IMP

Process View

Mus musculus

7 genes annotated in mouse

cardiac neural crest cell development involved in heart development

The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac neural crest cell development involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardiac neural crest cell development involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.997
Pitx2	paired-like homeodomain transcription factor 2	0.997
Otx2	orthodenticle homolog 2 (Drosophila)	0.986
Notch1	Notch gene homolog 1 (Drosophila)	0.977
Pax6	paired box gene 6	0.954
Foxc1	forkhead box C1	0.861
Isl1	ISL1 transcription factor, LIM/homeodomain	0.842
Fgf8	fibroblast growth factor 8	0.813
Emx1	empty spiracles homolog 1 (Drosophila)	0.812
Neurod1	neurogenic differentiation 1	0.805	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.802
Chd7	chromodomain helicase DNA binding protein 7	0.784
Tcfap2a	transcription factor AP-2, alpha	0.763
Gata4	GATA binding protein 4	0.728
Hand2	heart and neural crest derivatives expressed transcript 2	0.667
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.614
Pax3	paired box gene 3	0.576
Foxg1	forkhead box G1	0.532
Lhx3	LIM homeobox protein 3	0.486
Sox2	SRY-box containing gene 2	0.471
Pitx1	paired-like homeodomain transcription factor 1	0.462	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.438
Neurog2	neurogenin 2	0.438	Mouse
Hes1	hairy and enhancer of split 1 (Drosophila)	0.429
Notch2	Notch gene homolog 2 (Drosophila)	0.398
En1	engrailed 1	0.395
Gli3	GLI-Kruppel family member GLI3	0.393
Gsc	goosecoid homeobox	0.376
Msx1	homeobox, msh-like 1	0.358
Fgfr1	fibroblast growth factor receptor 1	0.335
Msx2	homeobox, msh-like 2	0.327
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.316
Meox2	mesenchyme homeobox 2	0.311
Hand1	heart and neural crest derivatives expressed transcript 1	0.305	Mouse
Foxc2	forkhead box C2	0.298
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.291
Eya1	eyes absent 1 homolog (Drosophila)	0.286
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.284
Tgfb2	transforming growth factor, beta 2	0.257
Ptf1a	pancreas specific transcription factor, 1a	0.246	Mouse
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.206
Bmp4	bone morphogenetic protein 4	0.188
Sox9	SRY-box containing gene 9	0.187
Dll1	delta-like 1 (Drosophila)	0.163	Mouse
Smo	smoothened homolog (Drosophila)	0.155
Tbx1	T-box 1	0.149
Hes5	hairy and enhancer of split 5 (Drosophila)	0.135	Mouse
Lhx5	LIM homeobox protein 5	0.122
Rb1	retinoblastoma 1	0.118
Prrx1	paired related homeobox 1	0.116
Jag1	jagged 1	0.113
Kiss1	KiSS-1 metastasis-suppressor	0.105
Hoxa13	homeobox A13	0.102
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.098
Pdx1	pancreatic and duodenal homeobox 1	0.095
Insm1	insulinoma-associated 1	0.091
Lmx1b	LIM homeobox transcription factor 1 beta	0.089
Nog	noggin	0.087
Vegfa	vascular endothelial growth factor A	0.080
Neurod4	neurogenic differentiation 4	0.080	Mouse
Prrx2	paired related homeobox 2	0.080
Evx2	even skipped homeotic gene 2 homolog	0.074
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.074
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.074
Hoxa1	homeobox A1	0.073
Psen1	presenilin 1	0.070
Pten	phosphatase and tensin homolog	0.068
Gbx2	gastrulation brain homeobox 2	0.063
Emx2	empty spiracles homolog 2 (Drosophila)	0.062
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.061
Hes3	hairy and enhancer of split 3 (Drosophila)	0.058	Mouse
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.055
Efna2	ephrin A2	0.052
Dlx2	distal-less homeobox 2	0.051
Gata6	GATA binding protein 6	0.051
Hoxb1	homeobox B1	0.049
Ntf3	neurotrophin 3	0.049
Pax2	paired box gene 2	0.049
Nhlh1	nescient helix loop helix 1	0.048	Mouse
Gpr50	G-protein-coupled receptor 50	0.047
Uncx	UNC homeobox	0.046
Sox11	SRY-box containing gene 11	0.045
Tlx3	T-cell leukemia, homeobox 3	0.044
Hoxa2	homeobox A2	0.043
Mesp1	mesoderm posterior 1	0.042
Neurog1	neurogenin 1	0.041	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.037
Tgfbr2	transforming growth factor, beta receptor II	0.037
Otx1	orthodenticle homolog 1 (Drosophila)	0.036
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.036
Vax1	ventral anterior homeobox containing gene 1	0.034
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.033
Ednra	endothelin receptor type A	0.031
Gli2	GLI-Kruppel family member GLI2	0.031
Foxe3	forkhead box E3	0.031
Fgf15	fibroblast growth factor 15	0.031
Rax	retina and anterior neural fold homeobox	0.031
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.030
Neurog3	neurogenin 3	0.030	Mouse
Btbd17	BTB (POZ) domain containing 17	0.029
Alx4	aristaless-like homeobox 4	0.028
Dlx1	distal-less homeobox 1	0.028
Gata1	GATA binding protein 1	0.027
Rarg	retinoic acid receptor, gamma	0.027
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.027
Efnb2	ephrin B2	0.026
Hoxd13	homeobox D13	0.026
Atoh7	atonal homolog 7 (Drosophila)	0.025	Mouse
Alx3	aristaless-like homeobox 3	0.024
Lhx9	LIM homeobox protein 9	0.023
Acvr1	activin A receptor, type 1	0.023
Nkx6-1	NK6 homeobox 1	0.023
Arx	aristaless related homeobox	0.022
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.022
Tbx3	T-box 3	0.021
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.021
Dlx5	distal-less homeobox 5	0.021
Hmx1	H6 homeobox 1	0.020
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.020
Krt14	keratin 14	0.018
Fgf4	fibroblast growth factor 4	0.018
Snai1	snail homolog 1 (Drosophila)	0.018
Srrm4	serine/arginine repetitive matrix 4	0.018
Runx2	runt related transcription factor 2	0.018
Eng	endoglin	0.017
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.017
Tal1	T-cell acute lymphocytic leukemia 1	0.017	Mouse
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.017
Hoxd11	homeobox D11	0.017
Myf5	myogenic factor 5	0.016
Rxra	retinoid X receptor alpha	0.016
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.016
Sall3	sal-like 3 (Drosophila)	0.016
Egfr	epidermal growth factor receptor	0.015
Pax9	paired box gene 9	0.015
Tcf15	transcription factor 15	0.015	Mouse
Twist1	twist homolog 1 (Drosophila)	0.014
Dlx6	distal-less homeobox 6	0.014
Amhr2	anti-Mullerian hormone type 2 receptor	0.014
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.014
Onecut1	one cut domain, family member 1	0.014
Tbx4	T-box 4	0.014
Pou4f3	POU domain, class 4, transcription factor 3	0.014
Shox2	short stature homeobox 2	0.013
Foxh1	forkhead box H1	0.013
Wnt6	wingless-related MMTV integration site 6	0.013
Fgf17	fibroblast growth factor 17	0.013
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.013
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.013
Rarb	retinoic acid receptor, beta	0.013
Gja1	gap junction protein, alpha 1	0.013
Trp53	transformation related protein 53	0.013
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.013
Hoxa10	homeobox A10	0.013
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.012
Barx1	BarH-like homeobox 1	0.012
Tcfap2c	transcription factor AP-2, gamma	0.012
Hoxc6	homeobox C6	0.012
Tlx2	T-cell leukemia, homeobox 2	0.012
Mecom	MDS1 and EVI1 complex locus	0.012
Wnt1	wingless-related MMTV integration site 1	0.012
Nos3	nitric oxide synthase 3, endothelial cell	0.012
Sim2	single-minded homolog 2 (Drosophila)	0.012
Mnx1	motor neuron and pancreas homeobox 1	0.012
Mab21l2	mab-21-like 2 (C. elegans)	0.012
Myog	myogenin	0.012
Pbx1	pre B-cell leukemia transcription factor 1	0.011
Sox3	SRY-box containing gene 3	0.011
Pou3f2	POU domain, class 3, transcription factor 2	0.011
Zfpm2	zinc finger protein, multitype 2	0.011
Nkx3-2	NK3 homeobox 2	0.011
Foxd3	forkhead box D3	0.011
Col22a1	collagen, type XXII, alpha 1	0.011
Wnt3a	wingless-related MMTV integration site 3A	0.011
Tbx5	T-box 5	0.011
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.010
Foxf2	forkhead box F2	0.010
Foxf1a	forkhead box F1a	0.010