IMP

Process View

Mus musculus

9 genes annotated in mouse

regulation of secondary heart field cardioblast proliferation

Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of secondary heart field cardioblast proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of secondary heart field cardioblast proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.998
Pitx2	paired-like homeodomain transcription factor 2	0.992
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.990
Otx2	orthodenticle homolog 2 (Drosophila)	0.987
Tbx3	T-box 3	0.978	Mouse
Pax2	paired box gene 2	0.952
Sox2	SRY-box containing gene 2	0.951
Pax6	paired box gene 6	0.937
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.877
Foxg1	forkhead box G1	0.846
Eya1	eyes absent 1 homolog (Drosophila)	0.818
Jag1	jagged 1	0.789
Fgf8	fibroblast growth factor 8	0.778
Hoxa1	homeobox A1	0.760
Emx1	empty spiracles homolog 1 (Drosophila)	0.686
Fgfr2	fibroblast growth factor receptor 2	0.659
Hes1	hairy and enhancer of split 1 (Drosophila)	0.608
Gli3	GLI-Kruppel family member GLI3	0.598
Notch1	Notch gene homolog 1 (Drosophila)	0.580
Hand2	heart and neural crest derivatives expressed transcript 2	0.573
Chd7	chromodomain helicase DNA binding protein 7	0.548
Foxc2	forkhead box C2	0.546
Emx2	empty spiracles homolog 2 (Drosophila)	0.512
Pax3	paired box gene 3	0.497
Pitx1	paired-like homeodomain transcription factor 1	0.488
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.424
Wt1	Wilms tumor 1 homolog	0.418
Lhx3	LIM homeobox protein 3	0.406	Mouse
Lhx9	LIM homeobox protein 9	0.402	Mouse
Hes5	hairy and enhancer of split 5 (Drosophila)	0.373	Mouse
Gata4	GATA binding protein 4	0.355
En1	engrailed 1	0.350
Tbx1	T-box 1	0.348
Foxc1	forkhead box C1	0.339
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.256
Hand1	heart and neural crest derivatives expressed transcript 1	0.243	Mouse
Gsc	goosecoid homeobox	0.235
Hoxa13	homeobox A13	0.216
Rarg	retinoic acid receptor, gamma	0.210
Tlx3	T-cell leukemia, homeobox 3	0.209
Isl1	ISL1 transcription factor, LIM/homeodomain	0.206
Tcfap2a	transcription factor AP-2, alpha	0.193
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.183	Mouse
Gbx2	gastrulation brain homeobox 2	0.176
Lhx1	LIM homeobox protein 1	0.172	Mouse
Vegfa	vascular endothelial growth factor A	0.162
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.143
Snai1	snail homolog 1 (Drosophila)	0.140
Gdnf	glial cell line derived neurotrophic factor	0.136
Kiss1	KiSS-1 metastasis-suppressor	0.127
Dlx1	distal-less homeobox 1	0.121
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.120	Mouse
Dll4	delta-like 4 (Drosophila)	0.119
Neurog2	neurogenin 2	0.116	Mouse
Hoxd13	homeobox D13	0.111
Fgf10	fibroblast growth factor 10	0.109
Ptf1a	pancreas specific transcription factor, 1a	0.102	Mouse
Efna2	ephrin A2	0.100
Dlx2	distal-less homeobox 2	0.094
Smad6	MAD homolog 6 (Drosophila)	0.092
Pou4f3	POU domain, class 4, transcription factor 3	0.091
Hoxa10	homeobox A10	0.091
Gata3	GATA binding protein 3	0.091
Nog	noggin	0.090
Hoxd3	homeobox D3	0.078
Msx1	homeobox, msh-like 1	0.075
Dll1	delta-like 1 (Drosophila)	0.074
Nhlh1	nescient helix loop helix 1	0.073	Mouse
Bmp4	bone morphogenetic protein 4	0.073
Neurod1	neurogenic differentiation 1	0.073	Mouse
Lmx1a	LIM homeobox transcription factor 1 alpha	0.070	Mouse
Hoxa11	homeobox A11	0.070
Insm1	insulinoma-associated 1	0.067
Hoxa2	homeobox A2	0.065
Uncx	UNC homeobox	0.065
Hoxb1	homeobox B1	0.064
Hoxd11	homeobox D11	0.063
Neurog1	neurogenin 1	0.063	Mouse
Lhx5	LIM homeobox protein 5	0.061	Mouse
Gata1	GATA binding protein 1	0.059
Otx1	orthodenticle homolog 1 (Drosophila)	0.058
Sall4	sal-like 4 (Drosophila)	0.056
Col22a1	collagen, type XXII, alpha 1	0.054
Sox11	SRY-box containing gene 11	0.053
Pcdh12	protocadherin 12	0.053
Zic3	zinc finger protein of the cerebellum 3	0.050
Gata6	GATA binding protein 6	0.049
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.047
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.047
Nodal	nodal	0.046
Bnc1	basonuclin 1	0.046
T	brachyury	0.044	Mouse
Hmx3	H6 homeobox 3	0.043
Tcf21	transcription factor 21	0.041
Tbx5	T-box 5	0.040
Lhx4	LIM homeobox protein 4	0.040	Mouse
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.035
Hoxa4	homeobox A4	0.035
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.035	Mouse
Hmx1	H6 homeobox 1	0.035
Tal1	T-cell acute lymphocytic leukemia 1	0.034	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.034
Tcfap2c	transcription factor AP-2, gamma	0.032
Prrx1	paired related homeobox 1	0.031
Meox1	mesenchyme homeobox 1	0.031
Lef1	lymphoid enhancer binding factor 1	0.031
Sim2	single-minded homolog 2 (Drosophila)	0.031
Efnb2	ephrin B2	0.030
Hoxd1	homeobox D1	0.030
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.029
Neurod4	neurogenic differentiation 4	0.029	Mouse
Pou4f2	POU domain, class 4, transcription factor 2	0.029
Osr1	odd-skipped related 1 (Drosophila)	0.028
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.026	Mouse
Shox2	short stature homeobox 2	0.026
Fgf15	fibroblast growth factor 15	0.025
Vangl2	vang-like 2 (van gogh, Drosophila)	0.025
Gja5	gap junction protein, alpha 5	0.025
Ush1g	Usher syndrome 1G homolog (human)	0.024
Scn5a	sodium channel, voltage-gated, type V, alpha	0.024
Tcf15	transcription factor 15	0.023	Mouse
Hoxb4	homeobox B4	0.023
Notch2	Notch gene homolog 2 (Drosophila)	0.023	Mouse
Srrm4	serine/arginine repetitive matrix 4	0.022
Smo	smoothened homolog (Drosophila)	0.022
Evx2	even skipped homeotic gene 2 homolog	0.022
Ptk7	PTK7 protein tyrosine kinase 7	0.022
Pax9	paired box gene 9	0.021
Myf5	myogenic factor 5	0.021
Foxa2	forkhead box A2	0.020
Foxf1a	forkhead box F1a	0.020
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.020
Sall3	sal-like 3 (Drosophila)	0.019
Rxra	retinoid X receptor alpha	0.019
Sox7	SRY-box containing gene 7	0.019
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.019
Nkx6-1	NK6 homeobox 1	0.018
Sim1	single-minded homolog 1 (Drosophila)	0.018
Hesx1	homeobox gene expressed in ES cells	0.017
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.017
Pdx1	pancreatic and duodenal homeobox 1	0.017
Pou5f1	POU domain, class 5, transcription factor 1	0.017
Hoxa3	homeobox A3	0.017
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.017
Lmx1b	LIM homeobox transcription factor 1 beta	0.017	Mouse
Twist2	twist homolog 2 (Drosophila)	0.016	Mouse
Sox3	SRY-box containing gene 3	0.016
Ntf3	neurotrophin 3	0.016
Alx3	aristaless-like homeobox 3	0.016
Foxh1	forkhead box H1	0.016
Tbx2	T-box 2	0.015	Mouse
Fgf3	fibroblast growth factor 3	0.015
Sox18	SRY-box containing gene 18	0.015
Hoxc6	homeobox C6	0.015
Gata2	GATA binding protein 2	0.015
Evx1	even skipped homeotic gene 1 homolog	0.014
Hoxc5	homeobox C5	0.014
Notch4	Notch gene homolog 4 (Drosophila)	0.014	Mouse
Pitx3	paired-like homeodomain transcription factor 3	0.014
Dab1	disabled homolog 1 (Drosophila)	0.013
Hoxd12	homeobox D12	0.013
She	src homology 2 domain-containing transforming protein E	0.013
Fev	FEV (ETS oncogene family)	0.013
Ebf3	early B-cell factor 3	0.013
Tal2	T-cell acute lymphocytic leukemia 2	0.013	Mouse
Pou3f4	POU domain, class 3, transcription factor 4	0.012
Wnt3a	wingless-related MMTV integration site 3A	0.012
Efnb1	ephrin B1	0.012
Cxadr	coxsackie virus and adenovirus receptor	0.012
Dmrt3	doublesex and mab-3 related transcription factor 3	0.012
Foxd3	forkhead box D3	0.012
Foxd2	forkhead box D2	0.012
Gli2	GLI-Kruppel family member GLI2	0.012
Dlx6	distal-less homeobox 6	0.012
Mnx1	motor neuron and pancreas homeobox 1	0.011
Mecom	MDS1 and EVI1 complex locus	0.011
Prrx2	paired related homeobox 2	0.011
Dlx5	distal-less homeobox 5	0.011
Rb1	retinoblastoma 1	0.011
Nkx2-1	NK2 homeobox 1	0.011
Hoxb7	homeobox B7	0.011
Esrrb	estrogen related receptor, beta	0.011
Hoxd10	homeobox D10	0.011
Nos3	nitric oxide synthase 3, endothelial cell	0.011
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.011
Tbx20	T-box 20	0.011	Mouse
Lama5	laminin, alpha 5	0.011
Vax1	ventral anterior homeobox containing gene 1	0.011
Hoxb3	homeobox B3	0.011
Trim10	tripartite motif-containing 10	0.011
Foxb1	forkhead box B1	0.010
Onecut1	one cut domain, family member 1	0.010
Ctnnb1	catenin (cadherin associated protein), beta 1	0.010
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.010