IMP
Process View
leukocyte tethering or rolling
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "leukocyte tethering or rolling"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Rgs14 | regulator of G-protein signaling 14 | 0.175 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.157 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.149 | ||
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.127 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.091 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.083 | ||
| Kif5b | kinesin family member 5B | 0.078 | ||
| Vegfa | vascular endothelial growth factor A | 0.076 | ||
| Cd151 | CD151 antigen | 0.065 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.053 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.053 | ||
| Ythdf3 | YTH domain family 3 | 0.051 | ||
| Meox2 | mesenchyme homeobox 2 | 0.050 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.048 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.046 | ||
| Itgb2 | integrin beta 2 | 0.046 | ||
| Lims1 | LIM and senescent cell antigen-like domains 1 | 0.044 | ||
| Cytip | cytohesin 1 interacting protein | 0.044 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.040 | ||
| Lcp2 | lymphocyte cytosolic protein 2 | 0.037 | ||
| Efnb2 | ephrin B2 | 0.034 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.034 | ||
| Dock2 | dedicator of cyto-kinesis 2 | 0.031 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.028 | ||
| Ltb | lymphotoxin B | 0.026 | ||
| Serping1 | serine (or cysteine) peptidase inhibitor, clade G, member 1 | 0.026 | ||
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.025 | ||
| Myo1f | myosin IF | 0.025 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.024 | ||
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.024 | ||
| Apoe | apolipoprotein E | 0.024 | ||
| Eea1 | early endosome antigen 1 | 0.024 | ||
| Ilk | integrin linked kinase | 0.023 | ||
| Wdr26 | WD repeat domain 26 | 0.023 | ||
| Sp3 | trans-acting transcription factor 3 | 0.023 | ||
| Arhgap9 | Rho GTPase activating protein 9 | 0.022 | ||
| Psen1 | presenilin 1 | 0.022 | ||
| Itgal | integrin alpha L | 0.021 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.021 | ||
| Lama5 | laminin, alpha 5 | 0.020 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.019 | ||
| Thbs1 | thrombospondin 1 | 0.019 | ||
| Rnd3 | Rho family GTPase 3 | 0.019 | ||
| Ppp1cb | protein phosphatase 1, catalytic subunit, beta isoform | 0.019 | ||
| Lepr | leptin receptor | 0.018 | ||
| Il27ra | interleukin 27 receptor, alpha | 0.017 | ||
| C5ar1 | complement component 5a receptor 1 | 0.017 | ||
| Cd37 | CD37 antigen | 0.017 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.017 | ||
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.017 | ||
| Il17ra | interleukin 17 receptor A | 0.017 | ||
| Pten | phosphatase and tensin homolog | 0.017 | ||
| Lum | lumican | 0.016 | ||
| Csf3r | colony stimulating factor 3 receptor (granulocyte) | 0.016 | ||
| Ms4a1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.016 | ||
| Was | Wiskott-Aldrich syndrome homolog (human) | 0.016 | ||
| Apbb1ip | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein | 0.016 | ||
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.016 | ||
| Chuk | conserved helix-loop-helix ubiquitous kinase | 0.015 | ||
| Zfx | zinc finger protein X-linked | 0.015 | ||
| Tmed7 | transmembrane emp24 protein transport domain containing 7 | 0.015 | ||
| Usp9x | ubiquitin specific peptidase 9, X chromosome | 0.014 | ||
| Rac2 | RAS-related C3 botulinum substrate 2 | 0.014 | ||
| Il18rap | interleukin 18 receptor accessory protein | 0.014 | ||
| Strn3 | striatin, calmodulin binding protein 3 | 0.014 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.014 | ||
| Stag2 | stromal antigen 2 | 0.014 | ||
| Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.014 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.014 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.014 | ||
| Qk | quaking | 0.013 | ||
| Ly9 | lymphocyte antigen 9 | 0.013 | ||
| Rod1 | ROD1 regulator of differentiation 1 (S. pombe) | 0.013 | ||
| Rrm2b | ribonucleotide reductase M2 B (TP53 inducible) | 0.013 | ||
| Il10ra | interleukin 10 receptor, alpha | 0.013 | ||
| Wt1 | Wilms tumor 1 homolog | 0.013 | ||
| Cdh11 | cadherin 11 | 0.012 | ||
| Rb1 | retinoblastoma 1 | 0.012 | ||
| Fermt2 | fermitin family homolog 2 (Drosophila) | 0.012 | ||
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 0.012 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.012 | ||
| Snap23 | synaptosomal-associated protein 23 | 0.012 | ||
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.012 | ||
| Hmha1 | histocompatibility (minor) HA-1 | 0.012 | ||
| Clec4d | C-type lectin domain family 4, member d | 0.012 | ||
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.012 | ||
| Itga3 | integrin alpha 3 | 0.011 | ||
| Il16 | interleukin 16 | 0.011 | ||
| Rhoh | ras homolog gene family, member H | 0.011 | ||
| Gja1 | gap junction protein, alpha 1 | 0.011 | ||
| Sos2 | son of sevenless homolog 2 (Drosophila) | 0.011 | ||
| Rab5a | RAB5A, member RAS oncogene family | 0.011 | ||
| Cd2ap | CD2-associated protein | 0.011 | ||
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.011 | ||
| Il1rl1 | interleukin 1 receptor-like 1 | 0.011 | ||
| Lyl1 | lymphoblastomic leukemia 1 | 0.011 | ||
| Sash3 | SAM and SH3 domain containing 3 | 0.011 | ||
| H2-Ob | histocompatibility 2, O region beta locus | 0.011 | ||
| Rasa1 | RAS p21 protein activator 1 | 0.011 | ||
| Cd244 | CD244 natural killer cell receptor 2B4 | 0.010 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.010 | ||
| Il7r | interleukin 7 receptor | 0.010 | ||
| Ddx3x | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked | 0.010 | ||
| Edem3 | ER degradation enhancer, mannosidase alpha-like 3 | 0.010 | ||
| Top2b | topoisomerase (DNA) II beta | 0.010 | ||
| Tas1r1 | taste receptor, type 1, member 1 | 0.010 | ||
| Ncf1 | neutrophil cytosolic factor 1 | 0.010 | ||
| Col14a1 | collagen, type XIV, alpha 1 | 0.010 | ||
| Fpr2 | formyl peptide receptor 2 | 0.010 | ||
| Lysmd3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.010 | ||
| Cd2 | CD2 antigen | 0.010 |