IMP

Process View

Mus musculus

4 genes annotated in mouse

hypothalamus gonadotrophin releasing hormone neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hypothalamus gonadotrophin releasing hormone neuron differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "hypothalamus gonadotrophin releasing hormone neuron differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Plxnd1	plexin D1	0.807
Dlg4	discs, large homolog 4 (Drosophila)	0.759
Plxna1	plexin A1	0.489
Flt1	FMS-like tyrosine kinase 1	0.437
Vegfa	vascular endothelial growth factor A	0.428
Ednra	endothelin receptor type A	0.406
Plxna4	plexin A4	0.359
Mgat3	mannoside acetylglucosaminyltransferase 3	0.177
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.151
Pcdh12	protocadherin 12	0.116
Grb10	growth factor receptor bound protein 10	0.096
Ptk2	PTK2 protein tyrosine kinase 2	0.079
Pppde2	PPPDE peptidase domain containing 2	0.078
Pcdh18	protocadherin 18	0.076
Aplnr	apelin receptor	0.075
Plcg1	phospholipase C, gamma 1	0.075
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.066
Arl10	ADP-ribosylation factor-like 10	0.065
Tubb4	tubulin, beta 4	0.063
Pdgfb	platelet derived growth factor, B polypeptide	0.062
Ednrb	endothelin receptor type B	0.062
Des	desmin	0.061
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.058
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.058
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.053
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.053
Ids	iduronate 2-sulfatase	0.052
Mid2	midline 2	0.051
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.050
Ptprb	protein tyrosine phosphatase, receptor type, B	0.050
Mkl2	MKL/myocardin-like 2	0.049
Fzd1	frizzled homolog 1 (Drosophila)	0.049
Dock4	dedicator of cytokinesis 4	0.048
She	src homology 2 domain-containing transforming protein E	0.048
Id1	inhibitor of DNA binding 1	0.045
Fign	fidgetin	0.045
Clip2	CAP-GLY domain containing linker protein 2	0.045
Bmp5	bone morphogenetic protein 5	0.044
Foxp2	forkhead box P2	0.043
Rdh10	retinol dehydrogenase 10 (all-trans)	0.042
Plcb1	phospholipase C, beta 1	0.040
Cdk14	cyclin-dependent kinase 14	0.040
Epha4	Eph receptor A4	0.039
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.038
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.038
Col12a1	collagen, type XII, alpha 1	0.038
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.038
Bcar1	breast cancer anti-estrogen resistance 1	0.037
Plxna2	plexin A2	0.035
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.034
Itga3	integrin alpha 3	0.034
Pecam1	platelet/endothelial cell adhesion molecule 1	0.033
Bcl6b	B-cell CLL/lymphoma 6, member B	0.033
Acvr1	activin A receptor, type 1	0.032
Epn2	epsin 2	0.031
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.031
Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.031
Mmp15	matrix metallopeptidase 15	0.031
Ltbp1	latent transforming growth factor beta binding protein 1	0.030
Epha3	Eph receptor A3	0.030
Stra6	stimulated by retinoic acid gene 6	0.030
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.030
Slit2	slit homolog 2 (Drosophila)	0.029
Pcdhb16	protocadherin beta 16	0.028
Tcf4	transcription factor 4	0.028
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.027
Tbx3	T-box 3	0.027
Wnt5a	wingless-related MMTV integration site 5A	0.027
Fgf18	fibroblast growth factor 18	0.027
Ece1	endothelin converting enzyme 1	0.027
Pcdha10	protocadherin alpha 10	0.026
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.026
Rasgrp3	RAS, guanyl releasing protein 3	0.025
Tspan9	tetraspanin 9	0.025
Cdx2	caudal type homeobox 2	0.025
Ldb2	LIM domain binding 2	0.024
Ccm2	cerebral cavernous malformation 2 homolog (human)	0.024
Fn1	fibronectin 1	0.023
Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.023
Spry4	sprouty homolog 4 (Drosophila)	0.023
Cdh11	cadherin 11	0.023
Kalrn	kalirin, RhoGEF kinase	0.023
Prox1	prospero-related homeobox 1	0.023
Lrp1	low density lipoprotein receptor-related protein 1	0.023
Cdh4	cadherin 4	0.023
Dnajb5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.022
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.022
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.022	Mouse
Gipc1	GIPC PDZ domain containing family, member 1	0.022
Npas2	neuronal PAS domain protein 2	0.021
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.021
Kif1a	kinesin family member 1A	0.021
Podxl	podocalyxin-like	0.021
Rbms3	RNA binding motif, single stranded interacting protein	0.021
Npnt	nephronectin	0.021
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.021
Sirpa	signal-regulatory protein alpha	0.020
Hgf	hepatocyte growth factor	0.020
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.020
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.020
Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	0.019
Gpc6	glypican 6	0.019
Bhlhe41	basic helix-loop-helix family, member e41	0.019
Cd93	CD93 antigen	0.019
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.019
Nrp1	neuropilin 1	0.019
Gjc1	gap junction protein, gamma 1	0.019
Rgs6	regulator of G-protein signaling 6	0.019
Msi1	Musashi homolog 1(Drosophila)	0.019
Ptprk	protein tyrosine phosphatase, receptor type, K	0.019
Angpt1	angiopoietin 1	0.018
Ptprs	protein tyrosine phosphatase, receptor type, S	0.018
Src	Rous sarcoma oncogene	0.018
Plekhh2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	0.018
Gab2	growth factor receptor bound protein 2-associated protein 2	0.018
Fzd7	frizzled homolog 7 (Drosophila)	0.018
Cdh13	cadherin 13	0.018
Hand2	heart and neural crest derivatives expressed transcript 2	0.018
Kitl	kit ligand	0.018
Fat4	FAT tumor suppressor homolog 4 (Drosophila)	0.017
Sh3kbp1	SH3-domain kinase binding protein 1	0.017
Pcdh1	protocadherin 1	0.017
Fjx1	four jointed box 1 (Drosophila)	0.017
Dll4	delta-like 4 (Drosophila)	0.017
Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.017
Hip1	huntingtin interacting protein 1	0.017
Gdpd5	glycerophosphodiester phosphodiesterase domain containing 5	0.017
Zc3h3	zinc finger CCCH type containing 3	0.017
Fgfr4	fibroblast growth factor receptor 4	0.017
Farp1	FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)	0.017
Srgap1	SLIT-ROBO Rho GTPase activating protein 1	0.017
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.016
Axin2	axin2	0.016
Zeb2	zinc finger E-box binding homeobox 2	0.016
Apc2	adenomatosis polyposis coli 2	0.016
Itm2c	integral membrane protein 2C	0.016
Sntb1	syntrophin, basic 1	0.016
Dtna	dystrobrevin alpha	0.016
Ptrf	polymerase I and transcript release factor	0.016
Dach1	dachshund 1 (Drosophila)	0.016
Cpne6	copine VI	0.016
Epas1	endothelial PAS domain protein 1	0.015
Nfib	nuclear factor I/B	0.015
Hdac9	histone deacetylase 9	0.015
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.015
Tead1	TEA domain family member 1	0.015
Nes	nestin	0.015
Lama5	laminin, alpha 5	0.015
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.015
Rgs4	regulator of G-protein signaling 4	0.015
Gprin1	G protein-regulated inducer of neurite outgrowth 1	0.015
Fam115a	family with sequence similarity 115, member A	0.015
Ptprg	protein tyrosine phosphatase, receptor type, G	0.015
Nrp2	neuropilin 2	0.015
Unc5b	unc-5 homolog B (C. elegans)	0.015
Plekha7	pleckstrin homology domain containing, family A member 7	0.015
Epha1	Eph receptor A1	0.014
Cdh6	cadherin 6	0.014
Dpysl2	dihydropyrimidinase-like 2	0.014
Notch3	Notch gene homolog 3 (Drosophila)	0.014
Peg10	paternally expressed 10	0.014
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.014
Id3	inhibitor of DNA binding 3	0.014
Sh3rf1	SH3 domain containing ring finger 1	0.014
Dchs1	dachsous 1 (Drosophila)	0.014
Cxadr	coxsackie virus and adenovirus receptor	0.014
Fgf7	fibroblast growth factor 7	0.014
Lamb1	laminin B1	0.013
Sox5	SRY-box containing gene 5	0.013
Palm2	paralemmin 2	0.013
Adamts9	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9	0.013
Fzd6	frizzled homolog 6 (Drosophila)	0.013
Gata5	GATA binding protein 5	0.013
Gulp1	GULP, engulfment adaptor PTB domain containing 1	0.013
Foxf1a	forkhead box F1a	0.013
Eno1	enolase 1, alpha non-neuron	0.013
Pcdhb18	protocadherin beta 18	0.013
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.013
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.013
Unc5c	unc-5 homolog C (C. elegans)	0.013
Gimap4	GTPase, IMAP family member 4	0.013
Nav1	neuron navigator 1	0.013
C030018P15Rik	RIKEN cDNA C030018P15 gene	0.013
Sycn	syncollin	0.012
Sstr1	somatostatin receptor 1	0.012
Col4a2	collagen, type IV, alpha 2	0.012
Sulf1	sulfatase 1	0.012
Adcy8	adenylate cyclase 8	0.012
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.012
Cttnbp2nl	CTTNBP2 N-terminal like	0.012
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.012
Pknox2	Pbx/knotted 1 homeobox 2	0.012
Epha7	Eph receptor A7	0.012
Ppfibp1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	0.012
Calcrl	calcitonin receptor-like	0.012
Adra1b	adrenergic receptor, alpha 1b	0.012
Lin7b	lin-7 homolog B (C. elegans)	0.012
Ccbp2	chemokine binding protein 2	0.012
Hipk2	homeodomain interacting protein kinase 2	0.012
Rarg	retinoic acid receptor, gamma	0.012
Etl4	enhancer trap locus 4	0.012
Rpl13	ribosomal protein L13	0.011
Gnao1	guanine nucleotide binding protein, alpha O	0.011
Poli	polymerase (DNA directed), iota	0.011
Zfp358	zinc finger protein 358	0.011
Ehd2	EH-domain containing 2	0.011
Vipr2	vasoactive intestinal peptide receptor 2	0.011
Sept11	septin 11	0.011
Gja5	gap junction protein, alpha 5	0.011
St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	0.011
Itga8	integrin alpha 8	0.011
Chst2	carbohydrate sulfotransferase 2	0.011
Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	0.011
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.011
Nkd1	naked cuticle 1 homolog (Drosophila)	0.011
Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.011
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.011
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.011
Nbr1	neighbor of Brca1 gene 1	0.011
Cldn5	claudin 5	0.011
Wwc1	WW, C2 and coiled-coil domain containing 1	0.010
Ppp4r4	protein phosphatase 4, regulatory subunit 4	0.010
Gpc3	glypican 3	0.010
Dab1	disabled homolog 1 (Drosophila)	0.010
Myct1	myc target 1	0.010
Pcdhb13	protocadherin beta 13	0.010
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.010
Colec12	collectin sub-family member 12	0.010
Sema3e	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.010
S1pr1	sphingosine-1-phosphate receptor 1	0.010
Flrt2	fibronectin leucine rich transmembrane protein 2	0.010
Tspan18	tetraspanin 18	0.010
Cnr1	cannabinoid receptor 1 (brain)	0.010