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Mus musculus

10 genes annotated in mouse

Multi-species View

positive regulation of heart rate

GO:0010460

Any process that activates or increases the frequency or rate of heart contraction.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of heart rate"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of heart rate" (in gray)

Name	Description	Probability	Func Analog Organism
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.954
Scn5a	sodium channel, voltage-gated, type V, alpha	0.930	Rat
Chrnb4	cholinergic receptor, nicotinic, beta polypeptide 4	0.921	Mouse
Cckbr	cholecystokinin B receptor	0.884
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.875	Mouse
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.852	Mouse
Tbx5	T-box 5	0.717
Hand1	heart and neural crest derivatives expressed transcript 1	0.650
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.649
Adrb1	adrenergic receptor, beta 1	0.614
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.590
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.505
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.441	Mouse
Sstr1	somatostatin receptor 1	0.435
Lhx6	LIM homeobox protein 6	0.423
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.395
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.393
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.376	Mouse
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.373	Mouse
Hand2	heart and neural crest derivatives expressed transcript 2	0.338
Smyd1	SET and MYND domain containing 1	0.336
Grm2	glutamate receptor, metabotropic 2	0.333
Drd2	dopamine receptor D2	0.324
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.318
Ryr2	ryanodine receptor 2, cardiac	0.293
Crhr2	corticotropin releasing hormone receptor 2	0.286	Rat
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.282
Sstr4	somatostatin receptor 4	0.271
Adra2c	adrenergic receptor, alpha 2c	0.268	Mouse
Kl	klotho	0.267
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.267
Crhr1	corticotropin releasing hormone receptor 1	0.246
Tbx3	T-box 3	0.227
Efnb2	ephrin B2	0.218
Adrb3	adrenergic receptor, beta 3	0.211	Mouse
Gja5	gap junction protein, alpha 5	0.180
Gata4	GATA binding protein 4	0.175
Adra1a	adrenergic receptor, alpha 1a	0.172
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.162
ND6	NADH dehydrogenase subunit 6	0.162
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.160
Pnpla2	patatin-like phospholipase domain containing 2	0.158
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.150
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.145
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.144
Adrb2	adrenergic receptor, beta 2	0.128	Mouse
Nodal	nodal	0.126
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.125	Mouse
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.124
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.123
Krtap5-1	keratin associated protein 5-1	0.112
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.112
Chrna10	cholinergic receptor, nicotinic, alpha polypeptide 10	0.111	Mouse
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.100
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.097	Mouse
Stx1b	syntaxin 1B	0.095
Kcnk3	potassium channel, subfamily K, member 3	0.093
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.088
Kcnk4	potassium channel, subfamily K, member 4	0.087
Mas1	MAS1 oncogene	0.087
Pgr	progesterone receptor	0.080
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.077
Grid1	glutamate receptor, ionotropic, delta 1	0.074
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.073	Mouse
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.068
Smr2	submaxillary gland androgen regulated protein 2	0.068
Gsx1	GS homeobox 1	0.067
Kifc2	kinesin family member C2	0.067
Glra1	glycine receptor, alpha 1 subunit	0.066
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.065
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.062
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.061
Galr1	galanin receptor 1	0.061
Pramel7	preferentially expressed antigen in melanoma like 7	0.060
Gjd3	gap junction protein, delta 3	0.060
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.060	Mouse
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.060
Oprk1	opioid receptor, kappa 1	0.059
Gpr12	G-protein coupled receptor 12	0.059
Scn1a	sodium channel, voltage-gated, type I, alpha	0.059
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.057
Eras	ES cell-expressed Ras	0.056
Mpz	myelin protein zero	0.053
Neurod2	neurogenic differentiation 2	0.053
Prox1	prospero-related homeobox 1	0.052
Cldn26	claudin 26	0.051
Gpr45	G protein-coupled receptor 45	0.051
Uts2r	urotensin 2 receptor	0.051
Msx1	homeobox, msh-like 1	0.050
Syt3	synaptotagmin III	0.050
Drd4	dopamine receptor D4	0.048
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.048	Mouse
Cntn2	contactin 2	0.047
Arpp21	cyclic AMP-regulated phosphoprotein, 21	0.047
Oprl1	opioid receptor-like 1	0.046
Ache	acetylcholinesterase	0.046
Sfrp5	secreted frizzled-related sequence protein 5	0.045
Clcn1	chloride channel 1	0.044
Gjc2	gap junction protein, gamma 2	0.044
Mobp	myelin-associated oligodendrocytic basic protein	0.044
Sox10	SRY-box containing gene 10	0.043
Npy5r	neuropeptide Y receptor Y5	0.043
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.043	Mouse
Tacr3	tachykinin receptor 3	0.042	Rat
Tectb	tectorin beta	0.042
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.042
Has1	hyaluronan synthase1	0.041
Actg1	actin, gamma, cytoplasmic 1	0.041
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.039
Musk	muscle, skeletal, receptor tyrosine kinase	0.039
Hpca	hippocalcin	0.039
Stk32b	serine/threonine kinase 32B	0.038
Shc3	src homology 2 domain-containing transforming protein C3	0.038
Gpr27	G protein-coupled receptor 27	0.037
Gja1	gap junction protein, alpha 1	0.036
Chst5	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	0.036
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.036
Csmd1	CUB and Sushi multiple domains 1	0.035
Fndc7	fibronectin type III domain containing 7	0.035
Lag3	lymphocyte-activation gene 3	0.034
Gzmm	granzyme M (lymphocyte met-ase 1)	0.034
Tff1	trefoil factor 1	0.033
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.033
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.032
Sult4a1	sulfotransferase family 4A, member 1	0.032
Kcnc4	potassium voltage gated channel, Shaw-related subfamily, member 4	0.032
Kcnn1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	0.031
Galntl1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1	0.031
Nell2	NEL-like 2 (chicken)	0.031
Epha6	Eph receptor A6	0.030
Galr2	galanin receptor 2	0.030
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.030
Csrp1	cysteine and glycine-rich protein 1	0.030
Inhbc	inhibin beta-C	0.030
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.030	Mouse
Fezf2	Fez family zinc finger 2	0.030
Fgf5	fibroblast growth factor 5	0.029
Lpar5	lysophosphatidic acid receptor 5	0.029
Krtap6-2	keratin associated protein 6-2	0.029
Ntsr2	neurotensin receptor 2	0.029
Diras1	DIRAS family, GTP-binding RAS-like 1	0.029
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.029
Cntn3	contactin 3	0.028
Gpr26	G protein-coupled receptor 26	0.028
Col19a1	collagen, type XIX, alpha 1	0.028
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.027
Cer1	cerberus 1 homolog (Xenopus laevis)	0.027
Scube1	signal peptide, CUB domain, EGF-like 1	0.027
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.027
Pvalb	parvalbumin	0.027
Rcvrn	recoverin	0.027
Prodh2	proline dehydrogenase (oxidase) 2	0.026
Hoxc6	homeobox C6	0.026
Mc3r	melanocortin 3 receptor	0.026
Srpk3	serine/arginine-rich protein specific kinase 3	0.026
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.026
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.026
Fgfr4	fibroblast growth factor receptor 4	0.026
Xirp1	xin actin-binding repeat containing 1	0.025
Chrna9	cholinergic receptor, nicotinic, alpha polypeptide 9	0.025	Mouse
Casq2	calsequestrin 2	0.025
Adra2b	adrenergic receptor, alpha 2b	0.025	Mouse
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.025
Igf2	insulin-like growth factor 2	0.024
Npy1r	neuropeptide Y receptor Y1	0.023
Prss32	protease, serine, 32	0.023
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.023
Ryr3	ryanodine receptor 3	0.023	Mouse
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.022
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.022
Hrh2	histamine receptor H2	0.022	Mouse
Gpr33	G protein-coupled receptor 33	0.021
Rps6kl1	ribosomal protein S6 kinase-like 1	0.021
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.021
Sncb	synuclein, beta	0.021
Adcyap1	adenylate cyclase activating polypeptide 1	0.021
Prkcc	protein kinase C, gamma	0.021
Sstr3	somatostatin receptor 3	0.021
Syt6	synaptotagmin VI	0.021
Sypl2	synaptophysin-like 2	0.020
Ngb	neuroglobin	0.020
Syn2	synapsin II	0.020
Mchr1	melanin-concentrating hormone receptor 1	0.020
Syt17	synaptotagmin XVII	0.020
Hrh1	histamine receptor H1	0.020
Col4a4	collagen, type IV, alpha 4	0.020
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.019
Oxt	oxytocin	0.019
Tead4	TEA domain family member 4	0.019
Bean1	brain expressed, associated with Nedd4, 1	0.019
Msn	moesin	0.019
Avil	advillin	0.019
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, subunit beta 1	0.018
Krt36	keratin 36	0.018
Entpd2	ectonucleoside triphosphate diphosphohydrolase 2	0.018
Apln	apelin	0.018
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.018
Ablim2	actin-binding LIM protein 2	0.018
Trh	thyrotropin releasing hormone	0.018
Rapsn	receptor-associated protein of the synapse	0.018
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.018
Lalba	lactalbumin, alpha	0.017
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.017
Hrh3	histamine receptor H3	0.017
Gpr37l1	G protein-coupled receptor 37-like 1	0.017
Cox8c	cytochrome c oxidase, subunit VIIIc	0.017
Grm1	glutamate receptor, metabotropic 1	0.017
Kcnk2	potassium channel, subfamily K, member 2	0.017
Oxtr	oxytocin receptor	0.017
Oprd1	opioid receptor, delta 1	0.017
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.017
Gcgr	glucagon receptor	0.017
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.017
Wnt6	wingless-related MMTV integration site 6	0.017
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.017
Sez6	seizure related gene 6	0.016
Slc6a17	solute carrier family 6 (neurotransmitter transporter), member 17	0.016
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.016
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.016
Kcna7	potassium voltage-gated channel, shaker-related subfamily, member 7	0.016
Psapl1	prosaposin-like 1	0.016
Sox7	SRY-box containing gene 7	0.016
Ptgfr	prostaglandin F receptor	0.016
Gjb1	gap junction protein, beta 1	0.016
Syt10	synaptotagmin X	0.016
Dlx4	distal-less homeobox 4	0.016
Syt1	synaptotagmin I	0.016
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.016
Onecut1	one cut domain, family member 1	0.016
Apoa5	apolipoprotein A-V	0.015
Trfr2	transferrin receptor 2	0.015
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.015
Wnt7a	wingless-related MMTV integration site 7A	0.015
Myog	myogenin	0.015
Cela2a	chymotrypsin-like elastase family, member 2A	0.015
Nmbr	neuromedin B receptor	0.015
She	src homology 2 domain-containing transforming protein E	0.015
Pramel6	preferentially expressed antigen in melanoma like 6	0.015
Myod1	myogenic differentiation 1	0.015
Gjd2	gap junction protein, delta 2	0.015
Npy2r	neuropeptide Y receptor Y2	0.015
Adarb2	adenosine deaminase, RNA-specific, B2	0.015
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.015
Ncam2	neural cell adhesion molecule 2	0.014
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.014
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.014
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.014
Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.014
Fgf22	fibroblast growth factor 22	0.014
Grm8	glutamate receptor, metabotropic 8	0.014
Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.014
Sox17	SRY-box containing gene 17	0.014
Ins2	insulin II	0.014
Otog	otogelin	0.014
Gpr83	G protein-coupled receptor 83	0.014
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.014
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.014
Adra1b	adrenergic receptor, alpha 1b	0.014
Meox1	mesenchyme homeobox 1	0.014
Thrb	thyroid hormone receptor beta	0.013
Speg	SPEG complex locus	0.013
Ednra	endothelin receptor type A	0.013
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.013
Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	0.013
Htra3	HtrA serine peptidase 3	0.013
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.013
Fgf3	fibroblast growth factor 3	0.013
Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.013
Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	0.013
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.013
Acta1	actin, alpha 1, skeletal muscle	0.013
Clcnka	chloride channel Ka	0.013
Ccbp2	chemokine binding protein 2	0.013
Fosb	FBJ osteosarcoma oncogene B	0.013
Scn4a	sodium channel, voltage-gated, type IV, alpha	0.013
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.012
Hbegf	heparin-binding EGF-like growth factor	0.012
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.012
Nrg3	neuregulin 3	0.012
Gad2	glutamic acid decarboxylase 2	0.012
Ghrl	ghrelin	0.012
Nos1	nitric oxide synthase 1, neuronal	0.012
Slc22a6	solute carrier family 22 (organic anion transporter), member 6	0.012
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.012
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.012
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.012
Tagln	transgelin	0.012
Zp2	zona pellucida glycoprotein 2	0.012
Trhr2	thyrotropin releasing hormone receptor 2	0.012
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.012
Sst	somatostatin	0.012
Adora2a	adenosine A2a receptor	0.012
Plcb1	phospholipase C, beta 1	0.012
Agxt	alanine-glyoxylate aminotransferase	0.011
Lin7b	lin-7 homolog B (C. elegans)	0.011
Kcnv1	potassium channel, subfamily V, member 1	0.011
Sycn	syncollin	0.011
Gpr88	G-protein coupled receptor 88	0.011
Cnn2	calponin 2	0.011
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.011
Gast	gastrin	0.011
Snta1	syntrophin, acidic 1	0.011
Col25a1	collagen, type XXV, alpha 1	0.011
Slit1	slit homolog 1 (Drosophila)	0.011
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.011
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.011
Edn2	endothelin 2	0.011
Upp2	uridine phosphorylase 2	0.011
Gnao1	guanine nucleotide binding protein, alpha O	0.011
Rnf112	ring finger protein 112	0.011
Myoc	myocilin	0.011
Il12b	interleukin 12b	0.011
Tnni1	troponin I, skeletal, slow 1	0.011
Nrip2	nuclear receptor interacting protein 2	0.011
Epha8	Eph receptor A8	0.011
Hes5	hairy and enhancer of split 5 (Drosophila)	0.011
Fam164c	family with sequence similarity 164, member C	0.011
Ltk	leukocyte tyrosine kinase	0.011
Dlx6	distal-less homeobox 6	0.011
Esrrb	estrogen related receptor, beta	0.010
Ntf3	neurotrophin 3	0.010
Ly6h	lymphocyte antigen 6 complex, locus H	0.010
Hsf4	heat shock transcription factor 4	0.010
Panx2	pannexin 2	0.010
Pou3f4	POU domain, class 3, transcription factor 4	0.010
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.010
Wnt10b	wingless related MMTV integration site 10b	0.010