IMP

Process View

Mus musculus

8 genes annotated in mouse

axial mesoderm development

The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "axial mesoderm development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "axial mesoderm development" (in gray)

Name	Description	Probability	Func Analog Organism
Nodal	nodal	0.994
Fgfr2	fibroblast growth factor receptor 2	0.981
Shh	sonic hedgehog	0.974
Lef1	lymphoid enhancer binding factor 1	0.934	Mouse
Gli3	GLI-Kruppel family member GLI3	0.838
Foxa2	forkhead box A2	0.765	Zebrafish
Bmp7	bone morphogenetic protein 7	0.758	Mouse
Ephb2	Eph receptor B2	0.751	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.711
Ctnnb1	catenin (cadherin associated protein), beta 1	0.705
Zic3	zinc finger protein of the cerebellum 3	0.684
Vangl2	vang-like 2 (van gogh, Drosophila)	0.613
Gli2	GLI-Kruppel family member GLI2	0.579
Fgfr3	fibroblast growth factor receptor 3	0.565
Epha4	Eph receptor A4	0.533	Mouse
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.509
Bmp4	bone morphogenetic protein 4	0.506
Gdf1	growth differentiation factor 1	0.387
Foxc1	forkhead box C1	0.374
Smo	smoothened homolog (Drosophila)	0.370
Dnahc11	dynein, axonemal, heavy chain 11	0.353
Epb4.1l5	erythrocyte protein band 4.1-like 5	0.344
Rpgrip1l	Rpgrip1-like	0.325
Gsk3b	glycogen synthase kinase 3 beta	0.301
Pitx2	paired-like homeodomain transcription factor 2	0.253
Fgfr1	fibroblast growth factor receptor 1	0.252
Smad6	MAD homolog 6 (Drosophila)	0.248
Efnb1	ephrin B1	0.237
Rarg	retinoic acid receptor, gamma	0.221
Smad3	MAD homolog 3 (Drosophila)	0.212
Chrd	chordin	0.191
Mks1	Meckel syndrome, type 1	0.187
Mecom	MDS1 and EVI1 complex locus	0.184
Tbx3	T-box 3	0.178
Tcf7	transcription factor 7, T-cell specific	0.155	Mouse
Hand1	heart and neural crest derivatives expressed transcript 1	0.150
Lhx1	LIM homeobox protein 1	0.141
Foxh1	forkhead box H1	0.136
Gsc	goosecoid homeobox	0.126
Lrp5	low density lipoprotein receptor-related protein 5	0.121
Lrp6	low density lipoprotein receptor-related protein 6	0.113
Apc	adenomatosis polyposis coli	0.106
Dlx5	distal-less homeobox 5	0.103
Gata5	GATA binding protein 5	0.101
Axin2	axin2	0.100	Mouse
Gata4	GATA binding protein 4	0.084
Hoxa5	homeobox A5	0.084
Sox11	SRY-box containing gene 11	0.084
Eomes	eomesodermin homolog (Xenopus laevis)	0.077
Kif3a	kinesin family member 3A	0.077
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.075
Tdgf1	teratocarcinoma-derived growth factor 1	0.075
Cfc1	cripto, FRL-1, cryptic family 1	0.073
Cdx2	caudal type homeobox 2	0.072
Efnb2	ephrin B2	0.071
Ptk2	PTK2 protein tyrosine kinase 2	0.069
Itga3	integrin alpha 3	0.062
Irs1	insulin receptor substrate 1	0.058
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.058
Foxc2	forkhead box C2	0.055
Wnt3	wingless-related MMTV integration site 3	0.055
Pax3	paired box gene 3	0.054
Msx1	homeobox, msh-like 1	0.053
Cldn6	claudin 6	0.051
Rps28	ribosomal protein S28	0.051
Efna4	ephrin A4	0.051
Msx2	homeobox, msh-like 2	0.050
Fgf8	fibroblast growth factor 8	0.050
Wnt5a	wingless-related MMTV integration site 5A	0.048
Tbx6	T-box 6	0.048
Sox9	SRY-box containing gene 9	0.047
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.045
Pax1	paired box gene 1	0.045
Meox2	mesenchyme homeobox 2	0.042
Smad7	MAD homolog 7 (Drosophila)	0.039
Foxj1	forkhead box J1	0.039
Ephb3	Eph receptor B3	0.038	Mouse
T	brachyury	0.036
Ptk7	PTK7 protein tyrosine kinase 7	0.036
Foxa1	forkhead box A1	0.035	Zebrafish
Smad2	MAD homolog 2 (Drosophila)	0.034
Ppap2b	phosphatidic acid phosphatase type 2B	0.033
Cldn3	claudin 3	0.031
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.031
Hnf4a	hepatic nuclear factor 4, alpha	0.030
Nkx2-1	NK2 homeobox 1	0.030
Gas1	growth arrest specific 1	0.029
Pbx1	pre B-cell leukemia transcription factor 1	0.029
Lefty1	left right determination factor 1	0.029
Sox3	SRY-box containing gene 3	0.029
Gata6	GATA binding protein 6	0.028
Isl1	ISL1 transcription factor, LIM/homeodomain	0.028
Gpc3	glypican 3	0.028
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.028
Hand2	heart and neural crest derivatives expressed transcript 2	0.027
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.025
Cdh1	cadherin 1	0.024
Hoxd13	homeobox D13	0.023
Syt9	synaptotagmin IX	0.023
Bmp2	bone morphogenetic protein 2	0.023
Ret	ret proto-oncogene	0.023
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.023
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.022
Emid2	EMI domain containing 2	0.022
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.022
Gdf3	growth differentiation factor 3	0.020
Zfhx4	zinc finger homeodomain 4	0.019
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.019
Gli1	GLI-Kruppel family member GLI1	0.019
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.018
Rnf111	ring finger 111	0.018
Nog	noggin	0.017
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.017
Tgif2	TGFB-induced factor homeobox 2	0.017
Htt	huntingtin	0.017
Hapln1	hyaluronan and proteoglycan link protein 1	0.017
Wnt3a	wingless-related MMTV integration site 3A	0.017
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.017
Spry4	sprouty homolog 4 (Drosophila)	0.017
Sfrp2	secreted frizzled-related protein 2	0.016
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.015
Pthlh	parathyroid hormone-like peptide	0.015
Fgf18	fibroblast growth factor 18	0.015
Hes1	hairy and enhancer of split 1 (Drosophila)	0.015
Pax9	paired box gene 9	0.015
Acvr2b	activin receptor IIB	0.015
Hic1	hypermethylated in cancer 1	0.015
Klf5	Kruppel-like factor 5	0.015
Padi3	peptidyl arginine deiminase, type III	0.015
Ptch1	patched homolog 1	0.014
Emx1	empty spiracles homolog 1 (Drosophila)	0.014
Acvr1	activin A receptor, type 1	0.014
Tcf21	transcription factor 21	0.014
Tbx2	T-box 2	0.014
Rps14	ribosomal protein S14	0.013
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.013
Pou3f1	POU domain, class 3, transcription factor 1	0.013
Rarb	retinoic acid receptor, beta	0.013
Fgf5	fibroblast growth factor 5	0.013
Efna2	ephrin A2	0.012
Kcnk2	potassium channel, subfamily K, member 2	0.012
Fzd9	frizzled homolog 9 (Drosophila)	0.012
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.012
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.012
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.011
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.011
Zfhx3	zinc finger homeobox 3	0.011
Rara	retinoic acid receptor, alpha	0.011
Epha2	Eph receptor A2	0.011
Pnliprp2	pancreatic lipase-related protein 2	0.011
Onecut1	one cut domain, family member 1	0.010
Clcn2	chloride channel 2	0.010
Lefty2	left-right determination factor 2	0.010