IMP
Process View
melanin metabolic process
The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "melanin metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Tyr | tyrosinase | 0.999 | ||
| Lyst | lysosomal trafficking regulator | 0.995 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.982 | ||
| Mitf | microphthalmia-associated transcription factor | 0.977 | ||
| Pomc | pro-opiomelanocortin-alpha | 0.743 | ||
| Kit | kit oncogene | 0.707 | ||
| Tyrp1 | tyrosinase-related protein 1 | 0.630 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.619 | ||
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.613 | ||
| Ephb2 | Eph receptor B2 | 0.471 | Fly | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.456 | ||
| Rac1 | RAS-related C3 botulinum substrate 1 | 0.445 | Fly | |
| Erbb2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.410 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.313 | ||
| Pycard | PYD and CARD domain containing | 0.242 | ||
| Ltb | lymphotoxin B | 0.236 | ||
| Bax | BCL2-associated X protein | 0.197 | Mouse | |
| Oca2 | oculocutaneous albinism II | 0.196 | ||
| Mapk8ip3 | mitogen-activated protein kinase 8 interacting protein 3 | 0.180 | ||
| Pak1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.178 | ||
| Trp53 | transformation related protein 53 | 0.172 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.162 | ||
| Bak1 | BCL2-antagonist/killer 1 | 0.158 | Mouse | |
| Tlr4 | toll-like receptor 4 | 0.146 | ||
| Mlph | melanophilin | 0.141 | ||
| Cd19 | CD19 antigen | 0.136 | ||
| Grb2 | growth factor receptor bound protein 2 | 0.131 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.099 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.092 | Fly | |
| Socs1 | suppressor of cytokine signaling 1 | 0.084 | ||
| Tnf | tumor necrosis factor | 0.080 | Fly | |
| Il7 | interleukin 7 | 0.077 | ||
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.076 | ||
| Cdc42 | cell division cycle 42 homolog (S. cerevisiae) | 0.075 | Fly | |
| Gbp5 | guanylate binding protein 5 | 0.075 | ||
| Il1b | interleukin 1 beta | 0.074 | ||
| Arhgap1 | Rho GTPase activating protein 1 | 0.072 | ||
| Src | Rous sarcoma oncogene | 0.071 | ||
| Efnb2 | ephrin B2 | 0.069 | ||
| Slc26a4 | solute carrier family 26, member 4 | 0.058 | ||
| Msn | moesin | 0.055 | ||
| Hps1 | Hermansky-Pudlak syndrome 1 homolog (human) | 0.053 | ||
| a | nonagouti | 0.052 | ||
| Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) | 0.049 | ||
| Efna3 | ephrin A3 | 0.048 | ||
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.045 | Fly | |
| Adam10 | a disintegrin and metallopeptidase domain 10 | 0.044 | ||
| Epha4 | Eph receptor A4 | 0.042 | Fly | |
| Pmel | premelanosome protein | 0.041 | ||
| Ifng | interferon gamma | 0.040 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.039 | ||
| Pmaip1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.039 | ||
| Tox | thymocyte selection-associated high mobility group box | 0.038 | ||
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.034 | ||
| Rab38 | RAB38, member of RAS oncogene family | 0.034 | ||
| Grin2b | glutamate receptor, ionotropic, NMDA2B (epsilon 2) | 0.032 | ||
| Atp7a | ATPase, Cu++ transporting, alpha polypeptide | 0.032 | ||
| Rnd3 | Rho family GTPase 3 | 0.031 | ||
| Efnb1 | ephrin B1 | 0.031 | ||
| Casp1 | caspase 1 | 0.030 | Fly | |
| Eda | ectodysplasin-A | 0.030 | ||
| Myo5a | myosin VA | 0.029 | ||
| Icos | inducible T-cell co-stimulator | 0.028 | ||
| Wdr1 | WD repeat domain 1 | 0.027 | ||
| Mapk10 | mitogen-activated protein kinase 10 | 0.026 | Fly | |
| Iqgap1 | IQ motif containing GTPase activating protein 1 | 0.026 | ||
| Ccdc88a | coiled coil domain containing 88A | 0.026 | ||
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.025 | ||
| Slc24a5 | solute carrier family 24, member 5 | 0.024 | ||
| Rho | rhodopsin | 0.024 | ||
| Il4 | interleukin 4 | 0.023 | ||
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.023 | ||
| Pstpip1 | proline-serine-threonine phosphatase-interacting protein 1 | 0.022 | ||
| Mapk8 | mitogen-activated protein kinase 8 | 0.022 | Fly | |
| Il18 | interleukin 18 | 0.021 | ||
| Slc45a2 | solute carrier family 45, member 2 | 0.021 | ||
| Tmpo | thymopoietin | 0.021 | ||
| Klc1 | kinesin light chain 1 | 0.021 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.021 | ||
| Nf1 | neurofibromatosis 1 | 0.020 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.020 | ||
| Krt2 | keratin 2 | 0.020 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.019 | ||
| Ltbr | lymphotoxin B receptor | 0.019 | ||
| Mc1r | melanocortin 1 receptor | 0.019 | ||
| Krt33b | keratin 33B | 0.018 | ||
| Prkce | protein kinase C, epsilon | 0.018 | ||
| Crb2 | crumbs homolog 2 (Drosophila) | 0.017 | ||
| Ephb3 | Eph receptor B3 | 0.017 | Fly | |
| Gata6 | GATA binding protein 6 | 0.016 | ||
| Drd4 | dopamine receptor D4 | 0.015 | ||
| Ednrb | endothelin receptor type B | 0.015 | ||
| Ptpn12 | protein tyrosine phosphatase, non-receptor type 12 | 0.015 | ||
| Gata4 | GATA binding protein 4 | 0.015 | ||
| Id2 | inhibitor of DNA binding 2 | 0.015 | ||
| Ikzf3 | IKAROS family zinc finger 3 | 0.014 | ||
| Ncf1 | neutrophil cytosolic factor 1 | 0.014 | ||
| Plxna4 | plexin A4 | 0.014 | ||
| Sav1 | salvador homolog 1 (Drosophila) | 0.013 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.013 | ||
| Il2rg | interleukin 2 receptor, gamma chain | 0.013 | ||
| Itga3 | integrin alpha 3 | 0.013 | ||
| Pxn | paxillin | 0.013 | ||
| Kcns2 | K+ voltage-gated channel, subfamily S, 2 | 0.013 | ||
| Mysm1 | myb-like, SWIRM and MPN domains 1 | 0.012 | ||
| Tcf3 | transcription factor 3 | 0.012 | ||
| Mobkl1b | MOB1, Mps One Binder kinase activator-like 1B (yeast) | 0.012 | ||
| Vegfa | vascular endothelial growth factor A | 0.012 | ||
| Mapk14 | mitogen-activated protein kinase 14 | 0.012 | ||
| Vcl | vinculin | 0.012 | ||
| Sema3f | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 0.012 | ||
| Gpr12 | G-protein coupled receptor 12 | 0.012 | ||
| Akr1c6 | aldo-keto reductase family 1, member C6 | 0.012 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.012 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.012 | ||
| Kitl | kit ligand | 0.012 | ||
| Lepr | leptin receptor | 0.011 | ||
| Chrm5 | cholinergic receptor, muscarinic 5 | 0.011 | ||
| Foxo4 | forkhead box O4 | 0.011 | ||
| Psen1 | presenilin 1 | 0.011 | ||
| Cdsn | corneodesmosin | 0.011 | ||
| Map1lc3a | microtubule-associated protein 1 light chain 3 alpha | 0.010 | ||
| Cryaa | crystallin, alpha A | 0.010 | ||
| Aim2 | absent in melanoma 2 | 0.010 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.010 |