IMP

Process View

Mus musculus

2 genes annotated in mouse

fourth ventricle development

The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fourth ventricle development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "fourth ventricle development" (in gray)

Name	Description	Probability	Func Analog Organism
Otx2	orthodenticle homolog 2 (Drosophila)	0.989
Rnf2	ring finger protein 2	0.984
Pax2	paired box gene 2	0.981
Fgf8	fibroblast growth factor 8	0.969
Otx1	orthodenticle homolog 1 (Drosophila)	0.941
Pitx2	paired-like homeodomain transcription factor 2	0.937
Tbx1	T-box 1	0.927
Gbx2	gastrulation brain homeobox 2	0.925
Foxc2	forkhead box C2	0.922
Hoxa1	homeobox A1	0.867
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.867
En1	engrailed 1	0.867
Hoxa2	homeobox A2	0.855
Foxc1	forkhead box C1	0.855
Shh	sonic hedgehog	0.839
Pax3	paired box gene 3	0.817
Pax6	paired box gene 6	0.817
En2	engrailed 2	0.792
Gli3	GLI-Kruppel family member GLI3	0.784
Lmx1b	LIM homeobox transcription factor 1 beta	0.574	Zebrafish
Tcfap2a	transcription factor AP-2, alpha	0.528
Isl1	ISL1 transcription factor, LIM/homeodomain	0.512
Eya1	eyes absent 1 homolog (Drosophila)	0.510
Zic2	zinc finger protein of the cerebellum 2	0.394
Hoxb2	homeobox B2	0.377
Foxg1	forkhead box G1	0.373
Msx1	homeobox, msh-like 1	0.361
Lmx1a	LIM homeobox transcription factor 1 alpha	0.342
Hoxa3	homeobox A3	0.329
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.271
Cbx3	chromobox homolog 3 (Drosophila HP1 gamma)	0.241
Zic3	zinc finger protein of the cerebellum 3	0.239
Sox2	SRY-box containing gene 2	0.174
Prrx1	paired related homeobox 1	0.172
Cbx8	chromobox homolog 8 (Drosophila Pc class)	0.164
Lhx1	LIM homeobox protein 1	0.130
Smo	smoothened homolog (Drosophila)	0.122
Ntf3	neurotrophin 3	0.122
Hand2	heart and neural crest derivatives expressed transcript 2	0.117
Chd7	chromodomain helicase DNA binding protein 7	0.113
Gli2	GLI-Kruppel family member GLI2	0.112
Rarg	retinoic acid receptor, gamma	0.110
Zeb1	zinc finger E-box binding homeobox 1	0.108
Emx2	empty spiracles homolog 2 (Drosophila)	0.107
Bmp7	bone morphogenetic protein 7	0.100
Actn1	actinin, alpha 1	0.094
Kdm1a	lysine (K)-specific demethylase 1A	0.092
Jag1	jagged 1	0.092
Chrm2	cholinergic receptor, muscarinic 2, cardiac	0.080
Bcor	BCL6 interacting corepressor	0.079
Sox13	SRY-box containing gene 13	0.079
Shox2	short stature homeobox 2	0.078
Sox9	SRY-box containing gene 9	0.078
Fgfr2	fibroblast growth factor receptor 2	0.077
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.077
Vangl2	vang-like 2 (van gogh, Drosophila)	0.076
Wnt1	wingless-related MMTV integration site 1	0.075	Zebrafish
Fgf10	fibroblast growth factor 10	0.072
Rarb	retinoic acid receptor, beta	0.071
Gsc	goosecoid homeobox	0.068
Adm	adrenomedullin	0.067
Dlx5	distal-less homeobox 5	0.066
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.066
Chrd	chordin	0.065
Hmx3	H6 homeobox 3	0.063
Sall4	sal-like 4 (Drosophila)	0.057
Neurod1	neurogenic differentiation 1	0.054
Foxf2	forkhead box F2	0.054
Bmp4	bone morphogenetic protein 4	0.053
Sox11	SRY-box containing gene 11	0.051
Cnn1	calponin 1	0.050
Ebf3	early B-cell factor 3	0.050
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.049
Wnt3a	wingless-related MMTV integration site 3A	0.049
Msx2	homeobox, msh-like 2	0.048
Ednra	endothelin receptor type A	0.046
Foxb1	forkhead box B1	0.044
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.043
Vegfa	vascular endothelial growth factor A	0.042
Hoxd3	homeobox D3	0.041
Emx1	empty spiracles homolog 1 (Drosophila)	0.041
Fgf4	fibroblast growth factor 4	0.041
Hoxd1	homeobox D1	0.040
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.039
Rpgrip1l	Rpgrip1-like	0.039
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.038
Nsf	N-ethylmaleimide sensitive fusion protein	0.038
Dync1h1	dynein cytoplasmic 1 heavy chain 1	0.037
Insm1	insulinoma-associated 1	0.037
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.036
Fgfr1	fibroblast growth factor receptor 1	0.036
Wiz	widely-interspaced zinc finger motifs	0.036
Itga3	integrin alpha 3	0.036
Irx5	Iroquois related homeobox 5 (Drosophila)	0.035
Ctbp1	C-terminal binding protein 1	0.034
Myf5	myogenic factor 5	0.034
Hoxa4	homeobox A4	0.034
Sim2	single-minded homolog 2 (Drosophila)	0.034
Tpbg	trophoblast glycoprotein	0.034
Dlx6	distal-less homeobox 6	0.033
Invs	inversin	0.033
Adam2	a disintegrin and metallopeptidase domain 2	0.033
Epn1	epsin 1	0.033
Gypa	glycophorin A	0.033
Wnt3	wingless-related MMTV integration site 3	0.033
Hoxb3	homeobox B3	0.032
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.031
Msn	moesin	0.031
Pou4f2	POU domain, class 4, transcription factor 2	0.030
Lhx5	LIM homeobox protein 5	0.030
Adcy9	adenylate cyclase 9	0.029
Ugt8a	UDP galactosyltransferase 8A	0.028
Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	0.028
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.027
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.027
Zfp423	zinc finger protein 423	0.027
Irx1	Iroquois related homeobox 1 (Drosophila)	0.027
Neurog2	neurogenin 2	0.027
Tbx15	T-box 15	0.026
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.026
Cd151	CD151 antigen	0.026
Tbx3	T-box 3	0.026
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.026
Efnb2	ephrin B2	0.025
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.024
Eya4	eyes absent 4 homolog (Drosophila)	0.024
Eno1	enolase 1, alpha non-neuron	0.024
Egr2	early growth response 2	0.023
Hmx1	H6 homeobox 1	0.023
Nhlh1	nescient helix loop helix 1	0.023
Nog	noggin	0.023
Mc5r	melanocortin 5 receptor	0.023
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.023
Csnk2a2	casein kinase 2, alpha prime polypeptide	0.022
Fgf15	fibroblast growth factor 15	0.022
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.022
Tgfb2	transforming growth factor, beta 2	0.022
Wdr1	WD repeat domain 1	0.021
Hoxa13	homeobox A13	0.021
Homer1	homer homolog 1 (Drosophila)	0.021
Neurod4	neurogenic differentiation 4	0.021
Tcfap2c	transcription factor AP-2, gamma	0.020
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.020
Rybp	RING1 and YY1 binding protein	0.020
Bdnf	brain derived neurotrophic factor	0.020
Map2k7	mitogen-activated protein kinase kinase 7	0.020
Pitx1	paired-like homeodomain transcription factor 1	0.019
Foxd2	forkhead box D2	0.019
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.019
Gpr172b	G protein-coupled receptor 172B	0.019
Tcfap2b	transcription factor AP-2 beta	0.019
Cux1	cut-like homeobox 1	0.019
1700081L11Rik	RIKEN cDNA 1700081L11 gene	0.018
Gja1	gap junction protein, alpha 1	0.018
Hoxd13	homeobox D13	0.018
Uncx	UNC homeobox	0.018
Nova1	neuro-oncological ventral antigen 1	0.018
Nphs2	nephrosis 2 homolog, podocin (human)	0.018
Foxd1	forkhead box D1	0.018
Irx3	Iroquois related homeobox 3 (Drosophila)	0.018
Chrm3	cholinergic receptor, muscarinic 3, cardiac	0.018
Fgf3	fibroblast growth factor 3	0.017
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.017
Hapln1	hyaluronan and proteoglycan link protein 1	0.017
Dlx2	distal-less homeobox 2	0.017
Matn3	matrilin 3	0.017
Maml1	mastermind like 1 (Drosophila)	0.017
Dlx1	distal-less homeobox 1	0.017
Foxe3	forkhead box E3	0.017
Gata3	GATA binding protein 3	0.017
Cdh3	cadherin 3	0.016
Myst3	MYST histone acetyltransferase (monocytic leukemia) 3	0.016
Hoxc8	homeobox C8	0.016
Map3k11	mitogen-activated protein kinase kinase kinase 11	0.016
Iqcb1	IQ calmodulin-binding motif containing 1	0.016
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.016
Mecom	MDS1 and EVI1 complex locus	0.016
Nynrin	NYN domain and retroviral integrase containing	0.016
Tox3	TOX high mobility group box family member 3	0.016
Zfpm2	zinc finger protein, multitype 2	0.015
Iqgap1	IQ motif containing GTPase activating protein 1	0.015
Hoxa10	homeobox A10	0.015
Tubb2c	tubulin, beta 2C	0.015
Fbn2	fibrillin 2	0.015
Ebf2	early B-cell factor 2	0.015
Gli1	GLI-Kruppel family member GLI1	0.015
Sim1	single-minded homolog 1 (Drosophila)	0.015
Trim10	tripartite motif-containing 10	0.015
Cldn8	claudin 8	0.015
Gata4	GATA binding protein 4	0.015
Lef1	lymphoid enhancer binding factor 1	0.014
Edil3	EGF-like repeats and discoidin I-like domains 3	0.014
Efna3	ephrin A3	0.014
Pcgf2	polycomb group ring finger 2	0.014
Atoh1	atonal homolog 1 (Drosophila)	0.014
Axin2	axin2	0.014
Sall3	sal-like 3 (Drosophila)	0.014
Phox2b	paired-like homeobox 2b	0.014
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.013
Wnt6	wingless-related MMTV integration site 6	0.013
Grik1	glutamate receptor, ionotropic, kainate 1	0.013
Phc2	polyhomeotic-like 2 (Drosophila)	0.013
Ncor2	nuclear receptor co-repressor 2	0.013
Zmiz2	zinc finger, MIZ-type containing 2	0.013
Irx2	Iroquois related homeobox 2 (Drosophila)	0.013
Ubr1	ubiquitin protein ligase E3 component n-recognin 1	0.013
T	brachyury	0.013
Pax7	paired box gene 7	0.013
Ehd3	EH-domain containing 3	0.013
Patz1	POZ (BTB) and AT hook containing zinc finger 1	0.013
Irx4	Iroquois related homeobox 4 (Drosophila)	0.013
Hoxb8	homeobox B8	0.013
Ncs1	neuronal calcium sensor 1	0.013
Tmem132c	transmembrane protein 132C	0.013
Jup	junction plakoglobin	0.013
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.012
Ina	internexin neuronal intermediate filament protein, alpha	0.012
Slc44a4	solute carrier family 44, member 4	0.012
Fign	fidgetin	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Npas3	neuronal PAS domain protein 3	0.012
Cdh10	cadherin 10	0.012
Prkci	protein kinase C, iota	0.012
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.012
Arpp21	cyclic AMP-regulated phosphoprotein, 21	0.012
Pax9	paired box gene 9	0.012
Unc5c	unc-5 homolog C (C. elegans)	0.012
Mlph	melanophilin	0.012
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.012
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.012
Mipol1	mirror-image polydactyly gene 1 homolog (human)	0.012
Rara	retinoic acid receptor, alpha	0.012
Nphp1	nephronophthisis 1 (juvenile) homolog (human)	0.012
Wnt2b	wingless related MMTV integration site 2b	0.012
Klc2	kinesin light chain 2	0.012
Des	desmin	0.012
Ap2a2	adaptor protein complex AP-2, alpha 2 subunit	0.012
Trim8	tripartite motif-containing 8	0.012
Usf2	upstream transcription factor 2	0.012
Hand1	heart and neural crest derivatives expressed transcript 1	0.012
Zim1	zinc finger, imprinted 1	0.012
Cyhr1	cysteine and histidine rich 1	0.012
Midn	midnolin	0.012
Kcnmb1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	0.012
Hoxd11	homeobox D11	0.012
Phf7	PHD finger protein 7	0.011
Hoxd9	homeobox D9	0.011
Eomes	eomesodermin homolog (Xenopus laevis)	0.011
Hoxa9	homeobox A9	0.011
Pdx1	pancreatic and duodenal homeobox 1	0.011
Prox1	prospero-related homeobox 1	0.011
Zbtb7b	zinc finger and BTB domain containing 7B	0.011
Pou3f3	POU domain, class 3, transcription factor 3	0.011
Fam109a	family with sequence similarity 109, member A	0.011
Glra1	glycine receptor, alpha 1 subunit	0.011
Flnb	filamin, beta	0.011
Crtc1	CREB regulated transcription coactivator 1	0.011
Sox21	SRY-box containing gene 21	0.011
Mgat3	mannoside acetylglucosaminyltransferase 3	0.011
Tpcn1	two pore channel 1	0.011
Podxl	podocalyxin-like	0.011
Tbx10	T-box 10	0.011
Tbl1xr1	transducin (beta)-like 1X-linked receptor 1	0.011
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.011
Cdh4	cadherin 4	0.011
Pou4f1	POU domain, class 4, transcription factor 1	0.011
Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	0.011
Ahnak	AHNAK nucleoprotein (desmoyokin)	0.011
Phox2a	paired-like homeobox 2a	0.011
Prrc1	proline-rich coiled-coil 1	0.011
Mesp1	mesoderm posterior 1	0.011
Kif1c	kinesin family member 1C	0.011
Ece1	endothelin converting enzyme 1	0.011
Wdtc1	WD and tetratricopeptide repeats 1	0.010
Mc1r	melanocortin 1 receptor	0.010
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.010
Hoxb4	homeobox B4	0.010
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.010
Klf3	Kruppel-like factor 3 (basic)	0.010
Bex6	brain expressed gene 6	0.010
Ank1	ankyrin 1, erythroid	0.010
Meox2	mesenchyme homeobox 2	0.010
Fam83h	family with sequence similarity 83, member H	0.010
Syngr4	synaptogyrin 4	0.010
Gdnf	glial cell line derived neurotrophic factor	0.010
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.010
1110032A04Rik	RIKEN cDNA 1110032A04 gene	0.010