IMP

Process View

Mus musculus

7 genes annotated in mouse

type i pneumocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a Type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type i pneumocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "type i pneumocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Thra	thyroid hormone receptor alpha	1.000
Rarg	retinoic acid receptor, gamma	0.989	Mouse
Pax8	paired box gene 8	0.988
Pten	phosphatase and tensin homolog	0.928
Ghr	growth hormone receptor	0.853
Fgfr2	fibroblast growth factor receptor 2	0.844
Rxra	retinoid X receptor alpha	0.838
Nfib	nuclear factor I/B	0.735
Nfic	nuclear factor I/C	0.678	Mouse
Pax2	paired box gene 2	0.672
Rara	retinoic acid receptor, alpha	0.620	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.609
Duox2	dual oxidase 2	0.569
Nfix	nuclear factor I/X	0.538	Mouse
Ar	androgen receptor	0.495
Fgfr1	fibroblast growth factor receptor 1	0.486
Lepr	leptin receptor	0.481
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.408
Thrb	thyroid hormone receptor beta	0.382
Igf1r	insulin-like growth factor I receptor	0.366
Rarb	retinoic acid receptor, beta	0.288	Mouse
Emx2	empty spiracles homolog 2 (Drosophila)	0.277
Pbx1	pre B-cell leukemia transcription factor 1	0.262
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.261
Ncoa1	nuclear receptor coactivator 1	0.254
Foxc1	forkhead box C1	0.226
Jun	Jun oncogene	0.222
Klf4	Kruppel-like factor 4 (gut)	0.216	Mouse
Ece1	endothelin converting enzyme 1	0.210
Sox9	SRY-box containing gene 9	0.205
Irs2	insulin receptor substrate 2	0.199
Adam17	a disintegrin and metallopeptidase domain 17	0.189
Esr1	estrogen receptor 1 (alpha)	0.169
Nos3	nitric oxide synthase 3, endothelial cell	0.164
Egfr	epidermal growth factor receptor	0.160
Rhob	ras homolog gene family, member B	0.120
Hoxb3	homeobox B3	0.118
Trp63	transformation related protein 63	0.115
Dusp1	dual specificity phosphatase 1	0.109
Insr	insulin receptor	0.106
Jag1	jagged 1	0.100
Eya1	eyes absent 1 homolog (Drosophila)	0.090
Pitx2	paired-like homeodomain transcription factor 2	0.090
Nfia	nuclear factor I/A	0.088	Mouse
Wnt9b	wingless-type MMTV integration site 9B	0.087
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.085
Sox2	SRY-box containing gene 2	0.085
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.082
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.080
Dbp	D site albumin promoter binding protein	0.080
Klf6	Kruppel-like factor 6	0.076	Mouse
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.072
Fos	FBJ osteosarcoma oncogene	0.071
Chd7	chromodomain helicase DNA binding protein 7	0.069
Gli3	GLI-Kruppel family member GLI3	0.064
Grb10	growth factor receptor bound protein 10	0.056
Ins2	insulin II	0.054	Mouse
Ncor1	nuclear receptor co-repressor 1	0.054	Mouse
Crebbp	CREB binding protein	0.052
Epor	erythropoietin receptor	0.046
Gli2	GLI-Kruppel family member GLI2	0.045
Mef2a	myocyte enhancer factor 2A	0.045
Fgf10	fibroblast growth factor 10	0.045
Ahr	aryl-hydrocarbon receptor	0.045
Lhx1	LIM homeobox protein 1	0.044
Pou5f1	POU domain, class 5, transcription factor 1	0.042
Ltbp4	latent transforming growth factor beta binding protein 4	0.042
Irs1	insulin receptor substrate 1	0.039
Foxa2	forkhead box A2	0.036
Irf2bp2	interferon regulatory factor 2 binding protein 2	0.036
Prlr	prolactin receptor	0.035
Vangl2	vang-like 2 (van gogh, Drosophila)	0.034
Adcy9	adenylate cyclase 9	0.034
Apoe	apolipoprotein E	0.033
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.033
Lep	leptin	0.032
Lhx3	LIM homeobox protein 3	0.032
Mcl1	myeloid cell leukemia sequence 1	0.032
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.031
Cav1	caveolin 1, caveolae protein	0.030
Abca3	ATP-binding cassette, sub-family A (ABC1), member 3	0.029
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.028
Gna11	guanine nucleotide binding protein, alpha 11	0.028
Tshr	thyroid stimulating hormone receptor	0.028
Ifrd1	interferon-related developmental regulator 1	0.027
Dio3	deiodinase, iodothyronine type III	0.027
Btg2	B-cell translocation gene 2, anti-proliferative	0.027
Efnb2	ephrin B2	0.027
Sox4	SRY-box containing gene 4	0.026
Tgfb2	transforming growth factor, beta 2	0.025
Frmd6	FERM domain containing 6	0.025
Mapk8	mitogen-activated protein kinase 8	0.024
LOC100503041	PDZ domain-containing protein 7-like	0.023
Hoxa5	homeobox A5	0.023
Ski	ski sarcoma viral oncogene homolog (avian)	0.022
Efnb1	ephrin B1	0.022
Shh	sonic hedgehog	0.021
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.020
Gata3	GATA binding protein 3	0.019
Ush1g	Usher syndrome 1G homolog (human)	0.019
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.018
Klf7	Kruppel-like factor 7 (ubiquitous)	0.018	Mouse
Slc26a5	solute carrier family 26, member 5	0.017
Egr1	early growth response 1	0.017
Vegfa	vascular endothelial growth factor A	0.017
Zeb1	zinc finger E-box binding homeobox 1	0.017
Zfp362	zinc finger protein 362	0.017
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.016
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.015
Idua	iduronidase, alpha-L-	0.015
Hdac7	histone deacetylase 7	0.014
Osr1	odd-skipped related 1 (Drosophila)	0.013
Igf2r	insulin-like growth factor 2 receptor	0.013
Pparg	peroxisome proliferator activated receptor gamma	0.013
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.013
Bcl2	B-cell leukemia/lymphoma 2	0.013
Tenc1	tensin like C1 domain-containing phosphatase	0.013
D530037H12Rik	RIKEN cDNA D530037H12 gene	0.013
Hipk2	homeodomain interacting protein kinase 2	0.013
Ldb1	LIM domain binding 1	0.013
Ptms	parathymosin	0.013
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.012
Tnks1bp1	tankyrase 1 binding protein 1	0.012
Klf3	Kruppel-like factor 3 (basic)	0.012	Mouse
Ednra	endothelin receptor type A	0.012
Vdr	vitamin D receptor	0.012
Otx1	orthodenticle homolog 1 (Drosophila)	0.012
Kiss1	KiSS-1 metastasis-suppressor	0.012
Bmper	BMP-binding endothelial regulator	0.012
Hbb-b2	hemoglobin, beta adult minor chain	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.011
Nkx2-1	NK2 homeobox 1	0.011
Dek	DEK oncogene (DNA binding)	0.011
Espn	espin	0.011
Ctdsp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	0.011
Bmp4	bone morphogenetic protein 4	0.011
Esr2	estrogen receptor 2 (beta)	0.011
Ins1	insulin I	0.010	Mouse
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.010
Pknox1	Pbx/knotted 1 homeobox	0.010