IMP

Process View

Mus musculus

12 genes annotated in mouse

Multi-species View

positive regulation of bone mineralization

GO:0030501

Any process that activates or increases the frequency, rate or extent of bone mineralization.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of bone mineralization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of bone mineralization" (in gray)

Name	Description	Probability	Func Analog Organism
Tgfb2	transforming growth factor, beta 2	0.853
Gli3	GLI-Kruppel family member GLI3	0.847
Fgfr2	fibroblast growth factor receptor 2	0.820
Msx1	homeobox, msh-like 1	0.799
Prrx2	paired related homeobox 2	0.791
Tbx1	T-box 1	0.762
Shh	sonic hedgehog	0.737
Prrx1	paired related homeobox 1	0.693
Lhx1	LIM homeobox protein 1	0.673
Sox9	SRY-box containing gene 9	0.645
Smo	smoothened homolog (Drosophila)	0.640
Fgfr1	fibroblast growth factor receptor 1	0.554
Gli2	GLI-Kruppel family member GLI2	0.511
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.482
Bmp4	bone morphogenetic protein 4	0.475	Human Rat
Pthlh	parathyroid hormone-like peptide	0.417
Fgf8	fibroblast growth factor 8	0.389
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.380
Foxc1	forkhead box C1	0.371
Runx2	runt related transcription factor 2	0.352
Fgfr3	fibroblast growth factor receptor 3	0.299
Kl	klotho	0.294
Bmp7	bone morphogenetic protein 7	0.266	Human
Acvr1	activin A receptor, type 1	0.243	Human
Bmp2	bone morphogenetic protein 2	0.193	Human
Chrd	chordin	0.141
Hand1	heart and neural crest derivatives expressed transcript 1	0.141
Ctnnb1	catenin (cadherin associated protein), beta 1	0.132
Hand2	heart and neural crest derivatives expressed transcript 2	0.129
Col1a1	collagen, type I, alpha 1	0.123
Tgfbr2	transforming growth factor, beta receptor II	0.120
Dlx5	distal-less homeobox 5	0.110
Msx2	homeobox, msh-like 2	0.109
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.100
Smad4	MAD homolog 4 (Drosophila)	0.094
Cd80	CD80 antigen	0.084
Nog	noggin	0.084
Pax3	paired box gene 3	0.082
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.082
Alx4	aristaless-like homeobox 4	0.078
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.073
Gata4	GATA binding protein 4	0.073
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.072
Smad6	MAD homolog 6 (Drosophila)	0.069
Gata6	GATA binding protein 6	0.065
Fzd1	frizzled homolog 1 (Drosophila)	0.061
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.061
Nodal	nodal	0.060
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.058
Vdr	vitamin D receptor	0.054
Wnt4	wingless-related MMTV integration site 4	0.053	Mouse
Pax9	paired box gene 9	0.051
Alx3	aristaless-like homeobox 3	0.051
ND6	NADH dehydrogenase subunit 6	0.044
Ednra	endothelin receptor type A	0.043
Pnpla2	patatin-like phospholipase domain containing 2	0.040
Tbx2	T-box 2	0.039
Hdac4	histone deacetylase 4	0.039
Ptch1	patched homolog 1	0.039
Fgf5	fibroblast growth factor 5	0.037
Rarb	retinoic acid receptor, beta	0.037
Sstr4	somatostatin receptor 4	0.036
Fgf18	fibroblast growth factor 18	0.036
Wnt7a	wingless-related MMTV integration site 7A	0.036	Mouse
Fgf23	fibroblast growth factor 23	0.036
Foxc2	forkhead box C2	0.034
Fzd2	frizzled homolog 2 (Drosophila)	0.034
Meox2	mesenchyme homeobox 2	0.034
Dlx6	distal-less homeobox 6	0.033
Twist1	twist homolog 1 (Drosophila)	0.033
Wnt10b	wingless related MMTV integration site 10b	0.033
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.032
Il6st	interleukin 6 signal transducer	0.030
Adrb2	adrenergic receptor, beta 2	0.030
Gdnf	glial cell line derived neurotrophic factor	0.030
En1	engrailed 1	0.029
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.029
Hoxa2	homeobox A2	0.029
Fzd8	frizzled homolog 8 (Drosophila)	0.027
Gpc3	glypican 3	0.027
Gas1	growth arrest specific 1	0.027
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.027
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.025
Grid1	glutamate receptor, ionotropic, delta 1	0.023
Wt1	Wilms tumor 1 homolog	0.023
Casr	calcium-sensing receptor	0.023
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.023
Rbl2	retinoblastoma-like 2	0.023
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.022
Tbx15	T-box 15	0.021
Smad2	MAD homolog 2 (Drosophila)	0.021
Hoxc5	homeobox C5	0.021
Wnt3	wingless-related MMTV integration site 3	0.020	Mouse
Bnc1	basonuclin 1	0.020
Emid2	EMI domain containing 2	0.020
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.019
Wnt3a	wingless-related MMTV integration site 3A	0.019	Mouse
Mmp2	matrix metallopeptidase 2	0.019
Apc	adenomatosis polyposis coli	0.019
Pbx1	pre B-cell leukemia transcription factor 1	0.019
Mef2c	myocyte enhancer factor 2C	0.019
Hoxd13	homeobox D13	0.019
Col2a1	collagen, type II, alpha 1	0.018
Tacr1	tachykinin receptor 1	0.018
Pou3f1	POU domain, class 3, transcription factor 1	0.018
Gli1	GLI-Kruppel family member GLI1	0.018
Adrb1	adrenergic receptor, beta 1	0.018	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.018
Rarg	retinoic acid receptor, gamma	0.018
Bmp5	bone morphogenetic protein 5	0.018
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.018
Fbn1	fibrillin 1	0.018	Mouse
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.018
Pdcd1	programmed cell death 1	0.017
Tgfbr1	transforming growth factor, beta receptor I	0.017
Mmp11	matrix metallopeptidase 11	0.016
Foxi3	forkhead box I3	0.016
Fgf9	fibroblast growth factor 9	0.016
Pparg	peroxisome proliferator activated receptor gamma	0.016
Csf1	colony stimulating factor 1 (macrophage)	0.016
Esr2	estrogen receptor 2 (beta)	0.016
Adra2c	adrenergic receptor, alpha 2c	0.016	Mouse
Crebbp	CREB binding protein	0.015
Cdh6	cadherin 6	0.015
Lrp6	low density lipoprotein receptor-related protein 6	0.015
Emp2	epithelial membrane protein 2	0.015
Rbl1	retinoblastoma-like 1 (p107)	0.015
Hoxd11	homeobox D11	0.015
Ihh	Indian hedgehog	0.015
Drd2	dopamine receptor D2	0.015
Wnt6	wingless-related MMTV integration site 6	0.015	Mouse
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.014
Pou3f3	POU domain, class 3, transcription factor 3	0.014
Rara	retinoic acid receptor, alpha	0.014
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.014
Trp63	transformation related protein 63	0.014
Lef1	lymphoid enhancer binding factor 1	0.014
Ddr2	discoidin domain receptor family, member 2	0.014
Wnt5b	wingless-related MMTV integration site 5B	0.013	Mouse
Hoxc8	homeobox C8	0.013
Fkbp10	FK506 binding protein 10	0.013
Gjb5	gap junction protein, beta 5	0.013
Hoxd9	homeobox D9	0.013
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.013
Fzd7	frizzled homolog 7 (Drosophila)	0.013
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.013
Efna4	ephrin A4	0.013
Mn1	meningioma 1	0.013
Tead2	TEA domain family member 2	0.013
Mpz	myelin protein zero	0.013
Smad7	MAD homolog 7 (Drosophila)	0.012
Ptk7	PTK7 protein tyrosine kinase 7	0.012
Sh3pxd2a	SH3 and PX domains 2A	0.012
Tcfap2a	transcription factor AP-2, alpha	0.012	Human
Sfrp2	secreted frizzled-related protein 2	0.012
Nf1	neurofibromatosis 1	0.012
Hdac5	histone deacetylase 5	0.012
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.012	Human
Hoxb3	homeobox B3	0.012
Zfp503	zinc finger protein 503	0.012
Lhx6	LIM homeobox protein 6	0.012
Sfrp1	secreted frizzled-related protein 1	0.012
Gja1	gap junction protein, alpha 1	0.012
Scube1	signal peptide, CUB domain, EGF-like 1	0.012
Pth1r	parathyroid hormone 1 receptor	0.011
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.011
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.011
Rspo1	R-spondin homolog (Xenopus laevis)	0.011
Acvr2a	activin receptor IIA	0.011	Human
Gpr3	G-protein coupled receptor 3	0.011
Ltbp3	latent transforming growth factor beta binding protein 3	0.011
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.011
Bmper	BMP-binding endothelial regulator	0.011
Gsc	goosecoid homeobox	0.011
Sox4	SRY-box containing gene 4	0.011
Dlx2	distal-less homeobox 2	0.010
Lmx1b	LIM homeobox transcription factor 1 beta	0.010
Ccdc24	coiled-coil domain containing 24	0.010
Timp2	tissue inhibitor of metalloproteinase 2	0.010
Sstr1	somatostatin receptor 1	0.010
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.010
Kcnk3	potassium channel, subfamily K, member 3	0.010
Wnt2	wingless-related MMTV integration site 2	0.010	Mouse
Col5a1	collagen, type V, alpha 1	0.010