IMP

Process View

Mus musculus

3 genes annotated in mouse

positive regulation of hh target transcription factor activity

Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of hh target transcription factor activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of hh target transcription factor activity" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Sox9	SRY-box containing gene 9	0.996
Bmp4	bone morphogenetic protein 4	0.994
Foxc1	forkhead box C1	0.988
Gli2	GLI-Kruppel family member GLI2	0.978
Bmp7	bone morphogenetic protein 7	0.976
Tcfap2a	transcription factor AP-2, alpha	0.961
Ctnnb1	catenin (cadherin associated protein), beta 1	0.920
Zeb1	zinc finger E-box binding homeobox 1	0.913
Fgfr3	fibroblast growth factor receptor 3	0.900
Pax3	paired box gene 3	0.896
Chrd	chordin	0.880
Msx1	homeobox, msh-like 1	0.879
Pax2	paired box gene 2	0.868
Otx2	orthodenticle homolog 2 (Drosophila)	0.864
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.837
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.819
Fgfr1	fibroblast growth factor receptor 1	0.798
Eya1	eyes absent 1 homolog (Drosophila)	0.797
Foxc2	forkhead box C2	0.794
Fgf8	fibroblast growth factor 8	0.771
Prrx1	paired related homeobox 1	0.760
Hand1	heart and neural crest derivatives expressed transcript 1	0.670
Tgfb2	transforming growth factor, beta 2	0.643
Pitx2	paired-like homeodomain transcription factor 2	0.555
Shh	sonic hedgehog	0.553
Dlx5	distal-less homeobox 5	0.544
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.523
Foxg1	forkhead box G1	0.466
Rarg	retinoic acid receptor, gamma	0.435
Ptch1	patched homolog 1	0.395
Rarb	retinoic acid receptor, beta	0.394
Runx2	runt related transcription factor 2	0.392
Lrp6	low density lipoprotein receptor-related protein 6	0.365
Isl1	ISL1 transcription factor, LIM/homeodomain	0.362
Hand2	heart and neural crest derivatives expressed transcript 2	0.332
Col2a1	collagen, type II, alpha 1	0.304
Kdm2b	lysine (K)-specific demethylase 2B	0.294
Tbx1	T-box 1	0.282
Ednra	endothelin receptor type A	0.263
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.263
Nog	noggin	0.243
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.241
Chd7	chromodomain helicase DNA binding protein 7	0.215
Msx2	homeobox, msh-like 2	0.194
Hoxa1	homeobox A1	0.194
Rnf2	ring finger protein 2	0.183
Fgf10	fibroblast growth factor 10	0.178
Bmp2	bone morphogenetic protein 2	0.176
Pthlh	parathyroid hormone-like peptide	0.170
Rxra	retinoid X receptor alpha	0.167
Gata4	GATA binding protein 4	0.145
Pten	phosphatase and tensin homolog	0.143
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.136
Gbx2	gastrulation brain homeobox 2	0.124
Emx2	empty spiracles homolog 2 (Drosophila)	0.122
Nf1	neurofibromatosis 1	0.112
Vangl2	vang-like 2 (van gogh, Drosophila)	0.110
Disp1	dispatched homolog 1 (Drosophila)	0.102
Sox4	SRY-box containing gene 4	0.100
Fgf9	fibroblast growth factor 9	0.093
Ar	androgen receptor	0.080
Otx1	orthodenticle homolog 1 (Drosophila)	0.078
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.074
Rara	retinoic acid receptor, alpha	0.073
Hes1	hairy and enhancer of split 1 (Drosophila)	0.071
Apc	adenomatosis polyposis coli	0.066
Clcnka	chloride channel Ka	0.063
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.060
Hoxa2	homeobox A2	0.059
Vegfa	vascular endothelial growth factor A	0.056
En1	engrailed 1	0.055
Lrp2	low density lipoprotein receptor-related protein 2	0.055
Ihh	Indian hedgehog	0.055	Mouse Fly
Lhx1	LIM homeobox protein 1	0.055
Sox11	SRY-box containing gene 11	0.050
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.048
Foxa2	forkhead box A2	0.047
Jag1	jagged 1	0.046
Kif3a	kinesin family member 3A	0.045
Mn1	meningioma 1	0.043
Pitx1	paired-like homeodomain transcription factor 1	0.041
Sox2	SRY-box containing gene 2	0.040
Rb1	retinoblastoma 1	0.039
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.038
Kdm1a	lysine (K)-specific demethylase 1A	0.036
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.035
Prrx2	paired related homeobox 2	0.035
Gja1	gap junction protein, alpha 1	0.034
Meox2	mesenchyme homeobox 2	0.034
Hoxb3	homeobox B3	0.033
Ece1	endothelin converting enzyme 1	0.032
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.031
Wnt5a	wingless-related MMTV integration site 5A	0.031
Bmper	BMP-binding endothelial regulator	0.031
Lef1	lymphoid enhancer binding factor 1	0.030
Npr2	natriuretic peptide receptor 2	0.029
Alx1	ALX homeobox 1	0.029
Alx4	aristaless-like homeobox 4	0.029
Smo	smoothened homolog (Drosophila)	0.029
Pbx1	pre B-cell leukemia transcription factor 1	0.029
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.028
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.027
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.026
Nodal	nodal	0.026
Ret	ret proto-oncogene	0.026
Efnb2	ephrin B2	0.026
Sall4	sal-like 4 (Drosophila)	0.025
Nkx3-2	NK3 homeobox 2	0.025
Set	SET nuclear oncogene	0.025
Slc22a18	solute carrier family 22 (organic cation transporter), member 18	0.023
Gsc	goosecoid homeobox	0.023
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.023
Trp63	transformation related protein 63	0.023
Tgfbr2	transforming growth factor, beta receptor II	0.023
Acvr1	activin A receptor, type 1	0.022
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.022
Foxi3	forkhead box I3	0.022
Trp53	transformation related protein 53	0.021
Bcor	BCL6 interacting corepressor	0.021
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.020
Tcte2	t-complex-associated testis expressed 2	0.020
Psen1	presenilin 1	0.020
Fzd8	frizzled homolog 8 (Drosophila)	0.019
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.019
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.019
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.018
Hoxa3	homeobox A3	0.018
Irf2bp1	interferon regulatory factor 2 binding protein 1	0.018
Prkar2b	protein kinase, cAMP dependent regulatory, type II beta	0.018
Hoxa5	homeobox A5	0.017
Lgals2	lectin, galactose-binding, soluble 2	0.017
Gata3	GATA binding protein 3	0.017
Tbx15	T-box 15	0.016
Zc3h18	zinc finger CCCH-type containing 18	0.016
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.016
Gm13290	predicted gene 13290	0.016
Spry4	sprouty homolog 4 (Drosophila)	0.016
Tcf21	transcription factor 21	0.016
Apln	apelin	0.016
Rdh10	retinol dehydrogenase 10 (all-trans)	0.016
Pax6	paired box gene 6	0.015
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.015
Ttc3	tetratricopeptide repeat domain 3	0.015
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.015
Fgfrl1	fibroblast growth factor receptor-like 1	0.015
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.014
Hoxd13	homeobox D13	0.014
Wt1	Wilms tumor 1 homolog	0.014
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.014
Crebbp	CREB binding protein	0.013
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.013
Aes	amino-terminal enhancer of split	0.013
Hoxb6	homeobox B6	0.013
Homer1	homer homolog 1 (Drosophila)	0.013
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.013
Tcp11	t-complex protein 11	0.013
Itga3	integrin alpha 3	0.012
Sox13	SRY-box containing gene 13	0.012
Pkdcc	protein kinase domain containing, cytoplasmic	0.012
Foxo4	forkhead box O4	0.012
Tgfa	transforming growth factor alpha	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Axin2	axin2	0.012
Plekha5	pleckstrin homology domain containing, family A member 5	0.012
Gsk3b	glycogen synthase kinase 3 beta	0.012
Wdr19	WD repeat domain 19	0.012
Src	Rous sarcoma oncogene	0.012
Hoxd11	homeobox D11	0.011
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
Add1	adducin 1 (alpha)	0.011
Ctbp1	C-terminal binding protein 1	0.011
Esr1	estrogen receptor 1 (alpha)	0.011
Pkd1	polycystic kidney disease 1 homolog	0.011
Cldn2	claudin 2	0.011
Tert	telomerase reverse transcriptase	0.011
Npepps	aminopeptidase puromycin sensitive	0.011
Srcrb4d	scavenger receptor cysteine rich domain containing, group B (4 domains)	0.011
Cbx3	chromobox homolog 3 (Drosophila HP1 gamma)	0.011
Rac1	RAS-related C3 botulinum substrate 1	0.010
Gata5	GATA binding protein 5	0.010
Tbx3	T-box 3	0.010
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.010