokine (C-C motif) ligand 11	0.043	Human
CCR3	chemokine (C-C motif) receptor 3	0.040
LAMP3	lysosomal-associated membrane protein 3	0.040
IL1R2	interleukin 1 receptor, type II	0.040
SLAMF7	SLAM family member 7	0.037
BCL2A1	BCL2-related protein A1	0.037
FLNB	filamin B, beta	0.034
IL21R	interleukin 21 receptor	0.033
ADAMDEC1	ADAM-like, decysin 1	0.032
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.031
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.031
XCL2	chemokine (C motif) ligand 2	0.031	Human
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.031
IL10RA	interleukin 10 receptor, alpha	0.030
STAT4	signal transducer and activator of transcription 4	0.030
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.029
CLEC10A	C-type lectin domain family 10, member A	0.028
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.028
CCL23	chemokine (C-C motif) ligand 23	0.028	Human
CD80	CD80 molecule	0.028
CCL17	chemokine (C-C motif) ligand 17	0.028	Human
TARP	TCR gamma alternate reading frame protein	0.027
MSC	musculin	0.027
CD40	CD40 molecule, TNF receptor superfamily member 5	0.026
CCL21	chemokine (C-C motif) ligand 21	0.026
IL18RAP	interleukin 18 receptor accessory protein	0.025
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.024
APOC1	apolipoprotein C-I	0.023
INHBA	inhibin, beta A	0.023
CCL20	chemokine (C-C motif) ligand 20	0.023	Human
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.023
TRAF1	TNF receptor-associated factor 1	0.022
GNLY	granulysin	0.022
IDO1	indoleamine 2,3-dioxygenase 1	0.022
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.021
DNASE1L3	deoxyribonuclease I-like 3	0.020
RGS16	regulator of G-protein signaling 16	0.020
SRGN	serglycin	0.019
CD69	CD69 molecule	0.019
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.019
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.018
CCRL2	chemokine (C-C motif) receptor-like 2	0.018
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.018
CXCR6	chemokine (C-X-C motif) receptor 6	0.018
PLEK	pleckstrin	0.017
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.017
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.017
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.017
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.016
IL1A	interleukin 1, alpha	0.016
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.016
ICOS	inducible T-cell co-stimulator	0.016
C1QA	complement component 1, q subcomponent, A chain	0.015
C2	complement component 2	0.015
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.015
TM7SF4	transmembrane 7 superfamily member 4	0.015
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.015
CXCR3	chemokine (C-X-C motif) receptor 3	0.015
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.015
XCL1	chemokine (C motif) ligand 1	0.015	Human
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.015
CCL1	chemokine (C-C motif) ligand 1	0.014	Human
SLAMF1	signaling lymphocytic activation molecule family member 1	0.014
PDPN	podoplanin	0.014
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.014
SOD2	superoxide dismutase 2, mitochondrial	0.013
IL13	interleukin 13	0.013
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.013
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.013
BATF	basic leucine zipper transcription factor, ATF-like	0.013
CD1B	CD1b molecule	0.013
IL18R1	interleukin 18 receptor 1	0.013
GAB2	GRB2-associated binding protein 2	0.013
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.013
CD40LG	CD40 ligand	0.013
RUNX3	runt-related transcription factor 3	0.013
CD48	CD48 molecule	0.013
IRF4	interferon regulatory factor 4	0.013
IL1RN	interleukin 1 receptor antagonist	0.013
PRDM1	PR domain containing 1, with ZNF domain	0.013
IL2RA	interleukin 2 receptor, alpha	0.012
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.012
C1QB	complement component 1, q subcomponent, B chain	0.012
PLAU	plasminogen activator, urokinase	0.011
IL11	interleukin 11	0.011
IL4	interleukin 4	0.011
CHIT1	chitinase 1 (chitotriosidase)	0.011
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.011
GPR109B	G protein-coupled receptor 109B	0.011
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.011
CCR6	chemokine (C-C motif) receptor 6	0.011
PI3	peptidase inhibitor 3, skin-derived	0.011
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.011
LAG3	lymphocyte-activation gene 3	0.011
MMP19	matrix metallopeptidase 19	0.011
C3AR1	complement component 3a receptor 1	0.011
CD247	CD247 molecule	0.011
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.011
NKG7	natural killer cell group 7 sequence	0.011
CSF1	colony stimulating factor 1 (macrophage)	0.010
CCBP2	chemokine binding protein 2	0.010
CD1A	CD1a molecule	0.010
CD160	CD160 molecule	0.010
DPT	dermatopontin	0.010
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.010